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HK1091417A1 - Sarsasapogenin and smilagenin for treating cognitive dysfunctions - Google Patents

Sarsasapogenin and smilagenin for treating cognitive dysfunctions Download PDF

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Publication number
HK1091417A1
HK1091417A1 HK06112803.6A HK06112803A HK1091417A1 HK 1091417 A1 HK1091417 A1 HK 1091417A1 HK 06112803 A HK06112803 A HK 06112803A HK 1091417 A1 HK1091417 A1 HK 1091417A1
Authority
HK
Hong Kong
Prior art keywords
receptor
receptors
compounds
effects
treatment
Prior art date
Application number
HK06112803.6A
Other languages
German (de)
English (en)
French (fr)
Chinese (zh)
Other versions
HK1091417B (en
Inventor
Zongqin Xia
Yaer Hu
Ian Rubin
Jonathan Brostoff
Brian Whittle
Weijun Wang
Phil Gunning
Original Assignee
Phytopharm Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9806513.9A external-priority patent/GB9806513D0/en
Priority claimed from GBGB9905275.5A external-priority patent/GB9905275D0/en
Application filed by Phytopharm Plc filed Critical Phytopharm Plc
Publication of HK1091417A1 publication Critical patent/HK1091417A1/en
Publication of HK1091417B publication Critical patent/HK1091417B/en

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8964Anemarrhena
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8965Asparagus, e.g. garden asparagus or asparagus fern
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/90Smilacaceae (Catbrier family), e.g. greenbrier or sarsaparilla
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • A61P39/02Antidotes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • A61P39/06Free radical scavengers or antioxidants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/02Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • G01N33/9406Neurotransmitters
    • G01N33/944Acetylcholine

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Mycology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Biochemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
HK06112803.6A 1998-03-26 2006-11-22 Sarsasapogenin and smilagenin for treating cognitive dysfunctions HK1091417B (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9806513.9A GB9806513D0 (en) 1998-03-26 1998-03-26 Membrane-bound receptors
GB9806513 1998-03-26
GB9905275 1999-03-08
GBGB9905275.5A GB9905275D0 (en) 1999-03-08 1999-03-08 Treatment of conditions associated with membrane-bound receptors and their function

Publications (2)

Publication Number Publication Date
HK1091417A1 true HK1091417A1 (en) 2007-01-19
HK1091417B HK1091417B (en) 2011-12-16

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Also Published As

Publication number Publication date
PL343423A1 (en) 2001-08-13
EP1066042B1 (en) 2006-08-30
IL174991A0 (en) 2006-08-20
HRP20000637A2 (en) 2001-04-30
NO20004804D0 (no) 2000-09-26
NZ507355A (en) 2004-02-27
JP2003524581A (ja) 2003-08-19
CA2325633A1 (en) 1999-09-30
MXPA00009437A (es) 2002-05-06
KR100713311B1 (ko) 2007-05-04
GB9907100D0 (en) 1999-05-19
EP1066042A2 (en) 2001-01-10
AU748138B2 (en) 2002-05-30
AU3157499A (en) 1999-10-18
DE69929177D1 (de) 2006-02-02
CA2325634A1 (en) 1999-09-30
HUP0103654A2 (hu) 2002-02-28
PL207723B1 (pl) 2011-01-31
HUP0101693A3 (en) 2002-08-28
KR20070007214A (ko) 2007-01-12
JP2002507572A (ja) 2002-03-12
IL138663A0 (en) 2001-10-31
PL195897B1 (pl) 2007-11-30
CN1198622C (zh) 2005-04-27
JP2004224797A (ja) 2004-08-12
NO20083993L (no) 2000-09-11
CN1302208A (zh) 2001-07-04
IS5637A (is) 2000-09-25
RU2004123463A (ru) 2006-01-27
HRP20000638A2 (en) 2001-04-30
TR200002773T2 (tr) 2001-11-21
GB2335599B (en) 2001-08-01
US20020193317A1 (en) 2002-12-19
WO1999048507A2 (en) 1999-09-30
KR20090009997A (ko) 2009-01-23
EP1066033A1 (en) 2001-01-10
AU3158199A (en) 1999-10-18
US20060182817A1 (en) 2006-08-17
ES2257042T3 (es) 2006-07-16
CN1679591A (zh) 2005-10-12
EP1719512B1 (en) 2011-05-04
BR9909109A (pt) 2000-12-12
DE69943415D1 (de) 2011-06-16
WO1999048482A2 (en) 1999-09-30
DK1066042T3 (da) 2006-12-18
KR101092050B1 (ko) 2011-12-12
IS5638A (is) 2000-09-25
ATE314057T1 (de) 2006-01-15
DE69933016T2 (de) 2007-03-29
NO20004803D0 (no) 2000-09-26
JP3768100B2 (ja) 2006-04-19
KR20010042205A (ko) 2001-05-25
NO20004804L (no) 2000-11-09
EP1719512A2 (en) 2006-11-08
CN100377714C (zh) 2008-04-02
PL343508A1 (en) 2001-08-27
PT1066042E (pt) 2006-12-29
US6812213B2 (en) 2004-11-02
CA2325633C (en) 2009-01-20
ID26781A (id) 2001-02-08
DK1719512T3 (da) 2011-08-15
GB2335599A (en) 1999-09-29
PL380866A1 (pl) 2001-08-13
KR20090007505A (ko) 2009-01-16
EP1066033B1 (en) 2005-12-28
KR20010042190A (ko) 2001-05-25
HUP0101693A2 (hu) 2001-12-28
CY1105653T1 (el) 2010-12-22
WO1999048507A3 (en) 1999-11-25
NO20085251L (no) 2000-11-09
HK1033903A1 (en) 2001-10-05
IL138664A0 (en) 2001-10-31
IL138663A (en) 2006-08-01
EP1719512A3 (en) 2007-04-11
ES2272060T3 (es) 2007-04-16
KR20070117001A (ko) 2007-12-11
ID26989A (id) 2001-02-22
CN1301166A (zh) 2001-06-27
WO1999048482A3 (en) 2000-11-23
DE69929177T2 (de) 2006-08-24
KR100632052B1 (ko) 2006-10-04
NO20004803L (no) 2000-11-27
CN1209112C (zh) 2005-07-06
ATE507834T1 (de) 2011-05-15
RU2297228C2 (ru) 2007-04-20
BR9909110A (pt) 2000-12-12
TR200002774T2 (tr) 2001-06-21
JP2004217666A (ja) 2004-08-05
DE69933016D1 (de) 2006-10-12
ATE337788T1 (de) 2006-09-15
HK1033742A1 (en) 2001-09-21

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20150326