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HK1143361A1 - Novel method for the synthesis of anticancer (poly)aminoalkylaminoacetamide derivatives of epipodophyllotoxin - Google Patents

Novel method for the synthesis of anticancer (poly)aminoalkylaminoacetamide derivatives of epipodophyllotoxin Download PDF

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Publication number
HK1143361A1
HK1143361A1 HK10109818.9A HK10109818A HK1143361A1 HK 1143361 A1 HK1143361 A1 HK 1143361A1 HK 10109818 A HK10109818 A HK 10109818A HK 1143361 A1 HK1143361 A1 HK 1143361A1
Authority
HK
Hong Kong
Prior art keywords
formula
demethylepipodophyllotoxin
chloroacetamido
compound
process according
Prior art date
Application number
HK10109818.9A
Other languages
English (en)
Chinese (zh)
Other versions
HK1143361B (en
Inventor
Y‧居敏斯基
M‧格鲁索
T‧安贝尔
Original Assignee
皮埃尔法博赫药品公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 皮埃尔法博赫药品公司 filed Critical 皮埃尔法博赫药品公司
Publication of HK1143361A1 publication Critical patent/HK1143361A1/xx
Publication of HK1143361B publication Critical patent/HK1143361B/xx

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Otolaryngology (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HK10109818.9A 2007-09-25 2008-09-23 Novel method for the synthesis of anticancer (poly)aminoalkylaminoacetamide derivatives of epipodophyllotoxin HK1143361B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0706692A FR2921368B1 (fr) 2007-09-25 2007-09-25 Nouveau procede de synthese de derives anticancereux de (poly) aminoalkylaminoacetamide d'epipodophyllotoxine.
FR0706692 2007-09-25
PCT/FR2008/051697 WO2009050363A1 (fr) 2007-09-25 2008-09-23 Procede de synthese de derives anticancereux de ( poly) aminoalkylaminoacetamide d ' epipodophyllotoxine

Publications (2)

Publication Number Publication Date
HK1143361A1 true HK1143361A1 (en) 2010-12-31
HK1143361B HK1143361B (en) 2013-05-10

Family

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Also Published As

Publication number Publication date
IL204636A0 (en) 2010-11-30
TN2010000095A1 (fr) 2011-09-26
CN101809022B (zh) 2012-07-04
CA2700161A1 (fr) 2009-04-23
RU2450009C2 (ru) 2012-05-10
KR101336921B1 (ko) 2013-12-04
JP2010540505A (ja) 2010-12-24
FR2921368A1 (fr) 2009-03-27
CN101809022A (zh) 2010-08-18
RU2010116166A (ru) 2011-11-10
AU2008313616B2 (en) 2012-01-19
IL204636A (en) 2013-11-28
FR2921368B1 (fr) 2012-10-12
MX2010001556A (es) 2010-03-15
BRPI0817326A2 (pt) 2015-03-24
EP2203455B1 (fr) 2017-08-30
US20100280263A1 (en) 2010-11-04
MY146171A (en) 2012-07-13
MA31689B1 (fr) 2010-09-01
US8148552B2 (en) 2012-04-03
CA2700161C (fr) 2013-11-19
JP5420549B2 (ja) 2014-02-19
ZA201001265B (en) 2010-11-24
KR20100058536A (ko) 2010-06-03
NZ583814A (en) 2012-01-12
EP2203455A1 (fr) 2010-07-07
AU2008313616A1 (en) 2009-04-23
WO2009050363A1 (fr) 2009-04-23

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20200919