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HU896005D0 - Process for producing plasminogen activator (t-pa) zymogenes of tissues and preparatives containing such active substances - Google Patents

Process for producing plasminogen activator (t-pa) zymogenes of tissues and preparatives containing such active substances

Info

Publication number
HU896005D0
HU896005D0 HU896005A HU600589A HU896005D0 HU 896005 D0 HU896005 D0 HU 896005D0 HU 896005 A HU896005 A HU 896005A HU 600589 A HU600589 A HU 600589A HU 896005 D0 HU896005 D0 HU 896005D0
Authority
HU
Hungary
Prior art keywords
zymogens
variants
plasminogen activator
zymogenes
tissues
Prior art date
Application number
HU896005A
Other languages
English (en)
Other versions
HUT58812A (en
HU213922B (en
Inventor
Stephen Anderson
William F Bennett
David Botstein
Deborah L Higginc
Nicholas A Paoni
Mark Zoller
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of HU896005D0 publication Critical patent/HU896005D0/hu
Publication of HUT58812A publication Critical patent/HUT58812A/hu
Publication of HU213922B publication Critical patent/HU213922B/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HU896005A 1988-09-02 1989-08-29 Process for producing new tissue plasminogen activator variants, pharmaceutical preparations containing them, and vectors capable of expressing them HU213922B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24085688A 1988-09-02 1988-09-02
US07/384,608 US5108901A (en) 1988-09-02 1989-07-24 Tissue plasminogen activator having zymogenic or fibrin specific properties

Publications (3)

Publication Number Publication Date
HU896005D0 true HU896005D0 (en) 1991-07-29
HUT58812A HUT58812A (en) 1992-03-30
HU213922B HU213922B (en) 1997-11-28

Family

ID=26933781

Family Applications (1)

Application Number Title Priority Date Filing Date
HU896005A HU213922B (en) 1988-09-02 1989-08-29 Process for producing new tissue plasminogen activator variants, pharmaceutical preparations containing them, and vectors capable of expressing them

Country Status (18)

Country Link
US (1) US5108901A (hu)
EP (1) EP0457758B1 (hu)
JP (1) JP2794028B2 (hu)
KR (1) KR0148575B1 (hu)
AT (1) ATE124452T1 (hu)
AU (1) AU626323B2 (hu)
CA (1) CA1341484C (hu)
DE (1) DE68923298T2 (hu)
DK (1) DK175958B1 (hu)
ES (1) ES2018729A6 (hu)
FI (1) FI109359B (hu)
HK (1) HK1007334A1 (hu)
HU (1) HU213922B (hu)
IE (1) IE67508B1 (hu)
IL (1) IL91306A (hu)
NO (1) NO310778B1 (hu)
NZ (1) NZ230509A (hu)
WO (1) WO1990002798A1 (hu)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5756093A (en) * 1985-04-22 1998-05-26 Genentech, Inc. Tissue plasminogen activator variants
US5736134A (en) * 1985-04-22 1998-04-07 Genentech, In.C Tissue plasminogen activator variants
GB8815135D0 (en) * 1988-06-24 1988-08-03 British Bio Technology Proteins & nucleic acids
DK395288D0 (da) * 1988-07-15 1988-07-15 Novo Industri As Proteiner
US5262170A (en) * 1988-09-02 1993-11-16 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties and substituted at amino acid positions 296-299, DNA molecules encoding them, vectors, and host cells
US5156969A (en) * 1988-09-02 1992-10-20 Genentech Inc. Tissue plasminogen activator variant with deletion of amino acids 466-470 having fibrin specific properties
US5714145A (en) * 1988-09-02 1998-02-03 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties
US5866413A (en) * 1989-03-06 1999-02-02 Board Of Regents Of The University Of Texas System Pai-1 mutants
US5550042A (en) * 1989-03-06 1996-08-27 The Board Of Regents Of The University Of Texas System Serine protease mutants of the chymotrypsin superfamily resistant to inhibition by their cognate inhibitors and genes encoding the same and serine protease inhibitor mutants and genes encoding the same
US5304482A (en) * 1989-03-06 1994-04-19 The Board Of Regents Of The University Of Texas System Serine protease mutants of the chymotrypsin superfamily resistant to inhibition by their cognate inhibitors
ATE226636T1 (de) * 1989-03-06 2002-11-15 Univ Texas Serpin-resistenter t-pa; mutanten; gene
PT786257E (pt) 1992-06-03 2003-12-31 Genentech Inc Variantes de glicosilacao do activador de plasminogenio tissular com propriedades terapeuticas meloradas
US5472692A (en) * 1993-07-02 1995-12-05 New England Deaconess Hospital Corporation Pro-urokinase mutants
US5877016A (en) 1994-03-18 1999-03-02 Genentech, Inc. Human trk receptors and neurotrophic factor inhibitors
US5656427A (en) * 1994-08-29 1997-08-12 Gen-Probe Incorporated Nucleic acid hybridization assay probes, helper probes and amplification oligonucleotides targeted to Mycoplasma pneumoniae nucleic acid
US5759775A (en) 1994-10-27 1998-06-02 Genetech, Inc. Methods for detecting nucleic acids encoding AL--1 neurotrophic factor
ZA966663B (en) 1995-08-17 1998-02-06 Genentech Inc Traf Inhibitors.
US6610296B2 (en) 1995-10-26 2003-08-26 Genentech, Inc. Methods of enhancing cognitive function using an AL-1 neurotrophic factor immunoadhesin
EP0950095A2 (en) * 1996-11-12 1999-10-20 The Scripps Research Institute TISSUE TYPE PLASMINOGEN ACTIVATOR (t-PA) VARIANTS: COMPOSITIONS AND METHODS OF USE
US6706504B1 (en) 1996-11-12 2004-03-16 The Scripps Research Institute Tissue type plasminogen activator (t-PA) variants: compositions and methods of use
US20030113271A1 (en) * 1997-01-29 2003-06-19 University Technology Corporation Formulations for pulmonary delivery
US20040241645A1 (en) * 1997-01-31 2004-12-02 Genentech, Inc. O-fucosyltransferase
AU729158B2 (en) 1997-01-31 2001-01-25 Genentech Inc. O-fucosyltransferase
WO1999009185A1 (de) * 1997-08-13 1999-02-25 Roche Diagnostics Gmbh Plasminogenaktivator mit verbesserter zymogenität
AU8864398A (en) * 1997-08-13 1999-03-08 Boehringer Mannheim Gmbh Plasminogen activator with enhanced zymogenic power and reduced fibrin linking
KR100408844B1 (ko) * 2000-07-29 2003-12-06 한국산업기술평가원 동물세포 발현벡터
WO2006023530A2 (en) * 2004-08-16 2006-03-02 Massachusetts Institute Of Technology Compositions and methods for enhancing structural and functional nervous system reorganization and recovery
EP2012815A4 (en) * 2006-04-14 2009-12-09 Massachusetts Inst Technology IDENTIFICATION AND MODULATION OF MOLECULAR PATHS FOR PROCESSING NEURONAL PLASTICITY
EP2056852A4 (en) * 2006-07-27 2010-01-13 Centocor Ortho Biotech Inc BMP-7 VARIANTS COMPOSITIONS, METHODS AND USES
WO2015023830A1 (en) 2013-08-14 2015-02-19 Stc.Unm Treatment and prevention of stroke and other neurological disorders
JP6826040B2 (ja) 2014-11-03 2021-02-03 スロンボリティック・サイエンス・リミテッド・ライアビリティ・カンパニーＴｈｒｏｍｂｏｌｙｔｉｃ Ｓｃｉｅｎｃｅ， Ｌｌｃ 安全かつ効果的な血栓溶解（Ｔｈｒｏｍｂｏｌｙｓｉｓ）のための方法および組成物
WO2018232305A1 (en) 2017-06-16 2018-12-20 Thrombolytic Science, Llc Methods and compositions for thrombolysis

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0125269A1 (en) * 1982-11-11 1984-11-21 Beecham Group Plc Pharmaceutically active compounds
EP0112122B1 (en) * 1982-12-14 1991-08-28 South African Inventions Development Corporation Plasminogen activator
US4753879A (en) * 1984-08-27 1988-06-28 Biogen N.V. Modified tissue plasminogen activators
EP0201153A3 (en) * 1985-02-09 1987-10-07 Beecham Group Plc Modified enzyme and process for its preparation
EP0199574B1 (en) * 1985-04-22 1991-10-23 Genentech, Inc. Human tissue plasminogen activator mutants, methods and intermediates therefor, and compositions using such mutants
GB8528321D0 (en) * 1985-11-18 1985-12-24 Ciba Geigy Ag Modified fibrinolytic agents
ES2031826T3 (es) * 1985-12-23 1993-01-01 Chiron Corporation Procedimiento para producir nuevos peptidos activadores del plasminogeno.
DK43387A (da) * 1986-01-29 1987-07-30 Beecham Group Plc Fibrinolytisk enzym
DE3789664T3 (de) * 1986-01-31 2004-09-16 Genetics Institute, LLC, Cambridge Neue thrombolytische proteine.
IE81073B1 (en) * 1986-03-18 2000-01-12 Genentech Inc Modified human tissue-type plasminogen activator and its preparation
PT84589B (en) * 1986-04-02 1989-05-09 Beecham Group Plc Process for preparing a fibrinolytic enzyme
DK345087A (da) * 1986-07-11 1988-01-12 Novo Industri As Modificeret vaevsplasminogenaktivator
WO1988005081A2 (en) * 1986-12-30 1988-07-14 Cetus Corporation Novel plasminogen activator
GB8705377D0 (en) * 1987-03-07 1987-04-08 Beecham Group Plc Compounds
DK275788A (da) * 1987-05-22 1989-02-03 Zymogenetics Inc Fibrinolytiske proteiner
EP0293936B1 (en) * 1987-06-04 1995-02-22 Zymogenetics, Inc. Tissue plasminogen activator analogs having modified growth factor domains
ATE110772T1 (de) * 1987-06-04 1994-09-15 Zymogenetics Inc Mutierter t-pa mit kringle-ersatz.
SE8702562L (sv) * 1987-06-18 1988-12-19 Kabigen Ab Nya fibrinolytiska enzymer
HUT51901A (en) * 1987-06-22 1990-06-28 Genetics Inst Process for production of new trombolitic ensimes
AU2081788A (en) * 1987-07-06 1989-01-30 Genetics Institute Inc. Novel thrombolytic proteins
AU1893988A (en) * 1987-07-13 1989-01-19 Collaborative Research Inc. Nonglycosylated plasminogen activator and method of preparation
DK395288D0 (da) * 1988-07-15 1988-07-15 Novo Industri As Proteiner

Also Published As

Publication number Publication date
HK1007334A1 (en) 1999-04-09
NO910811L (no) 1991-02-28
EP0457758A1 (en) 1991-11-27
HUT58812A (en) 1992-03-30
AU626323B2 (en) 1992-07-30
FI109359B (fi) 2002-07-15
NO310778B1 (no) 2001-08-27
US5108901A (en) 1992-04-28
AU4194689A (en) 1990-04-02
DE68923298D1 (de) 1995-08-03
JP2794028B2 (ja) 1998-09-03
ATE124452T1 (de) 1995-07-15
JPH04500157A (ja) 1992-01-16
KR900702019A (ko) 1990-12-05
CA1341484C (en) 2005-05-24
IE67508B1 (en) 1996-04-03
NZ230509A (en) 1991-06-25
IL91306A0 (en) 1990-03-19
HU213922B (en) 1997-11-28
DE68923298T2 (de) 1996-01-11
FI911049A0 (fi) 1991-03-01
ES2018729A6 (es) 1991-05-01
NO910811D0 (no) 1991-02-28
DK175958B1 (da) 2005-08-29
EP0457758B1 (en) 1995-06-28
DK36991A (da) 1991-05-02
DK36991D0 (da) 1991-03-01
KR0148575B1 (ko) 1998-10-15
IE892650L (en) 1990-03-02
IL91306A (en) 1997-08-14
WO1990002798A1 (en) 1990-03-22

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