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KR870002110A - 구아니디노티아졸 유도체의 제조방법 - Google Patents

구아니디노티아졸 유도체의 제조방법 Download PDF

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Publication number
KR870002110A
KR870002110A KR1019850006233A KR850006233A KR870002110A KR 870002110 A KR870002110 A KR 870002110A KR 1019850006233 A KR1019850006233 A KR 1019850006233A KR 850006233 A KR850006233 A KR 850006233A KR 870002110 A KR870002110 A KR 870002110A
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KR
South Korea
Prior art keywords
general formula
addition salt
acid addition
derivative represented
reacted
Prior art date
Application number
KR1019850006233A
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English (en)
Inventor
요시오 이시이
이사오 야나기사와
Original Assignee
모리오카 시게오
야마노우찌 세이야꾸 가부시끼가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 모리오카 시게오, 야마노우찌 세이야꾸 가부시끼가이샤 filed Critical 모리오카 시게오
Publication of KR870002110A publication Critical patent/KR870002110A/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/26—Radicals substituted by sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/48—Acylated amino or imino radicals by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

내용 없음

Description

구아니디노티아졸 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (5)

  1. 일반식(II)으로 표시되는 아미노티아졸 유도체 또는 그 산부가 염을 일반식(III1)으로 표시되는 시안아미드 유도체 또는 일반식(III2)으로 표시되는 아미디노피라졸 유도체와 반응시키는 것을 특징으로 하는 일반식(I)으로 표시되는 구아니디노티아졸 유도체 또는 그 산부가 염의 제조방법.
    상기 식중, R1및 R2는 서로 동일하거나 또는 상이한 것으로서, 각각 수소 원자 또는 알킬기(탄소원자수 1 내지 3개)이고, m은 1 또는 2이고, n은 2,3 또는 4이고, R3및 R4는 서로 동일하거나 또는 상이한 것으로서, 각각 수소 원자 또는 알킬기(탄소원자수 1 내지 3개)이다.
  2. 제1항에 있어서, 아미노티아졸 유도체 또는 그 산부가 염을 루이스 산촉매 존재하에서 시안아미드 유도체와 반응시키는 방법.
  3. 제3항에 있어서, -(2-아미노티아졸-4-일메틸티오)프로피오니트릴 또는 그 산부가 염을 시안아미드와 반응시키는 방법.
  4. 제3항에 있어서, 반응을 루이스 산촉매 존재하에서 행하는 방법.
  5. 제1항에 있어서, 3-(2-아미노티아졸-4-일메틸티오)프로피오니트릴을 아미디노피라졸 염산염과 반응시키는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019850006233A 1984-08-30 1985-08-29 구아니디노티아졸 유도체의 제조방법 KR870002110A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP182129 1984-08-30
JP59182129A JPS6160673A (ja) 1984-08-30 1984-08-30 グアニジノチアゾ−ル誘導体の製造法

Publications (1)

Publication Number Publication Date
KR870002110A true KR870002110A (ko) 1987-03-30

Family

ID=16112833

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019850006233A KR870002110A (ko) 1984-08-30 1985-08-29 구아니디노티아졸 유도체의 제조방법

Country Status (6)

Country Link
US (1) US4908454A (ko)
JP (1) JPS6160673A (ko)
KR (1) KR870002110A (ko)
DE (1) DE3530061A1 (ko)
FR (1) FR2569692B1 (ko)
GB (1) GB2165836B (ko)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR890014504A (ko) * 1988-03-11 1989-10-24 우대규 4-(2'-시아노 에틸티오)메틸-2-구아니디노티아졸의 제조방법
DE69503093T2 (de) * 1994-04-27 1999-02-04 F. Hoffmann-La Roche Ag, Basel Verfahren zur Herstellung von Guaniden
KR101080143B1 (ko) 2011-07-13 2011-11-07 박명자 개량 안강망

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3174997A (en) * 1961-01-06 1965-03-23 Parke Davis & Co Phenoxypropylguanidine compounds
US3248426A (en) * 1962-03-01 1966-04-26 American Home Prod Nu-(1-naphthylmethyl)-guanidine and acid addition salt thereof
US3203988A (en) * 1962-11-23 1965-08-31 Parke Davis & Co Cycloalkyloxyalkyl guanidine compounds
US3246031A (en) * 1965-02-23 1966-04-12 Parke Davis & Co Phenoxypropylguanidine compounds
US3444165A (en) * 1966-08-25 1969-05-13 Merck & Co Inc Process for the preparation of pyrazinoylguanidines
GB1159263A (en) * 1966-08-31 1969-07-23 Smith Kline French Lab Guanidine Derivatives and Process for Preparing the same
US4088769A (en) * 1969-10-29 1978-05-09 Smith Kline & French Laboratories Limited Method of inhibiting histamine activity with guanidine compounds
US3903159A (en) * 1970-09-17 1975-09-02 Armour Pharma Methanesulfonamidophenyl guanidine compounds
US3681459A (en) * 1970-10-01 1972-08-01 Armour Pharma Guanidine compounds and use of same
US4025652A (en) * 1975-03-31 1977-05-24 William H. Rorer, Inc. Amidinoureas
US3947455A (en) * 1974-04-15 1976-03-30 Armour Pharmaceutical Company 5'-(8'-Hydroxyquinolyl)guanidine compounds
US4000279A (en) * 1974-10-29 1976-12-28 Armour Pharmaceutical Company Pharmaceutical preparations containing 5'-(8'-hydroxyquinolyl)guanidine compounds and methods of using same
GR62452B (en) * 1977-04-20 1979-04-12 Ici Ltd Preparation process of guanidine derivatives
JPS6056143B2 (ja) * 1979-08-02 1985-12-09 山之内製薬株式会社 アミジン誘導体ならびにその製造法
PH16099A (en) * 1979-03-06 1983-06-24 Yamanouchi Pharma Co Ltd Guanidinothiazole compounds,process for preparing them and medical composition containing them
JPS5646873A (en) * 1979-09-26 1981-04-28 Yamanouchi Pharmaceut Co Ltd 2-guanidinothiazole derivative and its preparation
US4460584A (en) * 1981-03-13 1984-07-17 Imperial Chemical Industries Plc Nitrogen heterocycles
US4451463A (en) * 1981-03-24 1984-05-29 Imperial Chemical Industries Plc Alcohol derivatives

Also Published As

Publication number Publication date
US4908454A (en) 1990-03-13
DE3530061A1 (de) 1986-03-06
GB2165836B (en) 1987-11-25
FR2569692A1 (fr) 1986-03-07
GB2165836A (en) 1986-04-23
FR2569692B1 (fr) 1988-12-09
GB8521539D0 (en) 1985-10-02
JPS6160673A (ja) 1986-03-28

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