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Mahoney et al., 2021 - Google Patents

Evaluation of sex-aware PrediXcan models for predicting gene expression

Mahoney et al., 2021

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Document ID
2915286767810782523
Author
Mahoney E
Janve V
Hohman T
Dumitrescu L
Publication year
Publication venue
PACIFIC SYMPOSIUM ON BIOCOMPUTING 2022

External Links

Snippet

Gene-based methods such as PrediXcan use expression quantitative trait loci to build tissue- specific gene expression models when only genetic data is available. There are known sex differences in tissue-specific gene expression and in the genetic architecture of gene …
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Classifications

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    • G06F19/18Bioinformatics, i.e. methods or systems for genetic or protein-related data processing in computational molecular biology for functional genomics or proteomics, e.g. genotype-phenotype associations, linkage disequilibrium, population genetics, binding site identification, mutagenesis, genotyping or genome annotation, protein-protein interactions or protein-nucleic acid interactions
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    • G06F19/22Bioinformatics, i.e. methods or systems for genetic or protein-related data processing in computational molecular biology for sequence comparison involving nucleotides or amino acids, e.g. homology search, motif or SNP [Single-Nucleotide Polymorphism] discovery or sequence alignment
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    • G06F19/20Bioinformatics, i.e. methods or systems for genetic or protein-related data processing in computational molecular biology for hybridisation or gene expression, e.g. microarrays, sequencing by hybridisation, normalisation, profiling, noise correction models, expression ratio estimation, probe design or probe optimisation
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    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or micro-organisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or micro-organisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
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    • CCHEMISTRY; METALLURGY
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    • C12Q1/6802General aspects
    • C12Q1/6809Sequence identification involving differential detection

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