JPS61226661A - Automatic analyzing instrument - Google Patents
Automatic analyzing instrumentInfo
- Publication number
- JPS61226661A JPS61226661A JP6740985A JP6740985A JPS61226661A JP S61226661 A JPS61226661 A JP S61226661A JP 6740985 A JP6740985 A JP 6740985A JP 6740985 A JP6740985 A JP 6740985A JP S61226661 A JPS61226661 A JP S61226661A
- Authority
- JP
- Japan
- Prior art keywords
- absorbancy
- measuring
- sample
- wavelength
- absorbance
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000006243 chemical reaction Methods 0.000 claims abstract description 24
- 238000002835 absorbance Methods 0.000 claims description 31
- 239000003153 chemical reaction reagent Substances 0.000 claims description 20
- 230000035945 sensitivity Effects 0.000 claims description 3
- 238000005259 measurement Methods 0.000 abstract description 23
- 102000004420 Creatine Kinase Human genes 0.000 description 4
- 108010042126 Creatine kinase Proteins 0.000 description 4
- 239000012491 analyte Substances 0.000 description 4
- 210000002700 urine Anatomy 0.000 description 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- 102000003855 L-lactate dehydrogenase Human genes 0.000 description 2
- 108700023483 L-lactate dehydrogenases Proteins 0.000 description 2
- 239000013060 biological fluid Substances 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- 238000000691 measurement method Methods 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 108010050201 2-hydroxybutyrate dehydrogenase Proteins 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 102000004139 alpha-Amylases Human genes 0.000 description 1
- 108090000637 alpha-Amylases Proteins 0.000 description 1
- 229940024171 alpha-amylase Drugs 0.000 description 1
- 238000010876 biochemical test Methods 0.000 description 1
- 239000012490 blank solution Substances 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 229940088598 enzyme Drugs 0.000 description 1
- 238000003028 enzyme activity measurement method Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 125000002642 gamma-glutamyl group Chemical group 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000005375 photometry Methods 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
Landscapes
- Physics & Mathematics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Abstract
Description
【発明の詳細な説明】
（イ）産業上の利用分野
この発明は、自動分析装置に関し、更に詳しくは、臨床
生化学検査などにおける血清、尿などの生体液試料につ
いて特定の被検成分濃度を自動的に測定できる自動分析
装置に関する。DETAILED DESCRIPTION OF THE INVENTION (a) Industrial Application Field The present invention relates to an automatic analyzer, and more specifically, to an automatic analyzer for measuring the concentration of specific test components in biological fluid samples such as serum and urine in clinical biochemical tests. This invention relates to an automatic analyzer that can perform automatic measurements.
（ロ）従来の技術
上述のごとき自動分析装置は、従来、反応条件（試料量
、試薬量、試薬添加時間、反応時間）、測定条件（測定
波長、測定時間など）を、各被検成分ごとに、広い濃度
範囲について、必要な測定精度を維持できるようにして
いる。(b) Conventional technology Automatic analyzers such as those described above conventionally set reaction conditions (sample amount, reagent amount, reagent addition time, reaction time) and measurement conditions (measurement wavelength, measurement time, etc.) for each analyte. Additionally, the required measurement accuracy can be maintained over a wide concentration range.
、しかし、実際に扱う試料の中には、非常に高濃度のも
のがあり、測定精度を保障できないことがしばしば起こ
っている。例えば、被検成分としてのＣＰＫ （クレア
チンホスホキナーゼ）、グルコースなとは、健康人では
低い値を示すが、特定の病人ではきわめて高い値を示す
。この場合は、試料を希釈して再検査を行うことになり
、この際の試料および分析データの取扱いが？！雑で、
通常のものとの取違いなどのトラブルが多いという問題
があった。However, some of the samples actually handled have extremely high concentrations, and measurement accuracy is often not guaranteed. For example, CPK (creatine phosphokinase) and glucose as test components show low values in healthy people, but extremely high values in certain diseased people. In this case, the sample will be diluted and retested. How should the sample and analytical data be handled in this case? ! It's sloppy,
There was a problem in that there were many troubles such as confusion with regular products.
（ハ）目 的
この発明は、これらの事情に鑑みなされたちので、その
主要な目的の一つは、被検成分濃度の高い試料が含まれ
ていても、所定の測定精度を保障して自動的に濃度測定
が可能になる自動分析装置を提供することにある。(c) Purpose This invention was developed in view of these circumstances, and one of its main purposes is to automatically guarantee a predetermined measurement accuracy even if the sample contains a sample with a high concentration of analyte. The object of the present invention is to provide an automatic analyzer that enables concentration measurement in a timely manner.
（ニ）構 成
この発明は、多数の反応容器と、多数の試料容器と、こ
れらの試料容器から各反応容器に試料を採取する試料採
取器と、各反応容器の搬送手段と、各反応容器に分析試
薬を添加する試薬分注器と、各反応容器を一定温度に保
持する恒温槽と、各反応容器を測定する光度計とを備え
、この光度計が、複数波長について各反応容器の吸光度
を測定する測定部と、予め設定された吸光度直線性保障
値内にある測定吸光度値のうち、最も高感度に検出でき
る波長のものに基づいて、試料中の被検成分濃度を演算
し、出力する演算部とからなる自動分析装置である。(D) Configuration This invention includes a large number of reaction containers, a large number of sample containers, a sample collector for collecting samples from these sample containers into each reaction container, a means for transporting each reaction container, and a plurality of reaction containers. A reagent dispenser that adds analytical reagents to the sample, a constant temperature bath that maintains each reaction container at a constant temperature, and a photometer that measures each reaction container.This photometer measures the absorbance of each reaction container at multiple wavelengths. The concentration of the analyte in the sample is calculated and output based on the measurement unit that measures the wavelength and the wavelength that can be detected with the highest sensitivity among the measured absorbance values that are within the preset absorbance linearity guarantee value. This is an automatic analyzer consisting of a calculation section that performs the following steps.
すなわち、この発明は、光度計の測定波長を予め複数種
用意しておき、測定吸光度が予め設定された吸光度直線
性保障範囲内に収まるように、測定波長を選択でき、そ
れによって上記目的を達成するものである。That is, the present invention can prepare a plurality of measurement wavelengths for the photometer in advance, and select the measurement wavelength so that the measured absorbance falls within a preset guaranteed absorbance linearity range, thereby achieving the above object. It is something to do.
血清（漿）、尿などの生体液試料の被検成分としては、
種々知られているが、特にＣＰＫ （クレアチンホスホ
キナーゼ）、グルコース、ＬＤＨ（乳酸脱水素酵素）、
α−ＨＢＤ （α−ヒドロキシ酪酸脱水素酵素ン、γ−
ＧＴＰ（γ−グルタミルトランスペブチターゼ）、α−
ＡＭＹ （α−アミラーゼ〉等は超高値（高濃度値）を
示す可能性があり、この発明の自動分析装置での測定に
適している。特に、尿試料や酵素活性測定項目のように
、試料中のダイナミックレンジが広くしかも測定精度を
必要とするために微量サンプリングが雌しい被検成分の
分析に適している。Test components of biological fluid samples such as serum (plasma) and urine include:
Various types of enzymes are known, especially CPK (creatine phosphokinase), glucose, LDH (lactate dehydrogenase),
α-HBD (α-hydroxybutyrate dehydrogenase, γ-
GTP (γ-glutamyl transpebutidase), α-
AMY (α-amylase), etc. may show extremely high values (high concentration values), and are suitable for measurement with the automatic analyzer of this invention.Especially, samples such as urine samples and enzyme activity measurement items are suitable for measurement. Because the dynamic range of the sample is wide and measurement accuracy is required, trace sampling is suitable for analyzing the target components.
（ホ）実施例
以下図に示す実施例に基づいてこの発明を詳述する。な
お、これによってこの発明が限定を受けるものではない
。(e) Examples The present invention will be described in detail below based on examples shown in the drawings. Note that this invention is not limited by this.
第１図において、自動生化学分析装置（１）は、多数の
反応容器（２） ｆ３１・・・・・・と、多数の試料容
器［５） （６１・・・・・・と、試料採取器（８）と
、反応容器搬送用コンベア（９）と、試薬分注器ω）口
１１）（１２１と、反応容器を一定温度に保持する恒温
槽（図示省略）と、光度計０３）とから主として構成さ
れている。なお、（１４）は試料架設台、０５）は洗浄
水ライン、（社）は廃液ラインである。In Fig. 1, the automatic biochemical analyzer (1) includes a large number of reaction vessels (2) f31..., a large number of sample containers [5] (61...), and sample collection. (8), a conveyor (9) for transporting reaction containers, a reagent dispenser (ω) port 11) (121), a constant temperature bath (not shown) for keeping the reaction container at a constant temperature, and a photometer 03). It is mainly composed of. Note that (14) is a sample mounting stand, 05) is a washing water line, and 05) is a waste liquid line.
而して光度計０３）は、測定部面と演算部（１８１とか
らなり、測定部［Ｆ］は、光源ランプの、レンズ■、ミ
ラー＆１） Ｂ及びフィルタ架設ロータ弼を備え、この
フィルタ架設ロータには、第２図のごとく、干渉フィル
タ（波長λ１）に）、同（波長λ２）Ｖ！Ａ、同（波長
λ３）（ホ）、・・・・・・が架設され、モータ（２７
Ｉの回転によって、使用する干渉フィルタを切換えるこ
とができる。The photometer 03) consists of a measuring section and a calculating section (181), and the measuring section [F] is equipped with a light source lamp, a lens (1), a mirror &1) B, and a filter mounting rotor. As shown in Fig. 2, the rotor has an interference filter (wavelength λ1)) and an interference filter (wavelength λ2) V! A, the same (wavelength λ3) (e), ...... are installed, and the motor (27
By rotating I, the interference filter to be used can be changed.
次に演算部□□□は、検出器（至）、測定吸光度演算部
の、設定吸光度記憶部用、測定吸光度と設定吸光度とを
比較し、それによって所定の信号を出力する比較判定部
（３１）及び被検成分濃度演算部σ２から主としてなる
。Next, the calculation unit □□□ compares the detector (to), the measurement absorbance calculation unit, the set absorbance storage unit, the measured absorbance and the set absorbance, and outputs a predetermined signal accordingly. ) and a test component concentration calculating section σ2.
さて、反応容器（３）は、試料採取器（８）によって、
試料架設台（１４）の試料容器（６）から試料の供給を
受け、コンベア（９）で搬送されるうちに、試薬分注器
００１にて第１試薬を、試薬分注器（１１１にて第２試
薬を、更に試薬分注器色にて第３試薬をそれぞれ添加さ
れる。かくして、試料（被検成分）の反応が終了すると
、反応容器（３）に測定部（１３１から波長（Ａ１）の
光が照射され、そ′の測定吸光度Ａ１が、検出器（至）
及び測定吸光度演算部（ハ）によって得られ、更に比較
判定部ｌ３１）において、その測定吸光度Ａ１と、設定
吸光度記憶部用で記憶されていた、波長λ１について吸
光度直線性を保障する設定吸光度Ａｏ□とが比較される
。そして
Ａ１≦ＡＯ！
の場合は、十分吸光度直線性を保障できる範囲内での測
定として、測定吸光度Ａ１を被検成分濃度演算部■へ出
力し、被検成分濃度を次式で演算させ、濃度信号として
出力させる。Now, the reaction vessel (3) is sampled by the sample collector (8).
A sample is supplied from the sample container (6) of the sample mounting table (14), and while being transported by the conveyor (9), the first reagent is dispensed with the reagent dispenser 001 and the first reagent is dispensed with the reagent dispenser (111). The second reagent and then the third reagent are added using the color of the reagent dispenser.Thus, when the reaction of the sample (analyte component) is completed, the wavelength (A1 ) is irradiated with light, and its measured absorbance A1 is detected by the detector (toward).
and the measured absorbance A1 obtained by the measured absorbance calculating section (c), and further in the comparison/judgment section l31), the measured absorbance A1 and the set absorbance Ao□ which guarantees absorbance linearity for the wavelength λ1, which was stored for the set absorbance storage section. are compared. And A1≦AO! In the case of , the measured absorbance A1 is output to the test component concentration calculation section (2) as a measurement within a range that can ensure sufficient absorbance linearity, and the test component concentration is calculated by the following equation and output as a concentration signal.
（Ａ１ Ａｌ）１）Ｋｔ
但し、Ａｌ１１は測定波長λ１ （第３図のごとく最も
高感度に検出できる波長である）における試薬ブランク
液吸光度、Ｋ１は同λ１における濃度換算係数である。(A1 Al) 1) Kt However, Al11 is the absorbance of the reagent blank solution at the measurement wavelength λ1 (which is the wavelength that can be detected with the highest sensitivity as shown in FIG. 3), and K1 is the concentration conversion coefficient at the same wavelength λ1.
一方
Ａｔ＞ＡＯＬ
の場合は、フィルタ架設ロータ（ハ）のモータ弼に波長
λ２への切換信号を出力し、同様にして測定吸光度Ａ２
と波長λ２における設定吸光度ＡＯ２とを比較する。そ
して
Ａ２≦ＡＯ２
の場合は、被検成分濃度演算部■にて、（Ａ２ Ａｂ
２ ）Ｋ２より被検成分濃度を求める。On the other hand, if At>AOL, output a switching signal to the wavelength λ2 to the motor of the filter installation rotor (c), and similarly measure the absorbance A2.
and the set absorbance AO2 at wavelength λ2. In the case of A2≦AO2, the test component concentration calculation section ■ calculates (A2 Ab
2) Determine the concentration of the test component from K2.
更に
Ａ２ ＞Ａｏ ２
の場合は、同様にして波長λ３における測定吸光度Ａ３
を求める。通常この波長λ３で測定すれば、はとんど吸
光度直線性が保障できるので、得られた測定吸光度Ａ３
に基づいて被検成分濃度演算部（ト）にて
（Ａｔ −Ａｔｌ ｓ ＞ Ｋａ
を直接求め、出力する。Furthermore, in the case of A2 > Ao 2 , the measured absorbance A3 at wavelength λ3 is similarly calculated.
seek. Normally, if measurement is performed at this wavelength λ3, absorbance linearity can be almost guaranteed, so the measured absorbance A3
Based on this, the test component concentration calculation unit (G) directly calculates (At - Atls > Ka) and outputs it.
以上のごとく、この装置（１）によれば、被検成分濃度
が超高値の試料であっても再検査をほとんど行なうこと
なく、自動分析でき、試料、分析試薬、時間などを節約
できる。また試料や分析データの取扱いの複雑化をさけ
ることもできる。As described above, according to this device (1), even a sample with an extremely high concentration of a test component can be automatically analyzed with almost no retesting, thereby saving samples, analytical reagents, time, etc. It is also possible to avoid complicating the handling of samples and analytical data.
なお、以上の実施例では、濃度測定法は、エンドポイン
ト法を用いたが、レート法の採用も可能である。例えば
、実施例でのＡ１、Ａｂｌとして、単位時間あたりの吸
光度変化ΔＡｔ／Δｔ１ΔＡｂ□／Δ℃をそれぞれ用い
ればよい。In the above embodiments, the endpoint method was used as the concentration measurement method, but the rate method may also be used. For example, the absorbance change ΔAt/Δt1ΔAb□/Δ°C per unit time may be used as A1 and Abl in the example, respectively.
また異なる波長λ１、Ａ２、Ａ３を実施例のごとく、順
に（経時的に）用いて測定するのではなく、同時に測定
し、検出器にて異なる信号として各演算又は判定部へ出
力するようにしてもよい。In addition, instead of measuring the different wavelengths λ1, A2, and A3 sequentially (over time) as in the embodiment, they are measured simultaneously, and the detector outputs them as different signals to each calculation or judgment section. Good too.
更に測定法として二波長測光法を採用することも可能で
ある。Furthermore, it is also possible to employ dual wavelength photometry as a measurement method.
分析試薬は、実施例のごとく３種類用いられる例のほか
、１．２種類などの例もある。更に分析試薬（成分）と
して、平面的な媒体（フィルムなど）に展開保持された
ものを用いることもできる。In addition to examples in which three types of analytical reagents are used as in the example, there are also examples in which 1.2 types are used. Furthermore, as the analytical reagent (component), one developed and held on a flat medium (such as a film) can also be used.
またこれらの分析試薬（成分）の複数種と、試料被検成
分の浸透・濾過材とが多層に積層形成されてなる媒体を
用いてもよい。Alternatively, a medium may be used in which a plurality of these analytical reagents (components) and a permeation/filtration material for sample test components are laminated in multiple layers.
（へ）効 果
この発明によれば、試料中に被検成分濃度の高い試料が
含まれていても、再度測定しなおしすることもなく、所
定測定精度を保障して自動的に濃度測定できる。(F) Effects According to the present invention, even if a sample contains a sample with a high concentration of the component to be tested, the concentration can be automatically measured while ensuring the predetermined measurement accuracy without having to re-measure the sample. .
第１図はこの発明の一実施例を示す構成説明図、第２図
はそのフィルタ架設ロータの平面図、第３図は測定波長
（Ａ１、Ａ２、Ａ３）と得られる測定吸光度との関係を
示すグラフである。
（１）・・・・・・自動生化学分析装置、＋２１ ＋３
＋・・・・・・反応容器、 （５） （６１・・・・
・・試料容器、（８）・・・・・・試料採取器、
（９）・・・・・・反応容器搬送用コンベア、鳴αＤ面
・・・・・・試薬分注器、
０３・・・・・・光度計、 ０着・・・・・・測
定部、■・・・・・・演算部、
（ハ）・・・・・・測定吸光度演算部、田・・・・・・
設定吸光度記憶部、
（３１）・・・・・・比較判定部、
■・・・・・・被検成分濃度演算部。Fig. 1 is a configuration explanatory diagram showing an embodiment of the present invention, Fig. 2 is a plan view of the filter-installed rotor, and Fig. 3 shows the relationship between the measurement wavelengths (A1, A2, A3) and the measured absorbance obtained. This is a graph showing. (1)・・・Automatic biochemical analyzer, +21 +3
+...Reaction container, (5) (61...
... Sample container, (8) ... Sample collector, (9) ... Conveyor for conveying reaction containers, Ning αD surface ... Reagent dispenser, 03 ... ...Photometer, 0th place...Measurement section, ■...Calculation section, (c)...Measurement absorbance calculation section, field...
Setting absorbance storage section, (31)... Comparison/judgment section, ■... Test component concentration calculation section.
Claims (1)
料容器から各反応容器に試料を採取する試料採取器と、
各反応容器の搬送手段と、各反応容器に分析試薬を添加
する試薬分注器と、各反応容器を一定温度に保持する恒
温槽と、各反応容器を測定する光度計とを備え、 この光度計が、複数波長について各反応容器の吸光度を
測定する測定部と、予め設定された吸光度直線性保障値
内にある測定吸光度値のうち、最も高感度に検出できる
波長のものに基づいて、試料中の被検成分濃度を演算し
、出力する演算部とからなる自動分析装置。[Claims] 1. A large number of reaction containers, a large number of sample containers, and a sample collector for collecting samples from these sample containers into each reaction container;
It is equipped with a means for transporting each reaction container, a reagent dispenser for adding an analytical reagent to each reaction container, a constant temperature bath for maintaining each reaction container at a constant temperature, and a photometer for measuring each reaction container. The meter has a measuring section that measures the absorbance of each reaction container at multiple wavelengths, and the sample is selected based on the wavelength that can be detected with the highest sensitivity among the measured absorbance values that are within the preset absorbance linearity guaranteed value. An automatic analyzer consisting of a calculation section that calculates and outputs the concentration of the test component in the sample.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP6740985A JPS61226661A (en) | 1985-03-30 | 1985-03-30 | Automatic analyzing instrument |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP6740985A JPS61226661A (en) | 1985-03-30 | 1985-03-30 | Automatic analyzing instrument |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS61226661A true JPS61226661A (en) | 1986-10-08 |
| JPH0576572B2 JPH0576572B2 (en) | 1993-10-22 |
Family
ID=13344094
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP6740985A Granted JPS61226661A (en) | 1985-03-30 | 1985-03-30 | Automatic analyzing instrument |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS61226661A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9945880B2 (en) | 2013-07-05 | 2018-04-17 | Toshiba Medical Systems Corporation | Automatic analyzer |
-
1985
- 1985-03-30 JP JP6740985A patent/JPS61226661A/en active Granted
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9945880B2 (en) | 2013-07-05 | 2018-04-17 | Toshiba Medical Systems Corporation | Automatic analyzer |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0576572B2 (en) | 1993-10-22 |
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