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German et al., 2010 - Google Patents

Leptin deficiency causes insulin resistance induced by uncontrolled diabetes

German et al., 2010

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Document ID
7758242973826525802
Author
German J
Wisse B
Thaler J
Oh-I S
Sarruf D
Ogimoto K
Kaiyala K
Fischer J
Matsen M
Taborsky Jr G
Schwartz M
Morton G
Publication year
Publication venue
Diabetes

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OBJECTIVE Depletion of body fat stores during uncontrolled, insulin-deficient diabetes (uDM) results in markedly reduced plasma leptin levels. This study investigated the role of leptin deficiency in the genesis of severe insulin resistance and related metabolic and …
Continue reading at diabetesjournals.org (HTML) (other versions)

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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
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