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ES2163487T3 - Conjugados de hirudina a partir de hirudina y compuestos lipofilos. - Google Patents

Conjugados de hirudina a partir de hirudina y compuestos lipofilos.

Info

Publication number
ES2163487T3
ES2163487T3 ES95901432T ES95901432T ES2163487T3 ES 2163487 T3 ES2163487 T3 ES 2163487T3 ES 95901432 T ES95901432 T ES 95901432T ES 95901432 T ES95901432 T ES 95901432T ES 2163487 T3 ES2163487 T3 ES 2163487T3
Authority
ES
Spain
Prior art keywords
hirudina
compounds
conjugates
lipofilos
lipofilic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95901432T
Other languages
English (en)
Inventor
Jurgen Schweden
Peter Eckes
Wilfried Hornberger
Thomas Subkowski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF SE
Original Assignee
BASF SE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BASF SE filed Critical BASF SE
Application granted granted Critical
Publication of ES2163487T3 publication Critical patent/ES2163487T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/545—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Fats And Perfumes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Ink Jet (AREA)
  • Extrusion Moulding Of Plastics Or The Like (AREA)
  • Silicon Polymers (AREA)

Abstract

LA INVENCION TRATA DE NUEVOS CONJUGADOS DE HIRUDINA, FORMADOS A PARTIR DE UNA HIRUDINA Y UNO O MAS COMPUESTOS LIPOFILICOS, DONDE EL COMPUESTO LIPOFILICO POSEE UN COEFICIENTE DE REPARTO OCTANOL-AGUA DE MAS DE 1,8 Y ESTA UNIDO QUIMICAMENTE CON LA HIRUDINA, SU OBTENCION Y SU UTILIZACION.
ES95901432T 1993-12-02 1994-11-25 Conjugados de hirudina a partir de hirudina y compuestos lipofilos. Expired - Lifetime ES2163487T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4341115 1993-12-02
PCT/EP1994/003901 WO1995015183A1 (de) 1993-12-02 1994-11-25 Hirudin-konjugate aus hirudin und lipophilen verbindungen

Publications (1)

Publication Number Publication Date
ES2163487T3 true ES2163487T3 (es) 2002-02-01

Family

ID=6504029

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95901432T Expired - Lifetime ES2163487T3 (es) 1993-12-02 1994-11-25 Conjugados de hirudina a partir de hirudina y compuestos lipofilos.

Country Status (25)

Country Link
US (1) US5919762A (es)
EP (1) EP0730473B1 (es)
JP (1) JPH09505810A (es)
CN (1) CN1142776A (es)
AT (1) ATE204763T1 (es)
AU (1) AU679811B2 (es)
BR (1) BR9408195A (es)
CA (1) CA2176967A1 (es)
CZ (1) CZ157096A3 (es)
DE (2) DE4437502A1 (es)
DK (1) DK0730473T3 (es)
ES (1) ES2163487T3 (es)
FI (1) FI962299L (es)
GR (1) GR3036938T3 (es)
HR (1) HRP940968A2 (es)
HU (1) HUT74390A (es)
IL (1) IL111811A0 (es)
NO (1) NO962261D0 (es)
NZ (1) NZ276410A (es)
PL (1) PL314797A1 (es)
PT (1) PT730473E (es)
SG (1) SG49156A1 (es)
SK (1) SK67596A3 (es)
WO (1) WO1995015183A1 (es)
ZA (1) ZA949562B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4437604A1 (de) * 1994-10-21 1996-04-25 Basf Ag Konjugate aus einem Poly- oder Oligopeptid und einer niedermolekularen lipophilen Verbindung
US5726168A (en) * 1995-10-12 1998-03-10 Eli Lilly And Company Lipophilic benzothiophenes
DE19915862A1 (de) * 1999-04-08 2000-10-12 Max Planck Gesellschaft Verwendung von molekulargewichtserweitertem Hirudin als Antikoagulans bei der extrakorporalen Nierenersatztherapie
JP4394444B2 (ja) * 2001-10-24 2010-01-06 パワー ペーパー リミティド 活性物質の制御された皮膚内デリバリーのためのデバイス及び方法
US7438925B2 (en) * 2002-08-26 2008-10-21 Biovention Holdings Ltd. Drug eluting coatings for medical implants
BR102017005783A2 (pt) * 2017-03-21 2018-10-02 Fund Butantan processo de obtenção de esculptina e seus fragmentos, esculptina recombinante e seus usos
KR102366360B1 (ko) * 2021-06-29 2022-02-23 (주)네오팜 신규한 유사 세라마이드 화합물 및 이를 포함하는 피부 외용제 조성물

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3264782D1 (en) * 1981-10-16 1985-08-22 Sanol Arznei Schwarz Gmbh Medicinal formulation
DE3445532A1 (de) * 1984-12-13 1986-06-19 Plantorgan Werk Heinrich G.E. Christensen, KG, 2903 Bad Zwischenahn Hirudin-pa, desulfatohirudine-pa, verfahren zur herstellung und pharmazeutische mittel, die diese wirkstoffe enthalten
US4939174A (en) * 1988-02-26 1990-07-03 Shashoua Victor E Appetite suppression with dopamine-fatty acid conjugates
DE3819079A1 (de) * 1988-06-04 1989-12-07 Hoechst Ag Hirudin-derivate mit verzoegerter wirkung
DK0462145T3 (da) * 1989-03-07 1994-08-08 Genentech Inc Covalente konjugater mellem lipid og oligonucleotid
DE4014260A1 (de) * 1989-12-01 1991-06-06 Basf Ag Hirudinpolyalkylenglykolkonjugate
WO1991008229A1 (de) * 1989-12-01 1991-06-13 Basf Aktiengesellschaft Hirudinpolyalkylenglykolkonjugate
DE69024230T2 (de) * 1989-12-22 1996-05-02 Commw Scient Ind Res Org An fette gebundene aminosäuren, peptide oder deren derivate
EP0537299A1 (en) * 1990-03-29 1993-04-21 Gilead Sciences, Inc. Oligonucleotide-transport agent disulfide conjugates
US5256641A (en) * 1990-11-01 1993-10-26 State Of Oregon Covalent polar lipid-peptide conjugates for immunological targeting
WO1992019233A2 (en) * 1991-04-29 1992-11-12 Control Delivery Systems, Inc. Sustained release composition and methods of use thereof
DE69218888D1 (de) * 1991-05-02 1997-05-15 Pierre Baudet N-phenyl-cinnamamide, die einen schutz verleihen gegen schädigende effekte ultravioletten lichtes
US5359030A (en) * 1993-05-10 1994-10-25 Protein Delivery, Inc. Conjugation-stabilized polypeptide compositions, therapeutic delivery and diagnostic formulations comprising same, and method of making and using the same

Also Published As

Publication number Publication date
US5919762A (en) 1999-07-06
GR3036938T3 (en) 2002-01-31
CA2176967A1 (en) 1995-06-08
SG49156A1 (en) 1998-05-18
JPH09505810A (ja) 1997-06-10
CN1142776A (zh) 1997-02-12
NO962261L (no) 1996-05-31
FI962299A0 (fi) 1996-05-31
AU1067095A (en) 1995-06-19
ATE204763T1 (de) 2001-09-15
CZ157096A3 (en) 1996-09-11
HUT74390A (en) 1996-12-30
EP0730473A1 (de) 1996-09-11
NZ276410A (en) 1997-03-24
NO962261D0 (no) 1996-05-31
ZA949562B (en) 1996-06-03
SK67596A3 (en) 1996-12-04
WO1995015183A1 (de) 1995-06-08
DK0730473T3 (da) 2001-10-08
FI962299L (fi) 1996-05-31
BR9408195A (pt) 1997-08-26
EP0730473B1 (de) 2001-08-29
AU679811B2 (en) 1997-07-10
DE59409847D1 (de) 2001-10-04
HRP940968A2 (en) 1997-08-31
DE4437502A1 (de) 1995-06-08
PL314797A1 (en) 1996-09-30
HU9601471D0 (en) 1996-07-29
PT730473E (pt) 2002-02-28
IL111811A0 (en) 1995-01-24

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