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DK1181272T3 - Fremgangsmåde til fremstilling af rent citalopram - Google Patents

Fremgangsmåde til fremstilling af rent citalopram

Info

Publication number
DK1181272T3
DK1181272T3 DK01913727T DK01913727T DK1181272T3 DK 1181272 T3 DK1181272 T3 DK 1181272T3 DK 01913727 T DK01913727 T DK 01913727T DK 01913727 T DK01913727 T DK 01913727T DK 1181272 T3 DK1181272 T3 DK 1181272T3
Authority
DK
Denmark
Prior art keywords
preparation
pure citalopram
citalopram
pure
Prior art date
Application number
DK01913727T
Other languages
English (en)
Inventor
Andrea Castellin
Giulio Volpe
Federico Sbrogio
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Application granted granted Critical
Publication of DK1181272T3 publication Critical patent/DK1181272T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87Benzo [c] furans; Hydrogenated benzo [c] furans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK01913727T 2000-12-28 2001-03-07 Fremgangsmåde til fremstilling af rent citalopram DK1181272T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200001943 2000-12-28
PCT/DK2001/000148 WO2001047877A2 (en) 2000-12-28 2001-03-07 Process for the preparation of pure citalopram

Publications (1)

Publication Number Publication Date
DK1181272T3 true DK1181272T3 (da) 2002-12-30

Family

ID=8159933

Family Applications (1)

Application Number Title Priority Date Filing Date
DK01913727T DK1181272T3 (da) 2000-12-28 2001-03-07 Fremgangsmåde til fremstilling af rent citalopram

Country Status (41)

Country Link
US (2) US6855834B2 (da)
EP (1) EP1181272B1 (da)
JP (1) JP2003519121A (da)
KR (1) KR100430746B1 (da)
CN (1) CN1366526A (da)
AR (1) AR029898A1 (da)
AT (2) ATE222899T1 (da)
AU (3) AU2001100399B4 (da)
BE (2) BE1013417A6 (da)
BG (1) BG106219A (da)
BR (1) BR0106271A (da)
CA (1) CA2359810C (da)
CH (1) CH691536A5 (da)
CZ (1) CZ293140B6 (da)
DE (1) DE60100016T2 (da)
DK (1) DK1181272T3 (da)
EA (1) EA003459B1 (da)
ES (2) ES2181663T3 (da)
FI (2) FI108640B (da)
FR (1) FR2818977B1 (da)
GB (2) GB2356199B (da)
GR (1) GR20010100131A (da)
HK (1) HK1049332A1 (da)
HR (1) HRP20020005A2 (da)
HU (2) HU0101028D0 (da)
IE (2) IES20010253A2 (da)
IL (1) IL147162A0 (da)
IS (1) IS5884A (da)
IT (1) ITMI20010604A1 (da)
MX (1) MXPA01013336A (da)
NL (1) NL1017534C1 (da)
NO (1) NO313047B1 (da)
NZ (1) NZ516299A (da)
PL (1) PL353369A1 (da)
PT (1) PT1181272E (da)
SE (1) SE0103044L (da)
SK (1) SK284418B6 (da)
TR (1) TR200200018T1 (da)
UA (1) UA71635C2 (da)
WO (1) WO2001047877A2 (da)
ZA (1) ZA200110133B (da)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
HU227473B1 (en) * 1999-04-14 2011-07-28 Lundbeck & Co As H Method for preparation of citalopram
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ATE277032T1 (de) 1999-10-25 2004-10-15 Lundbeck & Co As H Verfahren zur herstellung von citalopram
GB2360281B (en) 1999-10-25 2002-01-16 Lundbeck & Co As H Method for the preparation of citalopram
AR026063A1 (es) 1999-11-01 2002-12-26 Lundbeck & Co As H Metodo para la preparacion de 5-carboxiftalida.
CZ20022213A3 (cs) 1999-12-28 2002-09-11 H. Lundbeck A/S Způsob výroby citalopramu
KR100653141B1 (ko) 1999-12-30 2006-12-01 하. 룬트벡 아크티에 셀스카브 시탈로프람의 제조 방법
AU3033700A (en) 2000-01-14 2001-07-24 H. Lundbeck A/S Method for the preparation of 5-cyanophthalide
NL1017417C1 (nl) 2000-03-03 2001-03-16 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
NL1017500C1 (nl) 2000-03-13 2001-04-26 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
PL357022A1 (en) * 2000-03-13 2004-07-12 H.Lundbeck A/S Stepwise alkylation of 5-substituted 1-(4-fluorophenyl)-1,3-dihydroisobenzofurans
BR0109176A (pt) 2000-03-13 2003-04-22 Lundbeck & Co As H Método para preparação de citalopram e composto da fórmula
BR0109268A (pt) 2000-03-14 2002-12-03 Lundbeck & Co As H Método de preparação de citalopram, composto e citaplopram
EA200200982A1 (ru) * 2000-03-16 2003-02-27 Х.Лундбекк А/С Способ получения 5-циано-1-(4-фторфенил)-1,3-дигидроизобензофуранов
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
CA2354877C (en) 2000-08-18 2006-05-02 H. Lundbeck A/S Method for the preparation of citalopram
ES2228824T3 (es) 2000-12-22 2005-04-16 H. Lundbeck A/S Metodo de preparacion de citalopram puro.
DE60100016T2 (de) 2000-12-28 2003-04-17 H. Lundbeck A/S, Valby Verfahren zur herstellung von reinem citalopram
GB2376945A (en) * 2001-06-27 2002-12-31 Cipla Ltd Citalopram preparation
US7148364B2 (en) 2002-01-07 2006-12-12 Sun Pharmaceutical Industries Process for the preparation of 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofuran carbonitrile
ES2194597B2 (es) * 2002-01-25 2004-08-01 Esteve Quimica, S.A. Procedimiento para la obtencion de citalopram.
GB2386119A (en) * 2002-02-27 2003-09-10 Cipla Ltd Purification of citalopram
GB0204607D0 (en) 2002-02-27 2002-04-10 Matrix Lab Ltd Process
EP1346989A1 (en) * 2002-03-21 2003-09-24 Jubilant Organosys Limited Improved process for the preparation of citalopram and its hydrobromide
AU2003223105A1 (en) * 2003-03-24 2004-10-18 Hetero Drugs Limited Novel crystalline forms of (s)-citalopram oxalate
US7019153B2 (en) 2003-06-10 2006-03-28 Sun Pharmaceutical Industries Limited Process for hydrogenolysis of [1-(3-dimethylamino)propyl)]-1-(4-fluorophenyl)-1,3-dihydro-5-halo-isobenzofuran acetamido-3-substituted-3-cephem-4-carboxylic acid
CN100569765C (zh) 2003-12-19 2009-12-16 杭州民生药业集团有限公司 西酞普兰中间体晶体碱
US7834201B2 (en) 2005-06-22 2010-11-16 H. Lundbeck A/S Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base
TWI358407B (en) * 2005-06-22 2012-02-21 Lundbeck & Co As H Crystalline base of escitalopram and orodispersibl

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL135959C (da) 1964-12-23
GB1143702A (da) * 1965-03-18
DE1619713A1 (de) * 1967-03-29 1970-12-17 Leybold Heraeus Gmbh & Co Kg Vorrichtung zur Vakuum- und Kurzwegdestillation
DE2135085C3 (de) 1971-07-14 1981-12-03 Basf Ag, 6700 Ludwigshafen Verfahren zur Wiedergewinnung von Caprolactam aus einem Gemisch, das Caprolactam und dessen Oligomere enthält
DE2442426C2 (de) * 1974-09-05 1983-04-07 Bayer Ag, 5090 Leverkusen Diisocyanatodiketene, Verfahren zu deren Herstellung und deren Verwendung
GB1526331A (en) * 1976-01-14 1978-09-27 Kefalas As Phthalanes
IT8020902A0 (it) 1980-03-25 1980-03-25 Snia Viscosa Procedimento ed apparecchiatura per la separazione continua per via termica di miscele liquide dicomposti termolabili.
JPS6082101A (ja) 1983-10-13 1985-05-10 Mitsui Toatsu Chem Inc 高沸点重合性化合物の薄膜蒸留による精製方法
GB8419963D0 (en) * 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
GB8814057D0 (en) * 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
FR2656305B1 (fr) 1989-12-22 1992-04-10 Norsolor Sa Procede de purification du (meth)acrylate de glycidyle.
US5296507A (en) * 1990-09-06 1994-03-22 H.Lundbeck A/S Treatment of cerbrovascular disorders
US5582692A (en) 1994-10-07 1996-12-10 Artisan Industries, Inc. Method for the purification of vitamin E
US6136991A (en) * 1996-05-21 2000-10-24 Exxon Chemical Patents Inc. Glycidyl ester adducts having increased glass transition temperatures
JP2001501587A (ja) 1996-05-21 2001-02-06 エクソン・ケミカル・パテンツ・インク エピハロヒドリン及びカルボン酸からのグリシジルエステルの改良された精製方法
DE19626659A1 (de) * 1996-07-03 1998-01-08 Basf Ag Verfahren zur Herstellung von Phthaliden
DE19627697A1 (de) * 1996-07-10 1998-01-15 Basf Ag Verfahren zur Herstellung von Phthaliden
JP3526581B2 (ja) * 1997-07-08 2004-05-17 ハー・ルンドベック・アクティーゼルスカブ シタロプラムの製造方法
DE19734673A1 (de) * 1997-08-11 1999-02-18 Rwe Dea Ag Verfahren zur Herstellung von metallfreien Guerbetalkoholen
UA62985C2 (en) * 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
AU738359B2 (en) 1997-11-11 2001-09-13 H. Lundbeck A/S Method for the preparation of citalopram
EP0965593B2 (en) * 1998-06-19 2008-12-03 Shin-Etsu Chemical Co., Ltd. Distillation of (meth)acryloxybearing alkoxysilane
WO2000023431A1 (en) * 1998-10-20 2000-04-27 H. Lundbeck A/S Method for the preparation of citalopram
AU764161B2 (en) 1998-12-23 2003-08-14 H. Lundbeck A/S Method for the preparation of 5-cyanophthalide
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
HU227473B1 (en) 1999-04-14 2011-07-28 Lundbeck & Co As H Method for preparation of citalopram
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991579A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
GB2360281B (en) 1999-10-25 2002-01-16 Lundbeck & Co As H Method for the preparation of citalopram
US6310222B1 (en) 1999-11-01 2001-10-30 Sumika Fine Chemicals Co., Ltd. Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate
GB0005477D0 (en) 2000-03-07 2000-04-26 Resolution Chemicals Limited Process for the preparation of citalopram
ES2228824T3 (es) * 2000-12-22 2005-04-16 H. Lundbeck A/S Metodo de preparacion de citalopram puro.
DE60100016T2 (de) 2000-12-28 2003-04-17 H. Lundbeck A/S, Valby Verfahren zur herstellung von reinem citalopram
US6781003B1 (en) * 2003-06-09 2004-08-24 Aurobindo Pharma Ltd. Preparation of pure citalopram

Also Published As

Publication number Publication date
CH691536A5 (de) 2001-08-15
BR0106271A (pt) 2002-05-21
WO2001047877A2 (en) 2001-07-05
FR2818977B1 (fr) 2003-12-05
NO313047B1 (no) 2002-08-05
GR20010100131A (el) 2002-10-09
HU0102818D0 (en) 2001-09-28
SK18472001A3 (sk) 2002-05-09
US20020087012A1 (en) 2002-07-04
AU3920201A (en) 2001-07-09
TR200200018T1 (tr) 2002-06-21
NO20011272L (no) 2002-07-01
FI20011578A0 (fi) 2001-07-26
EA003459B1 (ru) 2003-06-26
FI20010501A0 (fi) 2001-03-13
GB2356199A (en) 2001-05-16
EP1181272A2 (en) 2002-02-27
PT1181272E (pt) 2003-01-31
AU750006B1 (en) 2002-07-11
KR20020073379A (ko) 2002-09-26
EP1181272B1 (en) 2002-08-28
NL1017534C1 (nl) 2001-04-26
HRP20020005A2 (en) 2003-04-30
IES20010632A2 (en) 2002-03-06
CZ2001891A3 (cs) 2002-08-14
DE60100016T2 (de) 2003-04-17
ITMI20010604A0 (it) 2001-03-22
US20030178295A1 (en) 2003-09-25
ES2170733B1 (es) 2003-12-16
FR2818977A1 (fr) 2002-07-05
ITMI20010604A1 (it) 2002-09-22
GB0105981D0 (en) 2001-05-02
BG106219A (en) 2002-08-30
GB0117095D0 (en) 2001-09-05
US6855834B2 (en) 2005-02-15
HUP0102818A3 (en) 2003-07-28
HK1049332A1 (zh) 2003-05-09
ES2170733A1 (es) 2002-08-01
NZ516299A (en) 2002-12-20
DE60100016D1 (de) 2002-10-02
GB2356199B (en) 2001-10-03
CN1366526A (zh) 2002-08-28
WO2001047877A3 (en) 2001-12-27
SE0103044D0 (sv) 2001-09-14
EA200200016A1 (ru) 2002-04-25
ATE222899T1 (de) 2002-09-15
AR029898A1 (es) 2003-07-23
BE1013417A6 (fr) 2001-12-04
CA2359810C (en) 2002-11-05
AU2001100399A4 (en) 2001-11-01
KR100430746B1 (ko) 2004-05-10
AT4368U1 (de) 2001-06-25
HU0101028D0 (en) 2001-05-28
IS5884A (is) 2002-06-28
AU2001100399B4 (en) 2002-03-21
IL147162A0 (en) 2002-08-14
SE0103044L (sv) 2002-06-29
BE1013316A6 (fr) 2001-11-06
MXPA01013336A (es) 2002-07-09
HUP0102818A2 (hu) 2001-12-28
JP2003519121A (ja) 2003-06-17
FI108640B (fi) 2002-02-28
GB2361697A (en) 2001-10-31
IES20010253A2 (en) 2002-03-06
ZA200110133B (en) 2003-01-13
ES2181663T3 (es) 2003-03-01
NO20011272D0 (no) 2001-03-13
UA71635C2 (uk) 2004-12-15
SK284418B6 (sk) 2005-04-01
CA2359810A1 (en) 2001-07-05
PL353369A1 (en) 2003-11-17
CZ293140B6 (cs) 2004-02-18

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