[go: up one dir, main page]

Mével et al., 2016 - Google Patents

Important role of phosphoramido linkage in imidazole‐based dioleyl helper lipids for liposome stability and primary cell transfection

Mével et al., 2016

Document ID
11854800683074741698
Author
Mével M
Haudebourg T
Colombani T
Peuziat P
Dallet L
Chatin B
Lambert O
Berchel M
Montier T
Jaffrès P
Lehn P
Pitard B
Publication year
Publication venue
The journal of gene medicine

External Links

Snippet

Background To optimize synthetic gene delivery systems, there is a need to develop more efficient lipid formulations. Most cationic lipid formulations contain 'helper'neutral lipids because of their ability to increase DNA delivery, in particular by improving endosomal …
Continue reading at onlinelibrary.wiley.com (other versions)

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/87Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using micro-encapsulation, e.g. using amphiphile liposome vesicle
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/127Liposomes
    • A61K9/1271Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1272Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
    • A61K47/48Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
    • A61K47/48769Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates the conjugate being characterized by a special physical or galenical form
    • A61K47/48792Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates the conjugate being characterized by a special physical or galenical form the form being a colloid, emulsion, i.e. having at least a dispersed/continuous oil phase and a dispersed/continuous aqueous phase, dispersion or suspension
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51Nanocapsules; Nanoparticles
    • A61K9/5107Excipients; Inactive ingredients

Similar Documents

Publication Publication Date Title
Mével et al. Important role of phosphoramido linkage in imidazole‐based dioleyl helper lipids for liposome stability and primary cell transfection
Rodik et al. Virus‐sized DNA nanoparticles for gene delivery based on micelles of cationic calixarenes
Luo et al. A strategy to improve serum-tolerant transfection activity of polycation vectors by surface hydroxylation
US5908777A (en) Lipidic vector for nucleic acid delivery
Yuba et al. Effect of unsaturated alkyl chains on transfection activity of poly (amidoamine) dendron-bearing lipids
EP2532649B1 (en) Amino lipids, their synthesis and uses thereof
Rao et al. Cell biological and biophysical aspects of lipid-mediated gene delivery
US20030166601A1 (en) Novel colloid synthetic vectors for gene therapy
Colombani et al. Self-assembling complexes between binary mixtures of lipids with different linkers and nucleic acids promote universal mRNA, DNA and siRNA delivery
Thalmayr et al. Molecular chameleon carriers for nucleic acid delivery: the sweet spot between lipoplexes and polyplexes
Kono et al. Polyamidoamine dendron-bearing lipids as a nonviral vector: influence of dendron generation
Mével et al. Paromomycin and neomycin B derived cationic lipids: synthesis and transfection studies
Kumar et al. Enhanced gene transfection efficiency by polyamidoamine (PAMAM) dendrimers modified with ornithine residues
Gonçalves et al. Intracellular availability of pDNA and mRNA after transfection: A comparative study among polyplexes, lipoplexes, and lipopolyplexes
Mahato et al. Tetramethylguanidinium‐polyallylamine (Tmg‐PA): a new class of nonviral vector for efficient gene transfection
Arabzadeh et al. Design, synthesis, and in vitro evaluation of low molecular weight protamine (LMWP)-based amphiphilic conjugates as gene delivery carriers
Mignet et al. Anionic pH-sensitive pegylated lipoplexes to deliver DNA to tumors
Gopal et al. Synthesis and transfection efficiency of cationic oligopeptide lipids: role of linker
Prevette et al. Polycation-induced cell membrane permeability does not enhance cellular uptake or expression efficiency of delivered DNA
Sakaguchi et al. The correlation between fusion capability and transfection activity in hybrid complexes of lipoplexes and pH-sensitive liposomes
Ahmed et al. Varying the Unsaturation in N 4, N 9-Dioctadecanoyl Spermines: Nonviral Lipopolyamine Vectors for More Efficient Plasmid DNA Formulation: Ahmed, Pourzand, and Blagbrough
Gosangi et al. Effects of heterocyclic-based head group modifications on the structure–activity relationship of tocopherol-based lipids for non-viral gene delivery
Røise et al. Acid-sensitive surfactants enhance the delivery of nucleic acids
Gabrielson et al. Multiplexed supramolecular self-assembly for non-viral gene delivery
Marin et al. Dynameric frameworks for DNA transfection