FI80677B - Nya dihydropyridinmellanprodukter. - Google Patents
Nya dihydropyridinmellanprodukter. Download PDFInfo
- Publication number
- FI80677B FI80677B FI831778A FI831778A FI80677B FI 80677 B FI80677 B FI 80677B FI 831778 A FI831778 A FI 831778A FI 831778 A FI831778 A FI 831778A FI 80677 B FI80677 B FI 80677B
- Authority
- FI
- Finland
- Prior art keywords
- dihydropyridine
- ethyl
- compound
- dimethyl
- dichlorophenyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Claims (9)
1. Mellanprodukter enligt formeln I, syraadditionsalter eller optiska isomerer därav, R4OOC—.-- " COOAR2 R^^KI^5 H väri R1 betecknar en eller tvä (kan vara olika eller lika) substituenter i fenylringen, vilka är valda ur den grupp som best&r av lägre alkyl, NO2, CN, CF3, Cl och Br; A är en rak eller förgrenad alkylengrupp med 2-5 kolatomer; R2 . R3 är en grupp -S-B-N^ , väri B är en rak eller förgrenad \R6 alkylengrupp med 2-5 kolatomer och R1 och Re är lika eller olika och vardera betecknar en rak eller förgrenad alkyl-grupp med 1-4 kolatomer, bensyl eller de kan tillsammans bilda en morfolinogrupp; R4 är en rak eller förgrenad alkyl-grupp med 1-5 kolatomer eller en sädan rak eller förgrenad alkylgrupp med 1-5 kolatomer, väri kolkedjan är avbruten av en syreatom; och Rs är en alkylgrupp med 1-5 kolatomer.
2. Mellanprodukt enligt patentkrav 1, kännetecknad av att den är föreningen 2,6-dimetyl-4-(2,3-diklorfenyl)-1,4-dihydropyridin-3,5-dikarboxylsyra-3-[2-(2-N,N-dimetylamino-etyltio)etyl]-5-metylester. Mellanprodukt enligt patentkrav 1, kännetecknad av att den är föreningen 2,6-dimetyl-4-(2,3-diklorfenyl)-1,4-dihydropyridin-3,5-dikarboxylsyra-3-[2-(2-N,N-dietylamino-etyltio)etyl]-5-metylester. 33 80677
4. Mellanprodukt enligt patentkrav 1, kännetecknad av att den är föreningen 2,6-dimetyl-4-(2,3-diklorfenyl)-l,4-dihydropyridin-3,5-dikarboxylsyra-3-[2-(2-morfolinoetyl-tio)etyl]-5-metylester.
5. Mellanprodukt enligt patentkrav 1, kännetecknad av att den är föreningen 2,6-dimetyl-4-(2,3-diklorfenyl)-l,4-dihydropyridin-3,5-dikarboxylsyra-3-[2-(2-N-isopropyl-N-bensylaminoetyltio)etyl]-5-metylester.
6. Mellanprodukt enligt patentkrav lf kännetecknad av att den är föreningen 2,6-dimetyl-4-(2,3-diklorfenyl)-l,4-dihydropyridin-3,5-dikarboxylsyra-3-[2-(3-N,N-dimetylamino-propyltio)etyl]-5-metylester.
7. Mellanprodukt enligt nägot av patentkraven 1-6, kännetecknad av att föreningen framställs i form av sin optiska isomer.
8. Mellanprodukt enligt nägot av patentkraven 1-7, kännetecknad av att föreningen framställs i form av sitt syraad-ditionsalt.
9. Mellanprodukt enligt nägot av patentkraven 1-8, ett salt eller optisk isomer därav, kännetecknad av att den används som mellanprodukt vid framställning av terapeutiskt aktiva dihydropyridiner.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE8203176 | 1982-05-21 | ||
| SE8203176 | 1982-05-21 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI831778A0 FI831778A0 (fi) | 1983-05-19 |
| FI831778L FI831778L (fi) | 1983-11-22 |
| FI80677B true FI80677B (fi) | 1990-03-30 |
| FI80677C FI80677C (sv) | 1990-07-10 |
Family
ID=20346867
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI831778A FI80677C (sv) | 1982-05-21 | 1983-05-19 | Nya dihydropyridinmellanprodukter |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP0095451A3 (sv) |
| JP (1) | JPS58210063A (sv) |
| KR (1) | KR900006682B1 (sv) |
| AU (1) | AU1464583A (sv) |
| CA (1) | CA1205471A (sv) |
| DD (2) | DD209816A5 (sv) |
| DK (1) | DK223683A (sv) |
| ES (3) | ES522570A0 (sv) |
| FI (1) | FI80677C (sv) |
| GB (1) | GB2120668B (sv) |
| GR (1) | GR78566B (sv) |
| HU (2) | HU188342B (sv) |
| IL (1) | IL68524A0 (sv) |
| IS (1) | IS1381B6 (sv) |
| MW (1) | MW1783A1 (sv) |
| NO (1) | NO163327C (sv) |
| NZ (1) | NZ204283A (sv) |
| PT (1) | PT76733B (sv) |
| ZA (1) | ZA833112B (sv) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3600594A1 (de) * | 1986-01-11 | 1987-07-16 | Bayer Ag | Methioninsubstituierte 1,4-dihydropyridine, verfahren zur herstellung und ihre verwendung |
| US4814455A (en) * | 1986-04-16 | 1989-03-21 | Bristol-Myers Company | Dihydro-3,5-dicarboxylates |
| JPS63112560A (ja) * | 1986-10-29 | 1988-05-17 | Green Cross Corp:The | ジヒドロピリジン誘導体 |
| US5310917A (en) * | 1991-09-13 | 1994-05-10 | Merck & Co., Inc. | Process for the preparation of 4-substituted-1,4-dihydropydrines |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2747513A1 (de) * | 1977-10-22 | 1979-05-03 | Bayer Ag | Dihydropyridine mit schwefelhaltigen estergruppierungen |
| DE2861974D1 (en) * | 1977-11-11 | 1982-09-16 | Ciba Geigy Ag | Pyridine dicarboxylic acid derivatives, their mixtures with metallic stabilisers and their use in stabilising chlorine-containing thermoplasts |
| US4285955A (en) * | 1978-10-31 | 1981-08-25 | Bayer Aktiengesellschaft | 1,4-Dihydropyridinecarboxylic acids |
-
1983
- 1983-04-29 IL IL68524A patent/IL68524A0/xx unknown
- 1983-05-02 ZA ZA833112A patent/ZA833112B/xx unknown
- 1983-05-03 CA CA000427276A patent/CA1205471A/en not_active Expired
- 1983-05-06 MW MW17/83A patent/MW1783A1/xx unknown
- 1983-05-13 EP EP83850127A patent/EP0095451A3/en not_active Withdrawn
- 1983-05-18 NZ NZ204283A patent/NZ204283A/en unknown
- 1983-05-18 AU AU14645/83A patent/AU1464583A/en not_active Abandoned
- 1983-05-19 GR GR71397A patent/GR78566B/el unknown
- 1983-05-19 DK DK223683A patent/DK223683A/da not_active Application Discontinuation
- 1983-05-19 FI FI831778A patent/FI80677C/sv not_active IP Right Cessation
- 1983-05-20 NO NO831806A patent/NO163327C/no unknown
- 1983-05-20 ES ES522570A patent/ES522570A0/es active Granted
- 1983-05-20 DD DD25113583A patent/DD209816A5/de unknown
- 1983-05-20 PT PT76733A patent/PT76733B/pt not_active IP Right Cessation
- 1983-05-20 DD DD83264588A patent/DD216009A5/de not_active IP Right Cessation
- 1983-05-20 HU HU831792A patent/HU188342B/hu not_active IP Right Cessation
- 1983-05-20 JP JP58087768A patent/JPS58210063A/ja active Pending
- 1983-05-20 GB GB08314034A patent/GB2120668B/en not_active Expired
- 1983-05-20 IS IS2809A patent/IS1381B6/is unknown
- 1983-05-20 HU HU852491A patent/HU193786B/hu unknown
- 1983-05-21 KR KR1019830002237A patent/KR900006682B1/ko not_active IP Right Cessation
-
1984
- 1984-08-16 ES ES535215A patent/ES535215A0/es active Granted
- 1984-08-16 ES ES535216A patent/ES8504713A1/es not_active Expired
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM | Patent lapsed | ||
| MM | Patent lapsed |
Owner name: AKTIEBOLAGET HAESSLE |