KR910020075A - Porous Polymer Beads and Manufacturing Method Thereof - Google Patents

Abstract

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Description

Porous Polymer Beads and Manufacturing Method Thereof

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FIG. 1 is a light micrograph showing a skinless surface and magnified 500 times the microporous spherical poly (acrylonitrile) copolymer beads of the present invention. FIG. 2 is a light micrograph showing a 2000-fold magnification of the cross section of the microporous beads of FIG. 1 demonstrating 97% high pore volume and uniform, non-bubble pore morphology. 3 is a photomicrograph of a 1,440-fold magnification of a cross section of a poly (acrylonitrile) copolymer bead according to the present invention illustrating a non-aperture pore shape of uniform diameter, pore volume of 97% and substantial matrix uniformity .

Claims (14)

(Iii) the acrylonitrile polymer and its copolymers are heated and mixed together with a mixture consisting of a solvent and a non-solvent for the polymer to form a homogeneous solution, and (ii) using a high shear technique to obtain a homogeneous solution. Milling into droplets; (Iii) optionally cooling the droplet in the presence of an inert liquid to cause phase separation and solidification of the polymer in the droplet; (Iii) A process for preparing porous polymer beads having adjustable surface porosity consisting of separating the solidified droplets from any inert liquid and removing the solvent non-solvent mixture from the solidified droplets to produce the porous beads. The method of claim 1, wherein step (iii) comprises dispersing the solution in the hot inert liquid, and step (ii) dropping the dispersion by using or homogenizing a domestic mixer, ultrasonic nozzle, spray nozzle, lamina jet, or the like. Pulverizing. The process of claim 1, wherein the solvent comprises dimethyl sulfone, non-solvent urea, water, propylene glycol, ethylene glycol or mixtures thereof and step (iii) is performed at least about 130 ° C. 3. The method of claim 1 wherein the inert liquid comprises inorganic oil, kerosene, heptane, or a mixture thereof. The process of claim 1 wherein the inert liquid is extracted from the solidified droplets using a non-solvent for polymers comprising acetone, methanol, water or mixtures thereof. The method of claim 1 wherein the polyacrylonitrile copolymer is a (C ₂ -C ₆ ) monoolefin, vinylaromatic, vinylaminoaromatic, vinyl halide, (C ₁ -C ₆ ) alkyl (meth) acrylate, (meth ) Acrylamide, vinyl pyrrolidone, vinyl pyridine, (C ₁ -C ₆ ) hydroxyalkyl (meth) acrylate, (meth) acrylic acid, acrylamidomethylpropylsulfonic acid, N-hydroxy-containing (C _1- C ₆ ) A process for the preparation of porous beads consisting of acrylonitrile copolymerized with alkyl (meth) acrylamide, or any mixture of the foregoing. The method of claim 1, comprising at least partially filling the pores of the porous beads with a compound. 8. The method of claim 7, wherein said compound is selected from the group consisting of proteins, enzymes, hormones, peptides, polysaccharides, hexanes, dyes, pigments or any mixtures of these. The method of claim 1 wherein the homogeneous solution of step (i) contains less than about 10% by weight total polymer or copolymer solids and wherein the porous polymer beads are substantially shellless. The beads are substantially non-swellable in water, have substantially uniform pores that are not substantially greater than about 5 microns in diameter, and have a pore volume of substantially less than about 1.5 ml / g. Product of the method. The product of claim 10, wherein the beads are substantially spherical. The product of claim 10, wherein the beads consist of about 45- about 99.5 mole percent of a copolymer of acrylonitrile. The product of claim 10, wherein the beads are substantially isotropic. The product of the method as defined in claim 1. ※ Note: The disclosure is based on the initial application.