WO2003048134A1 - Compose de triazole et son utilisation therapeutique - Google Patents
Compose de triazole et son utilisation therapeutique Download PDFInfo
- Publication number
- WO2003048134A1 WO2003048134A1 PCT/JP2002/012735 JP0212735W WO03048134A1 WO 2003048134 A1 WO2003048134 A1 WO 2003048134A1 JP 0212735 W JP0212735 W JP 0212735W WO 03048134 A1 WO03048134 A1 WO 03048134A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- haloalkyl
- alkyl
- triazole compound
- halogeno
- nitro
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/12—Oxygen or sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2003549326A JPWO2003048134A1 (ja) | 2001-12-05 | 2002-12-04 | トリアゾール化合物及びその医薬用途 |
AU2002354410A AU2002354410A1 (en) | 2001-12-05 | 2002-12-04 | Triazole compound and medicinal use thereof |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2001371687 | 2001-12-05 | ||
JP2001/371687 | 2001-12-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2003048134A1 true WO2003048134A1 (fr) | 2003-06-12 |
Family
ID=19180699
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2002/012735 WO2003048134A1 (fr) | 2001-12-05 | 2002-12-04 | Compose de triazole et son utilisation therapeutique |
Country Status (3)
Country | Link |
---|---|
JP (1) | JPWO2003048134A1 (ja) |
AU (1) | AU2002354410A1 (ja) |
WO (1) | WO2003048134A1 (ja) |
Cited By (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2862060A1 (fr) * | 2003-11-06 | 2005-05-13 | Galderma Res & Dev | Procede de synthese en phase solide de composes de types sulfures de diaryle. |
WO2007015809A2 (en) * | 2005-07-22 | 2007-02-08 | Merck & Co., Inc. | Hiv reverse transcriptase inhibitors |
WO2011136269A1 (ja) | 2010-04-28 | 2011-11-03 | アステラス製薬株式会社 | テトラヒドロベンゾチオフェン化合物 |
WO2013062065A1 (ja) | 2011-10-27 | 2013-05-02 | アステラス製薬株式会社 | アミノアルキル置換n-チエニルベンズアミド誘導体 |
WO2014029983A1 (en) | 2012-08-21 | 2014-02-27 | Ardelyx, Inc. | Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
US8722695B2 (en) | 2009-12-11 | 2014-05-13 | Autifony Therapeutics Limited | Imidazolidinedione derivatives |
US9133175B2 (en) | 2010-12-06 | 2015-09-15 | Autifony Therapeutics Limited | Compounds |
US9193704B2 (en) | 2011-06-07 | 2015-11-24 | Autifony Therapeutics Limited | Hydantoin derivatives as KV3 inhibitors |
US9198923B2 (en) | 2009-01-26 | 2015-12-01 | Opko Ireland Global Holdings, Ltd. | Phosphate management with small molecules |
US9422252B2 (en) | 2012-05-22 | 2016-08-23 | Autifony Therapeutics Limited | Triazoles as Kv3 inhibitors |
US9669030B2 (en) | 2012-05-22 | 2017-06-06 | Autifony Therapeutics Limited | Hydantoin derivatives as Kv3 inhibitors |
WO2018129557A1 (en) | 2017-01-09 | 2018-07-12 | Ardelyx, Inc. | Inhibitors of nhe-mediated antiport |
WO2018129556A1 (en) | 2017-01-09 | 2018-07-12 | Ardelyx, Inc. | Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
WO2018129552A1 (en) | 2017-01-09 | 2018-07-12 | Ardelyx, Inc. | Compounds useful for treating gastrointestinal tract disorders |
EP3351248A1 (en) | 2008-12-31 | 2018-07-25 | Ardelyx, Inc. | Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
RU2662817C2 (ru) * | 2013-04-24 | 2018-07-31 | Дайити Санкио Компани, Лимитед | Соединение дикарбоновой кислоты |
US10272079B2 (en) | 2013-04-12 | 2019-04-30 | Ardelyx, Inc. | NHE3-binding compounds and methods for inhibiting phosphate transport |
US10376481B2 (en) | 2012-08-21 | 2019-08-13 | Ardelyx, Inc. | Compounds and methods for inhibiting NHE-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
WO2023219127A1 (ja) * | 2022-05-11 | 2023-11-16 | 中外製薬株式会社 | 嚢胞性疾患を治療または予防するための医薬組成物 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3769411A (en) * | 1968-09-04 | 1973-10-30 | Rohm & Haas | Fungicidal 1,2,4-4h-triazole derivatives |
US4372953A (en) * | 1980-02-29 | 1983-02-08 | Otsuka Pharmaceutical Company, Limited | Tetrazole derivatives, and anti-ulcer composition containing the same |
US4820625A (en) * | 1986-09-19 | 1989-04-11 | Fuji Photo Film Co., Ltd. | Direct positive silver halide photographic material |
WO1999002503A1 (de) * | 1997-07-07 | 1999-01-21 | Basf Aktiengesellschaft | Triazolverbindungen und deren verwendung als dopamin-d3-liganden |
-
2002
- 2002-12-04 AU AU2002354410A patent/AU2002354410A1/en not_active Abandoned
- 2002-12-04 WO PCT/JP2002/012735 patent/WO2003048134A1/ja active Application Filing
- 2002-12-04 JP JP2003549326A patent/JPWO2003048134A1/ja active Pending
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3769411A (en) * | 1968-09-04 | 1973-10-30 | Rohm & Haas | Fungicidal 1,2,4-4h-triazole derivatives |
US4372953A (en) * | 1980-02-29 | 1983-02-08 | Otsuka Pharmaceutical Company, Limited | Tetrazole derivatives, and anti-ulcer composition containing the same |
US4820625A (en) * | 1986-09-19 | 1989-04-11 | Fuji Photo Film Co., Ltd. | Direct positive silver halide photographic material |
WO1999002503A1 (de) * | 1997-07-07 | 1999-01-21 | Basf Aktiengesellschaft | Triazolverbindungen und deren verwendung als dopamin-d3-liganden |
Cited By (52)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2862060A1 (fr) * | 2003-11-06 | 2005-05-13 | Galderma Res & Dev | Procede de synthese en phase solide de composes de types sulfures de diaryle. |
WO2005047237A1 (fr) * | 2003-11-06 | 2005-05-26 | Galderma Research & Development, S.N.C. | Procede de synthese en phase solide de composes de types sulfures de diaryle |
WO2007015809A2 (en) * | 2005-07-22 | 2007-02-08 | Merck & Co., Inc. | Hiv reverse transcriptase inhibitors |
WO2007015809A3 (en) * | 2005-07-22 | 2007-03-29 | Merck & Co Inc | Hiv reverse transcriptase inhibitors |
US7807684B2 (en) | 2005-07-22 | 2010-10-05 | Merck Sharp & Dohme Corp. | HIV reverse transcriptase inhibitors |
EP3939964A1 (en) | 2008-12-31 | 2022-01-19 | Ardelyx, Inc. | Combinations for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
EP3351248A1 (en) | 2008-12-31 | 2018-07-25 | Ardelyx, Inc. | Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
US9198923B2 (en) | 2009-01-26 | 2015-12-01 | Opko Ireland Global Holdings, Ltd. | Phosphate management with small molecules |
US10632118B2 (en) | 2009-12-11 | 2020-04-28 | Autifony Therapeutics Limited | Imidazolidinedione derivatives |
US9849131B2 (en) | 2009-12-11 | 2017-12-26 | Autifony Therapeutics Limited | Imidazolidinedione derivatives |
US8722695B2 (en) | 2009-12-11 | 2014-05-13 | Autifony Therapeutics Limited | Imidazolidinedione derivatives |
US10058551B2 (en) | 2009-12-11 | 2018-08-28 | Autifony Therapeutics Limited | Imidazolidinedione derivatives |
US9216967B2 (en) | 2009-12-11 | 2015-12-22 | Autifony Therapeutics Limited | Imidazolidinedione derivatives |
US8729068B2 (en) | 2010-04-28 | 2014-05-20 | Astellas Pharma Inc. | Tetrahydrobenzothiophene compound |
KR20130073908A (ko) | 2010-04-28 | 2013-07-03 | 아스텔라스세이야쿠 가부시키가이샤 | 테트라하이드로벤조티오펜 화합물 |
JP5617919B2 (ja) * | 2010-04-28 | 2014-11-05 | アステラス製薬株式会社 | テトラヒドロベンゾチオフェン化合物 |
CN102869656A (zh) * | 2010-04-28 | 2013-01-09 | 安斯泰来制药株式会社 | 四氢苯并噻吩化合物 |
EA022521B1 (ru) * | 2010-04-28 | 2016-01-29 | Астеллас Фарма Инк. | Соединения тетрагидробензотиофена, фармацевтическая композиция на их основе, их применение и способ лечения гиперфосфатемии |
US9284295B2 (en) | 2010-04-28 | 2016-03-15 | Astellas Pharma Inc. | Tetrahydrobenzothiophene compound |
WO2011136269A1 (ja) | 2010-04-28 | 2011-11-03 | アステラス製薬株式会社 | テトラヒドロベンゾチオフェン化合物 |
US9133175B2 (en) | 2010-12-06 | 2015-09-15 | Autifony Therapeutics Limited | Compounds |
US9346790B2 (en) | 2010-12-06 | 2016-05-24 | Autifony Therapeutics Limited | Hydantoin derivatives useful as Kv3 inhibitors |
US9422272B2 (en) | 2010-12-06 | 2016-08-23 | Autifony Therapeutics Limited | Compounds |
US10835534B2 (en) | 2010-12-06 | 2020-11-17 | Autifony Therapeutics Limited | Compounds |
US11197859B2 (en) | 2010-12-06 | 2021-12-14 | Autifony Therapeutics Limited | Hydantoin derivatives useful as Kv3 inhibitors |
US9833452B2 (en) | 2010-12-06 | 2017-12-05 | Autifony Therapeutics Limited | Compounds |
US11541052B2 (en) | 2010-12-06 | 2023-01-03 | Autifony Therapeutics Limited | Compounds |
US10555945B2 (en) | 2010-12-06 | 2020-02-11 | Autifony Therapeutics Limited | Compounds |
US10265316B2 (en) | 2010-12-06 | 2019-04-23 | Autifony Therapeuctics Limited | Hydantoin derivatives useful as Kv3 inhibitors |
US10098881B2 (en) | 2010-12-06 | 2018-10-16 | Autifony Therapeutics Limited | Compounds |
US11583527B2 (en) | 2010-12-06 | 2023-02-21 | Autifony Therapeutics Limited | Hydantoin derivatives useful as Kv3 inhibitors |
US9193704B2 (en) | 2011-06-07 | 2015-11-24 | Autifony Therapeutics Limited | Hydantoin derivatives as KV3 inhibitors |
KR20140096322A (ko) | 2011-10-27 | 2014-08-05 | 아스텔라스세이야쿠 가부시키가이샤 | 아미노 알킬 치환 n-티에닐벤즈아미드 유도체 |
US9062032B2 (en) | 2011-10-27 | 2015-06-23 | Astellas Pharma Inc. | Aminoalkyl-substituted N-thienylbenzamide derivative |
WO2013062065A1 (ja) | 2011-10-27 | 2013-05-02 | アステラス製薬株式会社 | アミノアルキル置換n-チエニルベンズアミド誘導体 |
JPWO2013062065A1 (ja) * | 2011-10-27 | 2015-04-02 | アステラス製薬株式会社 | アミノアルキル置換n−チエニルベンズアミド誘導体 |
US11180461B2 (en) | 2012-05-22 | 2021-11-23 | Autifony Therapeutics Limited | Triazoles as Kv3 inhibitors |
US10160730B2 (en) | 2012-05-22 | 2018-12-25 | Autifony Therapeutics Limited | Triazoles as KV3 inhibitors |
US10611735B2 (en) | 2012-05-22 | 2020-04-07 | Autifony Therapeutics Limited | Triazoles as Kv3 inhibitors |
US9669030B2 (en) | 2012-05-22 | 2017-06-06 | Autifony Therapeutics Limited | Hydantoin derivatives as Kv3 inhibitors |
US9422252B2 (en) | 2012-05-22 | 2016-08-23 | Autifony Therapeutics Limited | Triazoles as Kv3 inhibitors |
US10376481B2 (en) | 2012-08-21 | 2019-08-13 | Ardelyx, Inc. | Compounds and methods for inhibiting NHE-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
WO2014029983A1 (en) | 2012-08-21 | 2014-02-27 | Ardelyx, Inc. | Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
US10940146B2 (en) | 2013-04-12 | 2021-03-09 | Ardelyx, Inc. | NHE3-binding compounds and methods for inhibiting phosphate transport |
US10272079B2 (en) | 2013-04-12 | 2019-04-30 | Ardelyx, Inc. | NHE3-binding compounds and methods for inhibiting phosphate transport |
RU2662817C2 (ru) * | 2013-04-24 | 2018-07-31 | Дайити Санкио Компани, Лимитед | Соединение дикарбоновой кислоты |
US11147884B2 (en) | 2017-01-09 | 2021-10-19 | Ardelyx, Inc. | Inhibitors of NHE-mediated antiport |
WO2018129556A1 (en) | 2017-01-09 | 2018-07-12 | Ardelyx, Inc. | Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
US11242337B2 (en) | 2017-01-09 | 2022-02-08 | Ardelyx, Inc. | Compounds useful for treating gastrointestinal tract disorders |
WO2018129557A1 (en) | 2017-01-09 | 2018-07-12 | Ardelyx, Inc. | Inhibitors of nhe-mediated antiport |
WO2018129552A1 (en) | 2017-01-09 | 2018-07-12 | Ardelyx, Inc. | Compounds useful for treating gastrointestinal tract disorders |
WO2023219127A1 (ja) * | 2022-05-11 | 2023-11-16 | 中外製薬株式会社 | 嚢胞性疾患を治療または予防するための医薬組成物 |
Also Published As
Publication number | Publication date |
---|---|
AU2002354410A1 (en) | 2003-06-17 |
JPWO2003048134A1 (ja) | 2005-04-14 |
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