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HK1083026A1 - Tumor-associated antigen derivatives from the mage family, used for the preparation of fusion proteins with t-helper epitopes and of compositions for vaccination - Google Patents

Tumor-associated antigen derivatives from the mage family, used for the preparation of fusion proteins with t-helper epitopes and of compositions for vaccination Download PDF

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Publication number
HK1083026A1
HK1083026A1 HK06101448.0A HK06101448A HK1083026A1 HK 1083026 A1 HK1083026 A1 HK 1083026A1 HK 06101448 A HK06101448 A HK 06101448A HK 1083026 A1 HK1083026 A1 HK 1083026A1
Authority
HK
Hong Kong
Prior art keywords
mage
protein
vaccine
lpd
fusion
Prior art date
Application number
HK06101448.0A
Other languages
German (de)
English (en)
French (fr)
Chinese (zh)
Other versions
HK1083026B (en
Inventor
Teresa Cabezon Silva
Moncef M. Slaoui
Joseph Cohen
Carlota Vinals Bassols
Original Assignee
Glaxosmithkline Biologicals S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9802543.0A external-priority patent/GB9802543D0/en
Priority claimed from GBGB9802650.3A external-priority patent/GB9802650D0/en
Priority claimed from HK01103307.1A external-priority patent/HK1033838B/en
Application filed by Glaxosmithkline Biologicals S.A. filed Critical Glaxosmithkline Biologicals S.A.
Priority to HK06111054.4A priority Critical patent/HK1093521B/en
Priority to HK06111055.3A priority patent/HK1093522B/en
Publication of HK1083026A1 publication Critical patent/HK1083026A1/en
Publication of HK1083026B publication Critical patent/HK1083026B/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001184—Cancer testis antigens, e.g. SSX, BAGE, GAGE or SAGE
    • A61K39/001186—MAGE
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/285—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pasteurellaceae (F), e.g. Haemophilus influenza
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C07K14/3156—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci from Streptococcus pneumoniae (Pneumococcus)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6068—Other bacterial proteins, e.g. OMP
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Communicable Diseases (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
HK06101448.0A 1998-02-05 2001-05-11 Tumor-associated antigen derivatives from the mage family, used for the preparation of fusion proteins with t-helper epitopes and of compositions for vaccination HK1083026B (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
HK06111054.4A HK1093521B (en) 1998-02-05 2001-05-11 Tumor-associated antigen derivatives from the mage family, and nucleic acid sequences encoding them, used for the preparation of fusion proteins and of compositions for vaccination
HK06111055.3A HK1093522B (en) 1998-02-05 2001-05-11 A process for the purification or production of a mage protein

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB9802543.0A GB9802543D0 (en) 1998-02-05 1998-02-05 Vaccine
GB9802543 1998-02-05
GB9802650 1998-02-06
GBGB9802650.3A GB9802650D0 (en) 1998-02-06 1998-02-06 Vaccine
HK01103307.1A HK1033838B (en) 1998-02-05 1999-02-02 Tumor-associated antigen derivatives from the mage family, and nucleic acid sequences encoding them, used for the preparation of fusion proteins and of compositions for vaccination

Related Parent Applications (3)

Application Number Title Priority Date Filing Date
HK01103307.1A Addition HK1033838B (en) 1998-02-05 1999-02-02 Tumor-associated antigen derivatives from the mage family, and nucleic acid sequences encoding them, used for the preparation of fusion proteins and of compositions for vaccination
HK06111054.4A Division HK1093521B (en) 1998-02-05 2001-05-11 Tumor-associated antigen derivatives from the mage family, and nucleic acid sequences encoding them, used for the preparation of fusion proteins and of compositions for vaccination
HK06111055.3A Division HK1093522B (en) 1998-02-05 2001-05-11 A process for the purification or production of a mage protein

Related Child Applications (3)

Application Number Title Priority Date Filing Date
HK01103307.1A Division HK1033838B (en) 1998-02-05 1999-02-02 Tumor-associated antigen derivatives from the mage family, and nucleic acid sequences encoding them, used for the preparation of fusion proteins and of compositions for vaccination
HK06111054.4A Addition HK1093521B (en) 1998-02-05 2001-05-11 Tumor-associated antigen derivatives from the mage family, and nucleic acid sequences encoding them, used for the preparation of fusion proteins and of compositions for vaccination
HK06111055.3A Addition HK1093522B (en) 1998-02-05 2001-05-11 A process for the purification or production of a mage protein

Publications (2)

Publication Number Publication Date
HK1083026A1 true HK1083026A1 (en) 2006-06-23
HK1083026B HK1083026B (en) 2011-12-09

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Also Published As

Publication number Publication date
EP1053325A2 (en) 2000-11-22
US20100204458A1 (en) 2010-08-12
WO1999040188A3 (en) 1999-10-14
CZ298347B6 (cs) 2007-09-05
DK1053325T3 (da) 2006-05-22
HK1033838A1 (en) 2001-09-28
IL188875A (en) 2011-08-31
SI1659179T1 (sl) 2011-10-28
PT1053325E (pt) 2006-05-31
HK1093521A1 (en) 2007-03-02
ATE462788T1 (de) 2010-04-15
EP1584685B1 (en) 2011-04-13
IL137442A (en) 2008-04-13
NO20091665L (no) 2000-10-04
SI1659178T1 (sl) 2010-07-30
AU737337B2 (en) 2001-08-16
EP1659179A3 (en) 2007-01-17
ATE505542T1 (de) 2011-04-15
DE69942214D1 (de) 2010-05-12
KR20010040675A (ko) 2001-05-15
IL137442A0 (en) 2001-07-24
PT1659178E (pt) 2010-06-28
EP1659178A3 (en) 2007-01-17
KR20060067977A (ko) 2006-06-20
JP4768121B2 (ja) 2011-09-07
IL188875A0 (en) 2009-02-11
TWI238853B (en) 2005-09-01
EP1584685A3 (en) 2005-12-07
HUP0102639A1 (hu) 2001-11-28
ES2255248T3 (es) 2006-06-16
KR100633212B1 (ko) 2006-10-11
CN1227360C (zh) 2005-11-16
CZ20002869A3 (cs) 2001-01-17
CY1110180T1 (el) 2015-01-14
ES2342416T3 (es) 2010-07-06
CA2319309A1 (en) 1999-08-12
EP1659179A2 (en) 2006-05-24
NO20003958D0 (no) 2000-08-04
BR9907691A (pt) 2000-11-14
PT1659179E (pt) 2011-09-16
JP2002502604A (ja) 2002-01-29
CA2319309C (en) 2010-08-10
DE69929310T2 (de) 2006-08-03
NO331719B1 (no) 2012-03-05
CZ298364B6 (cs) 2007-09-05
US8597656B2 (en) 2013-12-03
HU228467B1 (en) 2013-03-28
NO20003958L (no) 2000-10-04
NO328507B1 (no) 2010-03-08
DE69943359D1 (de) 2011-05-26
BR9907691B1 (pt) 2011-05-31
EP1659178A2 (en) 2006-05-24
SA99200126B1 (ar) 2006-08-20
US8044183B2 (en) 2011-10-25
US20100209444A1 (en) 2010-08-19
CY1111672T1 (el) 2015-10-07
EP1659178B1 (en) 2010-03-31
DE69929310D1 (de) 2006-03-30
EP1053325B1 (en) 2006-01-04
EP1659179B1 (en) 2011-06-15
NZ506086A (en) 2003-01-31
PL342852A1 (en) 2001-07-16
CN1295616A (zh) 2001-05-16
EP1584685A2 (en) 2005-10-12
HK1093522A1 (en) 2007-03-02
WO1999040188A2 (en) 1999-08-12
ATE513042T1 (de) 2011-07-15
CY1111831T1 (el) 2015-10-07
AU2722099A (en) 1999-08-23
CA2584482A1 (en) 1999-08-12
HUP0102639A3 (en) 2004-04-28
DK1584685T3 (da) 2011-07-11
DK1659178T3 (da) 2010-07-12
US8097257B2 (en) 2012-01-17
PT1584685E (pt) 2011-06-17
TR200002284T2 (tr) 2000-11-21
DK1659179T3 (da) 2011-10-10
JP2009201510A (ja) 2009-09-10
SI1584685T1 (sl) 2011-07-29
US20120269835A1 (en) 2012-10-25
CA2584482C (en) 2012-03-27
KR100824105B1 (ko) 2008-04-21
SI1053325T1 (sl) 2006-06-30
AR018064A1 (es) 2001-10-31
CY1105685T1 (el) 2010-12-22
IL179010A0 (en) 2007-03-08
ATE315088T1 (de) 2006-02-15

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20150202