FI83869B - Foerfarande foer framstaellning av nya terapeutiskt anvaendbara ergolinderivat. - Google Patents
Foerfarande foer framstaellning av nya terapeutiskt anvaendbara ergolinderivat. Download PDFInfo
- Publication number
- FI83869B FI83869B FI862561A FI862561A FI83869B FI 83869 B FI83869 B FI 83869B FI 862561 A FI862561 A FI 862561A FI 862561 A FI862561 A FI 862561A FI 83869 B FI83869 B FI 83869B
- Authority
- FI
- Finland
- Prior art keywords
- sub
- formula
- group
- ergoline
- carboxylic acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Emergency Protection Circuit Devices (AREA)
- Control Of Electric Motors In General (AREA)
- Diaphragms For Electromechanical Transducers (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Claims (8)
1. Förfarande för framställning av nya terapeutiskt användbara ergolinderivat med formeln I och farmaceutiskt 5 godtagbara salter därav, ^ / 6 10 ' ''JL N - (VV N HN _S 15 i vilken formel R3 är en kolvätegrupp med 1-4 kolatomer, R5 är väte och R6 är -CH=CH-CONHR7, där R7 är en 2-tiazolyl, 3-pyridazinyl-, 1,3,4-tiadiazol-2-yl eller 4-pyrimidinyl-grupp, som kan vara substituerad med en eller flera halo- 20 genatomer, C1.4-alkylgrupper, C1.4-alkoxigrupper, C1.4-alkyl-tiogrupper, di-C1.4-alkylaminogrupper, cyanogrupper eller nitrogrupper, eller R5 ja R6 bildar tillsammans en grupp =CHC0NHR7, där R7 betecknar samma som ovan, känne-t e c k n a t därav, att en karboxylsyra med formeln 25 \ R9 30 n\ ΓΤ J R3 HN__tl 35 II i3 83869 där R3 betecknar samma som ovan och R8 är väte och R9 är en karboxivinylengrupp eller R8 och R9 bildar tillsammans en karboxlmetylengrupp, eller reaktivt derivat av nämnda kar-boxylsyra omsätts med en amin med formeln R7NH2, där R7 be-5 tecknar sanuna som ovan.
2. Förfarande enligt patentkravet 1, känne-t e c k n a t därav, att karboxylsyran med formeln II omsätts med trifluorättiksyraanhydrid i ett inert lösnings-medel vid en temperatur av -20 - 0 °C och den erhällna 10 blandanhydriden omsätts med en amin R7NH2 vid en temperatur av -20 - 0 °C i närvaro av en organisk bas.
3. Förfarande enligt patentkravet 2, känne-t e c k n a t därav, att det inerta lösningsmedlet är tetrahydrofuran, dioxan eller acetonitril. 15
4. Förfarande enligt patentkravet 2 eller 3, kännetecknat därav, att den organiska basen är pyridin eller trietylamin.
5. Förfarande enligt nägot av patentkraven 1-4, kännetecknat därav, att karboxylsyran med for- 20 mein II är framställd genom att kondensera en förening med formeln R10 R11 H [ J 25 ‘SI N Lii 111 HN _U 30 där R3 betecknar samma som ovan och R10 är väte och Ru är en formylgrupp eller R10 och Rn bildar tillsammans en oxo-grupp, med natriumsalt av trialkylfosfonoacetat i ett lös-ningsmedel vid ett temperatur av -20 - 0 °C under 3 timmar 35 och genom att förtväla den erhällna alkylestern med alka li.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8515528 | 1985-06-19 | ||
| GB858515528A GB8515528D0 (en) | 1985-06-19 | 1985-06-19 | Ergoline derivatives |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI862561A0 FI862561A0 (fi) | 1986-06-16 |
| FI862561A FI862561A (fi) | 1986-12-20 |
| FI83869B true FI83869B (fi) | 1991-05-31 |
| FI83869C FI83869C (sv) | 1991-09-10 |
Family
ID=10580992
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI862561A FI83869C (sv) | 1985-06-19 | 1986-06-16 | Förfarande för framställning av nya terapeutiskt användbara ergolinder ivat |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US4746666A (sv) |
| EP (1) | EP0206206B1 (sv) |
| JP (1) | JPH0717639B2 (sv) |
| KR (1) | KR920010074B1 (sv) |
| AT (1) | ATE46510T1 (sv) |
| AU (1) | AU584431B2 (sv) |
| CA (1) | CA1285277C (sv) |
| DE (2) | DE3665715D1 (sv) |
| DK (1) | DK171117B1 (sv) |
| ES (1) | ES8707247A1 (sv) |
| FI (1) | FI83869C (sv) |
| GB (1) | GB8515528D0 (sv) |
| GR (1) | GR861538B (sv) |
| HU (1) | HU196397B (sv) |
| IE (1) | IE59020B1 (sv) |
| IL (1) | IL79119A (sv) |
| NZ (1) | NZ216545A (sv) |
| PT (1) | PT82767B (sv) |
| ZA (1) | ZA864481B (sv) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9006772D0 (en) * | 1990-03-27 | 1990-05-23 | Erba Carlo Spa | 4-piperidinyl-ergoline derivatives |
| PL304893A1 (en) * | 1992-12-24 | 1995-01-09 | Erba Carlo Spa | Serotoninergic derivatives of ergoline |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| YU33967B (en) * | 1969-05-13 | 1978-09-08 | Farmaceutici Italia | Process for preparing lumilysergic acid derivatives |
| DE2802023A1 (de) * | 1977-01-28 | 1978-08-03 | Sandoz Ag | Neue ergotderivate, ihre herstellung und verwendung |
| FI76085C (sv) * | 1981-07-21 | 1988-09-09 | Erba Farmitalia | Förfarande för framställning av ergolinderivat |
| GB2112382B (en) * | 1981-11-06 | 1985-03-06 | Erba Farmitalia | Ergoline derivatives |
| DE3362248D1 (en) * | 1982-04-13 | 1986-04-03 | Erba Farmitalia | Ergoline derivatives, process for producing the ergoline derivatives and pharmaceutical compositions containing them |
| PH21123A (en) * | 1983-04-28 | 1987-07-27 | Erba Farmitalia | Ergoline derivatives |
| IT1173489B (it) * | 1984-03-27 | 1987-06-24 | Inverni Della Beffa Spa | Procedimento di preparazione di 1-metil-10alfa-metossilumilisergolo e di suci esteri,e intermedi per la loro preparazione |
| IT1213206B (it) * | 1984-08-07 | 1989-12-14 | Inverni Della Beffa Spa | Procedimento per la preparazione di derivati del lisergolo. |
-
1985
- 1985-06-19 GB GB858515528A patent/GB8515528D0/en active Pending
-
1986
- 1986-06-03 ES ES555671A patent/ES8707247A1/es not_active Expired
- 1986-06-07 KR KR1019860004522A patent/KR920010074B1/ko not_active IP Right Cessation
- 1986-06-13 GR GR861538A patent/GR861538B/el unknown
- 1986-06-16 IL IL79119A patent/IL79119A/xx not_active IP Right Cessation
- 1986-06-16 AU AU58896/86A patent/AU584431B2/en not_active Ceased
- 1986-06-16 PT PT82767A patent/PT82767B/pt not_active IP Right Cessation
- 1986-06-16 NZ NZ216545A patent/NZ216545A/xx unknown
- 1986-06-16 DE DE8686108201T patent/DE3665715D1/de not_active Expired
- 1986-06-16 ZA ZA864481A patent/ZA864481B/xx unknown
- 1986-06-16 US US06/874,413 patent/US4746666A/en not_active Expired - Fee Related
- 1986-06-16 FI FI862561A patent/FI83869C/sv not_active IP Right Cessation
- 1986-06-16 DE DE198686108201T patent/DE206206T1/de active Pending
- 1986-06-16 AT AT86108201T patent/ATE46510T1/de not_active IP Right Cessation
- 1986-06-16 EP EP86108201A patent/EP0206206B1/en not_active Expired
- 1986-06-17 DK DK282786A patent/DK171117B1/da not_active IP Right Cessation
- 1986-06-17 JP JP61139413A patent/JPH0717639B2/ja not_active Expired - Lifetime
- 1986-06-17 HU HU862549A patent/HU196397B/hu not_active IP Right Cessation
- 1986-06-17 IE IE159986A patent/IE59020B1/en not_active IP Right Cessation
- 1986-06-18 CA CA000511866A patent/CA1285277C/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| KR920010074B1 (ko) | 1992-11-13 |
| FI83869C (sv) | 1991-09-10 |
| ZA864481B (en) | 1987-02-25 |
| ATE46510T1 (de) | 1989-10-15 |
| JPS61291587A (ja) | 1986-12-22 |
| GR861538B (en) | 1986-10-14 |
| KR870000333A (ko) | 1987-02-17 |
| JPH0717639B2 (ja) | 1995-03-01 |
| FI862561A0 (fi) | 1986-06-16 |
| ES555671A0 (es) | 1987-07-16 |
| PT82767B (pt) | 1989-01-17 |
| IL79119A0 (en) | 1986-09-30 |
| FI862561A (fi) | 1986-12-20 |
| HU196397B (en) | 1988-11-28 |
| DK282786D0 (da) | 1986-06-17 |
| DK171117B1 (da) | 1996-06-17 |
| CA1285277C (en) | 1991-06-25 |
| AU5889686A (en) | 1986-12-24 |
| DE3665715D1 (en) | 1989-10-26 |
| DE206206T1 (de) | 1987-05-21 |
| GB8515528D0 (en) | 1985-07-24 |
| EP0206206A1 (en) | 1986-12-30 |
| IE59020B1 (en) | 1993-12-15 |
| DK282786A (da) | 1986-12-20 |
| EP0206206B1 (en) | 1989-09-20 |
| AU584431B2 (en) | 1989-05-25 |
| IE861599L (en) | 1986-12-19 |
| US4746666A (en) | 1988-05-24 |
| NZ216545A (en) | 1989-06-28 |
| IL79119A (en) | 1989-06-30 |
| HUT41778A (en) | 1987-05-28 |
| ES8707247A1 (es) | 1987-07-16 |
| PT82767A (en) | 1986-07-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC | Transfer of assignment of patent |
Owner name: PHARMACIA & UPJOHN S.P.A. |
|
| MM | Patent lapsed | ||
| MM | Patent lapsed |
Owner name: PHARMACIA & UPJOHN S., P.A. |