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Zhang et al., 2018 - Google Patents

YL143, a novel mutant selective irreversible EGFR inhibitor, overcomes EGFRL858R, T790M‐mutant resistance in vitro and in vivo

Zhang et al., 2018

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Document ID
11023787930314221302
Author
Zhang Z
Zou J
Yu L
Luo J
Li Y
Tu Z
Ren X
Wei H
Song L
Lu X
Ding K
Publication year
Publication venue
Cancer Medicine

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Snippet

YL143 was identified as a novel wild‐type sparing EGFRT790M inhibitor with good pharmacokinetic properties. It potently suppresses EGFRL858R/T790M with an 50% inhibitory concentration (IC50) value of 2.0±0.3 nmol/L, but is approximately 92‐folds less …
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