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PE20040167A1 - Amidas del acido sulfamico - Google Patents

Amidas del acido sulfamico

Info

Publication number
PE20040167A1
PE20040167A1 PE2003000308A PE2003000308A PE20040167A1 PE 20040167 A1 PE20040167 A1 PE 20040167A1 PE 2003000308 A PE2003000308 A PE 2003000308A PE 2003000308 A PE2003000308 A PE 2003000308A PE 20040167 A1 PE20040167 A1 PE 20040167A1
Authority
PE
Peru
Prior art keywords
aryl
piperidinyl
atom
acid amides
alcoxycarbonyl
Prior art date
Application number
PE2003000308A
Other languages
English (en)
Inventor
Philipp Lehr
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0207500A external-priority patent/GB0207500D0/en
Priority claimed from GB0225679A external-priority patent/GB0225679D0/en
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PE20040167A1 publication Critical patent/PE20040167A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/26—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/08—Antiseborrheics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I DONDE R1 Y R2, JUNTO CON EL ATOMO DE NITROGENO CON EL QUE ESTAN UNIDOS, SON PIPERAZINILO EN DONDE EL SEGUNDO ATOMO DE NITROGENO ES ALCOXICARBONILO C1-C6, ARILO SUSTITUIDO, ENTRE OTROS; O R1 ES HIDROGENO Y R2 ES PIPERIDINILO, UNIDOS MEDIANTE UN ATOMO DE CARBONO DEL ANILLO PIPERIDINILO, EN DONDE EL ATOMO DE NITROGENO ESTA SUSTITUIDO POR ALCOXICARBONILO C1-C6, ARILO, ENTRE OTROS; R3 ES ARILO C6-C18 ENTRE OTROS. UN COMPUESTO PREFERIDO ES: N-[[4-[1-(2-AMINOCARBONIL-5-TRIFLUOROMETIL-FENIL)]-PIPERIDINIL]-AMINO]-SULFONIL-3,5-BIS-TRIFLUOROMETIL-BENZAMIDA, ENTRE OTROS. LOS COMPUESTOS DERIVADOS DE FORMULA I ACTUAN SOBRE LA SULFATASA DE ESTEROIDE Y SON UTILES PARA EL TRATAMIENTO LOCAL DE DESORDENES DEPENDIENTES DE ANDROGENOS TAL COMO ACNE, SEBORREA, ALOPECIA
PE2003000308A 2002-03-28 2003-03-26 Amidas del acido sulfamico PE20040167A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0207500A GB0207500D0 (en) 2002-03-28 2002-03-28 Organic compounds
GB0225679A GB0225679D0 (en) 2002-11-04 2002-11-04 Organic compounds

Publications (1)

Publication Number Publication Date
PE20040167A1 true PE20040167A1 (es) 2004-05-26

Family

ID=28676499

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2003000308A PE20040167A1 (es) 2002-03-28 2003-03-26 Amidas del acido sulfamico

Country Status (20)

Country Link
US (2) US7439362B2 (es)
EP (1) EP1492782A1 (es)
JP (1) JP4580652B2 (es)
KR (1) KR20040094877A (es)
CN (1) CN1293065C (es)
AR (1) AR039156A1 (es)
AU (1) AU2003226732B2 (es)
BR (1) BR0308795A (es)
CA (1) CA2480686A1 (es)
CO (1) CO5640113A2 (es)
IL (1) IL164267A0 (es)
MX (1) MXPA04009453A (es)
MY (1) MY136880A (es)
NO (1) NO20044321L (es)
NZ (1) NZ535617A (es)
PE (1) PE20040167A1 (es)
PL (1) PL372602A1 (es)
RU (1) RU2329258C2 (es)
TW (1) TW200306806A (es)
WO (1) WO2003082842A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0505539D0 (en) * 2005-03-17 2005-04-27 Novartis Ag Organic compounds
GB0505541D0 (en) * 2005-03-17 2005-04-27 Novartis Ag Organic compounds
GB0511190D0 (en) * 2005-06-01 2005-07-06 Sterix Ltd Use
BRPI0817045A2 (pt) 2007-09-17 2015-03-24 Preglem Sa Tratamento de condições estrogênio-dependentes em mulheres pré-menopáusicas
US11590239B2 (en) 2016-02-08 2023-02-28 Synaffix B.V. Antibody-conjugates with improved therapeutic index for targeting CD30 tumours and method for improving therapeutic index of antibody-conjugates
US11951175B2 (en) 2016-02-08 2024-04-09 Synaffix B.V. Bioconjugates containing sulfamide linkers for use in treatment
US10874746B2 (en) 2016-02-08 2020-12-29 Synaffix B.V. Sulfamide linkers for use in bioconjugates
WO2018102419A1 (en) * 2016-11-29 2018-06-07 Epizyme, Inc. Compounds containing a sulfonic group as kat inhibitors
CN114761383A (zh) * 2019-06-12 2022-07-15 诺瑟拉有限公司 磺酰胺衍生物及其用途
CN110590896B (zh) * 2019-11-04 2022-08-30 上海高准医药有限公司 雌酚酮硫酸酯哌嗪的制备方法

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US3004487A (en) * 1959-12-07 1961-10-17 Bank Of America Nat Trust & Savings Ass Imprinters
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DK101683A (da) * 1982-03-12 1983-09-13 Duphar Int Res Phenylpiperazinderivater og fremgangsmaade til fremstilling heraf
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EP1165013A4 (en) 1999-03-03 2002-08-07 Merck & Co Inc PRENYL PROTEIN TRANSFERASE INHIBITORS
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JP4320089B2 (ja) * 1999-07-06 2009-08-26 あすか製薬株式会社 フェニルスルファメート誘導体
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WO2003004487A1 (en) 2001-07-02 2003-01-16 Astrazeneca Ab Piperidine derivatives useful as modulators of chemokine receptor activity

Also Published As

Publication number Publication date
AU2003226732A1 (en) 2003-10-13
CN1293065C (zh) 2007-01-03
EP1492782A1 (en) 2005-01-05
US20060052393A1 (en) 2006-03-09
BR0308795A (pt) 2005-01-18
MY136880A (en) 2008-11-28
RU2329258C2 (ru) 2008-07-20
CN1646509A (zh) 2005-07-27
RU2004131822A (ru) 2005-07-10
US7439362B2 (en) 2008-10-21
NZ535617A (en) 2006-04-28
CA2480686A1 (en) 2003-10-09
AU2003226732B2 (en) 2006-12-21
CO5640113A2 (es) 2006-05-31
IL164267A0 (en) 2005-12-18
AR039156A1 (es) 2005-02-09
US20090042899A1 (en) 2009-02-12
PL372602A1 (en) 2005-07-25
WO2003082842A1 (en) 2003-10-09
MXPA04009453A (es) 2005-01-25
TW200306806A (en) 2003-12-01
JP2005526812A (ja) 2005-09-08
NO20044321L (no) 2004-10-12
KR20040094877A (ko) 2004-11-10
JP4580652B2 (ja) 2010-11-17

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Legal Events

Date Code Title Description
FG Grant, registration
FD Application declared void or lapsed