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PT85910A - Piperidin-4-yl-tetracyclic benzodiazepines a process for their preparation and their use as medicaments - Google Patents

Piperidin-4-yl-tetracyclic benzodiazepines a process for their preparation and their use as medicaments

Info

Publication number
PT85910A
PT85910A PT85910A PT8591087A PT85910A PT 85910 A PT85910 A PT 85910A PT 85910 A PT85910 A PT 85910A PT 8591087 A PT8591087 A PT 8591087A PT 85910 A PT85910 A PT 85910A
Authority
PT
Portugal
Prior art keywords
piperidin
medicaments
preparation
tetracyclic
benzodiazepines
Prior art date
Application number
PT85910A
Other languages
English (en)
Other versions
PT85910B (pt
Inventor
Edward J Glamkowski
Yulin Chiang
Frederick J Ehrgott Jr
Original Assignee
Hoechst Roussel Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma
Publication of PT85910A publication Critical patent/PT85910A/pt
Publication of PT85910B publication Critical patent/PT85910B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PT85910A 1986-10-14 1987-10-13 Processo de preparacao de piperidino-4-il-tetraciclobenzodiazepinas e de composicoes farmaceuticas que as contenham PT85910B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/918,242 US4840947A (en) 1986-10-14 1986-10-14 Antiinflammatory and analgesic piperidin-4-yl-tetracyclic benzodiazepines and use thereas

Publications (2)

Publication Number Publication Date
PT85910A true PT85910A (en) 1987-11-01
PT85910B PT85910B (pt) 1990-08-31

Family

ID=25440054

Family Applications (1)

Application Number Title Priority Date Filing Date
PT85910A PT85910B (pt) 1986-10-14 1987-10-13 Processo de preparacao de piperidino-4-il-tetraciclobenzodiazepinas e de composicoes farmaceuticas que as contenham

Country Status (6)

Country Link
US (1) US4840947A (pt)
EP (1) EP0265734A1 (pt)
JP (1) JPS63104980A (pt)
DK (1) DK535287A (pt)
IE (1) IE872741L (pt)
PT (1) PT85910B (pt)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4929615A (en) * 1989-06-12 1990-05-29 Hoechst-Roussel Pharmaceuticals Inc. 7H-benzo[b]pyrazino[1,2-d]pyrrolo[3,2,1-jk][1,4]benzodiazepines
FR2725719B1 (fr) * 1994-10-14 1996-12-06 Jouveinal Inst Rech Diazepino-indoles inhibiteurs de phosphodiesterases iv
FR2746800B1 (fr) * 1996-03-29 1998-06-05 Jouveinal Inst Rech Diazepino-indoles inhibiteurs de phosphodiesterases 4
US7501417B2 (en) * 2002-03-13 2009-03-10 Janssen Pharmaceutica, N.V. Aminocarbonyl-derivatives as novel inhibitors of histone deacetylase
US7550499B2 (en) * 2004-05-12 2009-06-23 Bristol-Myers Squibb Company Urea antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions
ATE499370T1 (de) * 2005-01-19 2011-03-15 Bristol Myers Squibb Co 2-phenoxy-n-(1,3,4-thiadizol-2-yl)pyridin-3- aminderivate und verwandte verbindungen als p2y1- rezeptor-hemmer zur behandlung thromboembolischer erkrankungen
US7700620B2 (en) * 2005-06-27 2010-04-20 Bristol-Myers Squibb Company C-linked cyclic antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions
US7714002B2 (en) * 2005-06-27 2010-05-11 Bristol-Myers Squibb Company Carbocycle and heterocycle antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions
ATE505468T1 (de) * 2005-06-27 2011-04-15 Bristol Myers Squibb Co N-gebundene heterocyclische antagonisten des p2y1-rezeptors zur behandlung von thromboseleiden
ES2360818T3 (es) 2005-06-27 2011-06-09 Bristol-Myers Squibb Company Miméticos de urea lineal antagonistas del receptor p2y, útiles en el tratamiento de afecciones trombóticas.
US7960569B2 (en) * 2006-10-17 2011-06-14 Bristol-Myers Squibb Company Indole antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions
CN107298683B (zh) * 2017-07-14 2019-07-30 吉林大学 一种手性苯并二氮杂*化合物的合成方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4186199A (en) * 1978-11-02 1980-01-29 American Hoechst Corporation Indolo-,1,2-dihydroindolo-, and 1,2,6,7-tetrahydroindolo [1,7-ab][1,5] benzodiazepines
US4761411A (en) * 1983-05-18 1988-08-02 Hoechst-Roussel Pharmaceuticals Inc. Dihydrobenzopyrrolobenzodiazepines useful for treating pyschoses

Also Published As

Publication number Publication date
DK535287D0 (da) 1987-10-13
DK535287A (da) 1988-04-15
US4840947A (en) 1989-06-20
EP0265734A1 (en) 1988-05-04
PT85910B (pt) 1990-08-31
IE872741L (en) 1988-04-14
JPS63104980A (ja) 1988-05-10

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Legal Events

Date Code Title Description
MM3A Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19910819