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HK1005037A1 - Hybrid plasminogen activators - Google Patents

Hybrid plasminogen activators Download PDF

Info

Publication number
HK1005037A1
HK1005037A1 HK98104184A HK98104184A HK1005037A1 HK 1005037 A1 HK1005037 A1 HK 1005037A1 HK 98104184 A HK98104184 A HK 98104184A HK 98104184 A HK98104184 A HK 98104184A HK 1005037 A1 HK1005037 A1 HK 1005037A1
Authority
HK
Hong Kong
Prior art keywords
human
junction
domain
chain
hybrid
Prior art date
Application number
HK98104184A
Other languages
German (de)
English (en)
French (fr)
Chinese (zh)
Other versions
HK1005037B (en
Inventor
Rajput Bhanu
Chaudhuri Bhabatosh
Alphonsus Maria Asselbergs Fredericus
Meyhack Bernd
Heim Jutta
Van Oostrum Jan
Alkan Sefik
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB868629153A external-priority patent/GB8629153D0/en
Priority claimed from GB878709656A external-priority patent/GB8709656D0/en
Priority claimed from GB878715890A external-priority patent/GB8715890D0/en
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of HK1005037A1 publication Critical patent/HK1005037A1/en
Publication of HK1005037B publication Critical patent/HK1005037B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Amplifiers (AREA)
  • Adhesives Or Adhesive Processes (AREA)
HK98104184.1A 1986-12-05 1998-05-14 Hybrid plasminogen activators HK1005037B (en)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
GB868629153A GB8629153D0 (en) 1986-12-05 1986-12-05 Hybrid proteins
GB8629153 1986-12-05
GB8701160 1987-01-20
GB878701160A GB8701160D0 (en) 1986-12-05 1987-01-20 Hybrid proteins
GB878709656A GB8709656D0 (en) 1986-12-05 1987-04-23 Hybrid proteins
GB8709656 1987-04-23
GB878715890A GB8715890D0 (en) 1986-12-05 1987-07-06 Hybrid proteins
GB8715890 1987-07-06

Publications (2)

Publication Number Publication Date
HK1005037A1 true HK1005037A1 (en) 1998-12-18
HK1005037B HK1005037B (en) 1998-12-18

Family

ID=

Also Published As

Publication number Publication date
AU621281B2 (en) 1992-03-12
DE3752008D1 (de) 1997-03-06
ES2095825T3 (es) 1997-03-01
NO177603B (no) 1995-07-10
NO177603C (no) 1995-10-18
JP2641875B2 (ja) 1997-08-20
DK638187D0 (da) 1987-12-04
IL84700A (en) 1992-11-15
FI875324A0 (fi) 1987-12-02
PT86276A (en) 1988-06-01
FI100106B (sv) 1997-09-30
DK638187A (da) 1988-06-06
NO875069L (no) 1988-06-06
JPH09117292A (ja) 1997-05-06
DK175483B1 (da) 2004-11-08
NO875069D0 (no) 1987-12-04
DE3752008T2 (de) 1997-08-14
FI875324L (fi) 1988-06-06
NZ222793A (en) 1990-09-26
GR3023047T3 (en) 1997-07-30
IE81116B1 (en) 2000-03-22
CY2156B1 (en) 2002-08-23
CA1341479C (en) 2005-04-12
IE873299L (en) 1988-06-05
PT86276B (pt) 1990-11-07
ATE148167T1 (de) 1997-02-15
IL84700A0 (en) 1988-05-31
AU8209187A (en) 1988-06-16
EP0277313B1 (en) 1997-01-22
JP2645237B2 (ja) 1997-08-25
JPS63160581A (ja) 1988-07-04
EP0277313A1 (en) 1988-08-10

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PF Patent in force
PE Patent expired

Effective date: 20071202