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HK1002551A1 - Diagnostic imaging contrast agents with extended blood retention - Google Patents

Diagnostic imaging contrast agents with extended blood retention Download PDF

Info

Publication number
HK1002551A1
HK1002551A1 HK98100980A HK98100980A HK1002551A1 HK 1002551 A1 HK1002551 A1 HK 1002551A1 HK 98100980 A HK98100980 A HK 98100980A HK 98100980 A HK98100980 A HK 98100980A HK 1002551 A1 HK1002551 A1 HK 1002551A1
Authority
HK
Hong Kong
Prior art keywords
blood
agents
imaging
mmol
agent
Prior art date
Application number
HK98100980A
Other languages
German (de)
English (en)
French (fr)
Chinese (zh)
Other versions
HK1002551B (en
Inventor
Thomas J. Mcmurry
Hironao Sajiki
Daniel M. Scott
Randall B. Lauffer
Original Assignee
Epix Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Epix Pharmaceuticals, Inc. filed Critical Epix Pharmaceuticals, Inc.
Publication of HK1002551A1 publication Critical patent/HK1002551A1/en
Publication of HK1002551B publication Critical patent/HK1002551B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/103—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being acyclic, e.g. DTPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/50—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications
    • A61B6/507—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications for determination of haemodynamic parameters, e.g. perfusion CT

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Apparatus For Radiation Diagnosis (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
HK98100980.5A 1995-02-01 1996-01-16 Diagnostic imaging contrast agents with extended blood retention HK1002551B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US38231795A 1995-02-01 1995-02-01
US08/382,317 1995-02-01
PCT/US1996/000164 WO1996023526A2 (en) 1995-02-01 1996-01-16 Diagnostic imaging contrast agents with extended blood retention

Publications (2)

Publication Number Publication Date
HK1002551A1 true HK1002551A1 (en) 1998-09-04
HK1002551B HK1002551B (en) 2007-05-11

Family

ID=

Also Published As

Publication number Publication date
CN1177806C (zh) 2004-12-01
US20020164289A1 (en) 2002-11-07
IS4523A (is) 1997-07-14
AR006510A1 (es) 1999-09-08
EP1716871A2 (en) 2006-11-02
EP1716871A3 (en) 2011-04-27
IS2505B (is) 2009-04-15
US20040208827A1 (en) 2004-10-21
EP0806968B1 (en) 2006-10-18
DE69636635T2 (de) 2007-10-31
US20030180223A1 (en) 2003-09-25
PT806968E (pt) 2007-01-31
BR9607136A (pt) 1997-11-25
JPH10513445A (ja) 1998-12-22
NL300253I1 (nl) 2007-03-01
DE122006000061I2 (de) 2012-06-21
AU4654396A (en) 1996-08-21
US8394356B2 (en) 2013-03-12
NO326114B1 (no) 2008-09-29
JP2008189683A (ja) 2008-08-21
US8017105B2 (en) 2011-09-13
IL116847A0 (en) 1996-07-23
US20120107249A1 (en) 2012-05-03
US7011815B2 (en) 2006-03-14
KR100403755B1 (ko) 2004-05-24
DK0806968T3 (da) 2007-02-05
HK1078468A1 (zh) 2006-03-17
NZ301181A (en) 1999-02-25
CA2211100C (en) 2007-03-20
DE69636635D1 (de) 2006-11-30
US7060250B2 (en) 2006-06-13
AU689700B2 (en) 1998-04-02
MX9705823A (es) 1997-11-29
NO20081355L (no) 1997-07-30
IL116847A (en) 1999-11-30
NO973510D0 (no) 1997-07-30
MY128089A (en) 2007-01-31
ZA96417B (en) 1996-08-08
US20070003479A1 (en) 2007-01-04
NL300253I2 (nl) 2007-04-02
US7229606B2 (en) 2007-06-12
FI973183A7 (fi) 1997-07-31
FI973183A0 (fi) 1997-07-31
CN1616111A (zh) 2005-05-18
TW319763B (pt) 1997-11-11
DE122006000061I1 (de) 2007-02-15
ATE342738T1 (de) 2006-11-15
JP2004026793A (ja) 2004-01-29
US20070020185A1 (en) 2007-01-25
ES2274523T3 (es) 2007-05-16
CA2211100A1 (en) 1996-08-08
KR19980701833A (ko) 1998-06-25
WO1996023526A2 (en) 1996-08-08
EP0806968A2 (en) 1997-11-19
JP4064458B2 (ja) 2008-03-19
WO1996023526A3 (en) 1996-10-17
CN100361711C (zh) 2008-01-16
US20040202613A1 (en) 2004-10-14
CN101011586A (zh) 2007-08-08
US6676929B2 (en) 2004-01-13
NO973510L (no) 1997-07-30
CN1172436A (zh) 1998-02-04
JP2006342181A (ja) 2006-12-21
US20070020184A1 (en) 2007-01-25
FI973183L (fi) 1997-07-31
JP4950110B2 (ja) 2012-06-13

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Legal Events

Date Code Title Description
PE Patent expired

Effective date: 20160115