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WO2004071408A3 - Aβ BINDING MOLECULES - Google Patents

Aβ BINDING MOLECULES Download PDF

Info

Publication number
WO2004071408A3
WO2004071408A3 PCT/US2004/002004 US2004002004W WO2004071408A3 WO 2004071408 A3 WO2004071408 A3 WO 2004071408A3 US 2004002004 W US2004002004 W US 2004002004W WO 2004071408 A3 WO2004071408 A3 WO 2004071408A3
Authority
WO
WIPO (PCT)
Prior art keywords
murine antibody
binding molecules
antibodies
syndrome
fragments
Prior art date
Application number
PCT/US2004/002004
Other languages
French (fr)
Other versions
WO2004071408A2 (en
Inventor
Julian Davies
Ying Tang
Jeffry Dean Watkins
Original Assignee
Applied Molecular Evolution
Julian Davies
Ying Tang
Jeffry Dean Watkins
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Molecular Evolution, Julian Davies, Ying Tang, Jeffry Dean Watkins filed Critical Applied Molecular Evolution
Priority to EP04708962A priority Critical patent/EP1596809B1/en
Priority to DE602004027348T priority patent/DE602004027348D1/en
Priority to AT04708962T priority patent/ATE468886T1/en
Priority to US10/544,050 priority patent/US7575747B2/en
Publication of WO2004071408A2 publication Critical patent/WO2004071408A2/en
Publication of WO2004071408A3 publication Critical patent/WO2004071408A3/en
Priority to US12/504,818 priority patent/US8105597B2/en
Priority to US13/332,753 priority patent/US8623365B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Steroid Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention encompasses isolated antibodies, or fragments thereof, that are humanized variants of murine antibody 266 which employ complementarity determining regions derived from murine antibody 266. The variant antibodies are useful for treatment or prevention of conditions and diseases associated with Aβ, including Alzheimer's disease, Down's syndrome, cerebral amyloid angiopathy, mild cognitive impairment, and the like.
PCT/US2004/002004 2003-02-10 2004-02-06 Aβ BINDING MOLECULES WO2004071408A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
EP04708962A EP1596809B1 (en) 2003-02-10 2004-02-06 Abeta binding molecules
DE602004027348T DE602004027348D1 (en) 2003-02-10 2004-02-06 ABETA-BINDING MOLECULES
AT04708962T ATE468886T1 (en) 2003-02-10 2004-02-06 ABETA-BINDING MOLECULES
US10/544,050 US7575747B2 (en) 2003-02-10 2004-02-06 Aβ binding molecules
US12/504,818 US8105597B2 (en) 2003-02-10 2009-07-17 Aβ binding molecules
US13/332,753 US8623365B2 (en) 2003-02-10 2011-12-21 Aβ binding molecules

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US44638003P 2003-02-10 2003-02-10
US60/446,380 2003-02-10

Related Child Applications (3)

Application Number Title Priority Date Filing Date
US10544050 A-371-Of-International 2004-02-06
US10/544,050 Continuation US7575747B2 (en) 2003-02-10 2004-02-06 Aβ binding molecules
US12/504,818 Continuation US8105597B2 (en) 2003-02-10 2009-07-17 Aβ binding molecules

Publications (2)

Publication Number Publication Date
WO2004071408A2 WO2004071408A2 (en) 2004-08-26
WO2004071408A3 true WO2004071408A3 (en) 2007-04-12

Family

ID=32869500

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/002004 WO2004071408A2 (en) 2003-02-10 2004-02-06 Aβ BINDING MOLECULES

Country Status (6)

Country Link
US (3) US7575747B2 (en)
EP (1) EP1596809B1 (en)
AT (1) ATE468886T1 (en)
DE (1) DE602004027348D1 (en)
ES (1) ES2344645T3 (en)
WO (1) WO2004071408A2 (en)

Cited By (9)

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US8497072B2 (en) 2005-11-30 2013-07-30 Abbott Laboratories Amyloid-beta globulomer antibodies
US8691224B2 (en) 2005-11-30 2014-04-08 Abbvie Inc. Anti-Aβ globulomer 5F7 antibodies
US8877190B2 (en) 2006-11-30 2014-11-04 Abbvie Inc. Aβ conformer selective anti-Aβ globulomer monoclonal antibodies
US8895004B2 (en) 2007-02-27 2014-11-25 AbbVie Deutschland GmbH & Co. KG Method for the treatment of amyloidoses
US8987419B2 (en) 2010-04-15 2015-03-24 AbbVie Deutschland GmbH & Co. KG Amyloid-beta binding proteins
US9146244B2 (en) 2007-06-12 2015-09-29 Ac Immune S.A. Polynucleotides encoding an anti-beta-amyloid monoclonal antibody
US9176150B2 (en) 2003-01-31 2015-11-03 AbbVie Deutschland GmbH & Co. KG Amyloid beta(1-42) oligomers, derivatives thereof and antibodies thereto, methods of preparation thereof and use thereof
US9221900B2 (en) 2010-07-30 2015-12-29 Ac Immune S.A. Methods for identifying safe and functional humanized antibodies
US9403902B2 (en) 2007-10-05 2016-08-02 Ac Immune S.A. Methods of treating ocular disease associated with amyloid-beta-related pathology using an anti-amyloid-beta antibody

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TWI255272B (en) 2000-12-06 2006-05-21 Guriq Basi Humanized antibodies that recognize beta amyloid peptide
MY139983A (en) 2002-03-12 2009-11-30 Janssen Alzheimer Immunotherap Humanized antibodies that recognize beta amyloid peptide
US8663650B2 (en) 2003-02-21 2014-03-04 Ac Immune Sa Methods and compositions comprising supramolecular constructs
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ES2434732T3 (en) 2004-12-15 2013-12-17 Janssen Alzheimer Immunotherapy Humanized beta-amyloid antibodies for use in improving cognition
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US8784810B2 (en) 2006-04-18 2014-07-22 Janssen Alzheimer Immunotherapy Treatment of amyloidogenic diseases
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CN101516911B (en) * 2006-07-14 2016-11-16 Ac免疫有限公司 Humanized antibody for amyloid-beta
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PT2121754E (en) * 2007-01-18 2015-05-11 Lilly Co Eli Pegylated amyloid beta fab
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US8003097B2 (en) 2007-04-18 2011-08-23 Janssen Alzheimer Immunotherapy Treatment of cerebral amyloid angiopathy
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CL2008001741A1 (en) * 2007-06-12 2008-11-21 Genentech Inc Chimeric or humanized antibody or fragment thereof that specifically bind to at least one epitope in the beta-amyloid protein; nucleic acid molecule that encodes it; composition that includes it; and its use to treat diseases associated with the formation of amyloid plaques.
PT2182983E (en) 2007-07-27 2014-09-01 Janssen Alzheimer Immunotherap Treatment of amyloidogenic diseases with humanised anti-abeta antibodies
SG178809A1 (en) * 2007-10-05 2012-03-29 Genentech Inc Use of anti-amyloid beta antibody in ocular diseases
NZ601858A (en) * 2007-10-05 2014-03-28 Genentech Inc Methods and compositions for diagnosis and treatment of amyloidosis
JO3076B1 (en) 2007-10-17 2017-03-15 Janssen Alzheimer Immunotherap Immunotherapy regimes dependent on apoe status
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EP2686313B1 (en) 2011-03-16 2016-02-03 Probiodrug AG Benzimidazole derivatives as inhibitors of glutaminyl cyclase
EP3683232A1 (en) 2013-09-13 2020-07-22 F. Hoffmann-La Roche AG Methods and compositions comprising purified recombinant polypeptides
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AU2016353553B2 (en) 2015-11-09 2022-01-20 The University Of British Columbia Amyloid beta epitopes and antibodies thereto
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US20180125920A1 (en) 2016-11-09 2018-05-10 The University Of British Columbia Methods for preventing and treating A-beta oligomer-associated and/or -induced diseases and conditions
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Cited By (12)

* Cited by examiner, † Cited by third party
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US9176150B2 (en) 2003-01-31 2015-11-03 AbbVie Deutschland GmbH & Co. KG Amyloid beta(1-42) oligomers, derivatives thereof and antibodies thereto, methods of preparation thereof and use thereof
US8497072B2 (en) 2005-11-30 2013-07-30 Abbott Laboratories Amyloid-beta globulomer antibodies
US8691224B2 (en) 2005-11-30 2014-04-08 Abbvie Inc. Anti-Aβ globulomer 5F7 antibodies
US9540432B2 (en) 2005-11-30 2017-01-10 AbbVie Deutschland GmbH & Co. KG Anti-Aβ globulomer 7C6 antibodies
US8877190B2 (en) 2006-11-30 2014-11-04 Abbvie Inc. Aβ conformer selective anti-Aβ globulomer monoclonal antibodies
US9359430B2 (en) 2006-11-30 2016-06-07 Abbvie Inc. Abeta conformer selective anti-Abeta globulomer monoclonal antibodies
US9394360B2 (en) 2006-11-30 2016-07-19 Abbvie Inc. Aβ conformer selective anti-Aβ globulomer monoclonal antibodies
US8895004B2 (en) 2007-02-27 2014-11-25 AbbVie Deutschland GmbH & Co. KG Method for the treatment of amyloidoses
US9146244B2 (en) 2007-06-12 2015-09-29 Ac Immune S.A. Polynucleotides encoding an anti-beta-amyloid monoclonal antibody
US9403902B2 (en) 2007-10-05 2016-08-02 Ac Immune S.A. Methods of treating ocular disease associated with amyloid-beta-related pathology using an anti-amyloid-beta antibody
US8987419B2 (en) 2010-04-15 2015-03-24 AbbVie Deutschland GmbH & Co. KG Amyloid-beta binding proteins
US9221900B2 (en) 2010-07-30 2015-12-29 Ac Immune S.A. Methods for identifying safe and functional humanized antibodies

Also Published As

Publication number Publication date
EP1596809A2 (en) 2005-11-23
US8623365B2 (en) 2014-01-07
US8105597B2 (en) 2012-01-31
WO2004071408A2 (en) 2004-08-26
US20120114560A1 (en) 2012-05-10
US7575747B2 (en) 2009-08-18
US20090297505A1 (en) 2009-12-03
EP1596809A4 (en) 2007-10-24
ATE468886T1 (en) 2010-06-15
US20060110388A1 (en) 2006-05-25
ES2344645T3 (en) 2010-09-02
DE602004027348D1 (en) 2010-07-08
EP1596809B1 (en) 2010-05-26

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