FI70715B - Foerfarande foer framstaellning av nya terapeutiskt anvaendbara cefemderivat - Google Patents
Foerfarande foer framstaellning av nya terapeutiskt anvaendbara cefemderivat Download PDFInfo
- Publication number
- FI70715B FI70715B FI821644A FI821644A FI70715B FI 70715 B FI70715 B FI 70715B FI 821644 A FI821644 A FI 821644A FI 821644 A FI821644 A FI 821644A FI 70715 B FI70715 B FI 70715B
- Authority
- FI
- Finland
- Prior art keywords
- ffi
- methyl
- group
- pyridinium
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
- C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Claims (3)
1. Förfarande för framställning av terapeutiskt an-vändbara cefemderivat med formeln I och fysiologiskt godtag-5 bara syraadditionssalter därav, /χη:τί>„,, m H~N 0 I @ ^
10. COO 1 2 i vilken formel R är väte eller halogen, R är lägre alkyl 15 och A är en pyridiniumgrupp _/ , som kan vara mono- eller disubstituerad med (1) lägre alkyl, som kan vara subs-tituerad med en eller tva kloratomer, hydroxi-, karboxi-, lägre-alkoxikarbonvl-, lägre-alkylkarbonyl-, karbamoyl-, sulfo-, lägre-alkoxi-, lägre-alkyltio-, lägre-alkylsulfinyl-20 eller lägre-alkylsufonylgrupper, varvid tvä närliggande al-kylgrupper även kan bilda med kolatomerna, tili vilka de är bundna, en med hydroxi eller oxo eventuellt substituerad 5-7-ledad ring, där en kolatom kan vara ersatt med en syre-atom; (2) cyano-lägre-alkyl; (3) trifluormetyl; (4) lägre-25 alkoxiiminometyl; (5) lägre alkenyl, som kan vara substituerad med metoxikarbonyl; (6) cykloalkyl eller cykloalkyl-metyl, varvid cykloalkylen innehäller 3-7 kolatomer och ringen kan vara avbruten av en syreatom eller substituerad med hydroxi eller metyl; (7) C^_^-cykloalkenyl, som kan 30 vara substituerad med metyl; (8) lägre alkoxi; (9) halogen; (10) cyano; f 11) hydroxi; (12) lägre-alkyltio; (13) en fenyl- eller ben-sylgrupp, som kan vara substituerad med halogen; (14) formyl, som kan vara ketaliserad med metyl; (15) lägre-alkylkarbonyl, som kan vara ketaliserad med metyl; (16) bensoyl; 35 (17) lägre-alkylkarbonylamino; (18) lägre-alkoxikarbonyl; (19) karbamoyl, där kväveatomen kan vara monosubstituerad 75 7071 5 med lägre alkyl, lägre-alkoxikarbonyl eller lägre-alkylami-nokarbonyl eller disubstituerad med lägre alkyl; (20) sulfa-moyl; (21) pyridyl; eller (22) 4-pyridon-1-yl; varvid, dä pyridiniumgruppen Sr disubstituerad, den ena substituenten 2
5 Sr en i punkt (1) definierad alkyl? och R O-gruppen Sr i syn-ställning, kännetecknat därav, att a) en förening med formeln nrju^TiX 3 τι M/^S 'Si1 VcH.,R3 (II) H2N O I “ COOH 15 12 3 där R och R betecknar sarana som ovan och R Sr en inom cefalosporinkemin konventionell grupp, som kan ersättas med en pyridiniumgrupp, eller ett salt därav omsätts med pyri- din eller ett pyridinderivat motsvarande gruppen A, eller 20 b) en 7-amino-cefemförening med formeln $ Νγ^ΧΗ2Α dll) cooe 25 där A betecknar samma som ovan och där aminogruppen kan vara i form av ett reaktivt derivat, eller ett syraaddi-tionssalt dära,v, omsätts med 2-(2-aminotiazol-4-yl) -2-syn-oxiimino-ättiksyra med formeln 30 I il ^,-=008 Λ»Λ3λ'»-“! %
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3118732 | 1981-05-12 | ||
| DE19813118732 DE3118732A1 (de) | 1981-05-12 | 1981-05-12 | Cephalosporinderivate und verfahren zu ihrer herstellung |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI821644A0 FI821644A0 (fi) | 1982-05-10 |
| FI821644L FI821644L (fi) | 1982-11-13 |
| FI70715B true FI70715B (fi) | 1986-06-26 |
| FI70715C FI70715C (fi) | 1986-10-06 |
Family
ID=6132055
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI821644A FI70715C (fi) | 1981-05-12 | 1982-05-10 | Foerfarande foer framstaellning av nya terapeutiskt anvaendbara cefemderivat |
Country Status (36)
| Country | Link |
|---|---|
| US (1) | US5071979A (sv) |
| EP (1) | EP0064740B1 (sv) |
| JP (2) | JPS57192394A (sv) |
| KR (1) | KR880001541B1 (sv) |
| AR (1) | AR241186A1 (sv) |
| AT (2) | ATE19085T1 (sv) |
| AU (1) | AU559727B2 (sv) |
| BE (1) | BE893163A (sv) |
| BG (1) | BG60838B2 (sv) |
| CA (1) | CA1228850A (sv) |
| CH (1) | CH654312A5 (sv) |
| CS (2) | CS248025B2 (sv) |
| DD (1) | DD202720A5 (sv) |
| DE (2) | DE3118732A1 (sv) |
| DK (1) | DK166500B1 (sv) |
| DZ (1) | DZ418A1 (sv) |
| ES (1) | ES511955A0 (sv) |
| FI (1) | FI70715C (sv) |
| FR (2) | FR2511682B1 (sv) |
| GB (2) | GB2098216A (sv) |
| GR (1) | GR75506B (sv) |
| HU (1) | HU186019B (sv) |
| IE (1) | IE53296B1 (sv) |
| IL (1) | IL65737A (sv) |
| IT (1) | IT1157275B (sv) |
| LU (1) | LU88736I2 (sv) |
| MA (1) | MA19474A1 (sv) |
| MT (1) | MTP909B (sv) |
| NL (3) | NL8201913A (sv) |
| NO (2) | NO162022C (sv) |
| NZ (1) | NZ200567A (sv) |
| PH (1) | PH20243A (sv) |
| PT (1) | PT74877B (sv) |
| SE (1) | SE8202961L (sv) |
| YU (1) | YU44346B (sv) |
| ZA (1) | ZA823226B (sv) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3118732A1 (de) * | 1981-05-12 | 1982-12-02 | Hoechst Ag, 6000 Frankfurt | Cephalosporinderivate und verfahren zu ihrer herstellung |
| SU1169542A3 (ru) * | 1981-09-08 | 1985-07-23 | Эли Лилли Энд Компани (Фирма) | Способ получени тиенопиридиний- или фуропиридиний-замещенных производных цефалоспорина |
| JPS5859991A (ja) * | 1981-09-14 | 1983-04-09 | Fujisawa Pharmaceut Co Ltd | 新規セフェム化合物 |
| US4501739A (en) * | 1982-01-19 | 1985-02-26 | Eli Lilly And Company | Thieno and furopyridinium-substituted cephalosporins |
| DE3207840A1 (de) * | 1982-03-04 | 1983-09-15 | Hoechst Ag, 6230 Frankfurt | "cephalosporinderivate und verfahren zu ihrer herstellung" |
| DE3374410D1 (en) * | 1982-06-28 | 1987-12-17 | Bristol Myers Co | Cephalosporin derivatives, a process for the manufacture thereof and pharmaceutical compositions containing said derivatives |
| DE3247613A1 (de) * | 1982-12-23 | 1984-07-05 | Hoechst Ag, 6230 Frankfurt | Cephalosporinderivate und verfahren zu ihrer herstellung |
| DE3248281A1 (de) * | 1982-12-28 | 1984-06-28 | Hoechst Ag, 6230 Frankfurt | Kristalisierte cephem-saeureadditionssalze und verfahren zu ihrer herstellung |
| DE3316798A1 (de) * | 1983-05-07 | 1984-11-08 | Hoechst Ag, 6230 Frankfurt | Verfahren zur herstellung von cephemverbindungen |
| DE3316797A1 (de) * | 1983-05-07 | 1984-11-08 | Hoechst Ag, 6230 Frankfurt | Verfahren zur herstellung von cephemverbindungen |
| US4690921A (en) * | 1983-10-11 | 1987-09-01 | Yamanouchi Pharmaceutical Co., Ltd. | Cephalosporin compounds and salts thereof |
| GB2148289B (en) * | 1983-10-17 | 1987-09-23 | Lilly Co Eli | 3-bicyclicpyridinium-methyl cephalosporins |
| US4692443A (en) * | 1983-10-17 | 1987-09-08 | Eli Lilly And Company | 3-bicyclicpyridinium-methyl cephalosporins |
| JPS6094984A (ja) * | 1983-10-28 | 1985-05-28 | Dai Ichi Seiyaku Co Ltd | セフエム誘導体 |
| GB8401093D0 (en) * | 1984-01-16 | 1984-02-15 | Fujisawa Pharmaceutical Co | Cephem compounds |
| JPS60169486A (ja) * | 1984-02-10 | 1985-09-02 | Yamanouchi Pharmaceut Co Ltd | ７−アミノ−３−置換メチル−３−セフエム−４−カルボン酸およびその低級アルキルシリル誘導体の製造法 |
| DE3404906A1 (de) * | 1984-02-11 | 1985-08-14 | Bayer Ag, 5090 Leverkusen | 1-oxadethiacephalosporinderivate sowie verfahren zu ihrer herstellung |
| JPS60222490A (ja) * | 1984-04-17 | 1985-11-07 | Dai Ichi Seiyaku Co Ltd | セフアロスポリン誘導体およびその塩 |
| IL74822A (en) * | 1984-04-17 | 1989-06-30 | Daiichi Seiyaku Co | Cephalosporin derivatives and salts thereof and their preparation |
| JPS60226884A (ja) * | 1984-04-25 | 1985-11-12 | Dai Ichi Seiyaku Co Ltd | セフアロスポリン誘導体 |
| EP0160546A3 (en) * | 1984-04-26 | 1986-12-17 | Yamanouchi Pharmaceutical Co. Ltd. | Cephalosporin compounds, and their production, and medicaments containing them |
| WO1985005106A1 (en) * | 1984-05-09 | 1985-11-21 | Takeda Chemical Industries, Ltd. | Cephem compounds |
| DE3419012A1 (de) * | 1984-05-22 | 1985-11-28 | Bayer Ag, 5090 Leverkusen | Ss-lactamantibiotika, verfahren zu deren herstellung sowie ihre verwendung als arzneimittel oder wachstumsfoerderer in der tieraufzucht oder als antioxidantien |
| JPH0613530B2 (ja) * | 1984-06-08 | 1994-02-23 | 武田薬品工業株式会社 | セフエム化合物 |
| GB8519606D0 (en) * | 1985-08-05 | 1985-09-11 | Fujisawa Pharmaceutical Co | 3 7-d substituted-3-cephem compounds |
| US4714760A (en) * | 1985-08-20 | 1987-12-22 | Bristol-Myers Company | Cephalosporin intermediates |
| CA1296012C (en) | 1986-03-19 | 1992-02-18 | Susumu Nakagawa | 6,7-dihydroxy-isoquinoline derivatives |
| DE3706020A1 (de) * | 1987-02-25 | 1988-09-08 | Hoechst Ag | Kristallisierte cephem-saeureadditionssalze und verfahren zu ihrer herstellung |
| JPH0242086A (ja) * | 1988-08-02 | 1990-02-13 | Banyu Pharmaceut Co Ltd | （３‐ヒドロキシ‐４‐ピリドン‐１‐イル）メチル基を有する新規セファロスポリン誘導体 |
| JPH02117679A (ja) * | 1989-09-22 | 1990-05-02 | Sankyo Co Ltd | チアゾリオメチル置換基を有するセファロスポリン誘導体 |
| US5698703A (en) * | 1991-09-10 | 1997-12-16 | Bristol-Myers Squibb Company | Syn-isomer of thiazolyl intermediate and process for the preparation thereof |
| US5594129A (en) * | 1991-09-10 | 1997-01-14 | Bristol-Myers Squibb Company | Process for the preparation of a cephalosporin antibiotic |
| EP0554004A3 (en) * | 1992-01-27 | 1993-11-24 | Katayama Seisakusho | Cephem compounds and antibacterial agents |
| JPH0741485A (ja) * | 1993-07-30 | 1995-02-10 | Katayama Seiyakushiyo:Kk | セフェム誘導体およびそれを含有する抗菌剤 |
| CA2190245A1 (en) * | 1994-05-23 | 1995-11-30 | Joong Hyup Kim | Cephalosporin compounds and processes for the preparation thereof |
| DE4440141A1 (de) * | 1994-11-10 | 1996-05-15 | Hoechst Ag | Neue kristalline Cephem-Säureadditionssalze und Verfahren zu ihrer Herstellung |
| JPH09110877A (ja) | 1995-10-17 | 1997-04-28 | Katayama Seiyakushiyo:Kk | セフェム化合物、その製造法及びそれを含有する抗菌剤 |
| AU2178497A (en) * | 1996-04-04 | 1997-10-29 | Shionogi & Co., Ltd. | Cephem compounds and drugs containing the compounds |
| US5929086A (en) | 1996-05-10 | 1999-07-27 | Pharmacia & Upjohn Company | Topical administration of antimicrobial agents for the treatment of systemic bacterial diseases |
| KR100293728B1 (ko) * | 1998-05-22 | 2001-09-17 | 손 경 식 | 결정성세피롬황산염의제조방법 |
| TWI335332B (en) * | 2001-10-12 | 2011-01-01 | Theravance Inc | Cross-linked vancomycin-cephalosporin antibiotics |
| ATE450540T1 (de) * | 2003-05-23 | 2009-12-15 | Theravance Inc | Quervernetzte glycopeptid-cephalosporin- antibiotika |
| JP4754275B2 (ja) * | 2005-06-13 | 2011-08-24 | 川崎重工業株式会社 | 壁掛機器用防振支持構造 |
| RS66326B1 (sr) | 2011-09-09 | 2025-01-31 | Merck Sharp & Dohme Llc | Ceftolozan/tazobaktam za lečenje intrapulmonalnih infekcija |
| CN102584856A (zh) * | 2011-12-27 | 2012-07-18 | 开封豫港制药有限公司 | 硫酸头孢匹罗的制备方法 |
| US8809314B1 (en) | 2012-09-07 | 2014-08-19 | Cubist Pharmacueticals, Inc. | Cephalosporin compound |
| US8476425B1 (en) | 2012-09-27 | 2013-07-02 | Cubist Pharmaceuticals, Inc. | Tazobactam arginine compositions |
| NZ700372A (en) | 2013-03-15 | 2016-01-29 | Merck Sharp & Dohme | Ceftolozane antibiotic compositions |
| US9872906B2 (en) | 2013-03-15 | 2018-01-23 | Merck Sharp & Dohme Corp. | Ceftolozane antibiotic compositions |
| US20140274990A1 (en) | 2013-03-15 | 2014-09-18 | Cubist Pharmaceuticals, Inc. | Ceftolozane pharmaceutical compositions |
| US10376496B2 (en) | 2013-09-09 | 2019-08-13 | Merck, Sharp & Dohme Corp. | Treating infections with ceftolozane/tazobactam in subjects having impaired renal function |
| US20150094293A1 (en) | 2013-09-27 | 2015-04-02 | Calixa Therapeutics, Inc. | Solid forms of ceftolozane |
| KR20180066264A (ko) * | 2015-12-10 | 2018-06-18 | 나에자-알지엠 파마슈티칼스 유엘씨 | 세펨 화합물, 그의 제조 및 용도 |
| CN105646543B (zh) * | 2016-03-17 | 2018-03-27 | 天津大学 | 一种头孢喹肟晶体及其制备方法 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1082962A (en) * | 1963-05-28 | 1967-09-13 | Glaxo Lab Ltd | Derivatives of 7-aminocephalosporanic acid |
| FR116F (sv) * | 1963-11-04 | |||
| GB1310642A (en) * | 1970-11-09 | 1973-03-21 | Pfizer | Alpha-sulfo-and alpha-sulfoalkylacylcephalosporins |
| DK154939C (da) * | 1974-12-19 | 1989-06-12 | Takeda Chemical Industries Ltd | Analogifremgangsmaade til fremstilling af thiazolylacetamido-cephemforbindelser eller farmaceutisk acceptable salte eller estere deraf |
| US4200746A (en) * | 1974-12-20 | 1980-04-29 | Glaxo Laboratories, Ltd. | Cephalosporins |
| GR63088B (en) * | 1976-04-14 | 1979-08-09 | Takeda Chemical Industries Ltd | Preparation process of novel cephalosporins |
| JPS6011713B2 (ja) * | 1976-09-08 | 1985-03-27 | 武田薬品工業株式会社 | セフアロスポリン誘導体およびその製造法 |
| DE2714880A1 (de) * | 1977-04-02 | 1978-10-26 | Hoechst Ag | Cephemderivate und verfahren zu ihrer herstellung |
| DE2716677C2 (de) * | 1977-04-15 | 1985-10-10 | Hoechst Ag, 6230 Frankfurt | Cephemderivate und Verfahren zu ihrer Herstellung |
| AR229883A1 (es) * | 1978-05-26 | 1983-12-30 | Glaxo Group Ltd | Procedimiento para la preparacion de antibiotico(6r,7r)-7-((z)-2-(2-aminotiazol-4-il)-2-(2-carboxiprop-2-oxiimino)-acetamido)-3-(1-piridinometil)-cef-3-em-4-carboxilato |
| US4336353A (en) * | 1979-09-11 | 1982-06-22 | Ciba-Geigy Corporation | Salts of 3-methyl-2-(2',4'-dimethyl-phenylimino)-4-thiazoline with polymers containing sulfonic acid groups |
| CA1215969A (en) * | 1979-10-12 | 1986-12-30 | Tsutomu Teraji | Cephem compounds and processes for preparation thereof |
| DE3006888A1 (de) * | 1980-02-23 | 1981-09-10 | Hoechst Ag, 6000 Frankfurt | Cephalosporinderivate und verfahren zu ihrer herstellung |
| GR75644B (sv) * | 1980-06-18 | 1984-08-02 | Fujisawa Pharmaceutical Co | |
| US4367228A (en) * | 1980-10-29 | 1983-01-04 | Fujisawa Pharmaceutical Co., Ltd. | Cephem compound and composition |
| US4427677A (en) * | 1980-12-31 | 1984-01-24 | Fujisawa Pharmaceutical Co., Ltd. | Cephem compounds |
| US4336253A (en) * | 1981-03-11 | 1982-06-22 | Eli Lilly And Company | Cephalosporin antibiotics |
| DE3118732A1 (de) * | 1981-05-12 | 1982-12-02 | Hoechst Ag, 6000 Frankfurt | Cephalosporinderivate und verfahren zu ihrer herstellung |
| US4379787A (en) * | 1981-10-02 | 1983-04-12 | Eli Lilly And Company | Oximino-substituted cephalosporin compounds |
| US4501739A (en) * | 1982-01-19 | 1985-02-26 | Eli Lilly And Company | Thieno and furopyridinium-substituted cephalosporins |
| DE3248281A1 (de) * | 1982-12-28 | 1984-06-28 | Hoechst Ag, 6230 Frankfurt | Kristalisierte cephem-saeureadditionssalze und verfahren zu ihrer herstellung |
| DE3706020A1 (de) * | 1987-02-25 | 1988-09-08 | Hoechst Ag | Kristallisierte cephem-saeureadditionssalze und verfahren zu ihrer herstellung |
-
1981
- 1981-05-12 DE DE19813118732 patent/DE3118732A1/de not_active Withdrawn
-
1982
- 1982-05-06 ES ES511955A patent/ES511955A0/es active Granted
- 1982-05-07 DE DE8282103989T patent/DE3270360D1/de not_active Expired
- 1982-05-07 LU LU88736C patent/LU88736I2/fr unknown
- 1982-05-07 AR AR82289339A patent/AR241186A1/es active
- 1982-05-07 EP EP82103989A patent/EP0064740B1/de not_active Expired
- 1982-05-07 AT AT82103989T patent/ATE19085T1/de active
- 1982-05-10 MT MT909A patent/MTP909B/xx unknown
- 1982-05-10 NL NL8201913A patent/NL8201913A/nl not_active Application Discontinuation
- 1982-05-10 FI FI821644A patent/FI70715C/fi not_active IP Right Cessation
- 1982-05-10 DD DD82239724A patent/DD202720A5/de not_active IP Right Cessation
- 1982-05-10 PH PH27254A patent/PH20243A/en unknown
- 1982-05-10 US US06/376,654 patent/US5071979A/en not_active Expired - Lifetime
- 1982-05-10 FR FR8208066A patent/FR2511682B1/fr not_active Expired
- 1982-05-10 JP JP57078063A patent/JPS57192394A/ja active Granted
- 1982-05-10 GR GR68118A patent/GR75506B/el unknown
- 1982-05-10 NZ NZ200567A patent/NZ200567A/en unknown
- 1982-05-10 CS CS823386A patent/CS248025B2/cs unknown
- 1982-05-10 CH CH2899/82A patent/CH654312A5/de not_active IP Right Cessation
- 1982-05-10 KR KR8202031A patent/KR880001541B1/ko active
- 1982-05-10 YU YU983/82A patent/YU44346B/xx unknown
- 1982-05-10 IT IT21182/82A patent/IT1157275B/it active
- 1982-05-11 AT AT0184382A patent/AT381945B/de not_active IP Right Cessation
- 1982-05-11 HU HU821467A patent/HU186019B/hu unknown
- 1982-05-11 PT PT74877A patent/PT74877B/pt unknown
- 1982-05-11 IL IL65737A patent/IL65737A/xx not_active IP Right Cessation
- 1982-05-11 ZA ZA823226A patent/ZA823226B/xx unknown
- 1982-05-11 IE IE1129/82A patent/IE53296B1/en not_active IP Right Cessation
- 1982-05-11 AU AU83589/82A patent/AU559727B2/en not_active Expired
- 1982-05-11 CA CA000402656A patent/CA1228850A/en not_active Expired
- 1982-05-11 DK DK211382A patent/DK166500B1/da not_active IP Right Cessation
- 1982-05-11 SE SE8202961A patent/SE8202961L/sv not_active Application Discontinuation
- 1982-05-11 NO NO821562A patent/NO162022C/no not_active IP Right Cessation
- 1982-05-12 GB GB8213782A patent/GB2098216A/en not_active Revoked
- 1982-05-12 MA MA19680A patent/MA19474A1/fr unknown
- 1982-05-12 BE BE0/208075A patent/BE893163A/fr not_active IP Right Cessation
- 1982-05-12 DZ DZ826531A patent/DZ418A1/fr active
- 1982-12-13 FR FR8220875A patent/FR2515654B1/fr not_active Expired
-
1984
- 1984-09-18 GB GB08423511A patent/GB2144424B/en not_active Expired
-
1987
- 1987-12-28 JP JP62336812A patent/JPH0670068B2/ja not_active Expired - Lifetime
-
1991
- 1991-12-30 CS CS914158A patent/CS415891A3/cs unknown
-
1994
- 1994-02-22 NL NL940003C patent/NL940003I2/nl unknown
- 1994-02-24 BG BG098550A patent/BG60838B2/bg unknown
-
1995
- 1995-08-08 NL NL950013C patent/NL950013I1/nl unknown
-
1999
- 1999-05-27 NO NO1999008C patent/NO1999008I1/no unknown
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| ND | Supplementary protection certificate (spc) granted | ||
| SPCG | Supplementary protection certificate granted |
Spc suppl protection certif: L24 Extension date: 20070510 |
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| MA | Patent expired |
Owner name: AVENTIS PHARMA DEUTSCHLAND GMBH |
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| PC | Transfer of assignment of patent |
Owner name: AVENTIS PHARMA DEUTSCHLAND GMBH Free format text: AVENTIS PHARMA DEUTSCHLAND GMBH |