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Mechanistically based blood proteomic markers in the TGF-β pathway stratify risk of hepatocellular cancer in patients with cirrhosis.
Xiang X, Bhowmick K, Shetty K, Ohshiro K, Yang X, Wong LL, Yu H, Latham PS, Satapathy SK, Brennan C, Dima RJ, Chambwe N, Sharifova G, Cacaj F, John S, Crawford JM, Huang H, Dasarathy S, Krainer AR, He AR, Amdur RL, Mishra L. Xiang X, et al. Among authors: dasarathy s. Genes Cancer. 2024 Feb 1;15:1-14. doi: 10.18632/genesandcancer.234. eCollection 2024. Genes Cancer. 2024. PMID: 38323119 Free PMC article.
Aldehydes alter TGF-β signaling and induce obesity and cancer.
Yang X, Bhowmick K, Rao S, Xiang X, Ohshiro K, Amdur RL, Hassan MI, Mohammad T, Crandall K, Cifani P, Shetty K, Lyons SK, Merrill JR, Vegesna AK, John S, Latham PS, Crawford JM, Mishra B, Dasarathy S, Wang XW, Yu H, Wang Z, Huang H, Krainer AR, Mishra L. Yang X, et al. Among authors: dasarathy s. Cell Rep. 2024 Sep 24;43(9):114676. doi: 10.1016/j.celrep.2024.114676. Epub 2024 Aug 31. Cell Rep. 2024. PMID: 39217614 Free article.
Fibrosis Progression Rate in Biopsy-Proven Nonalcoholic Fatty Liver Disease Among People With Diabetes Versus People Without Diabetes: A Multicenter Study.
Huang DQ, Wilson LA, Behling C, Kleiner DE, Kowdley KV, Dasarathy S, Amangurbanova M, Terrault NA, Diehl AM, Chalasani N, Neuschwander-Tetri BA, Sanyal AJ, Tonascia J; NASH Clinical Research Network; Loomba R. Huang DQ, et al. Among authors: dasarathy s. Gastroenterology. 2023 Aug;165(2):463-472.e5. doi: 10.1053/j.gastro.2023.04.025. Epub 2023 Apr 29. Gastroenterology. 2023. PMID: 37127100 Free PMC article.
Evidence that extracellular HSPB1 contributes to inflammation in alcohol-associated hepatitis.
Overstreet AC, Burge M, Bellar A, McMullen M, Czarnecki D, Huang E, Pathak V, Finney C, Vij R, Dasarathy S, Dasarathy J, Streem D, Welch N, Rotroff D, Schmitt AM, Nagy LE, Messer JS. Overstreet AC, et al. Among authors: dasarathy s. medRxiv [Preprint]. 2024 Sep 6:2024.09.06.24313193. doi: 10.1101/2024.09.06.24313193. medRxiv. 2024. PMID: 39281760 Free PMC article. Preprint.
In vivo Bruton's tyrosine kinase inhibition attenuates alcohol-associated liver disease by regulating CD84-mediated granulopoiesis.
Nagesh PT, Cho Y, Zhuang Y, Babuta M, Ortega-Ribera M, Joshi R, Brezani V, Patel A, Datta AA, Brezani V, Hsieh YC, Ramos A, Mehta J, Copeland C, Kanata E, Jiang ZG, Vlachos I, Asara J; AlcHepNet Consortium; Szabo G. Nagesh PT, et al. Sci Transl Med. 2024 Aug 7;16(759):eadg1915. doi: 10.1126/scitranslmed.adg1915. Epub 2024 Aug 7. Sci Transl Med. 2024. PMID: 39110779
315 results