FI73677B - Foerfarande foer framstaellning av nya, terapeutiskt anvaendbara 3-metylflavon-8-karboxylsyraestrar. - Google Patents
Foerfarande foer framstaellning av nya, terapeutiskt anvaendbara 3-metylflavon-8-karboxylsyraestrar. Download PDFInfo
- Publication number
- FI73677B FI73677B FI822493A FI822493A FI73677B FI 73677 B FI73677 B FI 73677B FI 822493 A FI822493 A FI 822493A FI 822493 A FI822493 A FI 822493A FI 73677 B FI73677 B FI 73677B
- Authority
- FI
- Finland
- Prior art keywords
- general formula
- methylflavone
- hydrogen atom
- carbon atoms
- group
- Prior art date
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A61P23/02—Local anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
- C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
- C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
- C07D311/30—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
- C07D451/12—Oxygen atoms acylated by aromatic or heteroaromatic carboxylic acids, e.g. cocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Obesity (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Neurosurgery (AREA)
- Endocrinology (AREA)
- Biomedical Technology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
Claims (4)
1. Förfarande för framställning av nya, terapeu-tiskt användbara 3-metylflavon-8-karbonsyraestrar med 5 den allmänna formeln (I) QÖT. · cooz väri Z betecknar N-metylpiperidyl, tropyl eller kinukli-dyl eller en grupp med den allmänna formeln (II) 15 f ? /-\ - C - C - (CH,) -N > (II) i ( 2 n v / R·, R, \_/ R3^ 20 väri n är 0 eller 1, R betecknar en väteatom, en alkyl-grupp med 1-4 kolatomer eller en fenylgrupp, R^ betecknar en väteatom eller en alkylgrupp med 1-4 kolatomer, R^ betecknar en väteatom eller en hydroxigrupp eller R, R^ och R^ tillsammans med de kolatomerna, vid vilka de 25 är bundna, bildar en cyklohexylgrupp, och R^ betecknar en väteatom eller en alkylgrupp med 1-4 kolatomer, under förutsättning, att R, R1, R2 och R3 inte alla samtidigt betecknar väte, samt farmaceutiskt godtagbara salter därav, kännetecknat därav, att man 30 a) kondenserar en 3-metylflavon-8-karbonsyrahalo- genid med den allmänna formeln (III) O CH 35 ij Ϊ 3 (III) co-x 18 7 3 6 7 7 väri X betecknar en haiogenatom, företrädesvis en klor-atom, raed en aminoalkohol mdd den allmänna forineln ZOH, varvid Σ betecknar samir.a som ovan, eller b) för fram.ställning av föreningar med den all-5 manna forineln (I), väri Z betecknar en grupp med den allmänna formeln (II1) - C - C - CH - N \ (II')
10. OH \_/ R3^ väri betecknar en väteatom eller en alkylgrupp med 1-4 ko.latomer, omsätter en förening med den allmänna 15 formeln (IV) n I (IV) ^ R-
20. J väri betecknar sar;r.a som ovan, med 2,3-epoxipropyl- 3-metylflavon-3-karboxyla 1 i närvaro av en katalysatorn, företrädesvis trietylamin, och 25 ifall önskvärt, omvandlar den erhällna produktcn tili ett syraadditionssalt.
2. Fbrfaranäe enligt punkten a) av patentkravet 1, k ä n n e t e o k n a t därav, att man uppvärmer aminoalkoholen med ett överskott av flavonderivatet vid 30 140-200°C i fränvaro av ett lösningsmedel.
3. Förfarande enligt punkten a) av patentkravet 1, känneteckna t därav, att man omsätter aminoalkoholen med en ekvimoiar mängd av flavonderivatet i närvaro av ett lösningsmedel vid en temperatur av 0°C 35 tili äterflödestemperaturen hos lösningsmedlet, even-tuellt i närvaro av ett syrabindande niedol. Il
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8122158 | 1981-07-17 | ||
| GB8122158 | 1981-07-17 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI822493A0 FI822493A0 (fi) | 1982-07-13 |
| FI822493L FI822493L (fi) | 1983-01-18 |
| FI73677B true FI73677B (fi) | 1987-07-31 |
| FI73677C FI73677C (sv) | 1987-11-09 |
Family
ID=10523330
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI822493A FI73677C (sv) | 1981-07-17 | 1982-07-13 | Förfarande för framställning av nya, terapeutiskt användbara 3-metylf lavon-8-karboxylsyraestrar. |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US4550115A (sv) |
| EP (1) | EP0072620B1 (sv) |
| JP (1) | JPS5835185A (sv) |
| KR (1) | KR870000275B1 (sv) |
| AR (1) | AR231543A1 (sv) |
| AT (1) | ATE16806T1 (sv) |
| AU (1) | AU553322B2 (sv) |
| CA (1) | CA1221969A (sv) |
| DE (1) | DE3267782D1 (sv) |
| DK (1) | DK160498C (sv) |
| ES (1) | ES513993A0 (sv) |
| FI (1) | FI73677C (sv) |
| GB (1) | GB2104507B (sv) |
| GR (1) | GR81300B (sv) |
| HU (1) | HU189601B (sv) |
| IE (1) | IE53525B1 (sv) |
| IL (1) | IL66187A0 (sv) |
| IT (1) | IT1198389B (sv) |
| NO (1) | NO157330C (sv) |
| NZ (1) | NZ200981A (sv) |
| PH (1) | PH18001A (sv) |
| PT (1) | PT75230B (sv) |
| SG (1) | SG77784G (sv) |
| YU (2) | YU136682A (sv) |
| ZA (1) | ZA824335B (sv) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58225083A (ja) * | 1982-06-23 | 1983-12-27 | Nippon Shinyaku Co Ltd | メチルフラボン誘導体 |
| FR2531083B1 (fr) * | 1982-06-29 | 1986-11-28 | Sandoz Sa | Nouveaux derives de la piperidine, leur preparation et leur utilisation comme medicaments |
| IT1229856B (it) * | 1989-04-20 | 1991-09-13 | Recordati Chem Pharm | Compresse a rilascio controllato contenenti flavossato. |
| US5605896A (en) * | 1992-02-25 | 1997-02-25 | Recordati S.A., Chemical And Pharmaceutical Company | Bicyclic heterocyclic derivatives having α1 adrenergic and 5HT1A activities |
| US5474994A (en) * | 1992-05-26 | 1995-12-12 | Recordati S.A., Chemical And Pharmaceutical Company | Bicyclic heterocyclic derivatives having α1 -adrenergic and 5HT1A |
| IT1254469B (it) * | 1992-02-25 | 1995-09-25 | Recordati Chem Pharm | Derivati benzopiranici e benzotiopiranici |
| SG65570A1 (en) | 1992-02-25 | 1999-06-22 | Recordati Chem Pharm | Heterobicyclic compounds |
| IT1258315B (it) * | 1992-04-10 | 1996-02-22 | Recordati Chem Pharm | Derivati del flavone |
| US6087366A (en) * | 1996-03-07 | 2000-07-11 | The Trustees Of Columbia University In The City Of New York | Use of flavopiridol or a pharmaceutically acceptable salt thereof for inhibiting cell damage or cell death |
| US7501443B2 (en) | 2002-12-23 | 2009-03-10 | Ranbaxy Laboratories Limited | Flavaxate derivatives as muscarinic receptor antagonists |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2921070A (en) * | 1957-11-05 | 1960-01-12 | Recordati Lab Farmacologico S | Basic esters of 3-methylflavone-8-carboxylic acid |
| US4217351A (en) * | 1976-08-04 | 1980-08-12 | Abbott Laboratories | Benzopyrano quinuclidines useful as antiglaucoma agents |
-
1982
- 1982-06-16 NZ NZ200981A patent/NZ200981A/en unknown
- 1982-06-18 GB GB08217744A patent/GB2104507B/en not_active Expired
- 1982-06-18 ZA ZA824335A patent/ZA824335B/xx unknown
- 1982-06-23 YU YU01366/82A patent/YU136682A/xx unknown
- 1982-06-24 NO NO822127A patent/NO157330C/no unknown
- 1982-06-29 AR AR289821A patent/AR231543A1/es active
- 1982-07-01 IL IL66187A patent/IL66187A0/xx not_active IP Right Cessation
- 1982-07-05 CA CA000406549A patent/CA1221969A/en not_active Expired
- 1982-07-06 DK DK301982A patent/DK160498C/da not_active IP Right Cessation
- 1982-07-07 IT IT22274/82A patent/IT1198389B/it active
- 1982-07-09 EP EP82303634A patent/EP0072620B1/en not_active Expired
- 1982-07-09 AT AT82303634T patent/ATE16806T1/de not_active IP Right Cessation
- 1982-07-09 DE DE8282303634T patent/DE3267782D1/de not_active Expired
- 1982-07-12 US US06/397,196 patent/US4550115A/en not_active Expired - Fee Related
- 1982-07-12 PH PH27559A patent/PH18001A/en unknown
- 1982-07-12 PT PT75230A patent/PT75230B/pt not_active IP Right Cessation
- 1982-07-12 IE IE1678/82A patent/IE53525B1/en not_active IP Right Cessation
- 1982-07-13 FI FI822493A patent/FI73677C/sv not_active IP Right Cessation
- 1982-07-14 JP JP57123732A patent/JPS5835185A/ja active Granted
- 1982-07-15 GR GR68773A patent/GR81300B/el unknown
- 1982-07-15 ES ES513993A patent/ES513993A0/es active Granted
- 1982-07-16 KR KR8203175A patent/KR870000275B1/ko active
- 1982-07-16 AU AU86098/82A patent/AU553322B2/en not_active Ceased
- 1982-07-16 HU HU822322A patent/HU189601B/hu not_active IP Right Cessation
-
1984
- 1984-07-16 YU YU01251/84A patent/YU125184A/xx unknown
- 1984-11-02 SG SG777/84A patent/SG77784G/en unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM | Patent lapsed | ||
| MM | Patent lapsed |
Owner name: RECORDATI S.A., CHEMICAL AND |