JP2003169823A - Patch - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To obtain a patch which has excellent transparency and anchorage between a base and a hydrous gel layer, well follows up the expansion and contraction of the skin and is wrinkle-free even after restoration from stretching. <P>SOLUTION: The patch is formed by interposing a knitted fabric between a resin layer and the hydrous gel layer and more preferably this knitted fabric consists of single yarn of 5 to 300 denier or multifilament yarn of 15 to 500 denier and has a basis weight of 5 to 150 g/m<SP>2</SP>. <P>COPYRIGHT: (C)2003,JPO

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to a patch, and more specifically, it has excellent anchoring properties between a support and a hydrous gel layer, and also follows the expansion and contraction of the skin well, and after stretching, its stretching force. When cancelled (hereinafter referred to as "after extension recovery")
The present invention relates to a patch which can be self-reliant and can also obtain good transparency.

[0002]

2. Description of the Related Art Conventionally, patches having a hydrogel spread on a support such as a nonwoven fabric have been known. However, when a nonwoven fabric alone is used as a support, the patch is There was a problem that the whole became opaque and became conspicuous when the patch was applied to the skin.

On the other hand, since the resin film which has been conventionally used has a hydrophobic surface, the anchoring property with the hydrous gel layer is poor and the resin film and the hydrous gel are separated from each other, so that the resin film is applied from the skin. There is a problem that the hydrogel remains on the skin when the agent is peeled off.

Therefore, in JP-A-2000-119129, a support and a hydrous gel layer are prepared by laminating a hydrous gel on the fiber layer of a support in which a fiber layer made of pulp or rayon and a transparent film are laminated. Although a gel sheet for cosmetics that gives a transparent feeling when applied without deteriorating the anchoring property with is described, even if a stretchable film is used, stretch back properties (shape before stretching) in pulp or rayon nonwoven fabric are described. When it is applied to the skin, it does not follow the expansion and contraction of the skin smoothly, so that it has a strong feeling of tension and wrinkles are formed after the extension is recovered, which causes a problem in appearance.

The present invention has been made in view of the above circumstances, and is excellent in anchoring properties between a support and a hydrous gel layer, and further has a skin sensation by following the expansion and contraction of the skin well, and even after extension and recovery. It is an object of the present invention to provide an adhesive patch which does not fit into the skin and can also obtain good transparency.

[0006]

Means for Solving the Problems and Embodiments of the Invention As a result of intensive investigations by the present inventors to solve the above problems,
It was found that when a knitted fabric is used as the anchor layer instead of the non-woven fabric, a good patch that does not cause wrinkles during expansion and contraction can be obtained, and as a result of further diligent studies, the thickness of the fibers constituting the knitted fabric was determined. The present invention has been made based on the finding that when the specific weight is set and the grammage is set in the specific range, particularly excellent anchoring property with the hydrogel layer can be obtained and transparency can be achieved.

That is, the present invention provides a patch comprising a knitted fabric interposed between a resin layer and a hydrogel layer. Here, when the knitted fabric is composed of a single yarn of 5 to 300 denier or a multifilament yarn of 15 to 500 denier and has a basis weight of 5 to 150 g / m ² ,
It is more suitable. Further, it is more preferable that the resin layer is transparent.

The present invention will be described in more detail below. In the patch of the present invention, a knitted fabric is interposed between a resin layer and a hydrogel layer. Here, the resin layer may be formed of a resin film, or may be formed by applying a molten resin to one surface of a knitted fabric described later. The type of the resin is not particularly limited, but a resin having transparency is suitable, and examples thereof include olefin resins such as polyethylene (PE) and polypropylene (PP), polyethylene terephthalate (PET), Polybutylene terephthalate (PB
T) and other ester-based resins, polyester-based polyurethanes, polyether-based polyurethanes and other urethane-based resins,
Nylon 12, amide resin such as polyether block amide copolymer, styrene resin such as polystyrene, polyvinyl chloride resin, ethylene-vinyl acetate copolymer,
Examples thereof include polyfluorocarbon-based resins. These may be used alone or in a blend of two or more. The degree of polymerization of these is not particularly limited, and those having a degree of polymerization usually used for the base material of the patch can be used.

When the transparent resin is used in the present invention, its transparency is not particularly limited, but for example, the following transparency (L value) is 10 or more, preferably 20 or more. If the L value is less than 10, it may be noticeable during application.

<Measurement of Transparency (L Value)> Measurement is carried out at 25 ° C. by a transmission method using a color difference meter to obtain (L, a, b) values, and the L value is used to evaluate transparency. The measurement standard is (L, a, b) = (94.59, 92.57,
A standard white plate having a characteristic value of 111.43) is used.

The elongation recovery rate of the resin layer is not particularly limited, but the following 50% elongation recovery rate is preferably 75% or more, preferably 85% or more in both the longitudinal and transverse directions. If it is less than 75%, it may not smoothly follow the expansion and contraction of the skin during application.

<50% elongation recovery rate> Samples of 10 × 150 mm were taken in both the vertical direction (flow direction during spreading) and the horizontal direction (direction perpendicular to the flowing direction during spreading) and gripped using a tensile tester. Distance 100 mm, pulling speed 200
Stretch 50 mm at mm / min and return at the same speed until the stress becomes zero. Read the initial length A (100 mm) of the sample and the length B of the sample after the tensile test from the chart paper,
It was calculated from the following formula.

50% elongation recovery rate (%) = 100- (B-
A) × 100 / (A × 0.5) (where A is the initial length of the sample (100 m
m) and B represent the length (mm) of the sample after the tensile test. )

Further, the water vapor permeability of the resin layer is preferably 100 (g / m ² · 24 hr) or more, more preferably 2
00 (g / m ² · 24 hr) or more, more preferably 25
It is preferably 0 (g / m ² · 24 hr) or more.
If the moisture vapor transmission rate is too low, it may peel off during application. The upper limit of the water vapor transmission rate is not particularly limited, but in consideration of versatility, it is 2500 (g / m ² ·
24 hours or less, preferably 2000 (g / m ² · 24)
hr) or less, more preferably 1500 (g / m ² · 24)
hr) or less, more preferably 1000 (g / m ² · 24)
It is desirable that it is not more than hr). Here, the water vapor transmission rate can be confirmed by measuring according to JIS Z 0208-1976 condition A (cup method).

The thickness of the resin layer is not particularly limited, but is usually 5 to 100 μm, particularly 10 to 10.
It is preferably 75 μm. If the thickness of the resin layer is too thin, the handleability as a patch may deteriorate, and if it is too thick, the desired transparency and stretchability may not be obtained. When the resin layer of the present invention is a knitted fabric coated with a molten resin on one side, the layer thickness is 15 to 110 μm.
m, especially 20 to 85 μm is suitable. If it is too thin, the handleability as a patch may deteriorate, and if it is too thick, the desired transparency and stretchability may not be obtained.

Further, the 30% modulus of the resin layer is
Although not particularly limited, 300 g / cm or less,
Preferably 200 g / cm or less, more preferably 100
It is preferably g / cm or less. If it exceeds 300 g / cm, it may not smoothly follow the expansion and contraction of the skin during application. The lower limit is not particularly limited, but is usually 3
It is 0 g / cm or more.

<30% Modulus> 10 × 200 mm samples were taken in both the vertical direction (flow direction at the time of spreading) and the horizontal direction (direction perpendicular to the flow direction at the time of spreading), and the gripping interval was 150 mm using a tensile tester. , Pulling speed 200
The stress when stretched 45 mm at mm / min is measured.

If necessary, a corona discharge treatment, ozone / ultraviolet irradiation, plasma treatment, chromic acid treatment, or the like may be performed on the pressure-sensitive adhesive layer (hydrogel layer) forming side of the resin layer (film-like support). Flame treatment, hot air treatment, surface irregularity treatment, etc. may be performed.

The patch of the present invention comprises a knitted fabric provided on the pressure-sensitive adhesive layer forming surface side of the above resin layer, and the knitted fabric is a non-woven fabric,
Compared to woven cloth, both vertical and horizontal have excellent stretch back properties after extension, and when attached to the skin, they smoothly follow the expansion and contraction of the skin, so there is no feeling of tension and a skin feeling. Is.

The knitted fabric of the present invention is not particularly limited in fiber material (type), and examples thereof include polyester, nylon, polyolefin (PE, PP, etc.), vinylon, polyvinylidene chloride, polyvinyl chloride, acrylic resin, polyurethane. And the like. The degree of polymerization of these is not particularly limited, and those having a degree of polymerization usually used as a knitted fabric material can be used.

The knitting method of the knitted fabric of the present invention is not particularly limited, for example, warp knitting (tricot knitting, denby tricot knitting, satin knitting, atlas knitting, plain knitting, rim knitting, pearl knitting), circular knitting (Double-sided knitting, single-sided knitting, fraise-knitting), weft knitting, circular knitting made of multifilament yarn, multi-step double-sided knitting, miss-knitting, cross-inlay knitting, inlay knitting, etc. are used. Preferably,
Tricot knitting, double-sided knitting, single-sided knitting, milling knitting, circular knitting made of multifilament yarn, and multi-step double-sided knitting are used.

The fiber thickness of the knitted fabric of the present invention is 5 to 300 denier, preferably 15 to 15 when a single yarn is used.
0 denier is preferred. If it is less than 5 denier, the resin layer and the hydrogel may not anchor. When it exceeds 300 denier, the contrast between the fiber and the surrounding area is large, and the fiber may be conspicuous.

When multifilament yarn is used, it is preferably 15 to 500 denier, preferably 30 to 300 denier. If it is less than 15 denier, the resin layer and the hydrogel may not anchor. When it exceeds 500 denier, the contrast between the fiber and its surroundings is large, and the fiber may be conspicuous.

The lower limit of the basis weight of the knitted fabric of the present invention is 5 g.
/ M ² or more, preferably 10 g / m ² or more, more preferably 20 g / m ² or more. If it is less than 5 g / m ² , the resin layer and the hydrogel may not anchor. The upper limit is 150 g / m ² or less, preferably 80 g / m ² or less, and more preferably 60 g / m ² or less. 150 g /
When it exceeds m ² , the transparency of the entire patch may not be obtained in some cases.

Further, the elongation recovery rate of the knitted fabric of the present invention is such that the 50% elongation recovery rate is 70% or more in the machine direction, preferably 8%.
It is preferably 0% or more, 75% or more in the lateral direction, and preferably 85% or more. If it is too low, it may not smoothly follow the expansion and contraction of the skin during application.

The 30% modulus of the knitted fabric is not particularly limited, but is 300 g / cm or less, preferably 200 g / cm or less, more preferably 100 g / cm.
The following is preferable. If it exceeds 300 g / cm, it may not smoothly follow the expansion and contraction of the skin during application. The lower limit is not particularly limited, but is usually 30 g.
/ Cm or more.

The patch of the present invention uses a laminate of the above resin layer and the above knitted fabric as a support, and the method for producing the support is not particularly limited, but for example, the above resin may be used. Method of heat-welding the film to the knitted fabric, or a method of laminating it using an adhesive or the like as appropriate, the molten resin is applied to one side of the knitted fabric and dried to form a resin layer on one side of the knitted fabric. It can be manufactured by a method such as.

The elongation recovery rate of the laminate of the resin layer and the knitted fabric is 70% or more in the machine direction, preferably 80% or more in the machine direction, and 75% or more in the machine direction, preferably 85.
% Or more is preferable. If it is too low, it may not smoothly follow the expansion and contraction of the skin during application.

30% of the laminate of the resin layer and the knitted fabric
The modulus is not particularly limited, but is 300
It is preferably g / cm or less, preferably 200 g / cm or less, and more preferably 100 g / cm or less. Three
If it exceeds 00 g / cm, it may not smoothly follow the expansion and contraction of the skin during application. The lower limit is not particularly limited, but is usually 30 g / cm or more.

The water-containing gel of the patch of the present invention is preferably a water-containing gel obtained by adding a crosslinking agent such as a polyvalent metal salt to a matrix containing polyacrylic acid and / or polyacrylic acid salt to form a gel. is there. Furthermore, it is more preferable to add another polymer compound to the matrix substrate, because an adhesive (hydrous gel) having a good feeling in use can be obtained.

Any of the above polyacrylic acids can be used, and its molecular weight and linear or branched shape are not particularly limited, but the weight average molecular weight is from 10,000 to 100.
It is preferable to use those having a weight average molecular weight of 10,000 to less than 500,000, 500,000 to less than 2,000,000, and 200 to 200,000.
It is preferable to combine two or more kinds of polyacrylic acid having an average molecular weight of 10,000 to 7,000,000 and salts thereof, since the feeling of use is improved. In addition to a polymer obtained by polymerizing ordinary acrylic acid, a partially crosslinked acrylic acid polymer such as carboxyvinyl polymer, for example, Carbopol (trade name: manufactured by Goodrich, USA) is also suitable. Can be used.

As the polyacrylic acid salt, monovalent metal salts of polyacrylic acid such as sodium polyacrylate and potassium polyacrylate, monoethanolamine polyacrylate, diethanolamine polyacrylate, triethanolamine polyacrylate, etc. 1 or 2 such as amine salt of polyacrylic acid and ammonium salt of polyacrylic acid
More than one species may be preferably used.

The amount of polyacrylic acid and / or polyacrylic acid salt compounded is 1 to 20% by mass, especially 3% by mass of the total hydrogel.
It is preferable to set it to -15 mass%. If the blending amount is too small, the anchoring force may be insufficient, and if the blending amount is too large, the viscosity of the water-containing gel may be high, which may cause a problem in workability during production or may cause pain when peeling the patch.

The polyvalent metal salt is a salt that releases polyvalent metal ions in an aqueous solution, and as the polyvalent metal salt, as long as a water-soluble polymer compound that crosslinks with a metal can be crosslinked with a metal, Is not particularly limited, for example magnesium compound, calcium compound, zinc compound,
Cadmium compounds, aluminum compounds, titanium compounds, tin compounds, iron compounds, chromium compounds, manganese compounds, cobalt compounds, nickel compounds and the like can be used, but the patch of the present invention is applied to the skin and is safe for the skin. Considering the properties, it is particularly preferable to use an aluminum compound, a magnesium compound, a calcium compound or the like.

In this case, any of aluminum compounds, magnesium compounds and calcium compounds can be preferably used, and examples thereof include alums such as potassium alum, ammonium alum, iron alum, aluminum hydroxide, aluminum sulfate, aluminum chloride and aluminum. Glycinate, aluminum acetate, aluminum oxide, aluminum silicate, aluminum metasilicate, calcium hydroxide, calcium carbonate, calcium sulfate, calcium nitrate, calcium chloride, calcium acetate, calcium oxide, calcium phosphate, magnesium hydroxide, magnesium carbonate, sulfuric acid Magnesium, magnesium acetate, magnesium silicate, magnesium oxide,
One or more of water-soluble compounds such as magnesium hydroxide aluminate, magnesium aluminometasilicate, magnesium aluminate silicate, synthetic hydrotalcite, double salts containing these metals, and poorly water-soluble compounds may be used.
In addition, an antacid containing aluminum or magnesium may be added as a polyvalent metal salt.

Here, when the polyvalent metal salt is blended,
The blending amount varies depending on the kind, and is not particularly limited, but 0.001 to 10 of the whole hydrogel.
It is preferable to set the content by mass%, particularly 0.01 to 5% by mass.

Further, when other water-soluble polymer compound is blended, the kind thereof is not particularly limited, and those conventionally used can be used. For example, gelatin, agar, polyvinyl alcohol, polyvinylpyrrolidone polyethylene oxide, carboxymethyl cellulose, carboxymethyl cellulose sodium, hydroxypropyl cellulose, hydroxyethyl cellulose, methyl cellulose, sodium alginate, xanthan gum, gum arabic, tragacanth gum, karaya gum, maleic anhydride copolymer, propylene glycol. ,
Examples include carboxymethyl starch sodium and carrageenan. These may be used alone or in combination of two or more, but in the case of the present invention,
In particular, it is desirable to mix sodium carboxymethyl cellulose with the above polyacrylic acid and / or polyacrylic acid salt, and further to mix and use other polymer compounds, if necessary. The amount of these other water-soluble polymer compounds to be compounded can be appropriately selected within a range that does not impair the transparency of the hydrogel of the present invention.

The water-containing gel of the present invention may optionally contain other components, if desired. For example, a medicinal component, a warming sensation-imparting component, an emulsifier, a moisturizing component (polyhydric alcohol), a refreshing agent, an inorganic powder, an antiseptic, a fragrance, a pigment, etc. can be added.

More specifically, the medicinal properties include, for example, indomethacin, glycol salicylate, methyl salicylate, ketoprofen, flurbiprofen, ibuprofen, suprofen, loxoprofen, zaltoprofen, piroxicam, felbinac, diphenhydramine, dibucaine, procaine, lidocaine, vitamins. Examples thereof include E derivatives, glycyrrhetinic acid and derivatives thereof, and these can be used alone or in combination of two or more kinds as appropriate.

Examples of the above-mentioned ingredients for imparting warmth include capsaicinoid, capsaicin, dihydroxycapsaicin, capsaicin analogues such as capsanthin, capsicoside, capsicum extract, capsicum tincture, capsicum-derived substances such as capsicum, benzyl nicotinate, β-butoxy nicotinate. Ethyl, N-acyl vanilamide, nonyl acid vanilamide, and vanillyl alcohol alkyl ether represented by the following general formula (1), which can be used alone or in combination of two or more kinds. .

[0041]

[Chemical 1] (In the formula, R is an alkyl group having 1 to 6 carbon atoms)

The blending amount of the above-mentioned warming sensation-imparting substance with respect to the hydrous gel of the present invention (total blending amount when two or more kinds are used in combination) is preferably 0.0001 to 5 mass% of the entire hydrous gel, and more preferably. The amount is 0.001 to 3% by mass, and more preferably 0.005 to 1% by mass. If the blending amount of the warming sensation-imparting substance is too small, sufficient warmth may not be imparted, and if it is too large, skin irritation may occur.

Examples of the emulsifier include polyglycerin fatty acid ester such as diglycerin monostearate, polyoxyethylene (POE) (10) polyoxyethylene glycerin fatty acid ester such as glyceryl monooleate, polyoxyethylene fatty acid ester, POE ( Two
5) Polyoxyethylene alkyl ether such as lauryl ether, polyoxyalkylene alkyl ether such as polyoxyethylene polyoxypropylene alkyl ether, polyoxyethylene alkyl ether sulfuric acid (ester) salt, fatty acid soap, sorbitan fatty acid ester, glycerin fatty acid ester, Polyoxyethylene sorbitan fatty acid ester, polyoxyethylene hydrogenated castor oil, alkyl sulfate, N-acylmethyl taurine salt,
Examples thereof include alkylammonium salt, betaine acetate, propylene glycol fatty acid ester, vitamin derivative, glycyrrhizic acid, glycyrrhetinic acid and derivatives thereof, and specifically, sorbitan monooleate, glyceryl monooleate, decaglyceryl monooleate, diglyceryl dioleate. , Hexaglyceryl monolaurate, propylene glycol monostearate, POE (20)
Sorbitan monooleate, POE (60) sorbit tetraoleate, POE (40) monostearate, PO
E (10) oleyl ether, POE (10) nonylphenyl ether, POE (50) hydrogenated castor oil, POE
(5) Oleic acid amide, sodium lauryl sulfate, P
Sodium OE alkyl ether sulfate, Sodium POE alkyl ether acetate, Tri-POE (10) alkyl ether phosphate, Stearyl trimethyl ammonium chloride, Benzalkonium chloride, Betaine lauryl dimethylaminoacetate, Egg yolk, Lecithin, Imidazolinium betaine, Diethyl sebacate Etc.

As the moisturizing component (polyhydric alcohol), glycerin, sorbitol, ethylene glycol,
Propylene glycol, polyethylene glycol, polypropylene glycol, 1,3-propanediol,
1,4-butanediol, maltitol, xylitol and the like can be mentioned, and these can be used alone or in an appropriate combination of two or more kinds.

As the above-mentioned cooling agent, menthol derivatives such as camphor, thymol, menthol, N-ethyl-p-menthane-carboxamide, p-menthane-3,8-diol, 1-isopulegol and 1-menthylglyceryl ether are used. And the like. These can be used alone or in combination of two or more kinds as appropriate.

Examples of the above-mentioned inorganic powder include smectite, kaolin, zinc oxide, titanium oxide, silicic acid anhydride, etc. These can be used alone or in combination of two or more kinds.

Examples of the above preservatives include methylparaben, propylparaben, thymol, etc. These can be used alone or in combination of two or more kinds.

Examples of the fragrance include fennel oil, castor oil, peppermint oil, peppermint oil, daisy leaf oil, cinnamon oil, clove oil, thymian oil, turpentine oil, henoposite oil, yamazine oil, eucalyptus oil, lavender oil, lemon oil, Orange oil, toka oil, bergamot oil, rose oil, citronella oil, lemongrass oil, camphor oil, geranium oil and the like can be mentioned. Further, as the plant extract, for example, aloe, anise, angelica, benzoin, immortelle, chamomile, chamomile, garlic, cardamom,
Galvanum, caraway, carrot seed, guaiac wood, grapefruit, cypress, sandalwood, cedarwood, juniper, star anise, sage, geranium, celery, thyme, tarragon, turpentine, frankincense, violet, pine, parsley, birch, patchouli, rose , Hyssop, Fennel, Black pepper, Bodaiju flower, Myrrh, Yarrow, Lemon, Lemongrass, Rosemary, Laurel, Spiraea, Spiraea, Cornflower, Almond, Thistle, Arnica, Cypress, Fennel, Enishida, Erica, Oguruma, mustard, calocon , Kanzui, yellow clover, ginkgo biloba, calendula, celandine, watercress, genka, gentian, sari ambo, sycamore, birch,
Fern, shirushi, camphor, chopsticks, syringa, plum, pear, halibut, taiso, takusha, dandelion, chimo, chervil, chorei, tenmondou, capsicum, neura, norangin, hagomogusa, mint, sycamore, sycamore, sycamore, sycamore. Extracts from bukuro, borigi, magwort, mayorana, melissa, mokutou, peach, mistletoe, eucalyptus, yokuinin, lavender, forsythia, wasabi radish and the like can be mentioned, but among these, especially chamomile, sage, parsley, rose. Extracts from marie, syringa, syringa, cornflower, anise, laurel, angelica, fennel, peppermint (peppermint, lemon balm), lavender, thyme, etc. are suitable. As specific components of such extract, for example, monoterpene hydrocarbon, cineole, borneol, camphor (camphor), linanol, berbenol, flavonoids, choline, amino acid, tannin, vegetable acid, fatty acid, hydrocyanic acid Glycoside, salicylic acid derivative, salvin, condensed tannin, phenolic acid, carnosic acid, triterpene acid, thujong, salben, pinene, apiol, apioline, myristicin, coumarin, kamaazulen, farnesene, bisabolol, geraniol, eugenol, terpene, ferrandrin,
Examples thereof include anethole, menthol, menthone, limonene, citral, citronellal and eugenol acetate.

The type of dye is not particularly limited, and dyes described in the Legal Dye Handbook can be blended.

The water-containing gel layer of the present invention is a water-containing system, and the water content is not particularly limited, but the water content per 100 parts by weight of the final composition is 30 to 98 parts by weight, More preferably, 40 to 95 parts by mass is desirable. If the water content is too low, the anchorability between the support and the water-containing gel layer may be poor, and if it is too high, the physical properties as an adhesive gel may not be obtained.

The patch of the present invention is obtained by spreading the hydrous gel on the support, and the amount of hydrous gel (the amount of paste) to be spread is not particularly limited, but usually 1 ~ 4
0 (g / 10 x 14 cm), preferably 1 to 30 (g /
10 × 14 cm) is desirable. If the spread amount is too large, it may be difficult to secure transparency (L value).

The method for producing the patch of the present invention is not particularly limited. For example, the composition components of the hydrogel layer are kneaded by a known method to prepare a hydrogel, and the hydrogel is used as the support. The water-containing gel layer is obtained by uniformly spreading on the knitted fabric side, and the surface of the water-containing gel layer (paste surface) is covered with a plastic film and cut into an appropriate size.
It can be a patch.

The extension recovery rate of the patch of the present invention (in the state where the plastic film as the release film covering the surface of the hydrous gel layer is released) is 65% or more, preferably 75%, in the longitudinal direction. As described above, it is preferably 70% or more, preferably 80% or more in the lateral direction. If it is too low, it may not smoothly follow the expansion and contraction of the skin during application.

The 30% modulus of the patch of the present invention (in which the plastic film as the release film covering the surface of the hydrous gel layer is peeled off) is not particularly limited, but it is 350 g / cm or less, preferably 250 g
/ Cm or less, more preferably 150 g / cm or less. If it exceeds 350 g / cm, it may not smoothly follow the expansion and contraction of the skin during application. The lower limit is not particularly limited, but is usually 60 g / cm or more.

The anchoring property of the patch of the present invention is not particularly limited, but when the anchoring property (residual rate to the skin) is measured by the anchoring property measuring method described in the examples below, it is 10 % Or less, and particularly preferably 5% or less.
If the residual rate is too large, it may be difficult to achieve the object of the present invention.

[0056]

EFFECTS OF THE INVENTION According to the present invention, the anchoring property of the support and the hydrous gel layer is excellent, and further, it follows the expansion and contraction of the skin well, and does not have wrinkles even after the elongation recovery, and it is possible to obtain good transparency. A possible patch is obtained.

[0057]

EXAMPLES The present invention will be described in more detail below by showing Examples and Comparative Examples, but the present invention is not limited to the following Examples. In addition, in the following examples,% means mass%.

Example 1 A knitted fabric in which a single yarn of 75 denier polyester was knitted on both sides (basis weight: 30 g /
m ² , the above 50% elongation recovery rate 100%, the above 30% modulus 120 g / cm) and a polyurethane film (thickness 30 μm, the above transparency 92, 50% elongation recovery rate 100).
%, Water vapor transmission rate 2250 g / m ² · 24 hr, the above 30% modulus 100 g / cm are bonded and integrated with a polyester adhesive to obtain a support (the above 50% elongation recovery rate 100).
%, The above 30% modulus was 150 g / cm), and the hydrous plaster shown in Example 1 of Table 1 was spread on the knitted fabric side of this support to obtain a patch.

Example 2 A knitted fabric in which a single yarn of 50 denier polyester was knitted by fly knitting (basis weight: 20 g / m).
² , the above 50% elongation recovery rate 96%, the above 30% modulus 100 g / cm) and a polyurethane film (thickness 25
μm, transparency 85, 50% elongation recovery rate 100%, water vapor transmission rate 1500 g / m ² · 24 hr, 30% modulus 85 g / cm) bonded and integrated with a polyurethane adhesive to obtain a support (50% elongation recovery rate). 96%, above 3
With a 0% modulus of 120 g / cm), the hydrous plaster shown in Example 2 of Table 1 was spread on the knitted fabric side of this support to obtain a patch.

[Example 3] A knitted fabric in which a single yarn of 30 denier polypropylene was knitted on one side (basis weight: 80 g / m 2)
^2. Polyurethane thin film (thickness 20 μm, transparency 97, 50% elongation recovery rate 100%, moisture permeability 1000 g / m ² ) melted from an extruder to the above 50% elongation recovery rate 97% and the above 30% modulus 190 g / cm ²・ 24 hr, the above 30% modulus 70 g / cm) was poured and heat-sealed to be integrated into a support (the above 50% elongation recovery rate 97%, the above 30% modulus 200 g / cm), and the knitted fabric side of this support The water-containing plaster shown in Example 3 of Table 1 was spread on
A patch was obtained.

[Example 4] A knitted fabric obtained by tricot knitting a single yarn of 20 denier polyurethane (basis weight: 120 g /
m ² , the above 50% elongation recovery rate 100%, the above 30% modulus 250 g / cm) is applied with a polyurethane solution and dried to obtain a resin layer having a thickness of 35 μm after drying (transparency 92, 50% elongation recovery) 100%, moisture permeability 250g /
m ² · 24 hr, above 30% modulus 150 g / c
m) are laminated to form a support (the above 50% elongation recovery rate is 100).
%, The above-mentioned 30% modulus was 270 g / cm), and the hydrous plaster shown in Example 4 of Table 1 was spread on the knitted fabric side of this support to obtain a patch.

[Example 5] A knitted fabric in which a single yarn of 50 denier nylon was flat-knitted (basis weight: 30 g / m ² , 50% elongation recovery rate: 98%, 30% modulus: 110 g / c).
m) polyester film (thickness 30 μm, transparency 92, 50% elongation recovery 87%, moisture permeability 500 g /
m ² · 24 hr, the above 30% modulus 180 g / c
m) was integrated by a high frequency (welder method) to form a support, and the support (50% elongation recovery rate 85%, 30% modulus 220 g / cm) of the support was shown in Example 5 of Table 1. The hydrous plaster was spread to obtain a patch.

[Example 6] A knitted fabric in which a mixed yarn of 75 denier polyester single yarn and 75 denier polypropylene single yarn was knitted on both sides (basis weight: 10 g / m ² , 50% above).
Elongation recovery rate 97%, above 30% modulus 90 g / c
m) polyester melted from the extruder (thickness 3
0 μm, the transparency 95, 50% elongation recovery rate 83%, water vapor transmission rate 105 g / m ² · 24 hr, the above 30% modulus 180 g / cm) were poured, and heat fusion was performed to form a support. The hydrous plaster shown in Example 6 of Table 1 was spread on the knitted fabric side having a 50% elongation recovery rate of 80% and the above 30% modulus of 200 g / cm) to obtain a patch.

[Example 7] A knitted fabric in which polyester single yarn of 30 denier was knitted in two steps on both sides (basis weight: 25 g /
m ² , the above 50% elongation recovery rate 100%, the above 30% modulus 210 g / cm), and a polyurethane film (thickness 35 μm, the above transparency 82, 50% elongation recovery rate 100).
%, Water vapor transmission rate 1000 g / m ² · 24 hr, the above 30% modulus 200 g / cm) are integrally bonded by a polyurethane adhesive to form a support (the above 50% elongation recovery rate 100).
%, The above-mentioned 30% modulus was 220 g / cm), and the hydrous plaster shown in Example 7 of Table 1 was spread on the knitted fabric side of this support to obtain a patch.

[Example 8] A knitted fabric knitted into a flat knit (a basis weight of 8) using a multifilament yarn made of polypropylene of 90 denier as a raw material and crimped
0 g / m ² , above 50% elongation recovery rate 100%, above 30
% Modulus 250 g / cm) polyurethane film (thickness 25 μm, transparency 88, 50% elongation recovery 1
00%, moisture vapor transmission rate 400g / m ² · 24hr, above 30%
A modulus (85 g / cm) is bonded and integrated with a polyurethane adhesive to form a support (the above 50% elongation recovery rate 100).
%, The above-mentioned 30% modulus was 290 g / cm), and the hydrous plaster shown in Example 8 of Table 1 was spread on the knitted fabric side of this support to obtain a patch.

[Comparative Example 1] A nonwoven fabric obtained by needle punching a polyester web of 1.5 denier (basis weight: 10).
0 g / m ² , above 50% elongation recovery rate 72%, above 30%
Polyurethane film (thickness: 30 μm, transparency: 92, 50% elongation recovery rate: 1)
00%, moisture permeability 2250 g / m ² · 24 hr, above 30
% Modulus 100 g / cm) is adhered and integrated with a polyester adhesive to obtain a support (50% elongation recovery rate 7 above).
0%, the above 30% modulus 270 g / cm), and the hydrous plaster shown in Comparative Example 1 of Table 1 was spread on the knitted fabric side of this support to obtain a patch.

[Comparative Example 2] A woven fabric using a 20-denier nylon single yarn (basis weight 80 g / m ² , 50% elongation recovery rate 61%, 30% modulus 850 g / cm).
Polyurethane film (thickness 30 μm, transparency 9 above)
2,50% elongation recovery rate 100%, moisture vapor transmission rate 2250g / m
² · 24hr, the 30% modulus of 100g / cm)
To a support (50% elongation recovery 59%, 30% modulus 880 g / cm) with a polyester adhesive, and the water content shown in Comparative Example 2 of Table 1 on the knitted fabric side of the support. The plaster was spread to obtain a patch.

With respect to the patches of Examples 1 to 8 and Comparative Examples 1 and 2, the anchoring property with a hydrogel was determined by the following evaluation method to determine the 50% elongation recovery rate and the appearance after extension recovery (support). The wrinkles on the body surface) were evaluated according to the following evaluation methods. The results are also shown in Table 1.

<Evaluation Method of Anchoring Property> Each patch was applied to the skin (sex; male, age 20 to 30 years) for 1 minute and left on the skin relative to the total amount of plaster (hydrated gel amount) when peeled off. The ratio (%) of the amount of plaster was calculated and used as an index of the anchoring property between the support and the hydrogel.

<Appearance after extension recovery (wrinkles on support surface)
The support after the above 50% elongation recovery rate was measured was visually observed, and the wrinkles on the surface of the support were evaluated based on the following evaluation criteria.

<Evaluation criteria> No wrinkles at all: 6 Almost no wrinkles: 5 No wrinkles: 4 There are some wrinkles: 3 Wrinkled: 2 Very wrinkled: 1

[0072]

[Table 1]

* 1: Polyacrylic acid (Jurimer 10SH) * 2: Sodium polyacrylate (Aronbis S) * 3: Carboxyvinyl polymer (Carbopol 94
0) * 4: Sodium carboxymethyl cellulose (CMC
12380) * 5: Sodium alginate (duck algin) * 6: Acrylic acid starch graft polymer crosslinked product (Sunfresh IM-1000) * 7: Acrylate polymer crosslinked product (Sunfresh ST
-500) * 8: Ethylene oxide crosslinked product (Aquacoke) * 9: N-vinylacetamide crosslinked product (Noniolex IM-010)

   ─────────────────────────────────────────────────── ─── Continued front page    (72) Inventor Norio Iida             1-3-7 Honjo, Sumida-ku, Tokyo Rio             Within the corporation F-term (reference) 4C081 AA03 AA12 BB04 BB07 BC02                       CA021 CA041 CA081 CA161                       CA211 CA231 DA02 DA05                       DA12 DB01 DC04 DC05 DC06                       EA03 EA06

Claims (3)

[Claims] 1. A patch comprising a knitted fabric interposed between a resin layer and a hydrogel layer. 2. The patch according to claim 1, wherein the knitted fabric is composed of a single yarn of 5 to 300 denier or a multifilament yarn of 15 to 500 denier and has a basis weight of 5 to 150 g / m ² . 3. The resin layer according to claim 1, wherein the resin layer is transparent.
The patch described above.