WO2016135331A1 - Cartridge, components and methods for generating an inhalable medium - Google Patents
Cartridge, components and methods for generating an inhalable medium Download PDFInfo
- Publication number
- WO2016135331A1 WO2016135331A1 PCT/EP2016/054159 EP2016054159W WO2016135331A1 WO 2016135331 A1 WO2016135331 A1 WO 2016135331A1 EP 2016054159 W EP2016054159 W EP 2016054159W WO 2016135331 A1 WO2016135331 A1 WO 2016135331A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- container
- liquid
- cartridge
- receptacle
- solid material
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
- A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
- A24F40/30—Devices using two or more structurally separated inhalable precursors, e.g. using two liquid precursors in two cartridges
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
- A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
- A24F40/40—Constructional details, e.g. connection of cartridges and battery parts
- A24F40/42—Cartridges or containers for inhalable precursors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/04—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised
- A61M11/041—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised using heaters
- A61M11/042—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised using heaters electrical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/06—Inhaling appliances shaped like cigars, cigarettes or pipes
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
- A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
- A24F40/10—Devices using liquid inhalable precursors
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
- A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
- A24F40/20—Devices using solid inhalable precursors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
- A61M16/10—Preparation of respiratory gases or vapours
- A61M16/105—Filters
Definitions
- the present invention relates to a cartridge for use with an apparatus for generating an inhalable medium, a method of generating an inhalable medium, certain components of a cartridge for use with an apparatus for generating an inhalable medium, and to a method of forming a cartridge.
- Smoking articles such as cigarettes, cigars and the like burn tobacco during use to create tobacco smoke. Attempts have been made to provide alternatives to these articles that burn tobacco by creating products that release compounds without burning. Examples of such products are heating devices which release compounds by heating, but not burning, the material.
- the material may be for example tobacco or other non- tobacco products, which may or may not contain nicotine.
- e-cigarette devices These devices typically contain a liquid which is heated to vaporise the liquid to produce an inhalable vapour or aerosol.
- the liquid may contain nicotine and/or flavourings and/or aerosol-generating substances, such as glycerol.
- the known e-cigarette devices typically do not contain or use tobacco.
- a receptacle for receiving a solid material
- the cartridge being arranged such that in use liquid exiting the container can flow, in the form of at least one of a vapour and an aerosol, through the channel to the receptacle and through solid material received by the receptacle in use
- the inhalable medium to have, for example, a flavour or flavours that are derived from the material contained in the receptacle in use.
- the vapour or aerosol passing over the material is hot and so heats the material to evaporate or volatilise one or more constituents from the material, allowing the constituents to be taken up into the inhalable medium.
- the material may be or include tobacco.
- tobacco One feature of so-called e-cigarette devices is that the flavour of the inhalable medium is often nothing like or at least is different from the flavour of a conventional tobacco product.
- the material in an embodiment of the present invention is or includes tobacco, the vapour or aerosol that passes over the tobacco picks up tobacco flavourings from the material.
- the cartridge has a single substantially tubular channel defined between the liquid container and the shell.
- the container is frustoconical.
- the cartridge comprises a heater associated with the container for volatilising a liquid held in the container in use.
- the cartridge comprises a heater associated with the receptacle for heating a solid material received by the receptacle in use. This enables the material to be heated by the heater, which encourages release of compounds from the material, and optionally allows a lower temperature to be used for the heated liquid.
- the container has one or more apertures to allow liquid to exit the container.
- the cartridge comprises a wick for wicking liquid held in the container in use out of the container.
- the container and the receptacle are provided as an integral component. In an embodiment, the container and the receptacle are provided as separate components which are detachably connected to each other.
- the receptacle has at least one retainer for retaining solid material within the receptacle in use.
- the at least one retainer has at least one through hole through which the vapour or aerosol can pass.
- the retainer is a disk.
- the retainer is an end wall of the receptacle.
- the cartridge comprises a wall between the container and the receptacle, the wall having at least one through hole through which the vapour or aerosol can pass.
- the receptacle has a transparent wall so that the contents of the receptacle are visible.
- the receptacle contains a solid material.
- the solid material is or comprises tobacco. In an embodiment, the solid material is wrapped in a transparent material.
- a cartridge and an apparatus for generating an inhalable medium the cartridge being a cartridge as described above, the apparatus having a battery section and a mouthpiece, the cartridge being connectable to the apparatus.
- the apparatus comprises a battery section and a mouthpiece
- the cartridge comprises a container containing a liquid, a receptacle containing a solid material, a shell around the outside of the liquid container, and a channel defined between the liquid container and the shell
- the at least one retainer has at least one through hole through which the vapour or aerosol can pass.
- the retainer is a disk.
- the retainer is an end wall of the receptacle.
- the receptacle contains a solid material.
- the solid material is or comprises tobacco.
- the tobacco may for example be cut tobacco, reconstituted tobacco, ground tobacco, etc., and may include different varieties of tobacco.
- the connector is in the form of an annular end wall that is receivable in or around a said receptacle.
- the cartridge has a single substantially tubular channel defined between the inner container and the shell. In an embodiment, the cartridge has plural channels defined between the inner container and the shell. In an embodiment, the channel is an annular channel defined between the inner container and the shell and substantially surrounding the inner container.
- the container is frustoconical. According to a fifth aspect of the present invention, there is provided a method of forming a cartridge for use with an apparatus for generating an inhalable medium, the method comprising:
- the solid material is wrapped in a transparent material.
- the solid material is or comprises tobacco.
- Figure 1 shows a schematic longitudinal cross-sectional view of an apparatus for generating an inhalable medium
- Figure 2 shows a schematic longitudinal cross-sectional view of another apparatus for generating an inhalable medium
- Figure 3 shows a schematic longitudinal cross-sectional view of another apparatus for generating an inhalable medium
- Figure 4 shows a schematic longitudinal cross-sectional view of an example of a cartridge having a liquid container and an integral container for solid material
- Figure 5 shows a schematic longitudinal cross-sectional view of an example of a cartridge having a liquid container and a detachable container for solid material
- Figures 6 and 7 show respectively a perspective view and a side elevation of an example of an apparatus for generating an inhalable medium
- Figures 8a to 8e show schematic longitudinal cross-sectional views of an example of a cartridge having a liquid container and an integral container for solid material and components thereof;
- Figures 9a to 9e show schematic longitudinal cross-sectional views of an example of a cartridge having a liquid container and a separate container for solid material and components thereof;
- Figures 10a to lOe show schematic longitudinal cross-sectional views of an example of a cartridge having a liquid container and a separate container for solid material and components thereof. Detailed Description
- the apparatus 1 volatilises a liquid to form a vapour or an aerosol which passes through a material so as to produce an inhalable medium that contains one or more constituents derived from the material.
- a vapour is a substance in the gas phase at a temperature lower than its critical temperature, which means that for example the vapour can be condensed to a liquid by increasing its pressure without reducing the temperature.
- an aerosol is a colloid of fine solid particles or liquid droplets, in air or another gas.
- a "colloid” is a substance in which microscopically dispersed insoluble particles are suspended throughout another substance.
- An O-ring or other seal 5 assists in sealing the mouthpiece 4 in the housing 2.
- a battery 7 for powering various components of the apparatus 1, as will be discussed further below.
- the battery 7 may be a rechargeable battery or a disposable battery.
- a controller 8 is also provided in the housing 2 for controlling the operation of various components of the apparatus 1, as will be discussed further below.
- the housing 2 has a container 9 for holding or containing a liquid 10.
- the container 9 is in the form of an annular chamber 9 provided in the housing 2 between the open end 3 and the other end 6.
- the housing 2 is in two parts, a first part 2a being towards the open end 3 and a second part 2b towards the other end 6.
- the first and second parts 2a,2b of the housing 2 may connect to each other via a screw thread, a bayonet fitting or the like.
- a user can separate the first and second parts 2a,2b of the housing 2 to allow the liquid 10 to be replenished or replaced as necessary.
- the mouthpiece 4 can be removed to provide access to the container 9.
- the liquid 10 may be provided in a discrete annular pot- like container which can be removed as a whole from the housing 2. Such a discrete container may be disposable so that the user replaces the liquid 10 by fitting a new container with liquid
- a heater 11 is provided generally centrally of the housing 2, that is, centrally along the length and width of the housing 2 in this example.
- the heater is provided generally centrally of the housing 2, that is, centrally along the length and width of the housing 2 in this example.
- the heater is provided generally centrally of the housing 2, that is, centrally along the length and width of the housing 2 in this example.
- the heater is provided generally centrally of the housing 2, that is, centrally along the length and width of the housing 2 in this example.
- the heater 11 is provided generally centrally of the housing 2, that is, centrally along the length and width of the housing 2 in this example.
- the heater 11 is powered by the battery 7 and is therefore electrically connected to the battery 7.
- the heater 11 may be an electrically resistive heater, including for example a nichrome resistive heater, a ceramic heater, etc.
- the heater 11 may be for example a wire, which may for example be in the form of a coil, a plate (which may be a multi-layer plate of two or more different materials, one or more of which may be electrically conductive and one or more of which may be electrically non-conductive), a mesh (which may be woven or non- woven for example, and which again may be similarly multi-layer), a film heater, etc.
- Other heating arrangements may be used, including non-electrical heating arrangements.
- This heater 11 is provided for volatilising the liquid 10.
- an annular wick 12 surrounds the heater 11 and is in (thermal) contact with the heater 11.
- the outermost surface of the annular wick 12 is in contact with liquid 10 contained in the liquid container 9.
- the wick 12 is generally absorbent and acts to draw in liquid 10 from the liquid container 9 by capillary action.
- the wick 12 is preferably non- woven and may be for example a cotton or wool material or the like, or a synthetic material, including for example polyester, nylon, viscose, polypropylene or the like, or a ceramic material. Whilst this will be described more fully below, it may be noted here that in use, liquid 10 drawn into the wick 12 is heated by the heater 11.
- the liquid 10 may be volatilised so as to produce an aerosol of liquid droplets or sufficiently heated to produce a vapour.
- the aerosol or vapour so produced exits the wick 12 and passes towards the mouthpiece 4 as shown by the arrows A under the action of the user drawing on the mouthpiece 4.
- the heater 11 and wick 12 may be provided as a single, effectively integral item such that the heating and wicking is effectively carried out by a single unit.
- the housing 2 further contains a chamber 13 which holds or contains a material 14 in the apparatus 1.
- a user can access the chamber 13 to replace or replenish the material 14 through the open end 3 of the housing 2 by removing the mouthpiece 4 and/or by separating the two parts 2a,2b of the housing 2.
- the chamber 13 may be a tube which is completely open at both ends and which contains the material 14.
- the chamber 13 may be a tube which has one or more end walls which have through holes through which a vapour or aerosol can pass. The chamber 13 may remain in situ within the housing 2 whilst the user removes and replaces the material 14.
- the chamber 13 containing the material may be a discrete item which in use is inserted into and removed from the housing 2 as a whole.
- a removable chamber 13 of this type may be disposable so that the user replaces the material 14 by fitting a new chamber 13 containing fresh material 14 into the housing 2.
- the chamber 13 may be reusable. In such a case, the user may replace the material 14 in the chamber 13 whilst the chamber 13 has been removed from the housing 2 and then replace the refilled chamber 13 in the housing 2.
- the chamber 13 containing the material may be a discrete item which in use is inserted into and removed from the housing 2 as a whole.
- a removable chamber 13 of this type may be disposable so that the user replaces the material 14 by fitting a new chamber 13 containing fresh material 14 into the housing 2.
- the chamber 13 may be reusable. In such a case, the user may replace the material 14 in the chamber 13 whilst the chamber 13 has been removed from the housing 2 and then replace the refilled chamber 13 in the housing 2.
- Such a dual function container 9/chamber or receptacle 13 for both containing the liquid 10 and receiving the material 14 may be in the form of a cartridge or the like and may be a disposable item or may be re-useable, with the liquid 10 and material 14 being replaced or topped up by the user as required. In some cases, it may be that the user only needs to top up or replace the material 14 from time to time, with sufficient liquid 10 being provided for several uses. Once the liquid 10 has been consumed, the user disposes of the dual function container 9/receptacle 13 and uses a new one. Likewise, it may be that the user only needs to top up or replace the liquid 10 from time to time, with sufficient material 14 being provided for several uses.
- the material 14 is located in the housing 2 downstream of the location where the aerosol or vapour is produced from the liquid 10 and upstream of the open end 3 of the housing 2 and the mouthpiece 4. In this particular example, the material 14 is effectively provided in the same portion or chamber of the housing 2 as the wick 12. The aerosol or vapour produced from the liquid 10 exits the wick 12 and passes as shown by the arrows A towards the material 14 under the action of the user drawing on the mouthpiece 4.
- the material 14 is porous so that the aerosol or vapour passes through the material 14 and then through the open end 3 of the housing 2 and the mouthpiece 4.
- the material 14 and/or its chamber 13 are arranged so that there is no air gap between the material 14/chamber 13 and the interior of the housing 2 so that the aerosol or vapour flows entirely through the material 14.
- the liquid 10 is preferably a liquid that is volatilisable at reasonable temperatures, preferably in the range of 100-300°C or more particularly around 150- 250°C, as that helps to keep down the power consumption of the apparatus 1.
- Suitable materials include those conventionally used in e-cigarette devices, including for example propylene glycol and glycerol (also known as glycerine).
- the material 14 is a material that may be used to impart a flavour to the aerosol or vapour produced from the liquid 10 as the aerosol or vapour passes through the material 14.
- the material 14 may for example consist of or comprise tobacco.
- the hot aerosol or vapour entrains organic and other compounds or constituents from the tobacco material 14 that lend tobacco its organoleptic properties, thus imparting the flavour to the aerosol or vapour as it passes to the mouthpiece 4.
- materials other than tobacco may be used to impart different flavours to the aerosol or vapour stream.
- flavourants could be included in the material or in the liquid.
- the material 14 is or includes tobacco
- the aerosol or vapour stream draws sufficient nicotine from the tobacco material 14.
- the material 14 may be enhanced with nicotine, for example by coating the material with nicotine. Indeed, even in the case that the material 14 is or includes tobacco, the material 14 may be coated or otherwise enhanced with nicotine.
- nicotine may be provided in the liquid 10.
- the nicotine may be provided in the liquid 10, may be obtained from the material 14 in the case that the material is or includes tobacco, may be provided as a coating or the like on non-tobacco material 14, may be provided as a coating or the like on tobacco material, or any combination of these.
- flavourings may be added to the material 14 (whether or not the material is or includes tobacco) and/or to the liquid 10.
- heating devices are known that release compounds by heating, but not burning, tobacco. It may be noted here that tobacco is a poor heat conductor, and yet the heating of tobacco in known tobacco heating devices is by heat conduction through the tobacco from an exterior surface of the tobacco (typically by virtue of an electrical resistive heating element which is in contact with the surface of the tobacco). This means that the tobacco may be heated inefficiently and/or the power consumption of the device is high. In the case of a battery-operated device, high power consumption is a problem for the user as the battery or batteries need to be recharged or replaced frequently.
- the material 14 is tobacco
- the only heat source for heating the material 14 in the apparatus 1, which is required so as to generate the organic and other compounds or constituents from the material 14, is the hot aerosol or vapour produced from heating the liquid 10.
- FIG. 2 there is shown another example of an apparatus for generating an inhalable medium.
- components and features that are the same as or similar to the corresponding components and features of the example described with reference to Figure 1 have the same reference numeral but increased by 200.
- the apparatus 201 of Figure 2 heats a liquid to form a vapour or an aerosol which passes through a material 214 so as to produce an inhalable medium that contains one or more constituents derived from the material 214.
- This encourages release of constituents from the material 214 as the vapour or aerosol passes through the material 214 in use.
- This also optionally allows a lower temperature to be used for the heated liquid 210, which reduces the power consumption of the first heater 211 which heats the liquid 210, and also may allow the amount of heated liquid 210 that has to be used to achieve sufficient heating of the material 214 to be reduced.
- the second heater 215 may be an electrically resistive heater, a ceramic heater, etc., powered by for example the battery 207.
- the second heater 215 may be for example a wire, which may for example be in the form of a coil, a plate (which may be a multilayer plate of two or more different materials, one or more of which may be electrically conductive and one or more of which may be electrically non-conductive), a mesh (which may be woven or non- woven for example, and which again may be similarly multi-layer), a film heater, etc.
- Other heating arrangements may be used for the second heater 215, including non-electrical heating arrangements.
- the heater 215 for heating the material 214 is provided externally of the material 214 and heats the material 214 by heat conduction from the exterior of the material 214.
- the heater 215 in this example is generally cylindrical.
- the heater 215 may in effect be an integral part of the apparatus 201 and be provided as part of the housing 202.
- the heater 215 may be provided integrally with the chamber 213 which holds or contains the material 214.
- the heater 215 will be replaced when a new chamber 213 with fresh material is loaded into the apparatus 201 by the user.
- FIG 3 there is shown another example of an apparatus for generating an inhalable medium.
- components and features that are the same as or similar to the corresponding components and features of the example described with reference to Figure 1 have the same reference numeral but increased by 300.
- the apparatus 301 of Figure 3 heats a liquid to form a vapour or an aerosol which passes through a material 314 so as to produce an inhalable medium that contains one or more constituents derived from the material 314.
- a second heater 318 is again provided in thermal contact with the material 314 to heat the material 314 to encourage release of constituents from the material 314 as the vapour or aerosol passes through the material 314 in use.
- the second heater 318 may be an electrically resistive heater, a ceramic heater, etc., powered by for example the battery 307.
- Other heating arrangements may be used for the second heater 318, including non-electrical heating arrangements.
- the heater 318 for heating the material 314 is provided internally of the material 314 and heats the material 314 by heat conduction from the interior of the material 314.
- the heater 318 in this example is generally in the form of a cylindrical rod located along the central longitudinal axis of the material 314.
- the heater 318 may be a wire, which may for example be in the form of a coil, a plate (which may be a multi-layer plate of two or more different materials, one or more of which may be electrically conductive and one or more of which may be electrically non-conductive), a mesh (which may be woven or non- woven for example, and which again may be similarly multi-layer), a film heater, etc.
- the material 314 in this case is generally tubular or otherwise has an internal aperture for receiving the heater 318.
- the heater 318 may in effect be an integral part of the apparatus 301 and be provided as part of the housing 302. In this case, as the material 314 is loaded into the apparatus 301 (for example, as the chamber
- the material 314 surrounds the second heater 318.
- the heater 318 may be provided integrally with the chamber 313 which holds or contains the material 314. In this alternative, in the case that the chamber 313 is disposable, the heater 318 will be replaced when a new chamber 313 with fresh material is loaded into the apparatus 301 by the user.
- plural internal heaters 318 may be provided, so as to provide for more efficient heating of the material 314.
- the material 3114 may be provided, so as to provide for more efficient heating of the material 314.
- FIG. 4 there is shown a schematic longitudinal cross- sectional view of an example of a cartridge 400 having a liquid container 401 for containing liquid 402 and a receptacle or container 403 for material 404, which will typically be solid material 404.
- the liquid container 401 and the material container 403 are provided as one integral component, either by being formed integrally initially or being formed initially of two parts which are then assembled in a substantially permanent fashion.
- the liquid container 401 and the material container 403 may be fixed to each other by for example friction welding, such as spin welding, ultrasonic welding, etc.
- the cartridge 400 is arranged so that as the liquid 402 is volatilised so as to produce an aerosol of liquid droplets or sufficiently heated to produce a vapour, at least some and preferably all or substantially all of the aerosol or vapour passes through the material 404 to pick up flavour from the material 404.
- the liquid container 401 is provided generally centrally of the cartridge 400.
- the liquid container 401 in the example shown is frustoconical in shape, but may have a different shape, such as conical, cylindrical, etc.
- the liquid container 401 is surrounded by an outer shell 405 which defines an annular channel 406 around the outside of the length of the liquid container 401 and which extends from one end of the liquid container 401 to the other.
- the outer shell 405 extends beyond a first end wall 407 of the liquid container 401 to define a chamber 408 beyond the first end wall 407 of the liquid container 401.
- both the chamber 408 and the annular channel 406 contain the material 404 and so can be regarded as together providing the container 403 for the material 404.
- the material 404 may be provided only in the chamber 408, which therefore defines the container 403 for the material 404, and the annular channel 406 is empty.
- the chamber 408 is closed off by an end wall 409 which is spaced from the end wall 407 of the liquid container 401.
- the end wall 409 may be part of the outer shell 405 or may be a separate plastics or rubber cap or the like.
- the annular channel 406 contains the material 404 and there is no material in the chamber 408, and indeed the chamber 408 may be omitted and the channel 406 effectively terminates at the end wall 409.
- the channel 406 and/or chamber 408 may be entirely filled with material 404 or may only contain a portion or plug of solid material 404.
- the end wall 409 is porous and/or has one or more through holes 410 to enable the aerosol or vapour to exit the cartridge 400 to be inhaled by a user.
- the liquid container 401 and the solid container 403 may each be formed of rigid, watertight and airtight materials, such as metal, suitable plastics, etc.
- the example cartridge 400 shown in Figure 4 is provided with a heater 411 and a wick 412 in (thermal) contact with the heater 411.
- the heater 411 and the wick 412 are provided as a single unit.
- the cartridge 400 includes a heater 411, such a cartridge is often referred to as a "cartomiser”.
- the orientation of the heater 411 is shown schematically and for example the heater 411 may be a coil having its longitudinal axis perpendicular to the longitudinal axis of the cartridge 400 rather than parallel as shown in Figure 4.
- the wick 412 is in contact with the liquid 402. This may be achieved by for example the wick 412 being inserted through a through hole (not shown) in the second end wall 413 of the liquid container 401.
- the second end wall 413 may be a porous member (shown schematically in Figure 4 by dashed lines) which allows liquid to pass through from the liquid container 401, and the wick 412 may be in contact with the porous second end wall 413.
- the second end wall 413 may be for example in the form of a porous ceramic disk.
- a porous second end wall 413 of this type helps to regulate the flow of liquid onto the wick 412.
- the wick 412 is generally absorbent and acts to draw in liquid 402 from the liquid container 401 by capillary action.
- the wick 412 is preferably non-woven and may be for example a cotton or wool material or the like, or a synthetic material, including for example polyester, nylon, viscose, polypropylene or the like, or a ceramic material.
- the cartridge 400 is connected by the user to a battery section of an apparatus to enable the heater 411 to be powered. (An example of such apparatus will be discussed further below.)
- the heater 411 is powered (which may be instigated for example by the user operating a button of the overall apparatus or by a puff detector of the overall apparatus, as is known per se)
- liquid 402 drawn in from the liquid container 401 by the wick 412 is heated by the heater 411 to volatilise or vaporise the liquid.
- the vapour or aerosol passes into the annular channel 406 around the outside of the length of the liquid container 401 and into the chamber 408 as shown by the arrows A.
- the vapour or aerosol picks up flavour from the material 404.
- the vapour or aerosol also contains nicotine entrained from the material 404.
- the vapour or aerosol can then exit the cartridge 400 through the end wall 409 as shown by the arrow B.
- a one way valve 414 may be provided inside the end wall 409 so that the vapour or aerosol can only exit the cartridge 400 and cannot back- flow to the heater 411 or the electronics of the apparatus as a whole.
- FIG. 5 there is shown a schematic longitudinal cross- sectional view of another example of a cartridge 500 having a liquid container 501 for containing liquid 502 and a container 503 which defines a chamber 508 for containing material 504, which will typically be solid material 504.
- a liquid container 501 for containing liquid 502 and a container 503 which defines a chamber 508 for containing material 504, which will typically be solid material 504.
- components and features that are the same as or similar to the corresponding components and features of the example described with reference to Figure 4 have the same reference numeral but increased by 100.
- the description of those components and features will not be repeated in its entirety here.
- the liquid container 501 and the material container 503 of the cartridge 500 are provided as separate components, which are detachably connected to each other in use.
- the liquid container 501 and the material container 503 may for example be clipped or otherwise detachably fixed to each other, or for example the material container 503 may simply rest on or be a tight friction fit on the liquid container 501.
- the cartridge 500 is arranged so that as the liquid 502 is volatilised so as to produce an aerosol of liquid droplets or sufficiently heated to produce a vapour, at least some and preferably all or substantially all of the aerosol or vapour passes through the material 504 to pick up flavour from the material 504.
- the liquid container 501 is surrounded by an outer shell 505 which defines an annular channel 506 around the outside of the length of the liquid container 501 and which extends from one end of the liquid container 501 to the other.
- the outer shell 505 extends beyond a first end wall 507 of the liquid container 401 and terminates in an end wall 509.
- the end wall 509 may be a separate plastics or rubber cap or the like.
- the end wall 509 is porous and/or has one or more through holes 510 to enable the aerosol or vapour to exit the annular channel 506.
- a one way valve 514 may be provided inside the end wall 509 so that the vapour or aerosol can only exit the annular channel 506 at the end remote from the heater 511 and wick 512 and cannot back- flow to the heater 511 or the electronics of the apparatus as a whole.
- the material container 503 is located in use over the end wall 509 so that vapour or aerosol exiting through the end wall 509 passed into the material container 503.
- the material container 503 has an exit aperture and/or or a porous end wall 515 to enable the aerosol or vapour to exit the cartridge 500 to be inhaled by a user.
- the cartridge 500 is connected by the user to a battery section of an apparatus to enable the heater 511 to be powered.
- a battery section of an apparatus to enable the heater 511 to be powered.
- the heater 511 is powered (which may be instigated for example by the user operating a button of the overall apparatus or by a puff detector of the overall apparatus as is known per se)
- liquid 502 drawn in from the liquid container 501 through the end wall 513 by the wick 512 is heated by the heater 511 to volatilise or vaporise the liquid.
- the vapour or aerosol passes into the annular channel 506 around the outside of the length of the liquid container 501 towards the end wall 509 of the outer shell 505 as shown by the arrows A.
- the vapour or aerosol then passes through the end wall 509 (via the one-way valve 514 if present) and into the material container 503 where it picks up flavour from the material 504 contained in the material container 503.
- the vapour or aerosol also contains nicotine entrained from the material 504.
- the vapour or aerosol can then exit the cartridge 500 through the end wall 515 of the material container 503 as shown by the arrow B.
- FIGs 6 and 7 show respectively a perspective view and a side elevation of an example of an apparatus 600 for generating an inhalable medium.
- the apparatus 600 may be used with any of the cartridges described herein and with other cartridges.
- the apparatus 600 has a battery section 601 and a cartridge section 602.
- the battery section 601 and the cartridge section 602 are shown connected to each other in the drawings, but can be separated by a user to allow a cartridge to be loaded into the cartridge section 602.
- the battery section 601 and the cartridge section 602 can be separably connected to each other using for example a snap-fit connection, clips, a screw thread, etc.
- the cartridge section 602 has a mouthpiece 603 at its remote end.
- the battery section 601 has an on-off or power button 604.
- the battery section 601 contains a power supply, such as a battery which may be a rechargeable battery or a disposable battery.
- the battery section 601 also contains a controller for controlling the operation of various components of the apparatus 600 and/or a puff detector.
- a user separates the battery section 601 and the cartridge section 602, inserts a cartridge into the cartridge section 602, and then connects the battery section 601 and the cartridge section 602 together again. The user can then operate the apparatus 600 using the on-off or power button 604.
- FIGs 8a to 8e there is shown a further example of a cartridge 800 having a liquid container 801 for containing liquid 802 and a receptacle or container 803 for material 804, which will typically be solid material 804.
- the liquid container 801 and the material container 803 are provided as one integral component by being formed initially of two parts, shown separately in Figures 8c and 8d, which are then assembled as shown in Figure 8b in a substantially permanent fashion.
- the liquid container 801 and the material container 803 may be fixed to each other by for example friction welding, such as spin welding, ultrasonic welding, etc.
- the cartridge 800 is arranged so that as the liquid 802 is volatilised so as to produce an aerosol of liquid droplets or sufficiently heated to produce a vapour, at least some and preferably all or substantially all of the aerosol or vapour passes through the material 804 to pick up flavour from the material 804.
- the liquid container 801 of the cartridge 800 has an outer shell 805 which defines a groove or channel 806 around the outside of the length of the inner liquid container part 810 and which extends from one end of the liquid container 801 to the other. In the example shown, this channel is provided by a groove 806 in the outer wall of the inner liquid container part 810, as can be seen most clearly in Fig. 8d.
- the cartridge 800 has a heater 811 for heating liquid and a wick 812 in thermal contact with the heater 811.
- the heater 811 may be for example an electrically resistive heater, a ceramic heater, etc.
- the heater 811 and the wick 812 are provided as a single unit.
- the cartridge 800 includes a heater 811, such a cartridge is often referred to as a "cartomiser”.
- the wick 812 is in contact with the liquid 802. As above, this may be achieved by for example the wick 812 being inserted through a through hole in the second end wall 813 of the inner liquid container part 810.
- the second end wall 813 may be a porous member which allows liquid to pass through from the inner liquid container part 810, and the wick 812 may be in contact with the porous second end wall 813.
- the second end wall 813 may be for example in the form of a porous ceramic disk.
- the wick 812 is generally absorbent and acts to draw in liquid 802 from the inner liquid container part 810 by capillary action.
- the wick 812 is preferably non- woven and may be for example a cotton or wool material or the like, or a synthetic material, including for example polyester, nylon, viscose, polypropylene or the like, or a ceramic material.
- the cartridge 800 is connected by the user to a battery section of an apparatus (which may for example be an apparatus 600 like that shown in Figures 6 and 7) to enable the liquid heater 811 to be powered.
- the vapour or aerosol can then exit the cartridge 800 as shown by the arrow A.
- a one way valve (not shown) may be provided so that the vapour or aerosol can only exit the cartridge 800 and cannot back-flow to the heater 811 or the electronics of the apparatus as a whole.
- the end wall 807 of the liquid container 801 may be provided by a separate retainer 807, for example in the form of a disk 807 which is fitted to the liquid container 801 during manufacture, or, as in the example shown, the end wall 807 may be part of the liquid container 801.
- the disk 807 may be formed of plastics or rubber or ceramic or the like and has one or more through holes 820 to allow aerosol or vapour to pass into the chamber 808 which contains the solid material 804.
- the end wall/disk 807 of the liquid container 801 and the end wall/disk 809 of the solid material chamber 808 assist in retaining the solid material 804 in position in the solid material chamber 808, both during transport of the cartridge 800 and during use of the cartridge 800.
- FIG. 9a to 9e there is shown a further example of a cartridge 900 having a liquid container 901 for containing liquid 902 and a receptacle or container 903 for material 904, which will typically be solid material 904.
- a liquid container 901 for containing liquid 902 and a receptacle or container 903 for material 904, which will typically be solid material 904.
- Many aspects and features of the example of Figures 9a to 9e are similar to the example described above with reference to of Figures 8a to 8e and a detailed description of those aspects and features will not be repeated here for the sake of brevity.
- the liquid container 901 and the material container 903 are provided as separate parts, shown separately in Figures 9c and 9d.
- the liquid container 901 and the material container 903 may be connected or fixed to each other during manufacture, by for example clipping them together, by friction welding, such as spin welding, ultrasonic welding, etc.
- the liquid container 901 and the material container 903 may be connected or fixed to each other by the user during use, with the material container 903 being in the form of a removable end cap.
- the user can easily replace one or other of the liquid container 901 and the material container 903 as required as the liquid 902 or solid material 904 as the case may be is consumed during use.
- the material container 903 may be fitted to the liquid container 903 by for example clips and/or as a friction fit.
- the cartridge 900 is again arranged so that as the liquid 902 is volatilised so as to produce an aerosol of liquid droplets or sufficiently heated to produce a vapour, at least some and preferably all or substantially all of the aerosol or vapour passes through the material 904 to pick up flavour from the material 904.
- the chamber 908 for the solid material 904 is closed off at the mouth end by an end wall 909.
- the end wall 909 at the mouth end of the chamber 908 is provided by a separate disk 909 which is inserted into the chamber 908 during manufacture.
- the disk 909 may be formed of plastics or rubber or ceramic or the like and has one or more through holes 920 to allow aerosol or vapour to pass through the mouth end of the cartridge 900.
- the end wall 909 may be part of the material container 903, and similarly has one or more through holes to allow aerosol or vapour to pass through the mouth end of the cartridge 900 to be inhaled by a user.
- the end wall 907 of the liquid container 901 is provided by a separate disk 907 which is fitted to the liquid container 901 during manufacture.
- the disk 907 may be formed of plastics or rubber or ceramic or the like and has one or more through holes 920 to allow aerosol or vapour to pass into the chamber 908 which contains the solid material 904.
- the end wall 907 may be part of the liquid container 901, and similarly has one or more through holes to allow aerosol or vapour to pass through. Either way, the liquid container 901 can be a complete, sealed unit that contains the liquid 902, which facilitates manufacture of the overall cartridge 900 and/or simplifies replacement of the liquid container 901 by the user once the liquid 902 has been consumed.
- the material container or end cap 903 is a female connector, having an annular end wall 921 which fits over the end of the liquid container 901 in use.
- FIGs 10a to lOe there is shown another example cartridge 1000 having a liquid container 1001 for containing liquid 1002 and a receptacle or container 1003 for material 1004, which will typically be solid material 1004.
- the example of Figures 10a to lOe is very similar to the example of Figures 9a to 9e except that in this case, the material container or end cap 1003 is a male connector, having an annular end wall 1021 which fits within the end of the liquid container 1001 in use.
- Figures 10a to lOe also show an example of the embodiment mentioned above in which the material container 1003 has a second end wall or cap 1009' having through holes, spaced from the end wall or disk 1009 at the mouth end, so that the chamber 1008 for the solid material 1004 provides a complete unit that contains the solid material 1004.
- FIGs 4, 5 and 8 to 10 are particularly suitable for use with so-called modular products, in which the cartomiser is fitted to a battery section of an overall apparatus (such as a battery section 601 of an apparatus 600 as shown in Figures 6 and 7), typically by a screw thread, a bayonet fitting or the like.
- the cartomiser as a whole is typically discarded after use and a new, replacement cartomiser used.
- the heater for the liquid may be provided separately of the liquid and material containers.
- the heater may for example be provided as part of the battery section 601 of the overall apparatus 600 to which the cartridge is detachably fitted by the user in use.
- a heater for the solid material so as to "pre-heat" the solid material.
- This solid material heater may be provided as part of the cartridge or as part of the battery section of the apparatus to which the cartridge is fitted in use.
- the solid material may be located, exclusively or additionally, in the mouthpiece of the apparatus (e.g. the mouthpiece 603 of an apparatus 600 as described above) which with the cartridge described above is used.
- the solid material may be omitted from the container, for example at the option of the user.
- This provides the user with more flexibility over the use of the cartridge as the user can use the cartridge as a classic "e-cigarette" device, only vaporising liquid and not having the vapour or aerosol pass over or through solid material, from time to time if they choose. This is particularly the case for the examples where the solid material in the solid material container is replaceable by the user.
- the outer shell 405, 505, etc. of the liquid container may extend beyond the heater 411 and wick 412 to form a skirt which in use fits around a part of the housing or battery section 601 of the apparatus 600 with which the cartridge 400, 500, 800, etc. is used.
- a skirt 821 is shown in particular for the example of Figures 8a to 8e. These figures also show an example of the screw thread 822 in the cartridge 800 for fitting the cartridge 800 to the battery section 601 of the apparatus 600 as mentioned above.
- the channel through which aerosol/vapour flows from the liquid heater to the solid material is annular and completely surrounds the liquid container in some examples (e.g. the channel 406, 506 for the examples shown in Figures 4 and 5).
- the channel is not annular and does not surround the liquid container 401,501,801, etc.
- one channel may be filled with or contain or lead to a material that imparts a first flavour to the vapour or aerosol
- a second channel may be filled with or lead to a material that imparts a second flavour to the vapour or aerosol
- the liquid container and the solid material/solid material container are arranged substantially in-line, along a longitudinal axis of the apparatus or cartridge.
- the liquid container and the solid material/solid material container are arranged so as to at least partially overlap in the longitudinal direction of the apparatus or cartridge; in such examples, the liquid container and the solid material/solid material container may still be arranged generally in-line along the longitudinal axis of the apparatus or cartridge, or may be arranged side by side, or with one partially or completely inside the other.
- the liquid container and the solid material/solid material container are arranged concentrically (either with the liquid container inside the solid material/solid material container or vice versa), and may be arranged to be entirely off-set with respect to each other along the longitudinal axis of the apparatus or cartridge, or overlapping, or one completely within the other.
- the solid material/solid material container is placed in at least one channel between the heater and the outlet, the channel at least partially overlapping with the liquid container in the longitudinal axis of the apparatus or cartridge. In other words, the vapour or aerosol flow channel goes past the liquid container and the material is located somewhere within the channel.
- the cartridge may comprise a cooler or heat exchanger, and/or the apparatus with which the cartridge 400,500, 800, etc. is used may comprise a cooler or heat exchanger.
- the material and the cooler in such an arrangement may be separate and spaced from each other.
- the cooler may be downstream of the liquid heater and upstream of the receptacle, the cooler or cooling zone being arranged to cool vaporised liquid to form an aerosol of liquid droplets which in use passes through material received in the receptacle.
- the cooler may be arranged in effect to act as a heat exchanger, allowing for recovery of heat from the vapour.
- the recovered heat can be used for example to pre-heat the material and/or to assist in heating the liquid
- the liquid is preferably a liquid that is volatilisable at reasonable temperatures, preferably in the range of 100-300°C or more particularly around 150-250°C, as that helps to keep down the power consumption of the apparatus with which the cartridge is used.
- Suitable materials include those conventionally used in e-cigarette devices, including for example propylene glycol and glycerol (also known as glycerine).
- the solid material is a material that may be used to impart a flavour to the aerosol or vapour produced from the liquid as the aerosol or vapour passes through the material.
- the material may for example consist of or comprise tobacco.
- the hot aerosol or vapour entrains organic and other compounds or constituents from the tobacco material that lend tobacco its organoleptic properties, thus imparting the flavour to the aerosol or vapour as it passes to the mouthpiece.
- materials other than tobacco may be used to impart different flavours to the aerosol or vapour stream.
- flavourants could be included in the material or in the liquid.
- the apparatus controller controls operation of the apparatus as a whole.
- the controller for example may cause the or each heating element to be powered as and when required and switch off the or each heating element when heating is not required.
- Operation of the one or more heating elements may be controlled so that the liquid and/or material is heated to an optimum temperature. Particular considerations include ensuring that the material does not burn, ensuring that adequate vaporisation of the liquid is achieved, ensuring that the vaporised liquid or aerosol is at an appropriate temperature to liberate compounds from the material, and ensuring that the vapour or aerosol that reaches the user is at a comfortable and safe temperature.
- a puff detector a device which is known per se, may be provided to signal to the controller when the one or more heating elements need to be energised.
- the apparatus may also have one or more filters for filtering the vapour or aerosol before it reaches the user, cooling arrangements for cooling the vapour or aerosol before it reaches the user, insulation internally of the apparatus to protect the user from the heat generated inside the housing, etc.
- the tobacco or at least the surface of the tobacco, be heated to a temperature of between around 190°C to 210°C and most preferably around 200°C so as to ensure that an adequate or appropriate amount of the compounds are released from the tobacco.
- the material may be heated only by the hot vapour or aerosol that passes through the material or the material may also be preheated or dual-heated using for example a dedicated heater.
- the liquid 10, 210, etc. may be heated to a temperature of between around 100-300°C or more particularly around 150°C to 250°C.
- Suitable materials 14, etc. include materials that provide volatilised components upon heating, typically in the form of an aerosol.
- Suitable materials 14, etc. include any tobacco-containing material and may, for example, include one or more of tobacco per se, different varieties of tobacco, tobacco derivatives, expanded tobacco, reconstituted tobacco, ground tobacco, tobacco extract, homogenised tobacco or tobacco substitutes.
- the material 14, etc. may be in the form of a rod of tobacco, a pod or plug of tobacco, loose tobacco, agglomerates, etc., and may be in relatively dry form or in relatively moist form for example.
- Suitable materials 14, etc. may include other, non-tobacco, products, which, depending on the product, may or may not contain nicotine.
- the tobacco may be in the form of a plug of tobacco rod which is cut to length and placed into the receptacle or container for the solid material before the receptacle or container for the solid material is combined with the liquid container (whether the receptacle or container for the solid material is combined with the liquid container during manufacture or by the user in use).
- the receptacle or container for the solid material is transparent, so that the user can see the contents (i.e. the solid material) in use, which is appealing to some users.
- the tobacco rod may be formed using a transparent material as a wrapping material, again so that the user can see the tobacco.
- a particularly suitable material is "NatureFlex” (trade mark), a biodegradable film made from renewable raw materials by Innovia Films Limited.
- the terms "flavour” and “flavourant” refer to materials which, where local regulations permit, may be used to create a desired taste or aroma in a product for adult consumers.
- extracts e.g., licorice, hydrangea, Japanese white bark magnolia leaf, chamomile, fenugreek, clove, menthol, Japanese mint, aniseed, cinnamon, herb, wintergreen, cherry, berry, peach, apple, Drambuie, bourbon, scotch, whiskey, spearmint, peppermint, lavender, cardamom, celery, cascarilla, nutmeg, sandalwood, bergamot, geranium, honey essence, rose oil, vanilla, lemon oil, orange oil, cassia, caraway, cognac, jasmine, ylang-ylang, sage, fennel, piment, ginger, anise, coriander, coffee, or a mint oil from any species of the genus Mentha), flavour enhancers, bitterness receptor site blockers, sensorial receptor site activators or stimulators, sugars and/or sugar substitutes (e.g., sucralose, acesulfame, cinnamon
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- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
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- Bioinformatics & Cheminformatics (AREA)
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- Disinfection, Sterilisation Or Deodorisation Of Air (AREA)
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Abstract
Description
Claims
Priority Applications (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HK18103679.2A HK1243893A1 (en) | 2015-02-27 | 2016-02-26 | Cartridge, components and methods for generating an inhalable medium |
| PL16709729.4T PL3261467T3 (en) | 2015-02-27 | 2016-02-26 | Cartridge, components and methods for generating an inhalable medium |
| JP2017545230A JP6725524B2 (en) | 2015-02-27 | 2016-02-26 | Cartridge, component and method for generating aspirable media |
| ES16709729T ES2913872T3 (en) | 2015-02-27 | 2016-02-26 | Cartridge, components and methods for generating an inhalable medium |
| US15/553,742 US10426199B2 (en) | 2015-02-27 | 2016-02-26 | Cartridge, components and methods for generating an inhalable medium |
| EP16709729.4A EP3261467B1 (en) | 2015-02-27 | 2016-02-26 | Cartridge, components and methods for generating an inhalable medium |
| RU2017133398A RU2664376C1 (en) | 2015-02-27 | 2016-02-26 | Cartridge, components and methods of the inhaled environment generating |
| CN201680024577.3A CN107529830B (en) | 2015-02-27 | 2016-02-26 | Cartridges, components, and methods for generating respirable media |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1503411.9 | 2015-02-27 | ||
| GB201503411A GB201503411D0 (en) | 2015-02-27 | 2015-02-27 | Apparatus and method for generating an inhalable medium, and a cartridge for use therewith |
| GBGB1504756.6A GB201504756D0 (en) | 2015-03-20 | 2015-03-20 | Apparatus and method for generating an inhalable medium, and a cartridge for use therewith |
| GB1504756.6 | 2015-03-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2016135331A1 true WO2016135331A1 (en) | 2016-09-01 |
Family
ID=55527527
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/EP2016/054159 Ceased WO2016135331A1 (en) | 2015-02-27 | 2016-02-26 | Cartridge, components and methods for generating an inhalable medium |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US10426199B2 (en) |
| EP (1) | EP3261467B1 (en) |
| JP (2) | JP6725524B2 (en) |
| CN (1) | CN107529830B (en) |
| ES (1) | ES2913872T3 (en) |
| HK (1) | HK1243893A1 (en) |
| PL (1) | PL3261467T3 (en) |
| RU (1) | RU2664376C1 (en) |
| WO (1) | WO2016135331A1 (en) |
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Also Published As
| Publication number | Publication date |
|---|---|
| CN107529830B (en) | 2021-06-29 |
| EP3261467B1 (en) | 2022-03-30 |
| RU2664376C1 (en) | 2018-08-16 |
| HK1243893A1 (en) | 2018-07-27 |
| US20180035719A1 (en) | 2018-02-08 |
| JP2018512117A (en) | 2018-05-17 |
| US10426199B2 (en) | 2019-10-01 |
| EP3261467A1 (en) | 2018-01-03 |
| JP6725524B2 (en) | 2020-07-22 |
| CN107529830A (en) | 2018-01-02 |
| JP6956833B2 (en) | 2021-11-02 |
| PL3261467T3 (en) | 2022-07-18 |
| JP2020162620A (en) | 2020-10-08 |
| ES2913872T3 (en) | 2022-06-06 |
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