MA26426A1 - PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF NEW MONOCYCLIC B-LACTAMS AND FOR PHARMACEUTICAL COMPOSITIONS CONTAINING THEM - Google Patents

PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF NEW MONOCYCLIC B-LACTAMS AND FOR PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Info

Publication number: MA26426A1
Authority: MA; Morocco
Prior art keywords: lactams; intermediates; processes; preparation; pharmaceutical compositions
Prior art date: 1996-04-26

Application number

MA24565A

Other languages

French (fr)

Inventor

Dr Dashyant Dhanak

Dr Deirdre Mary Hickey

Bernadette

Dr Colin Andrew Leach

Mr Colin J Theobald

Dr Robert John Ife

Original Assignee

Smithkline Beecham Plc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-04-26

Filing date

1997-04-24

Publication date

2004-12-20

1996-04-26 Priority claimed from GBGB9608646.7A external-priority patent/GB9608646D0/en

1996-11-15 Priority claimed from GBGB9623756.5A external-priority patent/GB9623756D0/en

1996-12-03 Priority claimed from GBGB9625121.0A external-priority patent/GB9625121D0/en

1997-04-24 Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc

2004-12-20 Publication of MA26426A1 publication Critical patent/MA26426A1/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
- C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Rheumatology (AREA)
Toxicology (AREA)
Dermatology (AREA)
Physical Education & Sports Medicine (AREA)
Hematology (AREA)
Obesity (AREA)
Pain & Pain Management (AREA)
Biochemistry (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Biomedical Technology (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

MA24565A 1996-04-26 1997-04-24 PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF NEW MONOCYCLIC B-LACTAMS AND FOR PHARMACEUTICAL COMPOSITIONS CONTAINING THEM MA26426A1 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GBGB9608646.7A GB9608646D0 (en)	1996-04-26	1996-04-26	Novel compounds
GBGB9623756.5A GB9623756D0 (en)	1996-11-15	1996-11-15	Novel compounds
GBGB9625121.0A GB9625121D0 (en)	1996-12-03	1996-12-03	Novel compounds

Publications (1)

Publication Number	Publication Date
MA26426A1 true MA26426A1 (en)	2004-12-20

Family

ID=27268259

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MA24565A MA26426A1 (en)	1996-04-26	1997-04-24	PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF NEW MONOCYCLIC B-LACTAMS AND FOR PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Country Status (17)

Country	Link
EP (1)	EP0915843A1 (en)
JP (1)	JP2000509049A (en)
AR (1)	AR006833A1 (en)
AU (1)	AU2698697A (en)
BR (1)	BR9709196A (en)
CA (1)	CA2252696A1 (en)
CZ (1)	CZ341098A3 (en)
HU (1)	HUP9901359A3 (en)
ID (1)	ID16660A (en)
IL (1)	IL126696A0 (en)
MA (1)	MA26426A1 (en)
NO (1)	NO984939L (en)
NZ (1)	NZ332476A (en)
PE (1)	PE64398A1 (en)
PL (1)	PL329530A1 (en)
TR (1)	TR199802160T2 (en)
WO (1)	WO1997041098A1 (en)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
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DE60121550T2 (en)	2000-02-16	2007-06-21	Smithkline Beecham Plc, Brentford	Pyrimidin-4-one derivative as LDL-PLA2 inhibitor
US6982251B2 (en)	2000-12-20	2006-01-03	Schering Corporation	Substituted 2-azetidinones useful as hypocholesterolemic agents
ES2266459T3 (en)	2001-01-26	2007-03-01	Schering Corporation	USE OF SUBSTITUTED AZETIDINONE COMPOUNDS FOR THE TREATMENT OF SITOSTEROLEMIA.
AU2002247019C1 (en)	2001-01-26	2017-05-11	Organon Llc	Combinations of peroxisome proliferator-activated receptor (PPAR) activator(s) and sterol absorption inhibitor(s) and treatments for vascular indications
US7071181B2 (en)	2001-01-26	2006-07-04	Schering Corporation	Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors
WO2002079174A2 (en)	2001-03-28	2002-10-10	Schering Corporation	Enantioselective synthesis of azetidinone intermediate compounds
ES2275007T3 (en) *	2001-05-25	2007-06-01	Schering Corporation	USE OF SUBSTITUTED AZETIDINONE DERIVATIVES IN THE TREATMENT OF ALZEIMER'S DISEASE.
US7056906B2 (en)	2001-09-21	2006-06-06	Schering Corporation	Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women
AU2002336609B2 (en)	2001-09-21	2006-08-24	Merck Sharp & Dohme Corp.	Treatment of xanthoma with azetidinone derivatives as sterol absorption inhibitors
US7053080B2 (en)	2001-09-21	2006-05-30	Schering Corporation	Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors
CA2504916A1 (en)	2002-11-06	2004-05-27	Schering Corporation	Cholesterol absorptions inhibitors for the treatment of autoimmune disorders
ATE406364T1 (en)	2003-03-07	2008-09-15	Schering Corp	SUBSTITUTED AZETIDINONE DERIVATIVES, THEIR PHARMACEUTICAL FORMULATIONS AND THEIR USE IN THE TREATMENT OF HYPERCHOLESTEROLEMIA
US7459442B2 (en)	2003-03-07	2008-12-02	Schering Corporation	Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
CA2517573C (en)	2003-03-07	2011-12-06	Schering Corporation	Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholesterolemia
CA2517572C (en)	2003-03-07	2011-12-13	Schering Corporation	Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholesterolemia
ES2540933T3 (en)	2007-05-11	2015-07-14	Thomas Jefferson University	Methods of treatment and prevention of diseases and neurodegenerative disorders
US8962633B2 (en)	2007-05-11	2015-02-24	Thomas Jefferson University	Methods of treatment and prevention of metabolic bone diseases and disorders
BRPI0810336A2 (en)	2007-05-11	2019-03-19	The Trustees Of The University Of Pennsylvania	"method for treating and / or preventing skin ulcers in an individual"
CA2820408C (en)	2010-12-06	2018-03-06	Glaxo Group Limited	Pyrimidinone compounds for use in the treatment of diseases or conditions mediated by lp-pla2
US20130267544A1 (en)	2010-12-17	2013-10-10	Peter Adamson	Use of LP-PLA2 Inhibitors in the Treatment and Prevention of Eye Diseases
WO2013000267A1 (en)	2011-06-27	2013-01-03	中国科学院上海药物研究所	Azole heterocyclic compound, preparation method, pharmaceutical composition and use
CA2842965A1 (en)	2011-07-27	2013-01-31	Glaxo Group Limited	2,3-dihydroimidazo[1,2-c] pyrimidin-5(1h)-one compounds use as lp-pla2 inhibitors
WO2013014185A1 (en)	2011-07-27	2013-01-31	Glaxo Group Limited	Bicyclic pyrimidone compounds
JP2016505053A (en)	2013-01-25	2016-02-18	グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅＩｎｔｅｌｌｅｃｔｕａｌＰｒｏｐｅｒｔｙＤｅｖｅｌｏｐｍｅｎｔＬｉｍｉｔｅｄ	Bicyclic pyrimidone compounds as inhibitors of Lp-PLA2
CA2899124A1 (en)	2013-01-25	2014-07-31	Glaxosmithkline Intellectual Property Development Limited	Compounds
PE20151251A1 (en)	2013-01-25	2015-09-10	Glaxosmithkline Ip Dev Ltd	DERIVATIVES [5,6] IMIDAZO PYRIMIDONE BICYCLIC WITH ACTIVITY ON LP-PLA2 ENZYMES
WO2016012917A1 (en)	2014-07-22	2016-01-28	Glaxosmithkline Intellectual Property Development Limited	1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidine derivatives useful in the treatment of diseases and disorders mediated by lp-pla2
WO2016012916A1 (en)	2014-07-22	2016-01-28	Glaxosmithkline Intellectual Property Development Limited	1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidine derivatives useful in the treatment of diseases and disorders mediated by lp-pla2
WO2021089032A1 (en)	2019-11-09	2021-05-14	上海赛默罗生物科技有限公司	Tricyclic dihydroimidazopyrimidone derivative, preparation method therefor, pharmaceutical composition and use thereof
CN115304620A (en)	2021-05-07	2022-11-08	上海赛默罗生物科技有限公司	Pyrimidone derivatives, preparation method, pharmaceutical composition and application thereof

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4680391A (en) *	1983-12-01	1987-07-14	Merck & Co., Inc.	Substituted azetidinones as anti-inflammatory and antidegenerative agents
IL89835A0 (en) *	1988-04-11	1989-12-15	Merck & Co Inc	Substituted azetidinones,their preparation and pharmaceutical compositions containing them
IL99658A0 (en) *	1990-10-15	1992-08-18	Merck & Co Inc	Substituted azetidinones and pharmaceutical compositions containing them
WO1993000332A1 (en) *	1991-06-25	1993-01-07	Merck & Co., Inc.	Substituted azetidinones as anti-inflammatory and antidegenerative agents
DE69222532T2 (en) *	1991-07-23	1998-02-26	Schering Corp	SUBSTITUTED BETA LACTAM COMPOUNDS AS HYPOCHOLESTEROLEMIC AGENTS AND METHOD FOR THE PRODUCTION THEREOF
MY128261A (en) *	1992-10-27	2007-01-31	Merck Sharp & Dohme	New substituted azetidinones as anti-inflammatory and antidegenerative agents
AU5802894A (en) *	1992-12-17	1994-07-04	Merck & Co., Inc.	New substituted azetidinones as anti-inflammatory and antidegenerative agents
EP0658205B1 (en) *	1993-06-25	2000-03-15	Smithkline Beecham Plc	Lipoprotein associated phospholipase a2, inhibitors thereof and use of the same in diagnosis and therapy
CA2151045C (en) *	1993-10-06	2002-04-30	Laurence S. Cousens	Platelet-activating factor acetylhydrolase
GB9421816D0 (en) *	1994-10-29	1994-12-14	Smithkline Beecham Plc	Novel compounds
PL320937A1 (en) *	1994-12-22	1997-11-10	Smithkline Beecham Plc	Substituted azetidin-2-ones for treating arterial atheromatosis
WO1996029307A1 (en) *	1995-03-23	1996-09-26	Japan Tobacco Inc.	Diphenylmethyl-azetidinone compounds and elastase inhibitor
JP2002515852A (en) *	1995-07-01	2002-05-28	スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー	Azetidinone derivatives for the treatment of atherosclerosis
WO1997021676A1 (en) *	1995-12-08	1997-06-19	Smithkline Beecham Plc	Azetidinone compounds for the treatment of atherosclerosis

1997
- 1997-04-15 JP JP9538507A patent/JP2000509049A/en active Pending
- 1997-04-15 IL IL12669697A patent/IL126696A0/en unknown
- 1997-04-15 AU AU26986/97A patent/AU2698697A/en not_active Abandoned
- 1997-04-15 WO PCT/EP1997/001898 patent/WO1997041098A1/en not_active Application Discontinuation
- 1997-04-15 TR TR1998/02160T patent/TR199802160T2/en unknown
- 1997-04-15 EP EP97920699A patent/EP0915843A1/en not_active Withdrawn
- 1997-04-15 BR BR9709196A patent/BR9709196A/en not_active Application Discontinuation
- 1997-04-15 HU HU9901359A patent/HUP9901359A3/en unknown
- 1997-04-15 NZ NZ332476A patent/NZ332476A/en unknown
- 1997-04-15 CA CA002252696A patent/CA2252696A1/en not_active Abandoned
- 1997-04-15 CZ CZ983410A patent/CZ341098A3/en unknown
- 1997-04-15 PL PL97329530A patent/PL329530A1/en unknown
- 1997-04-24 MA MA24565A patent/MA26426A1/en unknown
- 1997-04-24 AR ARP970101682A patent/AR006833A1/en unknown
- 1997-04-24 PE PE1997000311A patent/PE64398A1/en not_active Application Discontinuation
- 1997-04-25 ID IDP971394A patent/ID16660A/en unknown
1998
- 1998-10-23 NO NO984939A patent/NO984939L/en not_active Application Discontinuation

Also Published As

Publication number	Publication date
HUP9901359A2 (en)	1999-08-30
JP2000509049A (en)	2000-07-18
NO984939D0 (en)	1998-10-23
AR006833A1 (en)	1999-09-29
CZ341098A3 (en)	1999-03-17
CA2252696A1 (en)	1997-11-06
TR199802160T2 (en)	1999-04-21
AU2698697A (en)	1997-11-19
WO1997041098A1 (en)	1997-11-06
BR9709196A (en)	1999-05-25
NZ332476A (en)	2000-06-23
PL329530A1 (en)	1999-03-29
ID16660A (en)	1997-10-30
PE64398A1 (en)	1999-01-06
NO984939L (en)	1998-12-23
IL126696A0 (en)	1999-08-17
HUP9901359A3 (en)	2000-03-28
EP0915843A1 (en)	1999-05-19

Publication	Publication Date	Title
MA26426A1 (en)	2004-12-20	PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF NEW MONOCYCLIC B-LACTAMS AND FOR PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
MA23632A1 (en)	1996-04-01	PROCESS FOR THE PREPARATION OF NEW COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
DZ2745A1 (en)	2003-09-08	Novel bicycloÄ2.2.1Üheptanes for their preparation and pharmaceutical compositions containing them.
MA26439A1 (en)	2004-12-20	NOVEL INDAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
MA26430A1 (en)	2004-12-20	NOVEL 4 (3H) -QUINAZOLINONES 2,3-DISUBSTITUTED, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
FR2740136B1 (en)	1998-01-09	INDOLIN-2-ONE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
DZ2358A1 (en)	2002-12-28	Apide b / mtp secretion inhibiting amides, process for their preparation and pharmaceutical compositions containing them
MA26687A1 (en)	2004-12-20	4-CARBOXYAMINO-2-METHYL-1,2,3,4-TETRAHYDROQUINOLEINES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
MA26620A1 (en)	2004-12-20	NEW BICYCLIC HYDROXAMIC ACID DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
FR2729951B1 (en)	1997-04-18	NOVEL HETEROCYCLIC COMPOUNDS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
MA26415A1 (en)	2004-12-20	HETEROCYCLIC COMPOUNDS, PROCESS FOR THE PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
MA26638A1 (en)	2004-12-20	NOVEL ISOTHIAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
MA26686A1 (en)	2004-12-20	NOVEL 4,4-BIARYLPIPERIDINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
MA26443A1 (en)	2004-12-20	ARALKYL- AND ARALKYLIDENE-LACTAMES AND -IMIDES HETEROCYCLIC, METHODS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
MA26571A1 (en)	2004-12-20	HYDROXAMIC ACID DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESS FOR THEIR PREPARATION
FR04C0032I2 (en)	2005-10-21	NEW QUINUCLIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
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MA26428A1 (en)	2004-12-20	NEW INDOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL FORMULATIONS CONTAINING THEM
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MA26490A1 (en)	2004-12-20	NOVEL TETRAHYDROISOQUINOLEIN DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
MA23922A1 (en)	1996-12-31	PROCESS FOR THE PREPARATION OF NOVEL MONOCYCLIC B-LACTAM COMPOUNDS AND MEDICAMENT CONTAINING THEM
PT83896A (en)	1987-01-01	PROCESS FOR THE PREPARATION OF NEW CONJUGATES OF VINBLAS-TINE AND ITS DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME
MA26501A1 (en)	2004-12-20	NEW QUINOLEIN DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
DZ2624A1 (en)	2003-03-08	Isoquinoline derivatives new processes for their preparation and pharmaceutical compositions containing them.