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JPS54125651A - Monocyclic beta-lactam derivative and its preparation - Google Patents

Monocyclic beta-lactam derivative and its preparation

Info

Publication number
JPS54125651A
JPS54125651A JP3258778A JP3258778A JPS54125651A JP S54125651 A JPS54125651 A JP S54125651A JP 3258778 A JP3258778 A JP 3258778A JP 3258778 A JP3258778 A JP 3258778A JP S54125651 A JPS54125651 A JP S54125651A
Authority
JP
Japan
Prior art keywords
formula
reacted
derivative
preparation
azetidinone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP3258778A
Other languages
Japanese (ja)
Inventor
Hisayasu Ishimaru
Minoru Hatanaka
Noriyoshi Noguchi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SANGYO KAGAKU KENKYU KYOKAI
Original Assignee
SANGYO KAGAKU KENKYU KYOKAI
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SANGYO KAGAKU KENKYU KYOKAI filed Critical SANGYO KAGAKU KENKYU KYOKAI
Priority to JP3258778A priority Critical patent/JPS54125651A/en
Publication of JPS54125651A publication Critical patent/JPS54125651A/en
Pending legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Plural Heterocyclic Compounds (AREA)

Abstract

NEW MATERIAL:An azetidinone derivative of formula I: (R1 is protected amino group; R2 is 3W6C alkyl, 5W6C cycloalkyl or lower alkoxycarbonylmethyl group; R3 is H or OH-protecting group).
EXAMPLE: (3S)-1-(11-n-Butylaminocarbonyl-p-hydroxybenzyl)-3-t-butoxycarbonylamino-2-azetidinone.
USE: An intermediate for the synthesis of nocardin or its derivative.
PROCESS: An 3- amino-2-protected amino-propionic acid of formula II is reacted with a hydroxybenzaldehyde of formula III in the presence of an alkali in an inert solvent at 60W80°C, and neutralized with a mineral acid, then reacted with an isonitrile of formula IV to give the objective compound of formula I. Alternatively, the compounds of formulas II, III, and IV are reacted in an organic solvent, e.g. a lower aliphatic alcohol, with stirring.
COPYRIGHT: (C)1979,JPO&Japio
JP3258778A 1978-03-20 1978-03-20 Monocyclic beta-lactam derivative and its preparation Pending JPS54125651A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP3258778A JPS54125651A (en) 1978-03-20 1978-03-20 Monocyclic beta-lactam derivative and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP3258778A JPS54125651A (en) 1978-03-20 1978-03-20 Monocyclic beta-lactam derivative and its preparation

Publications (1)

Publication Number Publication Date
JPS54125651A true JPS54125651A (en) 1979-09-29

Family

ID=12362990

Family Applications (1)

Application Number Title Priority Date Filing Date
JP3258778A Pending JPS54125651A (en) 1978-03-20 1978-03-20 Monocyclic beta-lactam derivative and its preparation

Country Status (1)

Country Link
JP (1) JPS54125651A (en)

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