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HUP9900493A3 - General process for the epoxidation of olefinic double bonds - Google Patents

General process for the epoxidation of olefinic double bonds

Info

Publication number
HUP9900493A3
HUP9900493A3 HU9900493A HUP9900493A HUP9900493A3 HU P9900493 A3 HUP9900493 A3 HU P9900493A3 HU 9900493 A HU9900493 A HU 9900493A HU P9900493 A HUP9900493 A HU P9900493A HU P9900493 A3 HUP9900493 A3 HU P9900493A3
Authority
HU
Hungary
Prior art keywords
epoxidation
double bonds
general process
olefinic double
olefinic
Prior art date
Application number
HU9900493A
Other languages
English (en)
Original Assignee
G D Searle And Co Chicago
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by G D Searle And Co Chicago filed Critical G D Searle And Co Chicago
Priority claimed from PCT/US1996/020780 external-priority patent/WO1997021720A2/en
Publication of HUP9900493A2 publication Critical patent/HUP9900493A2/hu
Publication of HUP9900493A3 publication Critical patent/HUP9900493A3/hu
Publication of HU222453B1 publication Critical patent/HU222453B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/001—Lactones
    • C07J21/003—Lactones at position 17
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C07J71/0015—Oxiranes at position 9(11)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C12P33/005—Degradation of the lateral chains at position 17
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C12P33/06—Hydroxylating
    • C12P33/08—Hydroxylating at 11 position
    • C12P33/10—Hydroxylating at 11 position at 11 alpha-position
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HU9900493A 1995-12-11 1996-12-11 Általános eljárás olefines kettős kötés epoxidálására HU222453B1 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US845595P 1995-12-11 1995-12-11
PCT/US1996/020780 WO1997021720A2 (en) 1995-12-11 1996-12-11 Processes for preparation of 7 alpha-carboxyl 9,11-epoxy steroids and intermediates useful therein and a general process for the epoxidation of olifinic double bonds

Publications (3)

Publication Number Publication Date
HUP9900493A2 HUP9900493A2 (hu) 1999-05-28
HUP9900493A3 true HUP9900493A3 (en) 1999-11-29
HU222453B1 HU222453B1 (hu) 2003-07-28

Family

ID=21731702

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9900493A HU222453B1 (hu) 1995-12-11 1996-12-11 Általános eljárás olefines kettős kötés epoxidálására

Country Status (5)

Country Link
KR (3) KR100523227B1 (hu)
CN (1) CN1903872A (hu)
AU (1) AU719260B2 (hu)
CA (2) CA2347345C (hu)
HU (1) HU222453B1 (hu)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104844681B (zh) * 2014-02-13 2016-06-01 合肥久诺医药科技有限公司 一种l晶型依普利酮的精制方法
CN111505238A (zh) * 2019-01-31 2020-08-07 中国石油化工股份有限公司 一种岩石白云化计算方法及计算系统
CN110698529A (zh) * 2019-11-19 2020-01-17 湖南新合新生物医药有限公司 一种依普利酮中间体△9,11烯酯的制备方法
CN111593086B (zh) * 2020-05-27 2023-05-05 湖北葛店人福药业有限责任公司 一种利用混合溶剂减少乙基双酮11a羟化过程中杂质的方法

Also Published As

Publication number Publication date
AU719260B2 (en) 2000-05-04
KR20040071782A (ko) 2004-08-12
KR20050085950A (ko) 2005-08-29
CA2347346A1 (en) 1997-06-19
CA2347345C (en) 2007-05-15
KR19990076572A (ko) 1999-10-15
HU222453B1 (hu) 2003-07-28
CA2347345A1 (en) 1997-06-19
KR100523227B1 (ko) 2005-12-21
CA2347346C (en) 2007-01-02
KR100523146B1 (ko) 2005-10-24
HUP9900493A2 (hu) 1999-05-28
CN1903872A (zh) 2007-01-31
AU1355197A (en) 1997-07-03
KR100579527B1 (ko) 2006-05-12

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Legal Events

Date Code Title Description
HFG4 Patent granted, date of granting

Effective date: 20030523

AA1S Information on application for a supplementary protection certificate

Free format text: PRODUCT NAME: EPLERENONE OR PHARMACOLOGICALLY APPLICABLE SALTS THEREOF; REG. NO/DATE: OGYI-T-20042/001 20060203; FIRST REG.: NL RVG 29963 20040316

Spc suppl protection certif: S0600006

Filing date: 20060802

Expiry date: 20161211

MM4A Lapse of definitive patent protection due to non-payment of fees