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KR950704249A - 비타민 D 동족체의 신규 결정형(New crystalline from of a vitamin D analogue) - Google Patents

비타민 D 동족체의 신규 결정형(New crystalline from of a vitamin D analogue)

Info

Publication number
KR950704249A
KR950704249A KR1019950702271A KR19950702271A KR950704249A KR 950704249 A KR950704249 A KR 950704249A KR 1019950702271 A KR1019950702271 A KR 1019950702271A KR 19950702271 A KR19950702271 A KR 19950702271A KR 950704249 A KR950704249 A KR 950704249A
Authority
KR
South Korea
Prior art keywords
analogue
vitamin
pharmaceutical composition
new crystalline
calcipotriol
Prior art date
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Granted
Application number
KR1019950702271A
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English (en)
Other versions
KR100309751B1 (ko
Inventor
토른가아르트 한젠 에릭
스미트 라스트룹 안데르젠 닐스
호프메이어 링보르그 레네
Original Assignee
에른스트 룬딩
레오 파마슈티칼 프로덕츠 리미티드 에이/에스(뢰벤스 케미스케 파브릭 프로둑티 온스 악티젤스캅)
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10728784&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR950704249(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 에른스트 룬딩, 레오 파마슈티칼 프로덕츠 리미티드 에이/에스(뢰벤스 케미스케 파브릭 프로둑티 온스 악티젤스캅) filed Critical 에른스트 룬딩
Publication of KR950704249A publication Critical patent/KR950704249A/ko
Application granted granted Critical
Publication of KR100309751B1 publication Critical patent/KR100309751B1/ko
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/02—Apparatus characterised by being constructed of material selected for its chemically-resistant properties
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C5/00—Preparation of hydrocarbons from hydrocarbons containing the same number of carbon atoms
    • C07C5/32—Preparation of hydrocarbons from hydrocarbons containing the same number of carbon atoms by dehydrogenation with formation of free hydrogen
    • C07C5/321—Catalytic processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C5/00—Preparation of hydrocarbons from hydrocarbons containing the same number of carbon atoms
    • C07C5/32—Preparation of hydrocarbons from hydrocarbons containing the same number of carbon atoms by dehydrogenation with formation of free hydrogen
    • C07C5/327—Formation of non-aromatic carbon-to-carbon double bonds only
    • C07C5/333—Catalytic processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C5/00—Preparation of hydrocarbons from hydrocarbons containing the same number of carbon atoms
    • C07C5/32—Preparation of hydrocarbons from hydrocarbons containing the same number of carbon atoms by dehydrogenation with formation of free hydrogen
    • C07C5/327—Formation of non-aromatic carbon-to-carbon double bonds only
    • C07C5/333—Catalytic processes
    • C07C5/3335—Catalytic processes with metals
    • C07C5/3337—Catalytic processes with metals of the platinum group
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/02—Apparatus characterised by their chemically-resistant properties
    • B01J2219/0204—Apparatus characterised by their chemically-resistant properties comprising coatings on the surfaces in direct contact with the reactive components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/02—Apparatus characterised by their chemically-resistant properties
    • B01J2219/0204—Apparatus characterised by their chemically-resistant properties comprising coatings on the surfaces in direct contact with the reactive components
    • B01J2219/0236—Metal based
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/02—Apparatus characterised by their chemically-resistant properties
    • B01J2219/025—Apparatus characterised by their chemically-resistant properties characterised by the construction materials of the reactor vessel proper
    • B01J2219/0277—Metal based
    • B01J2219/0286—Steel
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2523/00—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group C07C2521/00
    • C07C2523/38—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group C07C2521/00 of noble metals
    • C07C2523/40—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group C07C2521/00 of noble metals of the platinum group metals
    • C07C2523/42—Platinum

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

본 발명은 우수한 기술적 특성과 우수한 안정성을 갖는 칼시포티리올 수화물―칼시포트리올의 신규 결정형에 관한 것이다.

Description

비타민 D 동족체의 신규 결정형(New crystalline from of a vitamin D analogue)
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (5)

  1. 칼시포트리올(1α, 3β, 5Z, 7E, 22E, 24S)―24―사이클로로프로필―9, 10―세코콜라―5,7,10(19),22―테트라엔―1,3,24―트리올)일수화물.
  2. 제1항에 따른 화합물을 함유하는 약제학적 조성물.
  3. 제2항에 있어서, 크림인 약제학적 조성물.
  4. 제2항에 있어서, 겔인 약제학적 조성물.
  5. 제2항 내지 제4항중 어느 한 항에 있어서, 활성 성분의 함량이 조성물 1g 당 1 내지 100㎍인 약제학적 조성물.
    ※ 참고사항:최초출원 내용에 의하여 공개하는 것임.
KR1019950702271A 1993-01-15 1994-01-07 비타민d동족체의신규결정형 Expired - Lifetime KR100309751B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9300763.1 1993-01-15
GB939300763A GB9300763D0 (en) 1993-01-15 1993-01-15 Chemical compound
PCT/DK1994/000011 WO1994015912A1 (en) 1993-01-15 1994-01-07 New crystalline form of a vitamin d analogue

Publications (2)

Publication Number Publication Date
KR950704249A true KR950704249A (ko) 1995-11-17
KR100309751B1 KR100309751B1 (ko) 2002-11-08

Family

ID=10728784

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019950702271A Expired - Lifetime KR100309751B1 (ko) 1993-01-15 1994-01-07 비타민d동족체의신규결정형

Country Status (17)

Country Link
US (2) US5763426A (ko)
EP (1) EP0679154B1 (ko)
JP (1) JP3729847B2 (ko)
KR (1) KR100309751B1 (ko)
CN (1) CN1040746C (ko)
AT (1) ATE159717T1 (ko)
AU (1) AU663249B2 (ko)
CA (1) CA2151730C (ko)
DE (1) DE69406529T2 (ko)
DK (1) DK0679154T3 (ko)
ES (1) ES2111287T3 (ko)
FI (1) FI108638B (ko)
GB (1) GB9300763D0 (ko)
GR (1) GR3025668T3 (ko)
NZ (1) NZ259679A (ko)
RU (1) RU2128646C1 (ko)
WO (1) WO1994015912A1 (ko)

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AU710931B2 (en) * 1996-02-28 1999-09-30 Sumitomo Pharmaceuticals Company, Limited Crystalline vitamin D derivative
US8263580B2 (en) 1998-09-11 2012-09-11 Stiefel Research Australia Pty Ltd Vitamin formulation
PT2915534T (pt) * 1999-04-23 2018-06-20 Leo Pharma As Composição farmacêutica para aplicação dérmica para uso no tratamento da psoríase compreendendo vitamina d e um corticosteroide
US20090098065A1 (en) * 2000-01-11 2009-04-16 Avikam Harel Composition and methods for the treatment of skin disorders
EP1458678A1 (en) * 2002-11-18 2004-09-22 Teva Pharmaceutical Industries Limited A crystallization method for purification of calcipotriene
MY139521A (en) 2004-03-18 2009-10-30 Leo Pharma As Stereoselective synthesis of vitamin d analogues
FR2871696B1 (fr) * 2004-06-17 2006-11-10 Galderma Sa Composition topique pour le traitement du psoriasis
TWI318203B (en) * 2004-09-01 2009-12-11 Leo Pharma As Epimerization of allylic alcohols
EP2526930B1 (en) 2005-06-01 2013-12-25 GlaxoSmithKline Intellectual Property Development Limited Vitamin formulation
EP1987023B1 (en) * 2006-02-10 2010-11-24 Amgen, Inc Hydrate forms of amg706
JP5204088B2 (ja) 2006-03-17 2013-06-05 レオ ファーマ アクティーゼルスカブ 医薬中間体の異性化
KR20110113664A (ko) * 2006-08-29 2011-10-17 테바 파마슈티컬 인더스트리즈 리미티드 비타민 ｄ 및 코르티코스테로이드를 포함하는 약학 조성물
WO2008065514A2 (en) * 2006-11-29 2008-06-05 Glenmark Pharmaceuticals Limited Pharmaceutical compositions containing anhydrous calcipotriene
ES2272198B1 (es) * 2006-12-28 2008-06-01 Laboratorios Viñas S.A. Procedimiento para la obtencion de hidrato de calcipotriol.
EP1970048A1 (en) * 2007-03-15 2008-09-17 Drug Delivery Solutions Limited Polyaphron topical composition with vitamin D
US10265265B2 (en) * 2007-03-15 2019-04-23 Drug Delivery Solutions Limited Topical composition
EP2008651A1 (en) 2007-06-26 2008-12-31 Drug Delivery Solutions Limited A bioerodible patch
CN102015613B (zh) * 2008-05-08 2013-07-31 联合治疗公司 曲前列素一水合物
WO2011002756A2 (en) * 2009-07-01 2011-01-06 Vitamin Derivatives, Inc. Vitamin d compounds and methods for preparing same
RU2500387C1 (ru) * 2009-12-22 2013-12-10 Лео Фарма А/С Фармацевтическая композиция, содержащая аналог витамина d и смесь сорастворитель - поверхностно-активное вещество
AU2010335655B2 (en) * 2009-12-22 2015-03-05 Leo Pharma A/S Calcipotriol monohydrate nanocrystals
RU2560677C2 (ru) 2009-12-22 2015-08-20 Лео Фарма А/С Кожная композиция, включающая аналог витамина d и смесь растворителя и поверхностно-активных веществ
MX2012007225A (es) 2009-12-22 2012-07-30 Leo Pharma As Composicion farmaceutica que comprende mezcla de solventes y derivado o analogo de vitamina d.
US9254296B2 (en) 2009-12-22 2016-02-09 Leo Pharma A/S Pharmaceutical composition comprising vitamin D analogue and cosolvent-surfactant mixture
BR112012030653B1 (pt) 2010-06-11 2021-10-13 Leo Pharma A/S Composição tópica em aerossol, e, recipiente pressurizado
BR112013023458B1 (pt) 2011-03-14 2020-04-07 Drug Delivery Solutions Ltd composição oftálmica, e, método para fabricar a composição oftálmica
JP2014508796A (ja) 2011-03-24 2014-04-10 レオ ファーマ アクティーゼルスカブ 脂質ナノ粒子とコルチコステロイドまたはビタミンｄ誘導体とを含む組成物
JP5652723B2 (ja) * 2012-08-17 2015-01-14 フォーモサ・ラボラトリーズ・インコーポレーテッド マキサカルシトールの新しい結晶形態
CN103724162A (zh) * 2014-01-07 2014-04-16 成都医路康医学技术服务有限公司 一种银屑病治疗药物卡泊三醇溶剂化物的制备方法
MA41818A (fr) 2015-03-27 2018-01-30 Leo Pharma As Timbre à micro-aiguilles pour administration d'un principe actif à la peau
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Also Published As

Publication number Publication date
AU5857394A (en) 1994-08-15
FI952797A0 (fi) 1995-06-07
GR3025668T3 (en) 1998-03-31
FI108638B (fi) 2002-02-28
FI952797L (fi) 1995-06-07
ES2111287T3 (es) 1998-03-01
CA2151730A1 (en) 1994-07-21
US5763426A (en) 1998-06-09
USRE39706E1 (en) 2007-06-26
JPH08505612A (ja) 1996-06-18
WO1994015912A1 (en) 1994-07-21
CN1115979A (zh) 1996-01-31
RU2128646C1 (ru) 1999-04-10
GB9300763D0 (en) 1993-03-03
KR100309751B1 (ko) 2002-11-08
DE69406529D1 (de) 1997-12-04
ATE159717T1 (de) 1997-11-15
AU663249B2 (en) 1995-09-28
EP0679154B1 (en) 1997-10-29
JP3729847B2 (ja) 2005-12-21
CN1040746C (zh) 1998-11-18
RU95116650A (ru) 1997-06-10
DK0679154T3 (da) 1998-03-30
CA2151730C (en) 2005-01-04
NZ259679A (en) 1996-11-26
DE69406529T2 (de) 1998-05-28
EP0679154A1 (en) 1995-11-02

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