[go: up one dir, main page]

DE69740113D1 - Vorrichtung und verfahren zur inkubation von zellen - Google Patents

Vorrichtung und verfahren zur inkubation von zellen

Info

Publication number
DE69740113D1
DE69740113D1 DE69740113T DE69740113T DE69740113D1 DE 69740113 D1 DE69740113 D1 DE 69740113D1 DE 69740113 T DE69740113 T DE 69740113T DE 69740113 T DE69740113 T DE 69740113T DE 69740113 D1 DE69740113 D1 DE 69740113D1
Authority
DE
Germany
Prior art keywords
incubating cells
incubating
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69740113T
Other languages
English (en)
Inventor
Raymond K Houck
Joel S Greenberger
Paul A Dimilla
Michael M Domach
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Pittsburgh
Original Assignee
University of Pittsburgh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24981507&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69740113(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by University of Pittsburgh filed Critical University of Pittsburgh
Application granted granted Critical
Publication of DE69740113D1 publication Critical patent/DE69740113D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/12—Well or multiwell plates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C12M41/36—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of biomass, e.g. colony counters or by turbidity measurements
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/46—Means for regulation, monitoring, measurement or control, e.g. flow regulation of cellular or enzymatic activity or functionality, e.g. cell viability
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/48—Automatic or computerized control
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/34—Microscope slides, e.g. mounting specimens on microscope slides
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/16—Microscopes adapted for ultraviolet illumination ; Fluorescence microscopes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/802—Logarithmic growth phase
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/808—Optical sensing apparatus
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/809—Incubators or racks or holders for culture plates or containers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/813—Continuous fermentation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Sustainable Development (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Clinical Laboratory Science (AREA)
  • Computer Hardware Design (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Optics & Photonics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Diabetes (AREA)
DE69740113T 1996-11-01 1997-10-31 Vorrichtung und verfahren zur inkubation von zellen Expired - Lifetime DE69740113D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/741,628 US6008010A (en) 1996-11-01 1996-11-01 Method and apparatus for holding cells
PCT/US1997/019834 WO1998020108A1 (en) 1996-11-01 1997-10-31 A method and apparatus for holding cells

Publications (1)

Publication Number Publication Date
DE69740113D1 true DE69740113D1 (de) 2011-03-17

Family

ID=24981507

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69740113T Expired - Lifetime DE69740113D1 (de) 1996-11-01 1997-10-31 Vorrichtung und verfahren zur inkubation von zellen

Country Status (7)

Country Link
US (6) US6008010A (de)
EP (1) EP0877792B1 (de)
JP (2) JP4099236B2 (de)
AU (1) AU742909B2 (de)
CA (1) CA2239815C (de)
DE (1) DE69740113D1 (de)
WO (1) WO1998020108A1 (de)

Families Citing this family (189)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6008010A (en) * 1996-11-01 1999-12-28 University Of Pittsburgh Method and apparatus for holding cells
AU9786798A (en) * 1997-10-10 1999-05-03 Biosepra Inc. Aligned multiwell multiplate stack and method for processing biological/chemicalsamples using the same
ATE205300T1 (de) * 1997-12-17 2001-09-15 Ecole Polytech Positionierung und elektrophysiologische charakterisierung einzelner zellen und rekonstituierter membransysteme auf mikrostrukturierten trägern
US7244349B2 (en) 1997-12-17 2007-07-17 Molecular Devices Corporation Multiaperture sample positioning and analysis system
US20020144905A1 (en) * 1997-12-17 2002-10-10 Christian Schmidt Sample positioning and analysis system
US20060105357A1 (en) * 1998-02-18 2006-05-18 Myomics, Inc. Tissue sensor and uses thereof
EP1088096B1 (de) * 1998-02-18 2005-10-12 Herman H. Vandenburgh Verfahren zum screenen von verbindungen mit bioaktivität in organgeweben
US6743576B1 (en) 1999-05-14 2004-06-01 Cytokinetics, Inc. Database system for predictive cellular bioinformatics
US6651008B1 (en) 1999-05-14 2003-11-18 Cytokinetics, Inc. Database system including computer code for predictive cellular bioinformatics
US7151847B2 (en) * 2001-02-20 2006-12-19 Cytokinetics, Inc. Image analysis of the golgi complex
EP1203227A4 (de) * 1999-06-04 2003-01-02 Bioseparations Inc Pränatales diagnostisches testsystem und -verfahren
US6545004B1 (en) 1999-10-27 2003-04-08 Cytokinetics, Inc. Methods and compositions utilizing quinazolinones
US7230000B1 (en) 1999-10-27 2007-06-12 Cytokinetics, Incorporated Methods and compositions utilizing quinazolinones
US7485454B1 (en) 2000-03-10 2009-02-03 Bioprocessors Corp. Microreactor
JP4402249B2 (ja) * 2000-03-31 2010-01-20 正仁 田谷 細胞培養方法、細胞培養装置及び記録媒体
GB0013261D0 (en) * 2000-05-31 2000-07-19 Surface Measurement Systems Lt Controlled sample environment for analytical devices
US20020049544A1 (en) * 2000-06-23 2002-04-25 Cytokinetics, Inc. Image analysis for phenotyping sets of mutant cells
US7193711B2 (en) * 2000-07-11 2007-03-20 Maven Technologies, Llc Imaging method and apparatus
US7518724B2 (en) * 2000-07-11 2009-04-14 Maven Technologies Image acquisition, processing, and display
US7126688B2 (en) * 2000-07-11 2006-10-24 Maven Technologies, Llc Microarray scanning
US6594011B1 (en) 2000-07-11 2003-07-15 Maven Technologies, Llc Imaging apparatus and method
US6833920B2 (en) 2000-07-11 2004-12-21 Maven Technologies Llc Apparatus and method for imaging
US7023547B2 (en) 2000-07-11 2006-04-04 Maven Technologies, Llc Apparatus including a biochip for imaging of biological samples and method
US7270730B2 (en) 2000-08-04 2007-09-18 Essen Instruments, Inc. High-throughput electrophysiological measurement system
US7067046B2 (en) 2000-08-04 2006-06-27 Essen Instruments, Inc. System for rapid chemical activation in high-throughput electrophysiological measurements
EP1325110A4 (de) * 2000-10-02 2009-03-25 Thomas F Cannon Automatisches system für biokulturen und biokulturexperimente
US20020146817A1 (en) * 2000-10-02 2002-10-10 Cannon Thomas F. Automated bioculture and bioculture experiments system
US7198940B2 (en) * 2000-10-25 2007-04-03 Shot Hardware Optimization Technology, Inc. Bioreactor apparatus and cell culturing system
US6699665B1 (en) * 2000-11-08 2004-03-02 Surface Logix, Inc. Multiple array system for integrating bioarrays
US7326563B2 (en) 2000-11-08 2008-02-05 Surface Logix, Inc. Device and method for monitoring leukocyte migration
US6864065B2 (en) * 2000-11-08 2005-03-08 Surface Logix, Inc. Assays for monitoring cell motility in real-time
US6844184B2 (en) * 2000-11-08 2005-01-18 Surface Logix, Inc. Device for arraying biomolecules and for monitoring cell motility in real-time
US7374906B2 (en) 2000-11-08 2008-05-20 Surface Logix, Inc. Biological assays using gradients formed in microfluidic systems
US6893851B2 (en) 2000-11-08 2005-05-17 Surface Logix, Inc. Method for arraying biomolecules and for monitoring cell motility in real-time
US7033819B2 (en) 2000-11-08 2006-04-25 Surface Logix, Inc. System for monitoring cell motility in real-time
US7033821B2 (en) * 2000-11-08 2006-04-25 Surface Logix, Inc. Device for monitoring cell motility in real-time
US20030007894A1 (en) * 2001-04-27 2003-01-09 Genoptix Methods and apparatus for use of optical forces for identification, characterization and/or sorting of particles
US6936811B2 (en) 2000-11-13 2005-08-30 Genoptix, Inc. Method for separating micro-particles
US20020121443A1 (en) * 2000-11-13 2002-09-05 Genoptix Methods for the combined electrical and optical identification, characterization and/or sorting of particles
US7218764B2 (en) * 2000-12-04 2007-05-15 Cytokinetics, Inc. Ploidy classification method
US6555365B2 (en) 2000-12-07 2003-04-29 Biocrystal, Ltd. Microincubator comprising a cell culture apparatus and a transparent heater
US6589780B2 (en) 2000-12-15 2003-07-08 Council Of Scientific And Industrial Research Bio-reactor for enhancing the biomass yield of plant organs
US6599694B2 (en) 2000-12-18 2003-07-29 Cytokinetics, Inc. Method of characterizing potential therapeutics by determining cell-cell interactions
US6635441B2 (en) 2001-02-08 2003-10-21 Irm, Llc Multi-sample fermentor and method of using same
FR2820756B1 (fr) * 2001-02-09 2004-01-23 Daniel Attias Incubateur et procede d'incubation menageant l'organisme mis a incuber
US7016787B2 (en) 2001-02-20 2006-03-21 Cytokinetics, Inc. Characterizing biological stimuli by response curves
US6956961B2 (en) * 2001-02-20 2005-10-18 Cytokinetics, Inc. Extracting shape information contained in cell images
JP2002315566A (ja) * 2001-04-24 2002-10-29 Takagi Ind Co Ltd 細胞・組織培養装置
US20040023310A1 (en) * 2001-04-27 2004-02-05 Genoptix, Inc Quantitative determination of protein kinase C activation using optophoretic analysis
US20030124516A1 (en) * 2001-04-27 2003-07-03 Genoptix, Inc. Method of using optical interrogation to determine a biological property of a cell or population of cells
US6830931B2 (en) * 2001-07-12 2004-12-14 Automated Cell, Inc. Method and apparatus for monitoring of proteins and cells
US7169578B2 (en) * 2001-07-27 2007-01-30 Surface Logix, Inc. Cell isolation and screening device and method of using same
US7169577B2 (en) * 2001-07-27 2007-01-30 Surface Logix, Inc. Cell isolation and screening device and method of using same
US7285412B2 (en) * 2001-07-27 2007-10-23 Surface Logix Inc. Device for magnetic immobilization of cells
US6673595B2 (en) 2001-08-27 2004-01-06 Biocrystal, Ltd Automated cell management system for growth and manipulation of cultured cells
US20040071328A1 (en) * 2001-09-07 2004-04-15 Vaisberg Eugeni A. Classifying cells based on information contained in cell images
TW581119U (en) * 2001-12-19 2004-03-21 Univ Nat Cheng Kung Petri dish for microscope
CA2476072A1 (en) 2002-02-13 2003-09-18 Reify Corporation Method and apparatus for acquisition, compression, and characterization of spatiotemporal signals
US7009049B2 (en) 2002-02-15 2006-03-07 Cytokinetics, Inc. Syntheses of quinazolinones
JP2005522679A (ja) 2002-04-12 2005-07-28 インストゥルメンテイション ラボラトリー カンパニー イムノアッセイプローブ
US7507579B2 (en) * 2002-05-01 2009-03-24 Massachusetts Institute Of Technology Apparatus and methods for simultaneous operation of miniaturized reactors
US20060199260A1 (en) * 2002-05-01 2006-09-07 Zhiyu Zhang Microbioreactor for continuous cell culture
US20040033539A1 (en) * 2002-05-01 2004-02-19 Genoptix, Inc Method of using optical interrogation to determine a biological property of a cell or population of cells
AU2003223786A1 (en) 2002-05-09 2003-11-11 Cytokinetics, Inc. Compounds, methods and compositions
US7214800B2 (en) 2002-05-09 2007-05-08 Cytokinetics, Inc. Compounds, compositions, and methods
WO2004015061A2 (en) * 2002-05-17 2004-02-19 Automated Cell, Inc. Determination of protein function
US7038048B2 (en) 2002-05-23 2006-05-02 Cytokinetics, Inc. 3H-pyridopyrimidin-4-one compounds, compositions, and methods of their use
JP2005538062A (ja) 2002-06-14 2005-12-15 サイトキネティクス・インコーポレーテッド 化合物、組成物、および方法
AU2003256805A1 (en) 2002-07-23 2004-02-09 Cytokinetics, Inc. Compounds compositions and methods
US11243494B2 (en) 2002-07-31 2022-02-08 Abs Global, Inc. Multiple laminar flow-based particle and cellular separation with laser steering
US20040044300A1 (en) * 2002-09-03 2004-03-04 Donnie Rudd Method of replenishing cells damaged by treatment for cancer
US20040043009A1 (en) * 2002-09-03 2004-03-04 Donnie Rudd Method of repairing primate mammalian tissue
US20040076620A1 (en) * 2002-09-03 2004-04-22 Donnie Rudd Method of repairing primate mammalian tissue
US20040076605A1 (en) * 2002-09-03 2004-04-22 Donnie Rudd Method of regenerating human tissue
US20040042997A1 (en) * 2002-09-03 2004-03-04 Donnie Rudd Method of regenerating human tissue
US20040077985A1 (en) * 2002-09-03 2004-04-22 Donnie Rudd Method of replenishing cells damaged by treatment for cancer
ATE531257T1 (de) 2002-09-27 2011-11-15 Gen Hospital Corp Mikrofluidische vorrichtung zur zelltrennung und verwendungen davon
US7557115B2 (en) 2002-09-30 2009-07-07 Cytokinetics, Inc. Compounds, compositions, and methods
US20040128077A1 (en) * 2002-12-27 2004-07-01 Automated Cell, Inc. Method and apparatus for following cells
US7091035B2 (en) * 2002-12-30 2006-08-15 The United States Of America As Represented By The Department Of Health And Human Services Cell culturing and storage systems, devices and methods
FI115060B (fi) * 2003-04-22 2005-02-28 Chip Man Technologies Oy Analyysi- ja kasvatuslaitteisto
WO2005010677A2 (en) * 2003-07-18 2005-02-03 Cytokinetics, Inc. Characterizing biological stimuli by response curves
US20050014217A1 (en) * 2003-07-18 2005-01-20 Cytokinetics, Inc. Predicting hepatotoxicity using cell based assays
US7235353B2 (en) * 2003-07-18 2007-06-26 Cytokinetics, Inc. Predicting hepatotoxicity using cell based assays
CN1860363B (zh) 2003-08-28 2011-12-28 赛路拉公司 用于在微流通道网络中使用光学开关将细胞分类的方法和设备
US7799559B2 (en) * 2003-10-24 2010-09-21 Olympus Corporation Culture microscope apparatus
JP2007513154A (ja) 2003-12-08 2007-05-24 サイトキネティクス・インコーポレーテッド 化合物、組成物及び方法
US20050273271A1 (en) * 2004-04-05 2005-12-08 Aibing Rao Method of characterizing cell shape
EP1756262B1 (de) * 2004-05-26 2013-12-04 Octane Biotech Inc. Fortgeschrittenes gewebekonstruktionssystem
US20050282268A1 (en) * 2004-05-26 2005-12-22 Olympus Corporation Culture microscope and computer program controlling culture microscope
US8211386B2 (en) 2004-06-08 2012-07-03 Biokit, S.A. Tapered cuvette and method of collecting magnetic particles
KR100563297B1 (ko) * 2004-06-16 2006-03-27 시 명 김 골프공 이송장치
US7456019B2 (en) 2004-06-30 2008-11-25 Regenetech, Inc. Three-dimensional cell to tissue development process
US20060228795A1 (en) * 2004-06-30 2006-10-12 Parker Clayton R Apparatus for enhancing proliferation of cells in a small-scale cell culturing container
US20080044890A1 (en) * 2004-06-30 2008-02-21 Parker Clayton R Interchangable sleeve for enhancing proliferation of cells in a rotating bioreactor
FI117899B (fi) * 2004-07-09 2007-04-13 Chip Man Technologies Oy Solujen kasvatusalusta ja sen käyttö
FI116946B (fi) * 2004-07-09 2006-04-13 Chip Man Technologies Oy Laitteisto solujen kuvaamiseksi
US20070031818A1 (en) * 2004-07-15 2007-02-08 Cytokinetics, Inc., A Delaware Corporation Assay for distinguishing live and dead cells
US7323318B2 (en) * 2004-07-15 2008-01-29 Cytokinetics, Inc. Assay for distinguishing live and dead cells
US20060133657A1 (en) * 2004-08-18 2006-06-22 Tripath Imaging, Inc. Microscopy system having automatic and interactive modes for forming a magnified mosaic image and associated method
JP2006197880A (ja) * 2005-01-21 2006-08-03 Fujitsu Ltd 細胞捕捉装置および細胞捕捉方法
JP4214124B2 (ja) * 2005-03-14 2009-01-28 株式会社バイオエコーネット 耳式体温計
JP4932703B2 (ja) * 2005-03-22 2012-05-16 株式会社メディネット 細胞培養評価システム、細胞培養評価方法および細胞培養評価プログラム
US20070196820A1 (en) 2005-04-05 2007-08-23 Ravi Kapur Devices and methods for enrichment and alteration of cells and other particles
JP2007024576A (ja) * 2005-07-13 2007-02-01 Fujifilm Holdings Corp 細胞重層培養物における毒性試験装置
US8921102B2 (en) 2005-07-29 2014-12-30 Gpb Scientific, Llc Devices and methods for enrichment and alteration of circulating tumor cells and other particles
JP5010867B2 (ja) * 2005-09-22 2012-08-29 オリンパス株式会社 培養顕微鏡装置
WO2007052716A1 (ja) * 2005-11-01 2007-05-10 Medinet Co., Ltd. 細胞培養装置、細胞培養方法、細胞培養プログラム、及び細胞培養システム
JP4821279B2 (ja) * 2005-11-11 2011-11-24 株式会社ニコン 培養装置
JP5086559B2 (ja) * 2006-04-10 2012-11-28 株式会社島津製作所 反応容器及び反応容器処理装置
EP2006371A4 (de) * 2006-04-13 2012-05-02 Res Org Information & Systems Inkubationsvorrichtung mit mehreren vertiefungen und analyseverfahren unter verwendung davon
JP4921858B2 (ja) 2006-06-07 2012-04-25 オリンパス株式会社 画像処理装置および画像処理プログラム
US20080050739A1 (en) 2006-06-14 2008-02-28 Roland Stoughton Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats
EP2589668A1 (de) 2006-06-14 2013-05-08 Verinata Health, Inc Analyse seltener Zellen mittels Probentrennung und DNA-Etiketten
JP2007334141A (ja) * 2006-06-16 2007-12-27 Sanyo Electric Co Ltd 培養物観察システム
JP5021254B2 (ja) * 2006-09-06 2012-09-05 オリンパス株式会社 顕微鏡装置の制御方法、顕微鏡装置
US20080180793A1 (en) * 2007-01-26 2008-07-31 Cellomics, Inc. High content screening system with live cell chamber
US7867783B2 (en) 2007-02-22 2011-01-11 Maven Technologies, Llc Apparatus and method for performing ligand binding assays on microarrays in multiwell plates
US20080206845A1 (en) * 2007-02-23 2008-08-28 Emilio Barbera-Guillem Bioreactor analysis system
US7863037B1 (en) 2007-04-04 2011-01-04 Maven Technologies, Llc Ligand binding assays on microarrays in closed multiwell plates
US20090041633A1 (en) * 2007-05-14 2009-02-12 Dultz Shane C Apparatus and method for performing ligand binding assays on microarrays in multiwell plates
US7799558B1 (en) 2007-05-22 2010-09-21 Dultz Shane C Ligand binding assays on microarrays in closed multiwell plates
JP5446082B2 (ja) * 2007-10-05 2014-03-19 株式会社ニコン 細胞観察装置および細胞観察方法
US8969257B1 (en) * 2007-12-28 2015-03-03 Intermolecular, Inc. Combinatorial flow system and method
US9921576B2 (en) * 2008-05-05 2018-03-20 Finesse Solutions, Inc. Virtual transmitter for bioreactor automation system
US8039270B2 (en) * 2008-05-22 2011-10-18 Maven Technologies, Llc Apparatus and method for performing ligand binding assays on microarrays in multiwell plates
US7981664B1 (en) 2008-05-22 2011-07-19 Maven Technologies, Llc Apparatus and method for performing ligand binding assays on microarrays in multiwell plates
JP5191292B2 (ja) * 2008-07-08 2013-05-08 オリンパス株式会社 培養装置
DK200801722A (en) 2008-12-05 2010-06-06 Unisensor As Optical sectioning of a sample and detection of particles in a sample
JPWO2011004568A1 (ja) * 2009-07-08 2012-12-20 株式会社ニコン 受精卵観察の画像処理方法、画像処理プログラム及び画像処理装置、並びに受精卵の製造方法
BR112012003847B1 (pt) 2009-08-22 2020-12-01 The Board Of Trustees Of The Leland Standford Junior University método para selecionar um ou mais embriões humanos que provavelmente alcançarão o estágio de blastocisto
KR20120089769A (ko) * 2009-12-04 2012-08-13 유니센서 에이/에스 생물학적 유기체의 시간-관련 현미경 검사용 시스템 및 방법
US8355133B2 (en) * 2009-12-30 2013-01-15 Maven Technologies, Llc Biological testing with sawtooth-shaped prisms
US8865630B2 (en) 2010-02-26 2014-10-21 Massachusetts Institute Of Technology High-throughput platform for in-vivo sub-cellular screens on vertebrate larvae
WO2011107102A1 (en) 2010-03-04 2011-09-09 Unisensor A/S Flexible sample container
EP2621344B1 (de) 2010-09-27 2023-12-27 Ares Trading S.A. Vorrichtung, verfahren und system zur automatisierten abbildung und bewertung von embryonen, eizellen und stammzellen
JP2014502146A (ja) * 2010-10-25 2014-01-30 政彦 佐藤 弁別的細胞イベントの定量的な識別を行う装置及び方法
US10908066B2 (en) 2010-11-16 2021-02-02 1087 Systems, Inc. Use of vibrational spectroscopy for microfluidic liquid measurement
US20120225475A1 (en) 2010-11-16 2012-09-06 1087 Systems, Inc. Cytometry system with quantum cascade laser source, acoustic detector, and micro-fluidic cell handling system configured for inspection of individual cells
US8941062B2 (en) 2010-11-16 2015-01-27 1087 Systems, Inc. System for identifying and sorting living cells
US8834794B2 (en) * 2010-11-22 2014-09-16 Mehdi M Yazdanpanah Apparatus and methods for detection of tumor cells in blood
EP2484750A1 (de) 2011-02-07 2012-08-08 Ecole Polytechnique Fédérale de Lausanne (EPFL) System zur Überwachung von Zellkulturen
WO2012116185A1 (en) 2011-02-23 2012-08-30 The Board Of Trustees Of The Leland Stanford Junior University Methods of detecting aneuploidy in human embryos
DE202011000688U1 (de) * 2011-03-25 2011-06-09 Leica Microsystems CMS GmbH, 35578 Vorrichtung zur Aufnahme von Filtern für Mikroskope
JP5707601B2 (ja) * 2011-03-28 2015-04-30 日本光電工業株式会社 細胞培養装置
WO2012140264A2 (en) * 2011-04-15 2012-10-18 Fluofarma System and method to visualize and analyze data from image-based cellular assays or high content screening
US8974606B2 (en) 2011-05-09 2015-03-10 Intermolecular, Inc. Ex-situ cleaning assembly
JP5802751B2 (ja) * 2011-06-27 2015-11-04 株式会社日立製作所 細胞培養装置および細胞培養方法
EP2612908A3 (de) * 2012-01-04 2014-10-15 Technion Research & Development Foundation Limited Optisch empfindliches Zellennetzwerk
JP2013145318A (ja) * 2012-01-13 2013-07-25 Sony Corp 測定装置、プログラム及び測定方法
US8741247B2 (en) 2012-03-27 2014-06-03 Alstom Technology Ltd Method and system for low energy carbon dioxide removal
JP2013255447A (ja) * 2012-06-12 2013-12-26 Nippon Koden Corp 細胞単離装置
JP5954079B2 (ja) * 2012-09-25 2016-07-20 ソニー株式会社 培養観察装置及び培養観察方法
CA2900741C (en) 2013-02-01 2022-01-18 Progyny, Inc. Abnormal syngamy phenotypes observed with time lapse imaging for early identification of embryos with lower developmental potential
CA2903069C (en) * 2013-03-01 2021-07-06 Genea Ltd Apparatus, method and system for cultured sample development monitoring
CN115074413A (zh) * 2013-03-28 2022-09-20 英属哥伦比亚大学 微流控装置及其在多细胞分泌检测中的使用方法
DE102013007463A1 (de) 2013-04-30 2014-10-30 Carl Zeiss Microscopy Gmbh Einrichtung zur Sterilisation eines Probenraums in einem Lebendzellmikroskop
US20140340499A1 (en) * 2013-05-14 2014-11-20 Life Technologies Corporation Systems and methods for sample image capture using integrated control
US8961904B2 (en) 2013-07-16 2015-02-24 Premium Genetics (Uk) Ltd. Microfluidic chip
US11796449B2 (en) 2013-10-30 2023-10-24 Abs Global, Inc. Microfluidic system and method with focused energy apparatus
JP2018509615A (ja) 2015-02-19 2018-04-05 プレミアム ジェネティクス （ユーケー） リミテッド 走査型赤外線測定システム
US11494578B1 (en) * 2015-09-21 2022-11-08 Ares Trading S.A. Systems and methods for automated assessment of embryo quality using image based features
US10510143B1 (en) * 2015-09-21 2019-12-17 Ares Trading S.A. Systems and methods for generating a mask for automated assessment of embryo quality
WO2017087698A1 (en) * 2015-11-18 2017-05-26 President And Fellows Of Harvard College Incubator insert for automated culture experimentation
US10691773B2 (en) 2015-12-30 2020-06-23 General Electric Company Cell processing techniques
US9995696B2 (en) * 2016-02-02 2018-06-12 Daniel Marc Himmel Open-air crystallization plate cooler
WO2017147427A1 (en) * 2016-02-26 2017-08-31 Seattle Biomedical Research Institute System and method for microscopic observation of microbial fitness
US10453551B2 (en) * 2016-06-08 2019-10-22 X Development Llc Simulating living cell in silico
US11473047B2 (en) * 2016-07-19 2022-10-18 The Automation Partnership (Cambridge) Limited Liquid filtration and pump system
WO2018044699A1 (en) 2016-08-27 2018-03-08 3D Biotek, Llc Bioreactor
US10144537B2 (en) 2016-11-30 2018-12-04 Mallinckrodt Nuclear Medicine Llc Systems and methods for dispensing radioactive liquids
JP2020528284A (ja) 2017-09-01 2020-09-24 ロンザ ウォーカーズヴィル，インコーポレーテッド エンドツーエンド細胞療法の自動化
US10247724B1 (en) 2017-09-28 2019-04-02 Autobiologic Inc. Optically clear sealable petri dish bioreactor
DE102017124840B3 (de) * 2017-10-24 2018-12-13 Testo SE & Co. KGaA Inkubator, Probenbehälter, Set und Verfahren zur Untersuchung eines Probenmaterials
BR112020023607A2 (pt) 2018-05-23 2021-02-17 Abs Global, Inc. sistemas e métodos para focalização de partículas em microcanais
US10988726B2 (en) 2018-08-19 2021-04-27 Cytera Cellworks Limited Systems and methods for automated cell culturing
SG11202106384YA (en) 2018-12-21 2021-07-29 Octane Biotech Inc Carousel for modular biologic production units
JP7598864B2 (ja) 2018-12-21 2024-12-12 ロンザ ウォーカーズヴィル，インコーポレーテッド ウイルスベクターの自動産生方法
KR20210110322A (ko) 2018-12-28 2021-09-07 옥테인 바이오테크 인코포레이티드 제어된 환경 존을 포함하는 세포 배양 및 조직 공학 시스템
EP3914690A4 (de) 2019-02-08 2022-11-09 Lonza Walkersville, Inc. Verfahren und vorrichtungen zur bestimmung der zellkonzentration in automatisierten bioreaktoren
CA3132973A1 (en) 2019-03-11 2020-09-17 Forever Labs, Inc. Dynamic incubator system and method
BR112021020390A2 (pt) 2019-04-18 2022-01-18 Abs Global Inc Sistema de distribuição de crioprotetor, sistema de criopreservação para distribuir um crioprotetor a um espécime biológico, método para distribuir um crioprotetor a um espécime biológico, sistema de distribuição e método para preparar um espécime biológico para criopreservação
WO2021068060A1 (en) * 2019-10-07 2021-04-15 Incuvers Inc. Incubator imaging system
IL292409A (en) 2019-10-24 2022-06-01 Octane Biotech Inc Cell culture chamber with improved cell-contacting surfaces
WO2021092612A1 (en) * 2019-11-08 2021-05-14 Colgate-Palmolive Company Apparatus, system, and method for testing biological samples
CN114667341A (zh) 2019-11-11 2022-06-24 隆萨沃克斯维尔股份有限公司 用于自动化细胞处理的质量控制方法
US11628439B2 (en) 2020-01-13 2023-04-18 Abs Global, Inc. Single-sheath microfluidic chip
US12135270B2 (en) 2020-11-23 2024-11-05 Abs Global, Inc. Modular flow cytometry systems and methods of processing samples
JPWO2022130884A1 (de) * 2020-12-18 2022-06-23

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5212982A (en) * 1975-07-22 1977-01-31 Olympus Optical Co Ltd Apparatus for automatic incubation
US4210724A (en) * 1977-03-28 1980-07-01 Olympus Optical Co., Ltd. Apparatus for liquid disposal and distribution in automatic culture system
US4344816A (en) 1980-12-19 1982-08-17 Bell Telephone Laboratories, Incorporated Selectively etched bodies
JPS58155087A (ja) 1982-03-12 1983-09-14 Olympus Optical Co Ltd 細胞の自動培養装置
US5310674A (en) * 1982-05-10 1994-05-10 Bar-Ilan University Apertured cell carrier
US4647531A (en) 1984-02-06 1987-03-03 Ortho Diagnostic Systems, Inc. Generalized cytometry instrument and methods of use
US4711851A (en) * 1984-05-21 1987-12-08 State University Of New York Test apparatus for determining a metabolic characteristic of microorganisms
FR2567538B1 (fr) * 1984-07-12 1986-12-26 Inst Nat Sante Rech Med Automate pour l'analyse et le clonage de cultures cellulaires ainsi que pour l'analyse bacteriologique
WO1986001824A1 (fr) * 1984-09-18 1986-03-27 Sumitomo Electric Industries, Ltd. Installation de triage de cellules
US4673988A (en) 1985-04-22 1987-06-16 E.I. Du Pont De Nemours And Company Electronic mosaic imaging process
US4676951A (en) * 1985-07-01 1987-06-30 American Hospital Supply Corp. Automatic specimen analyzing system
US4859584A (en) 1986-10-31 1989-08-22 Smithkline Beckman Corporation Cell growth rate determination by measurement of changes in cyanine dye levels in plasma membranes
US4783401A (en) 1986-10-31 1988-11-08 Smithkline Beckman Corporation Viable cell labelling
US4762701A (en) 1986-10-31 1988-08-09 Smithkline Beckman Corporation In vivo cellular tracking
US4892830A (en) * 1987-04-02 1990-01-09 Baylor College Of Medicine Environmentally controlled in vitro incubator
US5162204A (en) * 1988-05-06 1992-11-10 Hitachi, Ltd. Apparatus and method of culturing and diagnosis of animal cells using image processing
DE3836716A1 (de) 1988-10-28 1990-05-03 Zeiss Carl Fa Verfahren zur auswertung von zellbildern
US5072382A (en) 1989-10-02 1991-12-10 Kamentsky Louis A Methods and apparatus for measuring multiple optical properties of biological specimens
US5107422A (en) 1989-10-02 1992-04-21 Kamentsky Louis A Method and apparatus for measuring multiple optical properties of biological specimens
JP2510771B2 (ja) * 1990-07-25 1996-06-26 株式会社日立製作所 培養生体の活性診断方法及びシステム
US5548661A (en) 1991-07-12 1996-08-20 Price; Jeffrey H. Operator independent image cytometer
US5790710A (en) 1991-07-12 1998-08-04 Jeffrey H. Price Autofocus system for scanning microscopy
JPH0549467A (ja) 1991-08-23 1993-03-02 Tokimec Inc 培養細胞観察装置
US5612188A (en) * 1991-11-25 1997-03-18 Cornell Research Foundation, Inc. Automated, multicompartmental cell culture system
US5670113A (en) 1991-12-20 1997-09-23 Sibia Neurosciences, Inc. Automated analysis equipment and assay method for detecting cell surface protein and/or cytoplasmic receptor function using same
GB9212164D0 (en) 1992-06-09 1992-07-22 Medical Res Council Preparation of nucleic acids
US5355215A (en) 1992-09-30 1994-10-11 Environmental Research Institute Of Michigan Method and apparatus for quantitative fluorescence measurements
WO1994008759A1 (en) * 1992-10-16 1994-04-28 Thomas Jefferson University Method and apparatus for robotically performing sanger dideoxynucleotide dna sequencing reactions
ATE220200T1 (de) 1994-08-01 2002-07-15 Abbott Lab Pseudo-telezentrischer optischer aufbau für ein durchflusszytometrisches analysegerät für blutzellen
US5656499A (en) * 1994-08-01 1997-08-12 Abbott Laboratories Method for performing automated hematology and cytometry analysis
US5732150A (en) 1995-09-19 1998-03-24 Ihc Health Services, Inc. Method and system for multiple wavelength microscopy image analysis
US6103479A (en) 1996-05-30 2000-08-15 Cellomics, Inc. Miniaturized cell array methods and apparatus for cell-based screening
US6008010A (en) * 1996-11-01 1999-12-28 University Of Pittsburgh Method and apparatus for holding cells
US5885840A (en) 1997-02-10 1999-03-23 Compucyte Corp. Multiple assays of cell specimens
US6416959B1 (en) 1997-02-27 2002-07-09 Kenneth Giuliano System for cell-based screening

Also Published As

Publication number Publication date
EP0877792B1 (de) 2011-02-02
US8445261B2 (en) 2013-05-21
CA2239815C (en) 2011-10-25
JP4099236B2 (ja) 2008-06-11
EP0877792A1 (de) 1998-11-18
JP2001500744A (ja) 2001-01-23
US7867752B1 (en) 2011-01-11
US8859263B2 (en) 2014-10-14
JP4203108B2 (ja) 2008-12-24
US6008010A (en) 1999-12-28
AU5159298A (en) 1998-05-29
US20140371112A1 (en) 2014-12-18
EP0877792A4 (de) 2006-04-12
US20110195055A1 (en) 2011-08-11
WO1998020108A1 (en) 1998-05-14
AU742909B2 (en) 2002-01-17
CA2239815A1 (en) 1998-05-14
JP2008092957A (ja) 2008-04-24
US8241892B2 (en) 2012-08-14
US20020155487A1 (en) 2002-10-24
US20130023041A1 (en) 2013-01-24

Similar Documents

Publication Publication Date Title
DE69740113D1 (de) Vorrichtung und verfahren zur inkubation von zellen
DE69815085D1 (de) System und verfahren zur klassifizierrung von zellproben
DE69827019D1 (de) Gerät und verfahren zur verarbeitung von biologischen zellen
EP0927880A4 (de) Vorrichtung und verfahren zur probenvorbereitung
DE69731116D1 (de) Verfahren und vorrichtung zur energiegewinnung
DE69831991D1 (de) Verfahren und Vorrichtung zur Sprachdetektion
DE69434913D1 (de) Verfahren und Vorrichtung zur Isolierung von Mikrogefässzellen
DE69822687D1 (de) Vorrichtung und Verfahren zur Zusammenfassung
ATE237793T1 (de) Verfahren und vorrichtung zur kantenverfolgung und kantenprüfung
DE69835511D1 (de) Verfahren und Vorrichtung zur Durckimpulsbetätigte Telemetrie
DE69629098D1 (de) Verfahren und Vorrichtung zur Belastungsprüfung
DE69718453D1 (de) Verfahren und vorrichtung zur batterieladung
DE69940804D1 (de) Verfahren und vorrichtung zur unterdrückung von abklingartefakten
DE59705591D1 (de) Verfahren und vorrichtung zur qualitativen beurteilung von bearbeitetem material
DE59601862D1 (de) Verfahren und Vorrichtung zur Elektrolyse
DE69735547D1 (de) Verfahren zur induzierung von immunsupprimierten zellen und vorrichtung zu deren kultivierung
EP1222249A4 (de) Verfahren und vorrichtung zur kultivierung von zellen
DE69719477D1 (de) Vorrichtung und Verfahren zur Eingabe von Buchstaben
DE59610857D1 (de) Verfahren und Vorrichtung zur Ueberwachung von Systemeinheiten
DE69818981D1 (de) Vorrichtung und verfahren zur kristallisation
DE69719934D1 (de) Verfahren und Vorrichtung zur schnellen und sicheren Datensammlung
DE69534698D1 (de) Verfahren und Vorrichtung zum Vermittlen von Zellen
DE69819227D1 (de) Vorrichtung und Verfahren zur Trübungsmessung
DE69926451D1 (de) Verfahren und Vorrichtung zur Unterdrückung von Mehrkanalechos
DE69837575D1 (de) Vorrichtung und Verfahren zur Inkubation von Teststreifen