[go: up one dir, main page]

HK1186183A1 - Pyrazole compounds as crth2 antagonists - Google Patents

Pyrazole compounds as crth2 antagonists Download PDF

Info

Publication number
HK1186183A1
HK1186183A1 HK13113692.9A HK13113692A HK1186183A1 HK 1186183 A1 HK1186183 A1 HK 1186183A1 HK 13113692 A HK13113692 A HK 13113692A HK 1186183 A1 HK1186183 A1 HK 1186183A1
Authority
HK
Hong Kong
Prior art keywords
formula
pyrazole compounds
compounds
cycloalkyl
alkoxy
Prior art date
Application number
HK13113692.9A
Other languages
English (en)
Chinese (zh)
Other versions
HK1186183B (en
Inventor
Ralf Anderskewitz
Domnic Martyres
Thorsten Oost
Wolfgang Rist
Peter Seither
Original Assignee
勃林格殷格翰國際有限公司
Actimis Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43799503&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1186183(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 勃林格殷格翰國際有限公司, Actimis Pharmaceuticals, Inc. filed Critical 勃林格殷格翰國際有限公司
Publication of HK1186183A1 publication Critical patent/HK1186183A1/xx
Publication of HK1186183B publication Critical patent/HK1186183B/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4151,2-Diazoles
    • A61K31/41551,2-Diazoles non condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/02Nasal agents, e.g. decongestants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/04Antipruritics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/14Decongestants or antiallergics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Otolaryngology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
HK13113692.9A 2011-01-24 2012-01-20 Pyrazole compounds as crth2 antagonists HK1186183B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11151876 2011-01-24
EP11151876.7 2011-01-24
PCT/EP2012/050830 WO2012101043A1 (en) 2011-01-24 2012-01-20 Pyrazole compounds as crth2 antagonists

Related Parent Applications (2)

Application Number Title Priority Date Filing Date
HK16103130.7A Division HK1215247B (en) 2011-01-24 2013-12-10 Pyrazole compounds as crth2 antagonists
HK15111230.0A Division HK1210467B (en) 2011-01-24 2013-12-10 Pyrazole compounds as crth2 antagonists

Related Child Applications (2)

Application Number Title Priority Date Filing Date
HK16103130.7A Addition HK1215247B (en) 2011-01-24 2013-12-10 Pyrazole compounds as crth2 antagonists
HK15111230.0A Addition HK1210467B (en) 2011-01-24 2013-12-10 Pyrazole compounds as crth2 antagonists

Publications (2)

Publication Number Publication Date
HK1186183A1 true HK1186183A1 (en) 2014-03-07
HK1186183B HK1186183B (en) 2016-04-01

Family

ID=

Also Published As

Publication number Publication date
KR20140005931A (ko) 2014-01-15
HRP20150069T1 (hr) 2015-02-27
CA2825458C (en) 2021-01-26
SI2668181T1 (sl) 2015-02-27
PL2668181T3 (pl) 2015-04-30
IL226920A (en) 2016-11-30
PH12018501531A1 (en) 2019-04-08
WO2012101043A1 (en) 2012-08-02
CN107011332A (zh) 2017-08-04
CN104961732B (zh) 2017-07-11
EP2668181A1 (en) 2013-12-04
KR20180129962A (ko) 2018-12-05
CN104628705A (zh) 2015-05-20
DK2668181T3 (da) 2015-01-19
PH12013501356A1 (en) 2013-09-02
CN103339125B (zh) 2015-07-15
HK1210467A1 (en) 2016-04-22
GEP20156332B (en) 2015-07-27
MA34838B1 (fr) 2014-01-02
UA109696C2 (xx) 2015-09-25
SG192096A1 (en) 2013-08-30
MY163012A (en) 2017-07-31
US20130023576A1 (en) 2013-01-24
AU2012210718B2 (en) 2016-06-02
CN104961732A (zh) 2015-10-07
KR101923365B1 (ko) 2018-11-30
ES2529452T3 (es) 2015-02-20
TW201245184A (en) 2012-11-16
EA201300857A1 (ru) 2013-12-30
US8759386B2 (en) 2014-06-24
CY1116012T1 (el) 2017-01-25
KR102251939B1 (ko) 2021-05-14
AR084916A1 (es) 2013-07-10
PT2668181E (pt) 2015-02-05
TN2013000280A1 (en) 2014-11-10
MX2013008082A (es) 2013-09-13
EA022559B1 (ru) 2016-01-29
CN103339125A (zh) 2013-10-02
UY33873A (es) 2012-07-31
JP2014502986A (ja) 2014-02-06
AU2012210718A1 (en) 2013-07-04
AP3343A (en) 2015-07-31
CN107011332B (zh) 2020-03-13
BR112013017570A2 (pt) 2016-10-18
TWI527809B (zh) 2016-04-01
RS53785B1 (en) 2015-06-30
CN104628705B (zh) 2017-04-12
PE20140860A1 (es) 2014-07-20
AP2013006942A0 (en) 2013-06-30
CL2013001945A1 (es) 2013-10-25
CA2825458A1 (en) 2012-08-02
EP2668181B1 (en) 2014-11-05
JP5695216B2 (ja) 2015-04-01
BR112013017570B1 (pt) 2022-01-11
NZ611695A (en) 2015-04-24
ECSP13012832A (es) 2013-09-30
HK1215247A1 (zh) 2016-08-19
CO6801731A2 (es) 2013-11-29
MX342830B (es) 2016-10-14

Similar Documents

Publication Publication Date Title
TWI499416B (zh) 作為crth2拮抗劑之吡唑化合物
CN103339125B (zh) 作为crth2拮抗剂的吡唑化合物
US9206164B2 (en) Pyrazole compounds as CRTH2 antagonists
HK1236533A (en) Pyrazole compounds as crth2 antagonists
HK1186183B (en) Pyrazole compounds as crth2 antagonists
HK1215247B (en) Pyrazole compounds as crth2 antagonists
HK1210467B (en) Pyrazole compounds as crth2 antagonists
HK1236533B (zh) 作為crth2拮抗劑的吡唑化合物
HK1176062B (en) Pyrazole compounds as crth2 antagonists
OA16479A (en) Pyrazole compounds as CRTH2 antagonists.
NZ611695B2 (en) Pyrazole compounds as crth2 antagonists
TW201526891A (zh) 作為crth2拮抗劑之吡唑化合物

Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20230120