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Choong et al., 2003 - Google Patents

A novel role for proliferin-2 in the ex vivo expansion of hematopoietic stem cells

Choong et al., 2003

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Document ID
4162103875018865695
Author
Choong M
Tan A
Luo B
Lodish H
Publication year
Publication venue
FEBS letters

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Snippet

A family of proliferin genes was discovered on a microarray analysis of hematopoiesis supportive stromal cell lines. Proliferin-2 (PLF2) increased the frequency of long-term culture- initiating cells (LTC-IC) from 1 in 340 to 1 in 256 of the primary hematopoietic stem cell …
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    • C—CHEMISTRY; METALLURGY
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    • C12N—MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues ; Not used, see subgroups
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues ; Not used, see subgroups
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    • C12N5/0619—Neurons
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • G01—MEASURING; TESTING
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