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SG11201909814WA - Gene therapy - Google Patents

Gene therapy

Info

Publication number
SG11201909814WA
SG11201909814WA SG11201909814WA SG11201909814WA SG 11201909814W A SG11201909814W A SG 11201909814WA SG 11201909814W A SG11201909814W A SG 11201909814WA SG 11201909814W A SG11201909814W A SG 11201909814WA
Authority
SG
Singapore
Prior art keywords
international
gene therapy
milan
tiget
monocyte
Prior art date
Application number
Inventor
Luigi Naldini
Giulia Escobar
Bernhard Rudolf Gentner
Adele Mucci
Original Assignee
Ospedale San Raffaele Srl
Fond Telethon
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1706410.6A external-priority patent/GB201706410D0/en
Priority claimed from GBGB1801511.5A external-priority patent/GB201801511D0/en
Application filed by Ospedale San Raffaele Srl, Fond Telethon filed Critical Ospedale San Raffaele Srl
Publication of SG11201909814WA publication Critical patent/SG11201909814WA/en

Links

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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
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    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K—PEPTIDES
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Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 25 October 2018 (25.10.2018) WIPO I PCT oimiolollm °nolo Oil mum olom Env oimIE (10) International Publication Number WO 2018/193119 Al (51) International Patent Classification: C12N 5/0789 (2010.01) A61K 38/21 (2006.01) C12N 5/0786 (2010.01) A61K 39/395 (2006.01) C12N 5/10 (2006.01) A61K 48/00 (2006.01) A61K 31/405 (2006.01) A61P 35/00 (2006.01) A61K 35/15 (2015.01) (21) International Application Number: PCT/EP2018/060238 (22) International Filing Date: 20 April 2018 (20.04.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 1706410.6 21 April 2017 (21.04.2017) GB 1801511.5 30 January 2018 (30.01.2018) GB (71) Applicants: OSPEDALE SAN RAFFAELE S.R.L. [IT/IT]; Via Olgettina 60, 20132 Milan (IT). FON- DAZIONE TELETHON [IT/IT]; Via Varese 16B, 00185 Rome (IT). (72) Inventors: NALDINI, Luigi; San Raffaele Telethon Insti- tute for Gene Therapy (TIGET), Via Olgettina 58, 20132 Milan (IT). ESCOBAR, Giulia; San Raffaele Telethon In- stitute for Gene Therapy (TIGET), Via Olgettina 58, 20132 Milan (IT). GENTNER, Bernhard Rudolf; San Raffaele Telethon Institute for Gene Therapy (TIGET), Via Olget- tina 58, 20132 Milan (IT). MUCCI, Adele; San Raffaele Telethon Institute for Gene Therapy (TIGET), Via Olgetti- na 58, 20132 Milan (IT). (74) Agent: D YOUNG & CO LLP; 120 Holborn, London EC1N 2DY (GB). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) (54) Title: GENE THERAPY (57) : A hematopoietic stem cell (HSC), a hematopoietic progenitor cell (HPC) a myeloid/monocyte-committed progenitor cell, a macrophage or a monocyte comprising a vector wherein the vector comprises at least one mir-130a and/or mir-126 target sequence operably linked to a nucleotide sequence encoding interferon-alpha (IFNa) for use in treating or preventing a cancer in a patient, wherein the HSC, the HPC, the myeloid/monocyte-committed progenitor cell, the macrophage or the monocyte is used in combination with an immune checkpoint inhibitor and/or a tumor associated antigen (TAA)-specific T-cell.
SG11201909814W 2017-04-21 2018-04-20 Gene therapy SG11201909814WA (en)

Applications Claiming Priority (3)

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GBGB1706410.6A GB201706410D0 (en) 2017-04-21 2017-04-21 Type 1 interferon gene therapy
GBGB1801511.5A GB201801511D0 (en) 2018-01-30 2018-01-30 Gene therapy
PCT/EP2018/060238 WO2018193119A1 (en) 2017-04-21 2018-04-20 Gene therapy

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WO2024166936A1 (en) * 2023-02-08 2024-08-15 国立大学法人九州大学 Cell capable of being differentiated into m2 macrophage in tumor tissue and having property such that m2 macrophage differentiated from said cell express inflammatory cytokine, and composition containing said cell
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CA3060145A1 (en) 2018-10-25
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AU2018253959A1 (en) 2019-11-21
JP2020517261A (en) 2020-06-18
JP2023078376A (en) 2023-06-06
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IL320674A (en) 2025-07-01
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HRP20241603T1 (en) 2025-01-31
SMT202400506T1 (en) 2025-01-14

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