[go: up one dir, main page]

ZA200005797B - Imidazo pyridine derivatives which inhibit gastric acid secretion. - Google Patents

Imidazo pyridine derivatives which inhibit gastric acid secretion. Download PDF

Info

Publication number
ZA200005797B
ZA200005797B ZA200005797A ZA200005797A ZA200005797B ZA 200005797 B ZA200005797 B ZA 200005797B ZA 200005797 A ZA200005797 A ZA 200005797A ZA 200005797 A ZA200005797 A ZA 200005797A ZA 200005797 B ZA200005797 B ZA 200005797B
Authority
ZA
South Africa
Prior art keywords
compound
formula
carboxamide
pyridine
dimethyl
Prior art date
Application number
ZA200005797A
Other languages
English (en)
Inventor
Kosrat Amin
Michael Dahlstroem
Peter Nordberg
Ingemar Starke
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of ZA200005797B publication Critical patent/ZA200005797B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ZA200005797A 1998-04-29 2000-10-18 Imidazo pyridine derivatives which inhibit gastric acid secretion. ZA200005797B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9801526A SE9801526D0 (sv) 1998-04-29 1998-04-29 New compounds

Publications (1)

Publication Number Publication Date
ZA200005797B true ZA200005797B (en) 2002-01-18

Family

ID=20411154

Family Applications (2)

Application Number Title Priority Date Filing Date
ZA200005796A ZA200005796B (en) 1998-04-29 2000-10-18 Imidazo pyridine derivatives which inhibit gastric acid secretion.
ZA200005797A ZA200005797B (en) 1998-04-29 2000-10-18 Imidazo pyridine derivatives which inhibit gastric acid secretion.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ZA200005796A ZA200005796B (en) 1998-04-29 2000-10-18 Imidazo pyridine derivatives which inhibit gastric acid secretion.

Country Status (34)

Country Link
US (2) US6313136B1 (hu)
EP (4) EP1491543B1 (hu)
JP (2) JP3883383B2 (hu)
KR (3) KR100650472B1 (hu)
CN (2) CN1165535C (hu)
AR (2) AR015769A1 (hu)
AT (4) ATE372339T1 (hu)
AU (2) AU769190B2 (hu)
BR (2) BR9909995B1 (hu)
CA (2) CA2329922C (hu)
CZ (2) CZ292567B6 (hu)
DE (4) DE69927803T2 (hu)
DK (2) DK1073657T3 (hu)
EE (2) EE04916B1 (hu)
ES (2) ES2252975T3 (hu)
HK (5) HK1033457A1 (hu)
HU (2) HUP0102313A3 (hu)
ID (2) ID27530A (hu)
IL (4) IL139297A0 (hu)
IS (2) IS5683A (hu)
MY (2) MY121379A (hu)
NO (2) NO317262B1 (hu)
NZ (2) NZ507638A (hu)
PL (2) PL195000B1 (hu)
RU (2) RU2235725C2 (hu)
SA (2) SA99200065B1 (hu)
SE (1) SE9801526D0 (hu)
SI (1) SI1073656T1 (hu)
SK (2) SK285768B6 (hu)
TR (4) TR200102728T2 (hu)
TW (2) TWI250159B (hu)
UA (2) UA66846C2 (hu)
WO (2) WO1999055706A1 (hu)
ZA (2) ZA200005796B (hu)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6489346B1 (en) 1996-01-04 2002-12-03 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
US5840737A (en) 1996-01-04 1998-11-24 The Curators Of The University Of Missouri Omeprazole solution and method for using same
SE9802794D0 (sv) * 1998-08-21 1998-08-21 Astra Ab New compounds
US6900324B2 (en) 2000-09-07 2005-05-31 Astrazeneca Ab Process for preparing a substituted imidazopyridine compound
SE0003186D0 (sv) * 2000-09-07 2000-09-07 Astrazeneca Ab New process
UA80393C2 (uk) 2000-12-07 2007-09-25 Алтана Фарма Аг Фармацевтична композиція, яка містить інгібітор фде 4, диспергований в матриці
SE0100295D0 (sv) * 2001-02-01 2001-02-01 Astrazeneca Ab New compounds
SE0100296D0 (sv) * 2001-02-01 2001-02-01 Astrazeneca Ab New compounds
SE0100297D0 (sv) * 2001-02-01 2001-02-01 Astrazeneca Ab New compounds
DE60211130T2 (de) * 2001-02-13 2006-11-30 Astrazeneca Ab Neue formulierung mit modifizierter freisetzung
SK10982003A3 (sk) * 2001-03-08 2004-02-03 Astrazeneca Ab Nové použitie
SE0102808D0 (sv) * 2001-08-22 2001-08-22 Astrazeneca Ab New compounds
MY140561A (en) 2002-02-20 2009-12-31 Nycomed Gmbh Dosage form containing pde 4 inhibitor as active ingredient
SE0201940D0 (sv) * 2002-06-20 2002-06-20 Astrazeneca Ab New combination II
SE0201939D0 (sv) * 2002-06-20 2002-06-20 Astrazeneca Ab New combination
WO2004026867A2 (en) 2002-09-19 2004-04-01 Schering Corporation Imidazopyridines as cyclin dependent kinase inhibitors
RS20050377A (en) 2002-11-19 2007-11-15 Altana Pharma Ag., 8-substituted imidazopyridines
AR043002A1 (es) * 2003-02-18 2005-07-13 Altana Pharma Ag Imidazopirazinas 6-substituidos
MEP52808A (en) * 2003-02-26 2011-05-10 Sugen Inc Aminoheteroaryl compounds as protein kinase inhibitors
KR101179012B1 (ko) 2003-03-10 2012-09-03 니코메드 게엠베하 로플루미라스트 신규한 제조 방법
SE525349C2 (sv) * 2003-06-23 2005-02-08 Volvo Penta Ab Utombordsdrev för båtar
SE0301903D0 (sv) * 2003-06-26 2003-06-26 Astrazeneca Ab Novel imidazopyridine compound III with therapeutic effect
SE0301905D0 (sv) * 2003-06-26 2003-06-26 Astrazeneca Ab Novel imidazopyridine compound I with therapeutic effect
SE0301904D0 (sv) * 2003-06-26 2003-06-26 Astrazeneca Ab Novel imidazopyridine compound II with therapeutic effect
US8993599B2 (en) 2003-07-18 2015-03-31 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US20080280944A1 (en) * 2003-11-03 2008-11-13 Paula Fernstrom Imidazo[1,2-A]Pyridine Derivatives For The Treatment Of Silent Gastro-Esophageal Reflux
SE0303451D0 (sv) * 2003-12-18 2003-12-18 Astrazeneca Ab New compounds
EP1711498A2 (en) * 2004-01-26 2006-10-18 Altana Pharma AG 1,2,4-triazolo¬1,5-a|pyridines as gastric acid secretion inhibitors
US8906940B2 (en) 2004-05-25 2014-12-09 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
BRPI0519598A2 (pt) * 2004-12-17 2009-03-10 Pfizer derivados de cromano éteis como antagonistas de bomba de Ácido, composiÇço farmacÊutica e uso dos mesmos
WO2006097456A1 (en) 2005-03-16 2006-09-21 Nycomed Gmbh Taste masked dosage form containing roflumilast
US7666880B2 (en) 2005-03-21 2010-02-23 S*Bio Pte Ltd. Imidazo[1,2-A]pyridine derivatives: preparation and pharmaceutical applications
CA2602328C (en) * 2005-03-21 2014-07-29 S*Bio Pte Ltd Imidazo[1,2-a]pyridine derivatives: preparation and pharmaceutical applications
JP2008536817A (ja) * 2005-03-24 2008-09-11 グラクソ グループ リミテッド 胃腸疾患の処置用医薬として有用なイミダゾ（１，２−ａ）ピリジン誘導体
GB0513423D0 (en) * 2005-06-30 2005-08-03 Glaxo Group Ltd Novel compounds
KR101146852B1 (ko) * 2005-12-05 2012-05-16 화이자 프로덕츠 인크. Ｃ?ｍｅｔ／ｈｇｆｒ 억제제의 다형체
KR101026676B1 (ko) * 2005-12-05 2011-04-04 화이자 프로덕츠 인코포레이티드 비정상 세포 성장의 치료 방법
MX2008011044A (es) * 2006-03-17 2008-10-09 Raqualia Pharma Inc Derivados de cromano.
JP5571380B2 (ja) 2006-07-24 2014-08-13 ルミナス バイオサイエンシズ，インコーポレイテッド オストワルド熟成を減少させた水不溶性の医薬品物質の固体ナノ粒子処方物
WO2008059373A1 (en) * 2006-11-17 2008-05-22 Raqualia Pharma Inc. Imidazo [1, 2-a] pyrazine derivatives and their use as acid pump antagonists
EP1974729A1 (en) * 2007-03-28 2008-10-01 Santhera Pharmaceuticals (Schweiz) AG Substituted imidazopyridine derivates as melanocortin- 4 receptor antagonists
US8513226B2 (en) * 2008-03-31 2013-08-20 Council Of Scientific And Industrial Research Simultaneous method for the preparation of a mixture of 3-acetoxy-17-acetamido-16-formyl-androst-5,17-diene and 3-acetoxy-2'-chloro-5-androsteno[17,16-b]pyridine
AU2014201644B2 (en) * 2008-12-03 2015-05-21 Cinclus Pharma Holding AB (publ) Imidazopyridine derivatives which inhibit the secretion of gastric acid
FI20086158A0 (fi) * 2008-12-03 2008-12-03 Mikael Dahlstroem Imidatsopyridiinijohdannaiset
US8648080B2 (en) * 2009-07-09 2014-02-11 Raqualia Pharma Inc. Acid pump antagonist for the treatment of diseases involved in abnormal gastrointestinal motility
WO2014209841A2 (en) * 2013-06-25 2014-12-31 F. Hoffmann-La Roche Ag Compounds for treating spinal muscular atrophy
CA2933811C (en) 2013-12-16 2021-02-09 Asana Biosciences, Llc P2x3 and/or p2x2/3 compounds and methods
US9464083B2 (en) * 2014-03-24 2016-10-11 Arqule Inc. Process of preparing 3-(3-(4-(1-aminocyclobutyl)phenyl)-5-phenyl-3H-imidazo[4,5-B]pyridin-2-yl)pyridin-2-amine
CN106279151A (zh) * 2015-06-26 2017-01-04 江苏太瑞生诺生物医药科技有限公司 5-(2-(8-((2,6-二甲基苄基)氨基)-2,3-二甲基咪唑并[1,2-a]吡啶-6-甲酰胺基)乙氧基)-5-氧代戊酸的固体形式及其制备方法
KR101777971B1 (ko) * 2016-07-05 2017-09-12 제일약품주식회사 이미다조[1,2-a]피리딘 유도체, 이의 제조방법 및 이의 용도
KR20190057569A (ko) * 2017-11-20 2019-05-29 제일약품주식회사 7-아미노-1h-인돌-5-카르복사미드 유도체 및 이의 용도
EP3749697A4 (en) 2018-02-05 2021-11-03 Bio-Rad Laboratories, Inc. CHROMATOGRAPHY RESIN WITH LIGAND MIXED MODE ANIONIC / HYDROPHOBIC EXCHANGE
WO2019197232A1 (de) 2018-04-10 2019-10-17 Bayer Aktiengesellschaft Verfahren zur herstellung von 2,6-dialkylphenyl-essigsäuren
RU2732297C2 (ru) * 2018-11-14 2020-09-15 Общество с ограниченной ответственностью "Гурус БиоФарм" Производные нестероидных противовоспалительных средств
JP2023500904A (ja) 2019-11-04 2023-01-11 シンクルス・ファーマ・ホールディング・アクチエボラグ Ｘ８４２の経口製剤
IL312564A (en) 2021-11-05 2024-07-01 Cinclus Pharma Holding Ab Publ Polymorphs of the hydrochloride salt of linfarezan glurate
CN118414334A (zh) 2021-11-05 2024-07-30 辛克鲁斯制药控股有限公司 （Publ） 谷氨酸利那拉生甲磺酸盐的多晶型物
KR102496869B1 (ko) * 2022-07-29 2023-02-07 제일약품주식회사 이미다조[1,2-a]피리딘 화합물의 신규 염, 이의 결정형 및 제조방법
WO2024149834A1 (en) 2023-01-11 2024-07-18 Cinclus Pharma Holding AB (publ) Polymorphs of the hydrobromide salt of linaprazan glurate
WO2024149833A1 (en) 2023-01-11 2024-07-18 Cinclus Pharma Holding AB (publ) Polymorphs of the maleic acid salt of linaprazan glurate
WO2024161317A1 (ko) * 2023-02-01 2024-08-08 제일약품주식회사 약학적 제제, 이의 제조 방법, 및 정제용 조성물

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA81219B (en) * 1980-01-23 1982-01-27 Schering Corp Imidazo (1,2-a) pyridines ,process for their preparation and pharmaceutical compositions containing them
EP0068378B1 (en) * 1981-06-26 1986-03-05 Schering Corporation Novel imidazo(1,2-a)pyridines and pyrazines, processes for their preparation and pharmaceutical compositions containing them
US4725601A (en) 1985-06-04 1988-02-16 Fujisawa Pharmaceutical Co., Ltd. Certain imidazo[1,2-a]pyridines useful in the treatment of ulcers
EP0228006A1 (en) * 1985-12-16 1987-07-08 Fujisawa Pharmaceutical Co., Ltd. Imidazopyridine compounds and processes for preparation thereof
GB8722488D0 (en) * 1987-09-24 1987-10-28 Fujisawa Pharmaceutical Co Imidazopyridine compound

Also Published As

Publication number Publication date
EE200000664A (et) 2002-04-15
EP1491542B1 (en) 2007-09-05
AR015768A1 (es) 2001-05-16
SK14912000A3 (sk) 2001-06-11
IS5684A (is) 2000-10-25
SK14922000A3 (sk) 2001-06-11
US6313136B1 (en) 2001-11-06
NO20005451D0 (no) 2000-10-27
EE04676B1 (et) 2006-08-15
RU2238271C2 (ru) 2004-10-20
KR100650472B1 (ko) 2006-11-28
DE69927803T2 (de) 2006-07-06
CZ20003982A3 (cs) 2001-02-14
TR200003149T2 (tr) 2001-03-21
ZA200005796B (en) 2002-01-18
HUP0102425A2 (hu) 2001-11-28
ATE372339T1 (de) 2007-09-15
SE9801526D0 (sv) 1998-04-29
EP1491542A3 (en) 2005-01-05
TWI250159B (en) 2006-03-01
IL139297A0 (en) 2001-11-25
DE69928792T2 (de) 2006-07-20
EP1073656B1 (en) 2005-10-19
NZ507639A (en) 2004-01-30
EE200000626A (et) 2002-04-15
WO1999055706A9 (en) 2000-03-16
NO318203B1 (no) 2005-02-14
HK1033317A1 (en) 2001-08-24
NO20005450D0 (no) 2000-10-27
CA2329922C (en) 2006-04-11
BR9909995B1 (pt) 2010-07-13
TW490466B (en) 2002-06-11
JP3692034B2 (ja) 2005-09-07
NZ507638A (en) 2003-10-31
KR20010043133A (ko) 2001-05-25
CZ293977B6 (cs) 2004-09-15
DE69937076D1 (de) 2007-10-18
CA2329922A1 (en) 1999-11-04
HUP0102425A3 (en) 2002-12-28
AU4300699A (en) 1999-11-16
CN1174980C (zh) 2004-11-10
BR9909996B1 (pt) 2010-08-24
KR20050121760A (ko) 2005-12-27
EP1491543B1 (en) 2007-09-05
EP1491543A1 (en) 2004-12-29
DK1073656T3 (da) 2006-01-16
AU769108B2 (en) 2004-01-15
EP1073657A1 (en) 2001-02-07
PL343797A1 (en) 2001-09-10
JP2002513024A (ja) 2002-05-08
IL139200A (en) 2010-04-29
US6313137B1 (en) 2001-11-06
CA2329921A1 (en) 1999-11-04
CN1307577A (zh) 2001-08-08
NO317262B1 (no) 2004-09-27
DE69928792D1 (de) 2006-01-12
PL343801A1 (en) 2001-09-10
ES2252975T3 (es) 2006-05-16
ID27530A (id) 2001-04-12
DE69937076T2 (de) 2008-05-29
SI1073656T1 (sl) 2006-02-28
CZ292567B6 (cs) 2003-10-15
TR200102728T2 (tr) 2002-06-21
SA99200064B1 (ar) 2006-10-11
UA67769C2 (uk) 2004-07-15
AR015769A1 (es) 2001-05-16
UA66846C2 (uk) 2004-06-15
ATE312101T1 (de) 2005-12-15
DE69927803D1 (de) 2006-03-02
WO1999055705A1 (en) 1999-11-04
DE69937077D1 (de) 2007-10-18
EP1073656A1 (en) 2001-02-07
HUP0102313A3 (en) 2002-10-28
BR9909996A (pt) 2000-12-26
AU4300799A (en) 1999-11-16
JP3883383B2 (ja) 2007-02-21
MY121379A (en) 2006-01-28
SA99200065B1 (ar) 2006-11-07
MY121389A (en) 2006-01-28
HK1036984A1 (en) 2002-01-25
EE04916B1 (et) 2007-10-15
CZ20003981A3 (cs) 2001-03-14
KR100595806B1 (ko) 2006-07-03
KR100595805B1 (ko) 2006-07-03
AU769190B2 (en) 2004-01-22
ATE372340T1 (de) 2007-09-15
HK1071139A1 (en) 2005-07-08
BR9909995A (pt) 2000-12-26
NO20005450L (no) 2000-12-22
TR200102612T2 (tr) 2002-06-21
JP2002513025A (ja) 2002-05-08
IS5683A (is) 2000-10-25
HK1033457A1 (en) 2001-08-31
ATE307130T1 (de) 2005-11-15
ES2249913T3 (es) 2006-04-01
DK1073657T3 (da) 2006-03-13
ID26819A (id) 2001-02-15
CN1165535C (zh) 2004-09-08
HK1036981A1 (en) 2002-01-25
PL195000B1 (pl) 2007-07-31
DE69937077T2 (de) 2008-05-29
SK285768B6 (sk) 2007-07-06
HUP0102313A2 (hu) 2001-12-28
TR200003176T2 (tr) 2001-03-21
IL139297A (en) 2007-06-03
RU2235725C2 (ru) 2004-09-10
IL139200A0 (en) 2001-11-25
CN1306533A (zh) 2001-08-01
EP1073657B1 (en) 2005-12-07
KR20010043134A (ko) 2001-05-25
EP1491542A2 (en) 2004-12-29
NO20005451L (no) 2000-12-27
WO1999055706A1 (en) 1999-11-04
SA99200065A (ar) 2005-12-03

Similar Documents

Publication Publication Date Title
ZA200005797B (en) Imidazo pyridine derivatives which inhibit gastric acid secretion.
AU752187B2 (en) Heterocyclic compounds for inhibition of gastric acid secretion, processes for their preparation and pharmaceutical compositions thereof
US6613775B1 (en) Imidazo[1,2-a]pyridine compounds
US20040220209A1 (en) Novel imidazopyridine compounds with therapeutic effect
AU2002324402A1 (en) Novel imidazopyridine compounds with therapeutic effect