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EP1707205A2 - Pharazeutische zusammensetzungen aus anticholinergica und p38 kinase hemmern zur behandlung von erkrankungen der atemwege - Google Patents

Pharazeutische zusammensetzungen aus anticholinergica und p38 kinase hemmern zur behandlung von erkrankungen der atemwege Download PDF

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Publication number
EP1707205A2
EP1707205A2 EP06116683A EP06116683A EP1707205A2 EP 1707205 A2 EP1707205 A2 EP 1707205A2 EP 06116683 A EP06116683 A EP 06116683A EP 06116683 A EP06116683 A EP 06116683A EP 1707205 A2 EP1707205 A2 EP 1707205A2
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European Patent Office
Prior art keywords
alkyl
phenyl
optionally
amino
optionally substituted
Prior art date
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EP06116683A
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English (en)
French (fr)
Inventor
Christopher John Montague Maede
Michel Pairet
Michael P. Pieper
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Boehringer Ingelheim Pharmaceuticals Inc
Original Assignee
Boehringer Ingelheim Pharma GmbH and Co KG
Boehringer Ingelheim Pharmaceuticals Inc
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Priority to EP06116683A priority Critical patent/EP1707205A2/de
Publication of EP1707205A2 publication Critical patent/EP1707205A2/de
Withdrawn legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Definitions

  • the present invention relates to novel pharmaceutical compositions based on novel anticholinergics and p38 kinase inhibitors, processes for preparing them and their use in the treatment of respiratory diseases.
  • the present invention relates to novel pharmaceutical compositions based on novel anticholinergics and p38 kinase inhibitors, processes for preparing them and their use in the treatment of respiratory diseases.
  • an unexpectedly beneficial therapeutic effect particularly a synergistic effect can be observed in the treatment of diseases of the upper or lower respiratory tract, particularly in the treatment of allergic or non-allergic rhinitis, if one or more, preferably one anticholinergic of general formula A is or are used together with one or more, preferably one, p38 kinase inhibitor B . Thanks to this synergistic effect the pharmaceutical combinations according to the invention can be used in lower doses than is the case when the individual compounds are used in monotherapy in the usual way.
  • anticholinergics A denotes compounds of formula wherein
  • any reference to the cation of formula is indicated by use of the number A' . Any reference to compounds A naturally also includes a reference to the cation A' .
  • p38 kinase inhibitors applicable within the scope of the invention are known in the art.
  • the term p38 kinase inhibitors denotes compounds selected from the compounds that are disclosed for instance in US Patents 5,716,972 , US 5,686,455 , US 5,656,644 , US 5,593,992 , US 5,593,991 , US 5,663,334 , US 5,670,527 , US 5,559,137 , 5,658,903 , US 5,739,143 , US 5,756,499 , US 6,277,989 , US 6,340,685 , and US 5,716,955 and PCT applications WO 92/12154 , WO 94/19350 , WO 95/09853 , WO 95/09851 , WO 95/09847 ,
  • compositions according to the invention are those p38 inhibitors B disclosed in US 6,277,989 , US 6,340,685 , WO 00/12074 , WO 00/12497 , WO 00/59904 , WO 00/71535 , WO 01/64676 , WO 99/61426 , WO 00/10563 , WO 00/25791 , WO 01/37837 , WO 01/38312 , WO 01/38313 , WO 01/38314 , WO 01/47921 , WO 99/61437 , WO 99/61440 , WO 00/17175 , WO 00/17204 , WO 00/36096 , WO 98/27098 , WO 99/00357 , WO 99/58502 , WO 4 99/64400 , WO 99/01131 , WO 00/43384 , WO 00/55152 , WO
  • the invention relates to pharmaceutical compositions containing A and B , characterized in that the p38 kinase inhibitor B is selected from the compounds of formula 1 as disclosed in WO 99/01131 wherein
  • R 2 is a substituted alkyl derivative. It is recognised that the first methylene carbon in this chain is a tertiary carbon, and it will contain one hydrogen moiety. This ethylene group has two additional substituents, an R 22 moiety and an A moiety, -C(H)(A)(R 22 ). Both A and R 22 may not be unsubstituted C 1-10 alkyl moiety.
  • R 2 is a ⁇ C(AA 1 )(A) moiety, wherein AA 1 is the R 22 moiety, but is specifically the side chain residue (R) of an amino acid, as is further described herein.
  • A is an optionally substituted C 13-7 cycloalkyl, aryl, heteroaryl, or heterocyclic ring, or A is a substituted C 1-10 alkyl moiety.
  • the ring may be substituted independently one or more times, preferably, 1 to 3 times by C 1-10 alkyl; halogen; halo substituted C 1-10 alkyl such as CF 3 ; (CR 10 R 20 ) t OR 11 ; (CR 10 R 20 ) t NR 12 R 14 , especially amino or mono-or di-C 1-4 alkylamino; (CR 10 R 20 ) t S(O)m R 18 , wherein m is 0, 1 or 2; SH; NR 10 C(Z)R 3 (such NHCO(C 1-10 alkyl)); or NR 10 S(O)m R 8 (such as NHSO 2 (C 1-10 alkyl)).
  • t is 0, or an integer of 1 to 4.
  • A is an optionally substituted cycloalkyl it is as defined below with the R 22 substitution.
  • the ring is preferably a morpholino, pyrrolidinyl, piperazinyl or a piperidinyl ring.
  • A is an optionally substituted aryl moiety, it is preferably a phenyl ring.
  • A is an optionally substituted heteroaryl ring, it is as defined below in the definition section.
  • the alkyl chain may be straight or branched.
  • the chain is substituted independently 1 or more times, preferably 1 to 3 times by halogen, such as fluorine, chlorine, bromine or iodine; halosubstituted C 1-10 alkyl, such as CF 3 ; C 3-7 cycloaklyl, C 1-10 alkloxy, such as methoxy or ethoxy; hydroxy substituted C 1-10 alkoxy; halosubstituted C 1-10 alkoxy, such as OCF 2 CF 2 H; OR 11 ; S(O) m R 18 (wherein m is 0, 1 or 2); NR 13 R 14 ; C(Z)NR 13 R 14 ; S(O) m' NR 13 R 14 ; NR 23 C(Z)R 11 ; NHS(O) 2 R 18 ; C(Z)R 11 ; OC(Z)R 11 ; C(Z)OR 11 ; C
  • halogen such as fluorine, chlorine,
  • A is a C 3-7 cycloalkyl, or a C 1-6 alkyl, more preferably a C 1-2 alkyl, i.e. a methylene or ethylene moiety, more preferably a methylene moiety which is substituted by one of the above noted groups.
  • A is a C 1-10 alkyl
  • R 11 is preferably hydrogen, aryl or arylalkyl
  • NR 13 R 14 NR 13 R 14 ; OC(Z)R 11 ; C(Z)OR 11 .
  • A is substituted by OR 11 where R 11 is hydrogen.
  • R 22 is a C 1-10 alkyl chain, which chain may be straight or branched and which may be optionally substituted independently, one or more times, preferably 1 to 3 times, by halogen, such as fluorine, chlorine or iodine; halo substituted C 1-10 alkyl; C 1-10 alkoxy, such as methoxy or ethoxy; hydroxy substituted C 1-10 alkoxy; halosubstituted C 1-10 alkoxy, such as OCF 2 CF 2 H; OR 11 ; S(O) m R 18 ; NR 13 R 14 ; C(Z)NR 13 R 14 ; S(O) m ,NR 13 R 14 ; NR 23 C(Z)R 11 ; NHS(O) 2 R 18 ; C(Z)R 11 ; OC(Z)OR 11 ; C(Z)OR 11 ; C(Z)NR 11 OR 9 ; N(OR 6 )C(Z)NR 13 R 14 ; N(OR 6 )
  • the R 22 group may, for instance, be a carboxy, an aldehyde, or an amide, as well as being a substituent of a methylene unit, such as carbamoylmethyl, or acetamidomethyl.
  • R 22 is a C 1-6 unsubstituted or substituted alkyl group, such as a C 1-3 alkylene such as methyl, ethyl or isopropyl, or a methylene or ethylene moiety substituted by one of the above noted moieties, or as noted above those substituent groups which contain a carbon may substituent for the first methylene unit of the alkyl chain, such as carboxy, C(O)OR 11 ; C(O)NR 13 R 14 or R 22 is an optionally substituted aryl group, such as a benzyl or phenethyl.
  • R 22 is C 1-6 unsubstituted or substituted alkyl group, more preferably a C 1-2 alkylene chain, such as a methylene or ethylene moiety, more preferably methylene.
  • the alkyl chain is substituted by OR 11 , where R 11 is preferably hydrogen, aryl or arylalkyl; S(O) m R 18 , where m is 0 and R 18 is a C 1-6 alkyl; or an optionally substituted aryl, i.e. a benzyl or phenethyl moiety.
  • R 22 is phenyl, benzyl, CH 2 OH, or CH 2 -O-aryl.
  • one or both of A and R 22 contain hydroxy moieties, such as in C 1-6 alkyl OR 11 , wherein R 11 is hydrogen, i.e. CH 2 CH 2 OH.
  • AA 1 is the (R) side chain residue of an amino acid
  • it is a C 1-6 alkyl group, which may be straight or branched.
  • the R residue term is for example, CH 3 for alanine, (CH 3 ) 2 CH- for valine, (CH 3 ) 2 CH-CH 2 -for leucine, phenyl-CH 2 - for phenylalanine, CH 3 -S-CH 2 -CH 2 - for methionine, etc.
  • All generally recognised primary amino acids are included in this groups, such as but not limited to, alanine, arginine, asparagine, aspartic acid, cysteine, glutamine, glutamic acid, glycine, histidine, isoleucine, leucine, lysine, methionine, phenylalanine, serine, threonine, tryptophan, tyrosine, valine, hydroxylysine, methylhistidine, and other naturally accurring amino acids not found in proteins, such as ⁇ -alanine, ⁇ -aminobutyric acid, homocysteine, homoserine, citrulline, ornithine, canavanine, djenkolic acid, and ⁇ -cyanoalanine, or other naturally occurring non-mammalian amino acids.
  • AA 1 is the residue of phenylalanine, or alanine.
  • A is a hydroxy substituted C 1-10 alkyl and R 22 is a C 1-10 alkyl or a hydroxy substituted C 1-10 alkyl.
  • the invention relates to pharmaceutical compositions containing A and B, characterized in that the p38 kinase inhibitor B is selected from the following compounds disclosed in WO 99/01131 :
  • the invention relates to pharmaceutical compositions containing A and B , characterized in that the p38 kinase inhibitor B is selected from the compounds of formula 2 as disclosed in US 6,277,989 and the pharmaceutically acceptable salts thereof, wherein
  • the invention relates to pharmaceutical compositions containing A and B , characterized in that the p38 kinase inhibitor B is selected from the compounds of formula 2 as disclosed in US 6,277,989 , wherein
  • the invention relates to pharmaceutical compositions containing A and B , characterized in that the p38 kinase inhibitor B is selected from the follwoing compounds disclosed US 6,277,989 :
  • the invention relates to pharmaceutical compositions containing A and B , characterized in that the p38 kinase inhibitor B is selected from the follwoing compounds disclosed US 6,340,685 :
  • the invention relates to pharmaceutical compositions containing A and B , characterized in that the p38 kinase inhibitor B is selected from the compounds of formula 4 as disclosed in WO 00/43384 wherein
  • the invention relates to pharmaceutical compositions containing A and B , characterized in that the p38 kinase inhibitor B is selected from the compounds of formula 4 as disclosed in WO 00/43384 wherein Ar 2 is naphthyl, tetrahydronaphthyl, indanyl or indenyl.
  • a more preferred subgeneric aspect of the invention relates to pharmaceutical compositions containing A and B , characterized in that the p38 kinase inhibitor B is a compound of the formula 4 wherein Ar 2 is naphthyl.
  • a yet more preferred subgeneric aspect of the invention relates to pharmaceutical compositions containing A and B , characterized in that the p38 kinase inhibitor B is selected from compounds of the formula 4 , as described in the immediate previous paragraph, wherein:
  • a yet further preferred subgeneric aspect of the invention relates to pharmaceutical compositions containing A and B , characterized in that the p38 kinase inhibitor B is selected from compounds of the formula 4 , as described in the immediate previous paragraph, wherein Ar 1 is pyrazole.
  • a still yet further preferred subgeneric aspect of previous the invention relates to pharmaceutical compositions containing A and B , characterized in that the p38 kinase inhibitor B is selected from compounds of the formula 4 , as described in the immediate paragraph, wherein L is C 1-5 saturated carbon chain wherein one or more methylene groups are optionally independently replaced by O,N or S; and wherein said linking group is optionally substituted with 0-2 oxo groups and one or more C 1-4 branched or unbranched alkyl which may be substituted by one or more halogen atoms;
  • L is propoxy, ethoxy, methoxy, methyl, propyl, C 3-5 acetylene or methylamino each being optionally substituted are described herein.
  • a more particularly preferred embodiment of L is ethoxy optionally substituted.
  • the invention relates to pharmaceutical compositions containing A and B, characterized in that the p38 kinase inhibitor B is selected from the following compounds of formula 4 as disclosed in WO 00/43384 :
  • Particularly preferred p38 kinase inhibitors B within the scope of the present invention are the following compounds of the formula 4 :
  • the invention relates to pharmaceutical compositions containing A and B , characterized in that the p38 kinase inhibitor B is selected from the compounds of formula 5 as disclosed in WO 00/55139 wherein:
  • the invention relates to pharmaceutical compositions containing A and B , characterized in that the p38 kinase inhibitor B is selected from the compounds of formula 5 as disclosed in WO 00/55139 wherein:
  • the invention relates to pharmaceutical compositions containing A and B , characterized in that the p38 kinase inhibitor B is selected from the compounds of formula 5 as disclosed in WO 00/55139 wherein:
  • the invention relates to pharmaceutical compositions containing A and B , characterized in that the p38 kinase inhibitor B is selected from the compounds of formula 5 as disclosed in WO 00/55139 wherein:
  • the invention relates to pharmaceutical compositions containing A and B , characterized in that the p38 kinase inhibitor B is selected from the compounds of formula 5 as disclosed in WO 00/55139 wherein:
  • the invention relates to pharmaceutical compositions containing A and B , characterized in that the p38 kinase inhibitor B is selected from the compounds of formula 5 as disclosed in WO 00/55139 wherein:
  • the invention relates to pharmaceutical compositions containing A and B , characterized in that the p38 kinase inhibitor B is selected from the compounds of formula 5 as disclosed in WO 00/55139 wherein X is pyridinyl.
  • the invention relates to pharmaceutical compositions containing A and B , characterized in that the p38 kinase inhibitor B is selected from the compounds of formula 5 as disclosed in WO 00/55139 wherein the pyridinyl is attached to Ar 1 via the 3-pyridinyl position.
  • the invention relates to pharmaceutical compositions containing A and B , characterized in that the p38 kinase inhibitor B is selected from the compounds of formula 5 as disclosed in WO 00/55139 that are mentioned below:
  • the invention relates to pharmaceutical compositions containing A and B , characterized in that the p38 kinase inhibitor B is selected from the following compounds of formula 5 :
  • the invention relates to pharmaceutical compositions containing A and B , characterized in that the p38 kinase inhibitor B is selected from the compounds of formula 5a as disclosed in WO 00/55139 wherein:
  • the invention relates to pharmaceutical compositions containing A and B , characterized in that the p38 kinase inhibitor B is selected from the compounds of formula 5a wherein:
  • the invention relates to pharmaceutical compositions containing A and B , characterized in that the p38 kinase inhibitor B is selected from the compounds of formula 5a wherein:
  • the invention relates to pharmaceutical compositions containing A and B , characterized in that the p38 kinase inhibitor B is selected from the compounds of formula 5a wherein:
  • the invention relates to pharmaceutical compositions containing A and B , characterized in that the p38 kinase inhibitor B is selected from the compounds of formula 5a wherein:
  • compositions containing A and B characterized in that the p38 kinase inhibitor B is selected from the compounds of formula 5a wherein:
  • the invention relates to pharmaceutical compositions containing A and B , characterized in that the p38 kinase inhibitor B is selected from the compounds of formula 5a wherein X is pyridinyl.
  • the invention relates to pharmaceutical compositions containing A and B , characterized in that the p38 kinase inhibitor B is selected from the compounds of formula 5a wherein the pyridinyl is attached to Ar 1 via the 3-pyridinyl position.
  • the invention relates to pharmaceutical compositions containing A and B , characterized in that the p38 kinase inhibitor B is selected from the following compounds of formula 5a:
  • the invention relates to pharmaceutical compositions containing A and B, characterized in that the p38 kinase inhibitor B is selected from the following compounds of formula 5a :
  • the invention relates to pharmaceutical compositions containing A and B , characterized in that the p38 kinase inhibitor B is selected from the compounds of formula 6 as disclosed in WO 00/55139 wherein:
  • the invention relates to pharmaceutical compositions containing A and B , characterized in that the p38 kinase inhibitor B is selected from the compounds of formula 6 wherein
  • the invention relates to pharmaceutical compositions containing A and B , characterized in that the p38 kinase inhibitor B is selected from the compounds of formula 6 wherein
  • R 23 and R 24 taken together optionally form imidazolyl, piperidinyl, morpholinyl, piperazinyl or a pyridinyl ring.
  • the invention relates to pharmaceutical compositions containing A and B , characterized in that the p38 kinase inhibitor B is selected from the compounds of formula 6 wherein:
  • the invention relates to pharmaceutical compositions containing A and B , characterized in that the p38 kinase inhibitor B is selected from the compounds of formula 6 wherein
  • R 23 and R 24 are H or R 23 and R 24 taken together optionally form morpholino; and R 26 is morpholino.
  • the invention relates to pharmaceutical compositions containing A and B , characterized in that the p38 kinase inhibitor B is selected from the compounds of formula 6
  • the invention relates to pharmaceutical compositions containing A and B , characterized in that the p38 kinase inhibitor B is selected from the compounds of formula 6 wherein X is pyridinyl.
  • the invention relates to pharmaceutical compositions containing A and B , characterized in that the p38 kinase inhibitor B is selected from the compounds of formula 6 wherein the pyridinyl is attached to Ar via the 3-pyridinyl position.
  • the invention relates to pharmaceutical compositions containing A and B , characterized in that the p38 kinase inhibitor B is selected from the following compounds of formula 6
  • compositions containing A and B characterized in that the p38 kinase inhibitor B is selected from the following compounds of formula 6 :
  • the invention relates to pharmaceutical compositions containing A and B, characterized in that the p38 kinase inhibitor B is selected from the compounds of formula 7 as disclosed in WO 00/55139 wherein:
  • the invention relates to pharmaceutical compositions containing A and B , characterized in that the p38 kinase inhibitor B is selected from the compounds of formula 7 wherein:
  • the invention relates to pharmaceutical compositions containing A and B , characterized in that the p38 kinase inhibitor B is selected from the compounds of formula 7 wherein:
  • the invention relates to pharmaceutical compositions containing A and B , characterized in that the p38 kinase inhibitor B is selected from the compounds of formula 7 wherein:
  • Ar is naphthyl
  • the invention relates to pharmaceutical compositions containing A and B , characterized in that the p38 kinase inhibitor B is selected from the compounds of formula 7 wherein:
  • the invention relates to pharmaceutical compositions containing A and B , characterized in that the p38 kinase inhibitor B is selected from the compounds of formula 7 wherein:
  • the invention relates to pharmaceutical compositions containing A and B , characterized in that the p38 kinase inhibitor B is selected from the compounds of formula 7 wherein X is pyridinyl.
  • the invention relates to pharmaceutical compositions containing A and B , characterized in that the p38 kinase inhibitor B is selected from the compounds of formula 7 wherein the pyridinyl is attached to Ar via the 3-pyridinyl position.
  • the invention relates to pharmaceutical compositions containing A and B, characterized in that the p38 kinase inhibitor B is selected from the following compounds of formula 7 :
  • the invention relates to pharmaceutical compositions containing A and B , characterized in that the p38 kinase inhibitor B is selected from the following compounds of formula 7
  • compositions containing A and B characterized in that the p38 kinase inhibitor B is selected from the following compounds:
  • any reference to the abovementioned p38 kinase inhibitors B within the scope of the present invention includes a reference to any pharmaceutically acceptable acid addition salts thereof which may exist.
  • physiologically or pharmaceutically acceptable acid addition salts which may be formed from B are meant, according to the invention, pharmaceutically acceptable salts selected from among the salts of hydrochloric, hydrobromic, sulfuric, nitric, perchloric, fumaric, maleic, phosphoric, glycolic, lactic, salicylic, succinic, toluene-p-sulfuric, tartaric, acetic, citric, methanesulfonic, formic, benzoic, malonic, naphthalene-2-sulfuric and benzenesulfonic acids.
  • any reference to the abovementioned p38 kinase inhibitors B within the scope of the present invention includes a reference to any alkali metal and alkaline earth metal salts thereof which may exist. If the compounds of formula B are present in the form of their basic salts, the sodium or potassium salts are particularly preferred.
  • the pharmaceutical combinations of A and B according to the invention are preferably administered by parenteral or oral route or by inhalation, the latter being particularly preferred.
  • parenteral or parenteral administration the pharmaceutical compositions according to the invention may be administered in the form of solutions and tablets.
  • suitable inhalable powders may be used which are packed into suitable capsules (inhalettes) and administered using suitable powder inhalers.
  • the drug may be inhaled by the application of suitable inhalation aerosols. These include inhalation aerosols which contain HFA134a, HFA227 or a mixture thereof as propellant gas.
  • the drug may also be inhaled using suitable solutions of the pharmaceutical combination consisting of A and B.
  • the invention relates to a pharmaceutical composition which contains a combination of A and B.
  • the present invention relates to a pharmaceutical composition suitable for inhalation which contains one or more salts A and one or more compounds B, optionally in the form of their solvates or hydrates.
  • the active substances may either be combined in a single preparation or contained in two separate formulations.
  • Pharmaceutical compositions which contain the active substances A and B in a single preparation are preferred according to the invention.
  • the present invention relates to a pharmaceutical composition which contains, in addition to therapeutically effective quantities of A and B, a pharmaceutically acceptable carrier or excipient.
  • the present invention relates to a pharmaceutical composition which does not contain any pharmaceutically acceptable carrier or excipient in addition to therapeutically effective quantities of A and B .
  • the present invention also relates to the use of A and B for preparing a pharmaceutical composition containing therapeutically effective quantities of A and B for treating diseases of the upper or lower respiratory tract, particularly for treating asthma, chronic obstructive pulmonary diseases (COPD) and/or pulmonary hypertension, provided that treatment with p38 kinase inhibitors is not contraindicated from a therapeutic point of view, by simultaneous or successive administration.
  • a and B for preparing a pharmaceutical composition containing therapeutically effective quantities of A and B for treating diseases of the upper or lower respiratory tract, particularly for treating asthma, chronic obstructive pulmonary diseases (COPD) and/or pulmonary hypertension, provided that treatment with p38 kinase inhibitors is not contraindicated from a therapeutic point of view, by simultaneous or successive administration.
  • COPD chronic obstructive pulmonary diseases
  • the present invention preferably relates to the abovementioned use of A and B for preparing a pharmaceutical composition containing therapeutically effective quantities of A and B for treating asthma and/or chronic obstructive pulmonary diseases (COPD), which may possibly be associated with pulmonary hypertension, provided that treatment with p38 kinase inhibitors is not contraindicated from a therapeutic point of view, by simultaneous or successive administration.
  • COPD chronic obstructive pulmonary diseases
  • the present invention further relates to the simultaneous or successive use of therapeutically effective doses of the combination of the above pharmaceutical compositions A and B for treating inflammatory or obstructive diseases of the respiratory tract, particularly asthma, chronic obstructive pulmonary diseases (COPD) and/or pulmonary hypertension, provided that treatment with p38 kinase inhibitors is not contraindicated from a therapeutic point of view, by simultaneous or successive administration.
  • inflammatory or obstructive diseases of the respiratory tract particularly asthma, chronic obstructive pulmonary diseases (COPD) and/or pulmonary hypertension
  • the present invention preferably relates to the abovementioned use of therapeutically effective doses of the combination of the abovementioned pharmaceutical compositions A and B for treating asthma and/or chronic obstructive pulmonary diseases (COPD), which may possibly be associated with pulmonary hypertension, provided that treatment with p38 kinase inhibitors is not contraindicated from a therapeutic point of view, by simultaneous or successive administration.
  • COPD chronic obstructive pulmonary diseases
  • ingredients A and B may be present in the form of their enantiomers, mixtures of enantiomers or in the form of racemates.
  • the proportions in which the two active substances A and B may be used in the active substance combinations according to the invention are variable. Active substances A and B may possibly be present in the form of their solvates or hydrates.
  • the weight ratios which may be used within the scope of the present invention vary on the basis of the different molecular weights of the various compounds and their different potencies.
  • the pharmaceutical combinations according to the invention may contain compounds A and B in ratios by weight ranging from 1:300 to 20:1, preferably from 1:200 to 10:1.
  • the weight ratios of A to B are most preferably in a range in which A' and B are present in proportions of 1:100 to 5:1, more preferably from 1:80 to 1:1.
  • compositions according to the invention containing the combinations of A and B are normally administered so that A and B are present together in doses of about 100 to 10000 ⁇ g, preferably 1000 to 9000 ⁇ g, more preferably 1500 to 8000 ⁇ g, better still from about 2000 to about 7000 ⁇ g, more preferably 2500 to 6000 ⁇ g per single dose.
  • about 3000 to about 5500 ⁇ g of the combination of A and B according to the invention may be administered once or twice daily to the patient in need thereof.
  • combinations of A and B according to the invention contain a quantity of A' and p38 kinase inhibitor B such that the total dosage per single dose is about 2500 ⁇ g, 2550 ⁇ g, 2600 ⁇ g, 2650 ⁇ g, 2700 ⁇ g, 2750 ⁇ g, 2800 ⁇ g, 2850 ⁇ g, 2900 ⁇ g, 2950 ⁇ g,3000 ⁇ g,3050 ⁇ g,3100 ⁇ g,3150 ⁇ g,3200 ⁇ g,3250 ⁇ g,3300 ⁇ g,3350 ⁇ g, 3400 ⁇ g, 3450 ⁇ g, 3500 ⁇ g, 3550 ⁇ g, 3600 ⁇ g, 3650 ⁇ g, 3700 ⁇ g, 3750 ⁇ g, 3800 ⁇ g, 3850 ⁇ g,3900 ⁇ g,3950 ⁇ g,4000 ⁇ g,4050 ⁇ g,4100 ⁇ g,4150 ⁇ g,4200 ⁇ g,4250 ⁇ g, 4300 ⁇ g, 4350 ⁇ g, 4400 ⁇ g, 4450 ⁇ g, 4500 ⁇ g, 4550 ⁇ g, 4600 ⁇ g,
  • the combinations of A and B according to the invention may contain a quantity of A' and p38 kinase inhibitor B such that, in each individual dose, 16,5 ⁇ g of A' and 2500 ⁇ g of B , 16,5 ⁇ g of A' and 3000 ⁇ g of B , 16,5 ⁇ g of A' and 3500 ⁇ g of B , 16,5 ⁇ g of A' and 4000 ⁇ g of B , 16,5 ⁇ g of A' and 4500 ⁇ g of B , 16,5 ⁇ g of A' and 5000 ⁇ g of B , 16,5 ⁇ g of A' and 5500 ⁇ g of B , 16,5 ⁇ g of A' and 6000 ⁇ g of B , 16,5 ⁇ g of A' and 6500 ⁇ g of B , 16,5 ⁇ g of A' and 7000 ⁇ g of B , 33,1 ⁇ g of A' and 2500 ⁇ g of B , 33,1 ⁇ g of A' and 3000 ⁇ g of B , 33,1 ⁇ g of A
  • the quantities of active substance A' and B administered per single dose mentioned by way of example correspond to the following quantities of A and B administered per single dose: 20 ⁇ g of A and 2500 ⁇ g of B , 20 ⁇ g of A and 3000 ⁇ g of B , 20 ⁇ g of A and 3500 ⁇ g of B , 20 ⁇ g of A and 4000 ⁇ g of B , 20 ⁇ g of A and 4500 ⁇ g of B , 20 ⁇ g of A and 5000 ⁇ g of B , 20 ⁇ g of A and 5500 ⁇ g of B , 20 ⁇ g of A and 6000 ⁇ g of B , 20 ⁇ g of A and 6500 ⁇ g of B , 20 ⁇ g of A and 7000 ⁇ g of B , 40 ⁇ g of A and 2500 ⁇ g of B , 40 ⁇ g of A and 3000 ⁇ g of B , 40 ⁇ g of A and 3500 ⁇ g of B , 40 ⁇ g of A and 4000 ⁇ g of
  • the active substance combinations of A and B according to the invention are preferably administered by inhalation or by nasal application.
  • ingredients A and B have to be made available in inhalable forms.
  • Inhalable preparations include inhalable powders, propellant-containing metering aerosols or propellant-free inhalable solutions.
  • Inhalable powders according to the invention containing the combination of active substances A and B may consist of the active substances on their own or of a mixture of the active substances with physiologically acceptable excipients.
  • propellant-free inhalable solutions also includes concentrates or sterile inhalable solutions ready for use.
  • the preparations according to the invention may contain the combination of active substances A and B either together in one formulation or in two separate formulations. These formulations which may be used within the scope of the present invention are described in more detail in the next part of the specification.
  • the inhalable powders according to the invention may contain A and B either on their own or in admixture with suitable physiologically acceptable excipients.
  • physiologically acceptable excipients may be used to prepare these inhalable powders according to the invention:
  • the excipients have a maximum average particle size of up to 250 ⁇ m, preferably between 10 and 150 ⁇ m, most preferably between 15 and 80 ⁇ m. It may sometimes seem appropriate to add finer excipient fractions with an average particle size of 1 to 9 ⁇ m to the excipients mentioned above. These finer excipients are also selected from the group of possible excipients listed hereinbefore. Finally, in order to prepare the inhalable powders according to the invention, micronised active substance A and B, preferably with an average particle size of 0.5 to 10 ⁇ m, more preferably from 1 to 5 ⁇ m, is added to the excipient mixture.
  • inhalable powders according to the invention may be prepared and administered either in the form of a single powder mixture which contains both A and B or in the form of separate inhalable powders which contain only A or B.
  • the inhalable powders according to the invention may be administered using inhalers known from the prior art.
  • Inhalable powders according to the invention which contain a physiologically acceptable excipient in addition to A and B may be administered, for example, by means of inhalers which deliver a single dose from a supply using a measuring chamber as described in US 4570630A , or by other means as described in DE 36 25 685 A .
  • the inhalable powders according to the invention which contain A and B optionally combined with a physiologically acceptable excipient may be administered for example with an inhaler known by the name Turbuhaler® , for example with inhalers as disclosed in EP 237507 A , for example.
  • the inhalable powders according to the invention which contain physiologically acceptable excipient in addition to A and B are packed into capsules (to produce so-called inhalettes) which are used in inhalers as described, for example, in WO 94/28958 .
  • FIG. 1 A particularly preferred inhaler for administering the pharmaceutical combination according to the invention in inhalettes is shown in Figure 1.
  • the inhaler according to figure 1 is characterised by a housing 1 containing two windows 2, a deck 3 in which there are air inlet ports and which is provided with a screen 5 secured via a screen housing 4, an inhalation chamber 6 connected to the deck 3 on which there is a push button 9 provided with two sharpened pins 7 and movable counter to a spring 8, a mouthpiece 12 which is connected to the housing 1, the deck 3 and a cover 11 via a spindle 10 to enable it to be flipped open or shut and three holes 13 with diameters below 1 mm in the central region around the capsule chamber 6 and underneath the screen housing 4 and screen 5.
  • the main air flow enters the inhaler between deck 3 and base 1 near to the hinge.
  • the deck has in this range a reduced width, which forms the entrance slit for the air.
  • the flow reverses and enters the capsule chamber 6 through the inlet tube.
  • the flow is then further conducted through the filter and filter holder to the mouthpiece.
  • a small portion of the flow enters the device between mouthpiece and deck and flows then between filterholder and deck into the main stream. Due to production tolerances there is some uncertainty in this flow because of the actual width of the slit between filterholder and deck. In case of new or reworked tools the flow resistance of the inhaler may therefore be a little off the target value.
  • the deck has in the central region around the capsule chamber 6 and underneath the screen housing 4 and screen 5 three holes 13 with diameters below 1 mm. Through these holes 13 flows air from the base into the main air stream and reduces such slightly the flow resistance of the inhaler.
  • the actual diameter of these holes 13 can be chosen by proper inserts in the tools so that the mean flow resistance can be made equal to the target value.
  • the quantities packed into each capsule should be 1 to 30mg, preferably 3 to 20mg, more particularly 5 to 10mg of inhalable powder per capsule.
  • These capsules contain, according to the invention, either together or separately, the doses of A' and B mentioned hereinbefore for each single dose.
  • Inhalation aerosols containing propellant gas according to the invention may contain substances A and B dissolved in the propellant gas or in dispersed form.
  • a and B may be present in separate formulations or in a single preparation, in which A and B are either both dissolved, both dispersed or only one component is dissolved and the other is dispersed.
  • the propellant gases which may be used to prepare the inhalation aerosols according to the invention are known from the prior art. Suitable propellant gases are selected from among hydrocarbons such as n-propane, n-butane or isobutane and halohydrocarbons such as fluorinated derivatives of methane, ethane, propane, butane, cyclopropane or cyclobutane.
  • propellant gases mentioned above may be used on their own or in mixtures thereof.
  • Particularly preferred propellant gases are halogenated alkane derivatives selected from TG134a (1,1,1,2-tetrafluoroethane) and TG227(1,1,1,2,3,3,3-heptafluoropropane) and mixtures thereof.
  • the propellant-driven inhalation aerosols according to the invention may also contain other ingredients such as co-solvents, stabilisers, surfactants, antioxidants, lubricants and pH adjusters. All these ingredients are known in the art.
  • the inhalation aerosols containing propellant gas according to the invention may contain up to 5 wt.-% of active substance A and/or B .
  • Aerosols according to the invention contain, for example, 0.002 to 5 wt.-%, 0.01 to 3 wt.-%, 0.015 to 2 wt.-%, 0.1 to 2 wt.-%, 0.5 to 2 wt.-% or 0.5 to 1.5 wt.-% of active substance A and/or B.
  • the particles of active substance preferably have an average particle size of up to 10 ⁇ m, preferably from 0.1 to 5 ⁇ m, more preferably from 1 to 5 ⁇ m.
  • the present invention relates to pharmaceutical compositions in the form of propellant-driven aerosols as hereinbefore described combined with one or more inhalers suitable for administering these aerosols.
  • the present invention relates to inhalers which are characterised in that they contain the propellant gas-containing aerosols described above according to the invention.
  • the present invention also relates to cartridges which when fitted with a suitable valve can be used in a suitable inhaler and which contain one of the above-mentioned propellant gas-containing inhalation aerosols according to the invention. Suitable cartridges and methods of filling these cartridges with the inhalable aerosols containing propellant gas according to the invention are known from the prior art.
  • the solvent used may be an aqueous or alcoholic, preferably an ethanolic solution.
  • the solvent may be water on its own or a mixture of water and ethanol.
  • the relative proportion of ethanol compared with water is not limited but the maximum is up to 70 percent by volume, more particularly up to 60 percent by volume and most preferably up to 30 percent by volume. The remainder of the volume is made up of water.
  • the solutions or suspensions containing A and B are adjusted to a pH of 2 to 7, preferably 2 to 5, using suitable acids.
  • the pH may be adjusted using acids selected from inorganic or organic acids.
  • suitable inorganic acids include hydrochloric acid, hydrobromic acid, nitric acid, sulphuric acid and/or phosphoric acid.
  • suitable organic acids include ascorbic acid, citric acid, malic acid, tartaric acid, maleic acid, succinic acid, fumaric acid, acetic acid, formic acid and/or propionic acid etc.
  • Preferred inorganic acids are hydrochloric and sulphuric acids. It is also possible to use the acids which have already formed an acid addition salt with one of the active substances.
  • ascorbic acid, fumaric acid and citric acid are preferred.
  • mixtures of the above acids may be used, particularly in the case of acids which have other properties in addition to their acidifying qualities, e.g. as flavourings, antioxidants or complexing agents, such as citric acid or ascorbic acid, for example.
  • the addition of editic acid (EDTA) or one of the known salts thereof, sodium edetate, as stabiliser or complexing agent is unnecessary in the present formulation.
  • Other embodiments may contain this compound or these compounds.
  • the content based on sodium edetate is less than 100mg/100ml, preferably less than 50mg/100 ml, more preferably less than 20mg/100 ml.
  • inhalable solutions in which the content of sodium edetate is from 0 to 10mg/100ml are preferred.
  • Co-solvents and/or other excipients may be added to the propellant-free inhalable solutions according to the invention.
  • Preferred co-solvents are those which contain hydroxyl groups or other polar groups, e.g. alcohols ⁇ particularly isopropyl alcohol, glycols ⁇ particularly propyleneglycol, polyethyleneglycol, polypropyleneglycol, glycolether, glycerol, polyoxyethylene alcohols and polyoxyethylene fatty acid esters.
  • excipients and additives in this context denote any pharmacologically acceptable substance which is not an active substance but which can be formulated with the active substance or substances in the pharmacologically suitable solvent in order to improve the qualitative properties of the active substance formulation.
  • these substances have no pharmacological effect or, in connection with the desired therapy, no appreciable or at least no undesirable pharmacological effect.
  • the excipients and additives include, for example, surfactants such as soya lecithin, oleic acid, sorbitan esters, such as polysorbates, polyvinylpyrrolidone, other stabilisers, complexing agents, antioxidants and/or preservatives which guarantee or prolong the shelf life of the finished pharmaceutical formulation, flavourings, vitamins and/or other additives known in the art.
  • the additives also include pharmacologically acceptable salts such as sodium chloride as isotonic agents.
  • the preferred excipients include antioxidants such as ascorbic acid, for example, provided that it has not already been used to adjust the pH, vitamin A, vitamin E, tocopherols and similar vitamins and provitamins occurring in the human body.
  • Preservatives may be used to protect the formulation from contamination with pathogens. Suitable preservatives are those which are known in the art, particularly cetyl pyridinium chloride, benzalkonium chloride or benzoic acid or benzoates such as sodium benzoate in the concentration known from the prior art.
  • the preservatives mentioned above are preferably present in concentrations of up to 50mg/100ml, more preferably between 5 and 20mg/100ml.
  • Preferred formulations contain, in addition to the solvent water and the combination of active substances A and B, only benzalkonium chloride and sodium edetate. In another preferred embodiment, no sodium edetate is present.
  • the propellant-free inhalable solutions according to the invention are administered in particular using inhalers of the kind which are capable of nebulising a small amount of a liquid formulation in the therapeutic dose within a few seconds to produce an aerosol suitable for therapeutic inhalation.
  • preferred inhalers are those in which a quantity of less than 100 ⁇ L, preferably less than 50 ⁇ L, more preferably between 10 and 30 ⁇ L of active substance solution can be nebulised in preferably one spray action to form an aerosol with an average particle size of less than 20 ⁇ m, preferably less than 10 ⁇ m, in such a way that the inhalable part of the aerosol corresponds to the therapeutically effective quantity.
  • This nebuliser can advantageously be used to produce the inhalable aerosols according to the invention containing the combination of active substances A and B . Because of its cylindrical shape and handy size of less than 9 to 15 cm long and 2 to 4 cm wide, this device can be carried at all times by the patient.
  • the nebuliser sprays a defined volume of pharmaceutical formulation using high pressures through small nozzles so as to produce inhalable aerosols.
  • the preferred atomiser essentially consists of an upper housing part, a pump housing, a nozzle, a locking mechanism, a spring housing, a spring and a storage container, characterised by
  • the hollow plunger with valve body corresponds to a device disclosed in WO 97/12687 . It projects partially into the cylinder of the pump housing and is axially movable within the cylinder. Reference is made in particular to Figures 1 to 4, especially Figure 3, and the relevant parts of the description.
  • the hollow plunger with valve body exerts a pressure of 5 to 60 Mpa (about 50 to 600 bar), preferably 10 to 60 Mpa (about 100 to 600 bar) on the fluid, the measured amount of active substance solution, at its high pressure end at the moment when the spring is actuated. Volumes of 10 to 50 microlitres are preferred, while volumes of 10 to 20 microlitres are particularly preferred and a volume of 15 microlitres per spray is most particularly preferred.
  • the valve body is preferably mounted at the end of the hollow plunger facing the valve body.
  • the nozzle in the nozzle body is preferably microstructured, i.e. produced by microtechnology.
  • Microstructured valve bodies are disclosed for example in WO-94/07607 ; reference is hereby made to the contents of this specification, particularly Figure 1 therein and the associated description.
  • the valve body consists for example of two sheets of glass and/or silicon firmly joined together, at least one of which has one or more microstructured channels which connect the nozzle inlet end to the nozzle outlet end.
  • the directions of spraying of the nozzles in the nozzle body may extend parallel to one another or may be inclined relative to one another in the direction of the nozzle opening.
  • the directions of spraying may be at an angle of 20 to 160° to one another, preferably 60 to 150°, most preferably 80 to 100°.
  • the nozzle openings are preferably arranged at a spacing of 10 to 200 microns, more preferably at a spacing of 10 to 100 microns, most preferably 30 to 70 microns. Spacings of 50 microns are most preferred.
  • the directions of spraying will therefore meet in the vicinity of the nozzle openings.
  • the liquid pharmaceutical preparation strikes the nozzle body with an entry pressure of up to 600 bar, preferably 200 to 300 bar, and is atomised into an inhalable aerosol through the nozzle openings.
  • the preferred particle or droplet sizes of the aerosol are up to 20 microns, preferably 3 to 10 microns.
  • the locking mechanism contains a spring, preferably a cylindrical helical compression spring, as a store for the mechanical energy.
  • the spring acts on the power takeoff flange as an actuating member the movement of which is determined by the position of a locking member.
  • the travel of the power takeoff flange is precisely limited by an upper and lower stop.
  • the spring is preferably biased, via a power step-up gear, e.g. a helical thrust gear, by an external torque which is produced when the upper housing part is rotated counter to the spring housing in the lower housing part.
  • the upper housing part and the power takeoff flange have a single or multiple V-shaped gear.
  • the locking member with engaging locking surfaces is arranged in a ring around the power takeoff flange. It consists, for example, of a ring of plastic or metal which is inherently radially elastically deformable.
  • the ring is arranged in a plane at right angles to the atomiser axis. After the biasing of the spring, the locking surfaces of the locking member move into the path of the power takeoff flange and prevent the spring from relaxing.
  • the locking member is actuated by means of a button.
  • the actuating button is connected or coupled to the locking member. In order to actuate the locking mechanism, the actuating button is moved parallel to the annular plane, preferably into the atomiser; this causes the deformable ring to deform in the annual plane. Details of the construction of the locking mechanism are given in WO 97/20590 .
  • the lower housing part is pushed axially over the spring housing and covers the mounting, the drive of the spindle and the storage container for the fluid.
  • the upper housing part When the atomiser is actuated the upper housing part is rotated relative to the lower housing part, the lower housing part taking the spring housing with it.
  • the spring is thereby compressed and biased by means of the helical thrust gear and the locking mechanism engages automatically.
  • the angle of rotation is preferably a whole-number fraction of 360 degrees, e.g. 180 degrees.
  • the power takeoff part in the upper housing part is moved along by a given distance, the hollow plunger is withdrawn inside the cylinder in the pump housing, as a result of which some of the fluid is sucked out of the storage container and into the high pressure chamber in front of the nozzle.
  • a number of exchangeable storage containers which contain the fluid to be atomised may be pushed into the atomiser one after another and used in succession.
  • the storage container contains the aqueous aerosol preparation according to the invention.
  • the atomising process is initiated by pressing gently on the actuating button.
  • the locking mechanism opens up the path for the power takeoff member.
  • the biased spring pushes the plunger into the cylinder of the pump housing.
  • the fluid leaves the nozzle of the atomiser in atomised form.
  • the components of the atomiser are made of a material which is suitable for its purpose.
  • the housing of the atomiser and, if its operation permits, other parts as well are preferably made of plastics, e.g. by injection moulding.
  • physiologically safe materials are used for medicinal purposes.
  • Figures 2a/b attached to this patent application which are identical to Figures 6a/b of WO 97/12687 , show the nebuliser (Respimat®) which can advantageously be used for inhaling the aqueous aerosol preparations according to the invention.
  • Respimat® nebuliser
  • Figure 2a shows a longitudinal section through the atomiser with the spring biased while Figure 2b shows a longitudinal section through the atomiser with the spring relaxed.
  • the upper housing part (51) contains the pump housing (52) on the end of which is mounted the holder (53) for the atomiser nozzle.
  • the nozzle body (54) In the holder is the nozzle body (54) and a filter (55).
  • the hollow plunger (57) fixed in the power takeoff flange (56) of the locking mechanism projects partially into the cylinder of the pump housing.
  • the hollow plunger carries the valve body (58).
  • the hollow plunger is sealed off by means of the seal (59).
  • Inside the upper housing part is the stop (60) on which the power takeoff flange abuts when the spring is relaxed.
  • the stop (61) On the power takeoff flange is the stop (61) on which the power takeoff flange abuts when the spring is biased.
  • the locking member (62) moves between the stop (61) and a support (63) in the upper housing part.
  • the actuating button (64) is connected to the locking member.
  • the upper housing part ends in the mouthpiece (65) and is sealed off by means of the protective cover (66) which can be placed thereon.
  • the spring housing (67) with compression spring (68) is rotatably mounted on the upper housing part by means of the snap-in lugs (69) and rotary bearing.
  • the lower housing part (70) is pushed over the spring housing.
  • Inside the spring housing is the exchangeable storage container (71) for the fluid (72) which is to be atomised.
  • the storage container is sealed off by the stopper (73) through which the hollow plunger projects into the storage container and is immersed at its end in the fluid (supply of active substance solution).
  • the spindle (74) for the mechanical counter is mounted in the covering of the spring housing. At the end of the spindle facing the upper housing part is the drive pinion (75). The slider (76) sits on the spindle.
  • the nebuliser described above is suitable for nebulising the aerosol preparations according to the invention to produce an aerosol suitable for inhalation.
  • the quantity delivered should correspond to a defined quantity with a tolerance of not more than 25%, preferably 20% of this amount in at least 97%, preferably at least 98% of all operations of the inhaler (spray actuations).
  • a tolerance of not more than 25% preferably 20% of this amount in at least 97%, preferably at least 98% of all operations of the inhaler (spray actuations).
  • spray actuations Preferably, between 5 and 30 mg of formulation, most preferably between 5 and 20 mg of formulation are delivered as a defined mass on each actuation.
  • formulation according to the invention may also be nebulised by means of inhalers other than those described above, e.g. jet stream inhalers or other stationary nebulisers.
  • the invention relates to pharmaceutical formulations in the form of propellant-free inhalable solutions or suspensions as described above combined with a device suitable for administering these formulations, preferably in conjunction with the Respimat®.
  • the invention relates to propellant-free inhalable solutions or suspensions characterised by the combination of active substances A and B according to the invention in conjunction with the device known by the name Respimat®.
  • the present invention relates to the above-mentioned devices for inhalation, preferably the Respimat®, characterised in that they contain the propellant-free inhalable solutions or suspensions according to the invention as described hereinbefore.
  • Inhalable solutions which contain the active substances A and B in a single preparation are preferred according to the invention.
  • the term preparation also includes those which contain both ingredients A and B in two-chamber cartridges as disclosed for example in WO 00/23037 . Reference is hereby made to this publication in its entirety.
  • the propellant-free inhalable solutions or suspensions according to the invention may take the form of concentrates or sterile inhalable solutions or suspensions ready for use, as well as the above-mentioned solutions and suspensions designed for use in a Respimat®.
  • Formulations ready for use may be produced from the concentrates, for example, by the addition of isotonic saline solutions.
  • Sterile formulations ready for use may be administered using energy-operated fixed or portable nebulisers which produce inhalable aerosols by means of ultrasound or compressed air by the Venturi principle or other principles.
  • the present invention relates to pharmaceutical compositions in the form of propellant-free inhalable solutions or suspensions as described hereinbefore which take the form of concentrates or sterile formulations ready for use, combined with a device suitable for administering these solutions, characterised in that the device is an energy-operated free-standing or portable nebuliser which produces inhalable aerosols by means of ultrasound or compressed air by the Venturi principle or other methods.

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EP06116683A 2002-07-09 2003-06-26 Pharazeutische zusammensetzungen aus anticholinergica und p38 kinase hemmern zur behandlung von erkrankungen der atemwege Withdrawn EP1707205A2 (de)

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EP03738089A EP1534282B1 (de) 2002-07-09 2003-06-26 Pharazeutische zusammensetzungen aus anticholinergica und p38 kinase hemmern zur behandlung von erkrankungen der atemwege

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JP2005538066A (ja) 2005-12-15
DE60310730T2 (de) 2007-05-16
ATE349210T1 (de) 2007-01-15
AU2003245989A1 (en) 2004-01-23
EP1534282A2 (de) 2005-06-01
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WO2004004725A3 (en) 2004-05-27
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