[go: up one dir, main page]

HK1162951A1 - Synthesis of 18f-radiolabeled styrylpyridines from tosylate precursors and stable pharmaceutical compositions thereof - Google Patents

Synthesis of 18f-radiolabeled styrylpyridines from tosylate precursors and stable pharmaceutical compositions thereof Download PDF

Info

Publication number
HK1162951A1
HK1162951A1 HK12103613.7A HK12103613A HK1162951A1 HK 1162951 A1 HK1162951 A1 HK 1162951A1 HK 12103613 A HK12103613 A HK 12103613A HK 1162951 A1 HK1162951 A1 HK 1162951A1
Authority
HK
Hong Kong
Prior art keywords
ethoxy
pyridin
vinyl
methyl
imaging
Prior art date
Application number
HK12103613.7A
Other languages
English (en)
Chinese (zh)
Other versions
HK1162951B (en
Inventor
Tyler Benedum
Geoff Golding
Nathaniel Lim
Wei Zhang
Original Assignee
Avid Radiopharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Avid Radiopharmaceuticals, Inc. filed Critical Avid Radiopharmaceuticals, Inc.
Publication of HK1162951A1 publication Critical patent/HK1162951A1/xx
Publication of HK1162951B publication Critical patent/HK1162951B/xx

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/041Heterocyclic compounds
    • A61K51/044Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365Lactones
    • A61K31/375Ascorbic acid, i.e. vitamin C; Salts thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0069Devices for implanting pellets, e.g. markers or solid medicaments
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Psychology (AREA)
  • Dermatology (AREA)
  • Medical Informatics (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HK12103613.7A 2008-12-31 2009-12-29 Synthesis of 18f-radiolabeled styrylpyridines from tosylate precursors and stable pharmaceutical compositions thereof HK1162951B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14188508P 2008-12-31 2008-12-31
US61/141885 2008-12-31
PCT/US2009/069741 WO2010078370A1 (en) 2008-12-31 2009-12-29 Synthesis of 18f-radiolabeled styrylpyridines from tosylate precursors and stable pharmaceutical compositions thereof

Publications (2)

Publication Number Publication Date
HK1162951A1 true HK1162951A1 (en) 2012-09-07
HK1162951B HK1162951B (en) 2015-03-27

Family

ID=

Also Published As

Publication number Publication date
ZA201104824B (en) 2013-01-30
CY1118658T1 (el) 2017-07-12
TN2011000318A1 (en) 2012-12-17
WO2010078370A1 (en) 2010-07-08
US20100172836A1 (en) 2010-07-08
CO6341578A2 (es) 2011-11-21
EA201170911A1 (ru) 2011-12-30
MX2011007063A (es) 2011-12-16
ECSP11011242A (es) 2011-10-31
UA105914C2 (uk) 2014-07-10
CA2748705C (en) 2017-05-02
HUE033649T2 (en) 2017-12-28
RS55674B1 (sr) 2017-06-30
JP5717650B2 (ja) 2015-05-13
IL213674A0 (en) 2011-07-31
EP2381967A1 (en) 2011-11-02
SI2381967T1 (sl) 2017-03-31
MY162312A (en) 2017-05-31
NZ593848A (en) 2013-09-27
BRPI0923890A2 (pt) 2015-07-28
AU2009335049B2 (en) 2015-07-16
CR20110410A (es) 2011-12-08
CN102271716A (zh) 2011-12-07
DOP2011000210A (es) 2011-09-15
HRP20170453T1 (hr) 2017-06-02
SG172439A1 (en) 2011-07-28
PE20120007A1 (es) 2012-01-16
PL2381967T3 (pl) 2017-06-30
DK2381967T3 (en) 2017-03-27
PT2381967T (pt) 2017-02-24
HN2011001810A (es) 2013-08-12
KR20110119670A (ko) 2011-11-02
CN102271716B (zh) 2014-11-19
LT2381967T (lt) 2017-04-25
AU2009335049A1 (en) 2011-07-21
IL213674A (en) 2016-04-21
EP2381967B1 (en) 2017-01-18
EA023014B1 (ru) 2016-04-29
EP2381967A4 (en) 2013-01-02
ES2620402T3 (es) 2017-06-28
MA33004B1 (fr) 2012-01-02
JP2012514007A (ja) 2012-06-21
CA2748705A1 (en) 2010-07-08

Similar Documents

Publication Publication Date Title
CA2748705C (en) Synthesis of 18f-radiolabeled styrylpyridines from tosylate precursors and stable pharmaceutical compositions thereof
US20080219922A1 (en) Alzheimer's Disease Imaging Agents
US20210393809A1 (en) Labeled inhibitors of prostate specific membrane antigen (psma), their use as imaging agents and pharmaceutical agents for the treatment of psma-expressing cancers
HK1245645A1 (zh) 使用抗壞血酸穩定化放射性藥物組合物
US20090004106A1 (en) Radioligands for the 5 -Ht1b Receptor
KR20190015765A (ko) 영상화제의 합성 및 사용을 위한 조성물, 방법 및 시스템
EP2218464A1 (en) Compounds for non-invasive measurement of aggregates of amyloid peptides
Nguyen et al. IBETA: A new aβ plaque positron emission tomography imaging agent for Alzheimer’s disease
Lipowska et al. Re (CO) 3 ([18F] FEDA), a novel 18F PET renal tracer: radiosynthesis and preclinical evaluation
WO2014052454A1 (en) Imaging agents
HK1162951B (en) Synthesis of 18f-radiolabeled styrylpyridines from tosylate precursors and stable pharmaceutical compositions thereof
EP3835293B1 (en) Monoamine oxidase b imaging probe
WO2010135493A2 (en) Alzheimer's disease imaging agents
Nguyen et al. [124I] BETA, a new beta-amyloid plaque PET imaging agent for Alzheimer's disease
JP2021102593A (ja) タウを画像化する新規化合物
WO2014184682A1 (en) Radiolabeled gnrh antagonists as pet imaging agents
JP5128293B2 (ja) 橋頭標識化合物およびその使用方法
WO2012175702A1 (en) Rimfampicin analogue useful for infection imaging
WO2014163106A1 (ja) アセチルコリン小胞トランスポーターの検出に適した化合物
HK1170672B (en) Stabilization of radiopharmaceutical compositions using ascorbic acid
HK1170672A (en) Stabilization of radiopharmaceutical compositions using ascorbic acid

Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20200102