[go: up one dir, main page]

KR930004329A - 바이러스 불활성 면글로불린 용액 제조방법 - Google Patents

바이러스 불활성 면글로불린 용액 제조방법 Download PDF

Info

Publication number
KR930004329A
KR930004329A KR1019920013901A KR920013901A KR930004329A KR 930004329 A KR930004329 A KR 930004329A KR 1019920013901 A KR1019920013901 A KR 1019920013901A KR 920013901 A KR920013901 A KR 920013901A KR 930004329 A KR930004329 A KR 930004329A
Authority
KR
South Korea
Prior art keywords
solution
solid phase
extraction
phase extraction
nonionic surfactant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
KR1019920013901A
Other languages
English (en)
Other versions
KR100188448B1 (ko
Inventor
게링거 베르너
쎌로쎄 패트릭
Original Assignee
펠릭스 레너
옥타파마 아게
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6437560&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR930004329(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 펠릭스 레너, 옥타파마 아게 filed Critical 펠릭스 레너
Publication of KR930004329A publication Critical patent/KR930004329A/ko
Application granted granted Critical
Publication of KR100188448B1 publication Critical patent/KR100188448B1/ko
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
    • A61L2/0017—Filtration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0082—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using chemical substances
    • A61L2/0088—Liquid substances
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/20—Partition-, reverse-phase or hydrophobic interaction chromatography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

내용 없음.

Description

바이러스 불활성 면글로불린 용액 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (11)

  1. 면역글로불린이 비이온성 계면활성제(차후 소수성 물질상에서의 고상 추출로 제거되는)로 처리되는 정맥내사용을 위해 적합한 바이러스 -불활성된 면역글로불린 용액 제조방법.
  2. 제1항에 있어서, 용액의 pH가 5.0에서 5.5까지인 방법.
  3. 제1항 또는 2항에 있어서, TNBP 및/또는 Triton X 100이 비이온성 계면활성제로서 사용되는 방법.
  4. 제1항 내지 제3항중 어느 한 항에 있어서, 비이온성 계면활성제 처리뒤의 추출이 생물학적으로 혼화성이 있는 식물성 오일을 이용해 행해지고, 이 추출로 상기 계면활성제가 제거되는 방법.
  5. 제4항에 있어서, 캐스터 오일(caster oil) 및/또는 소이 오일(soy oil)이 식물성 오일로서 사용되는 방법.
  6. 제1항 내지 제5항중 어느 한 항에 있어서, 고상추출이, 또한 역상 크로마토그라피법에도 사용되는, 옥타데실-유도물질로 행해지는 방법.
  7. 제1항 내지 제6항중 어느 한항에 있어서, 고상추출이 C18역상 크로마토그라피법으로 행해지는 방법.
  8. 제1항에 내지 제7항중 어느 한항에 있어서, 고상추출 뒤의 이당류가 용액에 첨가되는 방법.
  9. 제1항 내지 제8항중 어느 한항에 있어서, 최종 용액이 단일 또는 다중 살균여과 처리를 받는 방법.
  10. 제1항 내지 제9항중 어느 한 항에 있어서, 면역글로불린 용액이 바이러스 불활성화전에 및/또는 살균여과 뒤에 한외여과 및 다이아필트레이션 처리되는 방법.
  11. 제1항에 내지 제10항중 어느 한 항에 있어서, 고상추출 또는 이당류 첨가뒤에, 제조 용액의 안정성 시험이 행해지는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019920013901A 1991-08-02 1992-08-01 바이러스 불활성 면역글로불린 용액 제조방법 Expired - Lifetime KR100188448B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4125625A DE4125625C2 (de) 1991-08-02 1991-08-02 Verfahren zur Herstellung von virusinaktivierten Immunglobulinlösungen
DE91P41256255 1991-08-02

Publications (2)

Publication Number Publication Date
KR930004329A true KR930004329A (ko) 1993-03-22
KR100188448B1 KR100188448B1 (ko) 1999-06-01

Family

ID=6437560

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019920013901A Expired - Lifetime KR100188448B1 (ko) 1991-08-02 1992-08-01 바이러스 불활성 면역글로불린 용액 제조방법

Country Status (14)

Country Link
US (1) US5648472A (ko)
EP (1) EP0525502B2 (ko)
JP (1) JP2969310B2 (ko)
KR (1) KR100188448B1 (ko)
AT (1) ATE143812T1 (ko)
CZ (1) CZ291813B6 (ko)
DE (2) DE4125625C2 (ko)
DK (1) DK0525502T4 (ko)
ES (1) ES2092604T5 (ko)
FI (1) FI107122B (ko)
IL (1) IL102525A (ko)
SK (1) SK280680B6 (ko)
YU (1) YU48242B (ko)
ZA (1) ZA925764B (ko)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4424935C1 (de) * 1994-07-14 1996-03-21 Immuno Ag Humanes virussicheres monomeres Immunglobulin A und Verfahren zu seiner Herstellung
US6136865A (en) * 1995-05-20 2000-10-24 Octapharma Ag Method for reduction of the infectiousness of potentially infectious material
AT403477B (de) * 1996-04-30 1998-02-25 Immuno Ag Biologisches material frei von viralen und molekularen pathogenen und verfahren zur herstellung
IL121900A (en) * 1997-10-07 2001-12-23 Omrix Biopharmaceuticals Ltd A method for the purification of immunoglobulins
DE69808012T3 (de) † 1997-10-23 2008-01-24 Mitsubishi Pharma Corp. Bei Raumtemperatur lagerfähiges Immunoglobolin-Präparat für intravenöse Injektion
DE10016877A1 (de) * 2000-04-05 2001-10-18 Scintec Diagnostics Gmbh Zug (Glyko-)Proteine mit hoher Immunreaktivität sowie ein Verfahren zu ihrer Herstellung
IL136552A (en) 2000-06-05 2005-05-17 Omrix Biopharmaceuticals Ltd Method for the inactivation of viruses by a solvent - detergent combination and by nanofiltration
US6893639B2 (en) * 2001-10-19 2005-05-17 Hemacare Corporation Method for high yield purification of immune globulins from blood plasma and blood plasma intermediates
ES2318145T3 (es) 2002-02-19 2009-05-01 Resolution Chemicals Limited Esterilizacion de esteroides por medio de disolventes.
RU2370500C2 (ru) * 2003-08-12 2009-10-20 Октафарма Аг Способ очистки раствора альфа-1-антитрипсина
US6881573B2 (en) * 2003-09-12 2005-04-19 Allan L. Louderback Augmented solvent/detergent method for inactivating enveloped and non-enveloped viruses
US20060234907A1 (en) * 2004-02-13 2006-10-19 Werner Gehringer Albumin solution and process for the production thereof
JP5042817B2 (ja) 2004-02-27 2012-10-03 オクタフアルマ・アー・ゲー ウイルス安全精製抗体調製物を提供する方法
FR2944281B1 (fr) * 2009-04-08 2011-07-29 Fabre Pierre Dermo Cosmetique Derives soufres de resorcinol, leur preparation et leurs utilisations cosmetiques
EP3684921A1 (en) * 2017-09-18 2020-07-29 Bayer Healthcare LLC Methods of inactivation of viruses using n-methylglucamide and its derivatives
WO2019086463A1 (en) 2017-10-30 2019-05-09 Baxalta GmbH Environmentally compatible detergents for inactivation of lipid-enveloped viruses

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57140724A (en) * 1981-02-25 1982-08-31 Green Cross Corp:The Heat-treatment of aqueous solution containing cold insoluble globulin
US4396608A (en) * 1981-08-24 1983-08-02 Cutter Laboratories Intravenously injectable immune serum globulin
US4481189A (en) * 1982-04-14 1984-11-06 New York Blood Center Inc. Process for preparing sterilized plasma and plasma derivatives
US4540573A (en) * 1983-07-14 1985-09-10 New York Blood Center, Inc. Undenatured virus-free biologically active protein derivatives
US4789545A (en) * 1986-03-31 1988-12-06 New York Blood Center, Inc. Removal of lipid soluble process chemicals from biological materials by extraction with naturally occurring oils or synthetic substitutes thereof
US4909940A (en) * 1987-12-30 1990-03-20 New York Blood Center, Inc. Extraction of process chemicals from labile biological mixtures with organic alcohols or with halogenated hydrocarbons
US5094960A (en) * 1988-10-07 1992-03-10 New York Blood Center, Inc. Removal of process chemicals from labile biological mixtures by hydrophobic interaction chromatography

Also Published As

Publication number Publication date
DK0525502T4 (da) 2005-09-19
SK236992A3 (en) 1995-01-05
DE4125625A1 (de) 1993-02-04
EP0525502B1 (de) 1996-10-09
KR100188448B1 (ko) 1999-06-01
YU74092A (sh) 1995-10-24
FI923425L (fi) 1993-02-03
IL102525A (en) 2005-05-17
ZA925764B (en) 1993-04-28
DE59207324D1 (de) 1996-11-14
ATE143812T1 (de) 1996-10-15
CZ236992A3 (en) 1993-02-17
JPH05202100A (ja) 1993-08-10
ES2092604T5 (es) 2006-03-01
FI923425A0 (fi) 1992-07-29
ES2092604T3 (es) 1996-12-01
EP0525502A1 (de) 1993-02-03
JP2969310B2 (ja) 1999-11-02
CZ291813B6 (cs) 2003-06-18
IL102525A0 (en) 1993-01-14
DK0525502T3 (da) 1997-03-17
FI107122B (fi) 2001-06-15
SK280680B6 (sk) 2000-06-12
EP0525502B2 (de) 2005-08-10
YU48242B (sh) 1997-08-22
DE4125625C2 (de) 1999-12-02
US5648472A (en) 1997-07-15

Similar Documents

Publication Publication Date Title
KR930004329A (ko) 바이러스 불활성 면글로불린 용액 제조방법
DE68913422T2 (de) Entfernen von Verfahrenschemikalien aus labilen biologischen Gemischen durch hydrophobe Austauschchromatographie.
DE3767077D1 (de) Verfahren zur abtrennung von cholesterin aus fettsubstanzen tierischen ursprungs und cholesterinarme fettsubstanzen.
ATE72121T1 (de) Verfahren zur herstellung von apolipoproteinen aus blutplasma- oder serumfraktionen.
DK0710124T3 (da) Fremgangsmåde til sterilisering af produkter
ATE138575T1 (de) Verfahren zur inaktivierung von viren in mit viren verunreinigten pharmazeutischen zusammensetzungen
DK0429570T3 (da) Osteoinducerende præparater
DK0473671T3 (da) Anvendelse af sigma-receptorligander til fremstilling af et anxiolytisk middel
ES521422A0 (es) Procedimiento para la obtencion de derivados de carboxilamida n-glicosilados.
ES2137225T3 (es) Eliminacion de anticuerpos de composiciones de derivados sanguineos reteniendo los factores de coagulacion.
MX23889A (es) Derivados de cromanos y tiocromanos, procedimiento para su preparacion y composicion farmaceutica.
ATE112937T1 (de) Sterilfiltrierte kolostralmilch.
KR870010188A (ko) 핵산 또는 엔도톡신의 제거제 및 제거방법
SE8302483D0 (sv) Forfarande vid rening av biologiskt aktiva substanser
DK0693278T3 (da) Kombinationer af vasoaktive stoffer med fedtsyrer for at forebygge tab af hår
DK430989D0 (da) Transdermalt anvendeligt laegemiddel med et indhold af farmaceutisk anvendelige glykosider
MX9302487A (es) Piridonas sustituidas por bifenilmetilo, procedimiento para su obtencion y medicamentos que las contienen.
DE3786708D1 (de) Verfahren zur gewinnung aktiver proteine aus einer biologisch inaktiven form.
WO1992009309A3 (en) Method of liquid sterilization
KR950700895A (ko) 2,3-디히드로-2,2,4,6,7- 펜타알킬-5-벤조푸라놀의 신규 유도체(Novel Derivatives of 2,3-Dihydro-2,2,4,6,7-Pentaalkyl-5-Benzofuranols)
RU94045868A (ru) Способ получения активного комплекса биологического назначения и активный комплекс, полученный данным способом
ATE130304T1 (de) Neue alpha-glukosidaseinhibitoren.
EP0841954B1 (de) Verfahren zur herstellung eines virussicheren, therapeutischen, biologischen präparates
DE69615685D1 (de) Impstoff gegen krankheitserreger, zusammensetzung zur behandlung und vorbeugung von hiv infektionen
KR950700896A (ko) 신규의 심장 보호제(Novel Cardioprotective Agents)

Legal Events

Date Code Title Description
PA0109 Patent application

Patent event code: PA01091R01D

Comment text: Patent Application

Patent event date: 19920801

PG1501 Laying open of application
A201 Request for examination
AMND Amendment
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 19951011

Comment text: Request for Examination of Application

Patent event code: PA02011R01I

Patent event date: 19920801

Comment text: Patent Application

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 19980414

Patent event code: PE09021S01D

AMND Amendment
E601 Decision to refuse application
PE0601 Decision on rejection of patent

Patent event date: 19980710

Comment text: Decision to Refuse Application

Patent event code: PE06012S01D

Patent event date: 19980414

Comment text: Notification of reason for refusal

Patent event code: PE06011S01I

J201 Request for trial against refusal decision
PJ0201 Trial against decision of rejection

Patent event date: 19981013

Comment text: Request for Trial against Decision on Refusal

Patent event code: PJ02012R01D

Patent event date: 19980710

Comment text: Decision to Refuse Application

Patent event code: PJ02011S01I

Appeal kind category: Appeal against decision to decline refusal

Decision date: 19981126

Appeal identifier: 1998101003300

Request date: 19981013

PB0901 Examination by re-examination before a trial

Comment text: Request for Trial against Decision on Refusal

Patent event date: 19981013

Patent event code: PB09011R01I

Comment text: Amendment to Specification, etc.

Patent event date: 19980615

Patent event code: PB09011R02I

Comment text: Amendment to Specification, etc.

Patent event date: 19951011

Patent event code: PB09011R02I

B701 Decision to grant
PB0701 Decision of registration after re-examination before a trial

Patent event date: 19981126

Comment text: Decision to Grant Registration

Patent event code: PB07012S01D

Patent event date: 19981120

Comment text: Transfer of Trial File for Re-examination before a Trial

Patent event code: PB07011S01I

GRNT Written decision to grant
PR0701 Registration of establishment

Comment text: Registration of Establishment

Patent event date: 19990112

Patent event code: PR07011E01D

PR1002 Payment of registration fee

Payment date: 19990113

End annual number: 3

Start annual number: 1

PG1601 Publication of registration
PR1001 Payment of annual fee

Payment date: 20011226

Start annual number: 4

End annual number: 4

PR1001 Payment of annual fee

Payment date: 20021227

Start annual number: 5

End annual number: 5

PR1001 Payment of annual fee

Payment date: 20031231

Start annual number: 6

End annual number: 6

PR1001 Payment of annual fee

Payment date: 20041230

Start annual number: 7

End annual number: 7

PR1001 Payment of annual fee

Payment date: 20060103

Start annual number: 8

End annual number: 8

PR1001 Payment of annual fee

Payment date: 20070109

Start annual number: 9

End annual number: 9

PR1001 Payment of annual fee

Payment date: 20080108

Start annual number: 10

End annual number: 10

PR1001 Payment of annual fee

Payment date: 20090105

Start annual number: 11

End annual number: 11

PR1001 Payment of annual fee

Payment date: 20100112

Start annual number: 12

End annual number: 12

PR1001 Payment of annual fee

Payment date: 20110106

Start annual number: 13

End annual number: 13

FPAY Annual fee payment

Payment date: 20120109

Year of fee payment: 14

PR1001 Payment of annual fee

Payment date: 20120109

Start annual number: 14

End annual number: 14

EXPY Expiration of term
PC1801 Expiration of term

Termination date: 20130509

Termination category: Expiration of duration