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Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2.
PLoS Biol. 2009 Feb 10;7(2):e38. doi: 10.1371/journal.pbio.1000038.
PLoS Biol. 2009.
PMID: 19209957
Free PMC article.
Discovery of drug-resistant and drug-sensitizing mutations in the oncogenic PI3K isoform p110 alpha.
Zunder ER, Knight ZA, Houseman BT, Apsel B, Shokat KM.
Zunder ER, et al. Among authors: apsel b.
Cancer Cell. 2008 Aug 12;14(2):180-92. doi: 10.1016/j.ccr.2008.06.014.
Cancer Cell. 2008.
PMID: 18691552
Free PMC article.
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Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases.
Apsel B, Blair JA, Gonzalez B, Nazif TM, Feldman ME, Aizenstein B, Hoffman R, Williams RL, Shokat KM, Knight ZA.
Apsel B, et al.
Nat Chem Biol. 2008 Nov;4(11):691-9. doi: 10.1038/nchembio.117. Epub 2008 Oct 12.
Nat Chem Biol. 2008.
PMID: 18849971
Free PMC article.
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Discovery of trypanocidal compounds by whole cell HTS of Trypanosoma brucei.
Mackey ZB, Baca AM, Mallari JP, Apsel B, Shelat A, Hansell EJ, Chiang PK, Wolff B, Guy KR, Williams J, McKerrow JH.
Mackey ZB, et al. Among authors: apsel b.
Chem Biol Drug Des. 2006 May;67(5):355-63. doi: 10.1111/j.1747-0285.2006.00389.x.
Chem Biol Drug Des. 2006.
PMID: 16784460
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Regulation of metalloproteinases and NF-kappaB activation in rabbit synovial fibroblasts via E prostaglandins and Erk: contrasting effects of nabumetone and 6MNA.
Pillinger MH, Dinsell V, Apsel B, Tolani SN, Marjanovic N, Chan ES, Gomez P, Clancy R, Chang LF, Abramson SB.
Pillinger MH, et al. Among authors: apsel b.
Br J Pharmacol. 2004 Jul;142(6):973-82. doi: 10.1038/sj.bjp.0705864. Epub 2004 Jun 21.
Br J Pharmacol. 2004.
PMID: 15210577
Free PMC article.
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Cyclooxygenase-2-derived E prostaglandins down-regulate matrix metalloproteinase-1 expression in fibroblast-like synoviocytes via inhibition of extracellular signal-regulated kinase activation.
Pillinger MH, Rosenthal PB, Tolani SN, Apsel B, Dinsell V, Greenberg J, Chan ES, Gomez PF, Abramson SB.
Pillinger MH, et al. Among authors: apsel b.
J Immunol. 2003 Dec 1;171(11):6080-9. doi: 10.4049/jimmunol.171.11.6080.
J Immunol. 2003.
PMID: 14634122
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