JPS55167221A - Anticancer drug - Google Patents
Anticancer drugInfo
- Publication number
- JPS55167221A JPS55167221A JP7493879A JP7493879A JPS55167221A JP S55167221 A JPS55167221 A JP S55167221A JP 7493879 A JP7493879 A JP 7493879A JP 7493879 A JP7493879 A JP 7493879A JP S55167221 A JPS55167221 A JP S55167221A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- anticancer drug
- activity
- organs
- cancers
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000002246 antineoplastic agent Substances 0.000 title abstract 3
- 229940041181 antineoplastic drug Drugs 0.000 title abstract 3
- 230000000694 effects Effects 0.000 abstract 3
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 239000000470 constituent Substances 0.000 abstract 2
- WETAFDAZIGZTBW-ODZAUARKSA-N 1,2-dihydropyridazine-3,6-dione (Z)-4-hydrazinyl-4-oxobut-2-enoic acid Chemical compound O=C1C=CC(=O)NN1.NNC(=O)\C=C/C(O)=O WETAFDAZIGZTBW-ODZAUARKSA-N 0.000 abstract 1
- BGRDGMRNKXEXQD-UHFFFAOYSA-N Maleic hydrazide Chemical compound OC1=CC=C(O)N=N1 BGRDGMRNKXEXQD-UHFFFAOYSA-N 0.000 abstract 1
- 230000001093 anti-cancer Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 210000004392 genitalia Anatomy 0.000 abstract 1
- 230000000366 juvenile effect Effects 0.000 abstract 1
- 231100000053 low toxicity Toxicity 0.000 abstract 1
- FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical compound O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 abstract 1
- 210000000056 organ Anatomy 0.000 abstract 1
- 210000004798 organs belonging to the digestive system Anatomy 0.000 abstract 1
- 230000000241 respiratory effect Effects 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PURPOSE: An anticancer drug having activity against almost all cancers, comprising maleic hydragide as an active constituent.
CONSTITUTION: An anticancer drug comprising as an active constituent maleic hydrazide (1,2-dihydropyridazine-3,6-dione) of formula I which is obtained as a ketoenol tautomer with 3,6-dihydroxypyridazine of formula II by reacting maleic anhydride with hydrazine. Although known to have a growth-regulating activity on the juvenile cells of plants, the compound of formula I was found to have not only low toxicity snd little side effects but also the anticancer activity or human bodies by being administered orally or parenterally particularly with the efficacy of 57% against the cancers in digestive organs, genital organs, respiratory organs, etc.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP7493879A JPS55167221A (en) | 1979-06-13 | 1979-06-13 | Anticancer drug |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP7493879A JPS55167221A (en) | 1979-06-13 | 1979-06-13 | Anticancer drug |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS55167221A true JPS55167221A (en) | 1980-12-26 |
Family
ID=13561782
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP7493879A Pending JPS55167221A (en) | 1979-06-13 | 1979-06-13 | Anticancer drug |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS55167221A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0665223A1 (en) * | 1994-01-28 | 1995-08-02 | Takeda Chemical Industries, Ltd. | Antitumor agent, novel 3(2H)-pyridazinone derivatives and their preparation |
| JP2011121984A (en) * | 2003-11-19 | 2011-06-23 | Array Biopharma Inc | Bicyclic inhibitor of mek and method of use thereof |
| KR101336692B1 (en) * | 2011-12-27 | 2013-12-03 | 경희대학교 산학협력단 | Poly(ethylene oxide)-based block copolymer bearing hydrazide moiety and iron oxide nanoparticle stabilized by the same |
-
1979
- 1979-06-13 JP JP7493879A patent/JPS55167221A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0665223A1 (en) * | 1994-01-28 | 1995-08-02 | Takeda Chemical Industries, Ltd. | Antitumor agent, novel 3(2H)-pyridazinone derivatives and their preparation |
| JP2011121984A (en) * | 2003-11-19 | 2011-06-23 | Array Biopharma Inc | Bicyclic inhibitor of mek and method of use thereof |
| KR101336692B1 (en) * | 2011-12-27 | 2013-12-03 | 경희대학교 산학협력단 | Poly(ethylene oxide)-based block copolymer bearing hydrazide moiety and iron oxide nanoparticle stabilized by the same |
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