WO2005044973A1 - 新規アセトアセチルＣｏＡ還元酵素および光学活性アルコールの製造方法 - Google Patents
新規アセトアセチルＣｏＡ還元酵素および光学活性アルコールの製造方法Info
- Publication number
- WO2005044973A1 WO2005044973A1 PCT/JP2004/016666 JP2004016666W WO2005044973A1 WO 2005044973 A1 WO2005044973 A1 WO 2005044973A1 JP 2004016666 W JP2004016666 W JP 2004016666W WO 2005044973 A1 WO2005044973 A1 WO 2005044973A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- optically active
- coa reductase
- novel
- acetoacetyl
- producing optically
- Prior art date
Links
- 108091000039 acetoacetyl-CoA reductase Proteins 0.000 title abstract 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 title 1
- FXHRDEQPODSZQL-RXMQYKEDSA-N (3R)-3-hydroxypentanenitrile Chemical compound CC[C@@H](O)CC#N FXHRDEQPODSZQL-RXMQYKEDSA-N 0.000 abstract 3
- 108090000790 Enzymes Proteins 0.000 abstract 3
- 102000004190 Enzymes Human genes 0.000 abstract 3
- 150000001298 alcohols Chemical class 0.000 abstract 3
- KOYWUYIBEXFRFH-UHFFFAOYSA-N 3-oxopentanenitrile Chemical compound CCC(=O)CC#N KOYWUYIBEXFRFH-UHFFFAOYSA-N 0.000 abstract 2
- WAPNOHKVXSQRPX-UHFFFAOYSA-N 1-phenylethanol Chemical class CC(O)C1=CC=CC=C1 WAPNOHKVXSQRPX-UHFFFAOYSA-N 0.000 abstract 1
- XYIBRDXRRQCHLP-UHFFFAOYSA-N Ethyl acetoacetate Chemical compound CCOC(=O)CC(C)=O XYIBRDXRRQCHLP-UHFFFAOYSA-N 0.000 abstract 1
- 230000000875 corresponding Effects 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- KWOLFJPFCHCOCG-UHFFFAOYSA-N methylphenylketone Chemical class CC(=O)C1=CC=CC=C1 KWOLFJPFCHCOCG-UHFFFAOYSA-N 0.000 abstract 1
- 230000003287 optical Effects 0.000 abstract 1
Abstract
本発明は、（Ｒ）−３−ヒドロキシペンタンニトリル、光学活性３−ヒドロキシブタン酸エステル及び光学活性１−フェニルエタノール誘導体の光学活性アルコールの簡便な製法の提供、並びに、上記光学活性アルコール、特に（Ｒ）−３−ヒドロキシペンタンニトリルの製造に有用な新規酵素の提供を目的とする。
本発明は、３−ケトペンタンニトリルを不斉還元して、光学純度９９％ｅ．ｅ．以上の（Ｒ）−３−ヒドロキシペンタンニトリルを生成しうる新規アセトアセチルＣｏＡ還元酵素；３−ケトペンタンニトリル、アセト酢酸エステル及び１−フェニルエタノン誘導体それぞれに、当該新規酵素もしくは既知のアセトアセチルＣｏＡ還元酵素を作用させ、対応する光学活性アルコールを製造する方法である。
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/577,601 US20070037263A1 (en) | 2003-11-11 | 2004-11-10 | Novel acetoacetyl-coa reductase and process for producing optically active alcohol |
| EP04818252A EP1688480A4 (en) | 2003-11-11 | 2004-11-10 | NOVEL ACETOACETYL-COA REDUCTASE AND PROCESS FOR PRODUCING OPTICALLY ACTIVE ALCOHOL |
| JP2005515359A JPWO2005044973A1 (ja) | 2003-11-11 | 2004-11-10 | 新規アセトアセチルＣｏＡ還元酵素および光学活性アルコールの製造方法 |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2003-380987 | 2003-11-11 | ||
| JP2003380987 | 2003-11-11 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| WO2005044973A1 true WO2005044973A1 (ja) | 2005-05-19 |
| WO2005044973A2 WO2005044973A2 (ja) | 2005-05-19 |
| WO2005044973A3 WO2005044973A3 (ja) | 2005-06-30 |
Family
ID=34567260
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/JP2004/016666 WO2005044973A2 (ja) | 2003-11-11 | 2004-11-10 | 新規アセトアセチルＣｏＡ還元酵素および光学活性アルコールの製造方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20070037263A1 (ja) |
| EP (1) | EP1688480A4 (ja) |
| JP (1) | JPWO2005044973A1 (ja) |
| KR (1) | KR20060113697A (ja) |
| WO (1) | WO2005044973A2 (ja) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7148055B2 (en) | 2001-10-05 | 2006-12-12 | Kaneka Corporation | Process for production of optically active 3-hydroxypentanenitrile |
| WO2007010944A1 (ja) | 2005-07-20 | 2007-01-25 | Kaneka Corporation | 光学活性２－（ｎ－置換アミノメチル）－３－ヒドロキシ酪酸エステル類の製造方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3092946A (en) * | 1961-02-01 | 1963-06-11 | Bernard C Mathews | Rotary cutter |
| US4539798A (en) * | 1982-03-26 | 1985-09-10 | National Research Development Corporation | Apparatus and method for conveying and/or treating crop |
| US5894716A (en) * | 1996-06-28 | 1999-04-20 | New Holland North America, Inc. | Apparatus for macerating plant material |
| FR2767633B1 (fr) * | 1997-09-02 | 1999-10-08 | Kuhn Sa | Dispositif de conditionnement ameliore, machine pour le conditionnement et faucheuse conditionneuse comportant un tel dispositif |
| DE69924830T2 (de) * | 1998-01-19 | 2006-03-02 | Lg Chemical Ltd. | Gene von alcaligenes latus, die mit der biosynthese von polyhydroxyalkanoaten assoziiert sind. |
| JP2000189170A (ja) * | 1998-05-08 | 2000-07-11 | Daicel Chem Ind Ltd | 光学活性４―ハロ―３―ヒドロキシ酪酸エステルの製造方法 |
| US7148055B2 (en) * | 2001-10-05 | 2006-12-12 | Kaneka Corporation | Process for production of optically active 3-hydroxypentanenitrile |
-
2004
- 2004-11-10 US US10/577,601 patent/US20070037263A1/en not_active Abandoned
- 2004-11-10 JP JP2005515359A patent/JPWO2005044973A1/ja not_active Withdrawn
- 2004-11-10 WO PCT/JP2004/016666 patent/WO2005044973A2/ja active Application Filing
- 2004-11-10 KR KR1020067008603A patent/KR20060113697A/ko not_active Application Discontinuation
- 2004-11-10 EP EP04818252A patent/EP1688480A4/en not_active Withdrawn
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