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Melton, 2010 - Google Patents

Opposing microRNAs Regulate Mouse Embryonic Stem Cell Self-Renewal

Melton, 2010

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Document ID
9937376550104964838
Author
Melton C
Publication year

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When an embryonic stem cell (ESC) differentiates, it must both silence the ESC self-renewal program as well as activate new tissue-specific programs. In the absence of DGCR8, a protein required for microRNA (miRNA) biogenesis, mouse ESCs are unable to silence the …
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • C12N2310/141—MicroRNAs, miRNAs
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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