[go: up one dir, main page]

DE68918004D1 - Verfahren zur Analyse von Zellbestandteilen in einer Flüssigkeit. - Google Patents

Verfahren zur Analyse von Zellbestandteilen in einer Flüssigkeit.

Info

Publication number
DE68918004D1
DE68918004D1 DE68918004T DE68918004T DE68918004D1 DE 68918004 D1 DE68918004 D1 DE 68918004D1 DE 68918004 T DE68918004 T DE 68918004T DE 68918004 T DE68918004 T DE 68918004T DE 68918004 D1 DE68918004 D1 DE 68918004D1
Authority
DE
Germany
Prior art keywords
analysis
liquid
cell components
nucleic acid
cell surface
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE68918004T
Other languages
English (en)
Other versions
DE68918004T2 (de
Inventor
Michael R Loken
Leon W M M Terstappen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Becton Dickinson and Co
Original Assignee
Becton Dickinson and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Becton Dickinson and Co filed Critical Becton Dickinson and Co
Publication of DE68918004D1 publication Critical patent/DE68918004D1/de
Application granted granted Critical
Publication of DE68918004T2 publication Critical patent/DE68918004T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • G01N33/56972—White blood cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1456—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
    • G01N15/1459—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals the analysis being performed on a sample stream
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • G01N33/56977—HLA or MHC typing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N2015/1006—Investigating individual particles for cytology
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N2015/1402—Data analysis by thresholding or gating operations performed on the acquired signals or stored data
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/973—Simultaneous determination of more than one analyte
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/80—Fluorescent dyes, e.g. rhodamine
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/805—Optical property
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333—Saccharide [e.g., DNA, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Dispersion Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Optical Measuring Cells (AREA)
DE68918004T 1988-06-15 1989-06-14 Verfahren zur Analyse von Zellbestandteilen in einer Flüssigkeit. Expired - Lifetime DE68918004T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/207,099 US5047321A (en) 1988-06-15 1988-06-15 Method for analysis of cellular components of a fluid

Publications (2)

Publication Number Publication Date
DE68918004D1 true DE68918004D1 (de) 1994-10-13
DE68918004T2 DE68918004T2 (de) 1995-01-05

Family

ID=22769201

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68918004T Expired - Lifetime DE68918004T2 (de) 1988-06-15 1989-06-14 Verfahren zur Analyse von Zellbestandteilen in einer Flüssigkeit.

Country Status (11)

Country Link
US (1) US5047321A (de)
EP (1) EP0347210B1 (de)
JP (1) JPH0726954B2 (de)
AT (1) ATE111227T1 (de)
AU (1) AU613197B2 (de)
CA (1) CA1340170C (de)
DE (1) DE68918004T2 (de)
DK (1) DK296889A (de)
ES (1) ES2063820T3 (de)
FI (1) FI94180C (de)
NO (1) NO175506C (de)

Families Citing this family (98)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO164622C (no) * 1988-05-11 1990-10-24 Tore Lindmo Binaer immunometrisk partikkelbasert metode for maaling av spesifikke serum-antigener ved hjelp av vaeskestroemsmikrofotometri og et ferdigpreparert maaloppsett derav.
US4963478A (en) * 1988-07-05 1990-10-16 Immucor, Inc. Article for preforming immunological assays utilizing organic dyes and method for producing and utilizing same
FR2638848B1 (fr) * 1988-11-04 1993-01-22 Chemunex Sa Procede de detection et/ou de dosage dans un milieu liquide ou semi-liquide d'au moins une substance organique, biologique ou medicamenteuse soluble, par une methode d'agglutination
US5547839A (en) 1989-06-07 1996-08-20 Affymax Technologies N.V. Sequencing of surface immobilized polymers utilizing microflourescence detection
FR2653447B1 (fr) * 1989-10-20 1991-12-27 Bio Merieux Procede et reactifs pour la detection de micro-organismes.
EP0448931B1 (de) * 1990-01-26 1996-04-03 Canon Kabushiki Kaisha Verfahren zur Messung einer Spezies unter Verwendung von Fluoreszenzlicht
US5229265A (en) * 1990-03-13 1993-07-20 Litron Laboratories Process for analyzing clastogenic agents
US5401847A (en) * 1990-03-14 1995-03-28 Regents Of The University Of California DNA complexes with dyes designed for energy transfer as fluorescent markers
US5622853A (en) * 1990-05-01 1997-04-22 Becton Dickinson And Company T lymphocyte precursor
US5641629A (en) * 1990-06-11 1997-06-24 Nexstar Pharmacueticals Inc Spectroscopically detectable nucleic acid ligands
US5650275A (en) * 1990-06-11 1997-07-22 Nexstar Pharmacueticals Inc Target detection method using spectroscopically detectable nucleic acid ligands
IE76732B1 (en) * 1990-08-07 1997-11-05 Becton Dickinson Co One step test for absolute counts
AU1248292A (en) * 1990-12-06 1992-07-08 Affymax Technologies N.V. Sequencing by hybridization of a target nucleic acid to a matrix of defined oligonucleotides
JP2927979B2 (ja) * 1991-02-22 1999-07-28 シスメックス株式会社 フローサイトメトリーによる赤芽球の分類方法
US5776709A (en) * 1991-08-28 1998-07-07 Becton Dickinson And Company Method for preparation and analysis of leukocytes in whole blood
CA2087086A1 (en) 1992-01-22 1993-07-23 Leon Wmm Terstappen Multidimensional cell differential analysis
EP0586183B1 (de) * 1992-09-04 1999-10-13 Becton, Dickinson and Company Kontroll-Teilchen für die Zellzählung und Instrumentenlinearität
EP0608987B1 (de) * 1993-01-26 2001-10-10 Becton, Dickinson and Company Verfahren zum Nachweis von seltenen Ereignissen
US5294799A (en) * 1993-02-01 1994-03-15 Aslund Nils R D Apparatus for quantitative imaging of multiple fluorophores
JP2716267B2 (ja) * 1993-02-25 1998-02-18 アボツト・ラボラトリーズ 全血試料を高速溶解するための多目的試薬系
EP0685071A4 (de) * 1993-11-12 2000-12-13 Becton Dickinson Co Verfahren zu absoluter zählung von seltenen zellen
GB9326238D0 (en) * 1993-12-23 1994-02-23 Sinvent As Method of assay
DE69533660T2 (de) * 1994-04-29 2005-11-10 Johnson & Johnson Clinical Diagnostics, Inc. Homogenes Verfahren zum Nachweis von Doppelstrang-Nukleinsäuren mittels fluoreszierender Farbstoffe und dafür nützliche Kits
US5631165A (en) * 1994-08-01 1997-05-20 Abbott Laboratories Method for performing automated hematology and cytometry analysis
US5891734A (en) * 1994-08-01 1999-04-06 Abbott Laboratories Method for performing automated analysis
US5656499A (en) * 1994-08-01 1997-08-12 Abbott Laboratories Method for performing automated hematology and cytometry analysis
US5559037A (en) * 1994-12-15 1996-09-24 Abbott Laboratories Method for rapid and simultaneous analysis of nucleated red blood cells
US5879900A (en) * 1994-12-15 1999-03-09 Abbott Laboratories Method for simultaneous analysis of cell viability, nucleated red blood cells and white blood cell differentials
US6329158B1 (en) * 1995-09-15 2001-12-11 Becton Dickinson And Company Use of dimly fluorescing nucleic acid dyes in the identification of nucleated cells
DE69638209D1 (de) * 1995-12-15 2010-08-12 Abbott Lab Verfahren für gleichzeitige analyse von zelllebensfähigkeit, nukleierten roten blutkörperchen und leukozytendifferential
JP3308441B2 (ja) * 1995-12-19 2002-07-29 シスメックス株式会社 尿中有形成分分析装置
TW438973B (en) * 1995-12-19 2001-06-07 Sysmex Corp Apparatus and method for analyzing solid components in urine
JP3783808B2 (ja) * 1997-05-19 2006-06-07 シスメックス株式会社 白血球分類計数用試薬
DE19756782A1 (de) * 1997-12-19 1999-06-24 Dade Behring Marburg Gmbh Nachweis und Bestimmung festphasenassoziierter Faktoren
US6911313B2 (en) * 1998-02-06 2005-06-28 Sysmex Corporation Process for discriminating and counting erythroblasts
DE19857692C1 (de) * 1998-12-14 2000-08-24 Evotec Biosystems Ag Verfahren und Vorrichtung zur zellspurbasierten Zelluntersuchung
JP3817091B2 (ja) * 1999-07-02 2006-08-30 テルモ株式会社 細胞数測定装置
JP3929283B2 (ja) * 2000-11-08 2007-06-13 シスメックス株式会社 骨髄有核細胞の分類計数方法
US6403378B1 (en) * 2001-04-26 2002-06-11 Guava Technologies, Inc. Cell viability assay reagent
GB0118995D0 (en) * 2001-08-03 2001-09-26 Univ Wales Medicine Detection of mutations in nucleic acids
WO2003016866A2 (en) * 2001-08-16 2003-02-27 Litron Laboratories Ltd Method for the enumeration of mammalian micronucleated erythrocyte populations with a single-laser flow cytometer
DK1363126T3 (da) * 2002-05-14 2006-04-18 Univ Salamanca Flerdimensionel differentiel analyse af leukocyter
JP4299597B2 (ja) * 2002-07-29 2009-07-22 シスメックス株式会社 血液分析装置及び方法
US7507548B2 (en) 2003-03-04 2009-03-24 University Of Salamanca Multidimensional detection of aberrant phenotypes in neoplastic cells to be used to monitor minimal disease levels using flow cytometry measurements
US7625712B2 (en) 2004-05-21 2009-12-01 Beckman Coulter, Inc. Method for a fully automated monoclonal antibody-based extended differential
US7674598B2 (en) * 2004-05-21 2010-03-09 Beckman Coulter, Inc. Method for a fully automated monoclonal antibody-based extended differential
US7321843B2 (en) * 2005-09-30 2008-01-22 Universidad De Salamanca Method for generating new flow cytometry data files containing an infinite number of dimensions based on data estimation
US8958990B2 (en) * 2005-10-03 2015-02-17 Sysmex Corporation Sample analyzer and sample analyzing method
EP1984737A2 (de) * 2006-01-17 2008-10-29 Cellumen, Inc. Verfahren zur vorhersage von reaktionen biologischer systeme
US8114615B2 (en) 2006-05-17 2012-02-14 Cernostics, Inc. Method for automated tissue analysis
WO2008060483A2 (en) * 2006-11-10 2008-05-22 Cellumen, Inc. Protein-protein interaction biosensors and methods of use thereof
WO2009058876A1 (en) * 2007-10-29 2009-05-07 Beckman Coulter, Inc. Method for a rapid antibody-based analysis of platelet populations
US8159670B2 (en) * 2007-11-05 2012-04-17 Abbott Laboratories Method and apparatus for rapidly counting and identifying biological particles in a flow stream
DE102008030515A1 (de) * 2008-06-27 2009-12-31 Christian Seliger Durchflusszytometrisches Verfahren zur Bestimmung von Gesamtleukozytenzahl und Thrombozytenzahl sowie zur Leukozytendifferenzierung in Blutproben von Vögeln
WO2010056732A1 (en) 2008-11-12 2010-05-20 Marv Enterprises Llc Utilization of stents for the treatment of blood borne carcinomas
WO2010068812A1 (en) * 2008-12-10 2010-06-17 Abqmr, Inc. Nuclear magnetic resonance apparatus, methods and associated technology
US9216386B2 (en) 2009-03-17 2015-12-22 Marv Enterprises, LLC Sequential extracorporeal treatment of bodily fluids
JP5452058B2 (ja) * 2009-03-31 2014-03-26 シスメックス株式会社 血液分析装置
EP2259065A1 (de) 2009-06-03 2010-12-08 Erasmus University Medical Center Rotterdam Verfahren, Reagenzien und Kits für die strömungszytometrische Immunphänotypisierung
JP2011092104A (ja) * 2009-10-30 2011-05-12 Hitachi Engineering & Services Co Ltd 微生物などの検査方法及び検査装置
SG174650A1 (en) * 2010-03-31 2011-10-28 Agency Science Tech & Res A method of monitoring parasite development in blood
US20110262989A1 (en) 2010-04-21 2011-10-27 Nanomr, Inc. Isolating a target analyte from a body fluid
US9476812B2 (en) 2010-04-21 2016-10-25 Dna Electronics, Inc. Methods for isolating a target analyte from a heterogeneous sample
US9428547B2 (en) 2010-04-21 2016-08-30 Dna Electronics, Inc. Compositions for isolating a target analyte from a heterogeneous sample
US8841104B2 (en) 2010-04-21 2014-09-23 Nanomr, Inc. Methods for isolating a target analyte from a heterogeneous sample
EP2686688B1 (de) 2011-03-17 2019-05-08 Cernostics, Inc. Systeme und zusammensetzungen zur diagnose von barrett-ösophagen und verwendungsverfahren dafür
EP3650831A1 (de) * 2011-05-04 2020-05-13 Abbott Laboratories System und verfahren zur analyse basophiler stoffe
WO2013148405A2 (en) * 2012-03-27 2013-10-03 Felder Mitchell S Treatment for atherosclerosis
US20150056608A1 (en) * 2012-05-21 2015-02-26 Marv Enterprises, LLC Method for Treating Infectious Diseases Using Emissive Energy
US9551704B2 (en) 2012-12-19 2017-01-24 Dna Electronics, Inc. Target detection
US9599610B2 (en) 2012-12-19 2017-03-21 Dnae Group Holdings Limited Target capture system
US9434940B2 (en) 2012-12-19 2016-09-06 Dna Electronics, Inc. Methods for universal target capture
US9995742B2 (en) 2012-12-19 2018-06-12 Dnae Group Holdings Limited Sample entry
US9804069B2 (en) 2012-12-19 2017-10-31 Dnae Group Holdings Limited Methods for degrading nucleic acid
US10000557B2 (en) 2012-12-19 2018-06-19 Dnae Group Holdings Limited Methods for raising antibodies
EP3227662B1 (de) 2014-12-04 2023-07-12 Becton, Dickinson and Company Durchflusszytometriezellsortierungssysteme und verfahren zur verwendung davon
US9709769B2 (en) 2014-12-10 2017-07-18 Becton, Dickinson And Company Methods for optically aligning light collection components and optically aligned light collection systems thereof
US10900885B2 (en) 2014-12-19 2021-01-26 Captl Llc Flow cytometry using hydrodynamically planar flow
WO2016099538A1 (en) 2014-12-19 2016-06-23 Captl Llc Flow cytometry using hydrodynamically planar flow
WO2016133760A1 (en) 2015-02-18 2016-08-25 Becton, Dickinson And Company Optical detection systems and methods of using the same
CN107923836B (zh) 2015-06-17 2020-12-01 贝克顿·迪金森公司 具有可移除散射杆的光学检测器散射帽组件及其使用方法
GB201601073D0 (en) * 2016-01-20 2016-03-02 Ucb Biopharma Sprl Antibodies
CN108474728B (zh) 2015-10-13 2022-04-26 贝克顿·迪金森公司 多模态荧光成像流式细胞术系统
CA3002401A1 (en) * 2015-10-23 2017-04-27 Geosyntec Consultants, Inc. Use of visibly detectable compounds as performance reference compounds in passive sampling devices
EP3426296A4 (de) 2016-03-10 2019-11-20 Becton, Dickinson and Company Verfahren zur bewertung einer zellulären probe für her-2/neu-expression und zusammensetzungen zur durchführung davon
BR112018068866B1 (pt) 2016-03-17 2022-11-29 Bd Biosciences Classificação de células utilizando um citômetro de fluxo de fluorescência de alto rendimento
CN118218035A (zh) 2016-04-22 2024-06-21 贝克顿迪金森公司 用于阵列产生的高密度沉积
CN109477785B (zh) 2016-09-13 2022-09-27 贝克顿·迪金森公司 具有光学均衡的流式细胞仪
CN109073530B (zh) 2016-10-03 2022-04-26 贝克顿·迪金森公司 用于确定流式细胞仪中的流体流的液滴延迟的方法和系统
ES2950436T3 (es) 2016-12-14 2023-10-10 Becton Dickinson Co Métodos y composiciones para obtener una valoración de tuberculosis en un sujeto
EP3579974A4 (de) 2017-02-08 2020-12-30 Becton, Dickinson and Company Vorrichtungen für getrocknete farbstoffreagenzien und verfahren zur herstellung und verwendung davon
CA3052979A1 (en) 2017-02-27 2018-08-30 Becton, Dickinson And Company Light detection systems and methods for using thereof
EP3743706A4 (de) 2018-01-23 2021-10-20 Becton, Dickinson and Company Systeme zur dynamischen verdunkelung von lichtdetektion und verfahren zur verwendung davon
JP2021519841A (ja) 2018-03-30 2021-08-12 ベクトン・ディキンソン・アンド・カンパニーＢｅｃｔｏｎ， Ｄｉｃｋｉｎｓｏｎ Ａｎｄ Ｃｏｍｐａｎｙ ペンダントクロモフォアを有する水溶性ポリマー色素
JP7374124B2 (ja) 2018-04-27 2023-11-06 ベクトン・ディキンソン・アンド・カンパニー フローサイトメトリで選別された試料のための収集システムおよびそれを使用する方法
CN112449680B (zh) 2018-06-19 2024-08-09 贝克顿·迪金森公司 用于检测器阵列、系统的可变多路复用开关及其使用方法
EP3867626A4 (de) 2019-03-22 2022-11-09 Becton, Dickinson and Company Spektrale zerlegung von fluoreszenzbildgebung unter verwendung von radiofrequenz-multiplex anregungsdaten
CN117178179A (zh) 2021-04-23 2023-12-05 贝克顿·迪金森公司 用于分析仪和/或分选型流型微粒分析仪的流体管理系统

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3826364A (en) * 1972-05-22 1974-07-30 Univ Leland Stanford Junior Particle sorting method and apparatus
US4284412A (en) * 1979-07-13 1981-08-18 Ortho Diagnostics, Inc. Method and apparatus for automated identification and enumeration of specified blood cell subclasses
US4544546A (en) * 1980-04-21 1985-10-01 Abbott Laboratories Fluorescent nucleic acid stains
US4520110A (en) * 1981-10-06 1985-05-28 The Board Of Trustees Of The Leland Stanford Junior University Fluorescent immunoassay employing a phycobiliprotein labeled ligand or receptor
CA1254134A (en) * 1984-03-28 1989-05-16 Mount Sinai School Of Medicine Of The City University Of New York Specific binding flow cytometry method
US4661913A (en) * 1984-09-11 1987-04-28 Becton, Dickinson And Company Apparatus and method for the detection and classification of articles using flow cytometry techniques
US4727020A (en) * 1985-02-25 1988-02-23 Becton, Dickinson And Company Method for analysis of subpopulations of blood cells
CA1279008C (en) * 1985-10-11 1991-01-15 Smith Kline & French Canada Ltd. Methods and reagents for performing subset analysis
ZA867698B (en) * 1985-10-11 1987-07-29 Smithkline Beckman Corp Methods and reagents for performing subset analysis
US4883867A (en) * 1985-11-01 1989-11-28 Becton, Dickinson And Company Detection of reticulocytes, RNA or DNA
US5016283A (en) * 1985-11-04 1991-05-14 Cell Analysis Systems, Inc. Methods and apparatus for immunoploidy analysis

Also Published As

Publication number Publication date
US5047321A (en) 1991-09-10
FI94180B (fi) 1995-04-13
EP0347210B1 (de) 1994-09-07
NO892302L (no) 1989-12-18
NO175506B (no) 1994-07-11
JPH0273157A (ja) 1990-03-13
ES2063820T3 (es) 1995-01-16
EP0347210A2 (de) 1989-12-20
AU613197B2 (en) 1991-07-25
JPH0726954B2 (ja) 1995-03-29
ATE111227T1 (de) 1994-09-15
FI892926A0 (fi) 1989-06-14
DE68918004T2 (de) 1995-01-05
DK296889D0 (da) 1989-06-15
NO175506C (no) 1994-10-19
EP0347210A3 (en) 1990-10-17
DK296889A (da) 1989-12-16
CA1340170C (en) 1998-12-08
NO892302D0 (no) 1989-06-05
FI892926L (fi) 1989-12-16
AU3596189A (en) 1989-12-21
FI94180C (fi) 1995-07-25

Similar Documents

Publication Publication Date Title
DE68918004D1 (de) Verfahren zur Analyse von Zellbestandteilen in einer Flüssigkeit.
FI96639B (fi) Omavarainen immunokoe-elementti
DE3875456D1 (de) Verfahren zur analyse haematopoietischer zellen in einer probe.
DE68910730D1 (de) Verfahren zur Unterscheidung zwischen intakten und beschädigten Zellen in einer Probe.
DE3583414D1 (de) Bestandteil eines analytischen elements zur analyse von einem festkoerper in einer fluessigen probe.
EP0106339A3 (de) Verfahren zur simultanen quantitativen Bestimmung der Zellen und Reagenz hierfür
DE69024955D1 (de) Ermittlung und quantifizierung mehrerer analyten unter verwendung von markierungstechniken
BR8108803A (pt) Processo e aparelho para determinacao quantitativa do nivel de hemoglobina em uma amostra biologica
DE69029556D1 (de) Trockenes analytisches Element zur quantitativen Analyse von in Vollblut enthaltenen Analyten
JPS6418059A (en) Analysis method and element for protein analysis
BR9300639A (pt) Particulas marcadoras para uso no ensaio de uma amostra de um fluido biologico,processo pra ensaiar uma amostra de fluido biologico,e,processo para ensaiar uma amostra de sangue
FI874129L (fi) Analyysiväline biologiselle nesteelle
ATE111533T1 (de) Verfahren zur bestimmung von nukleinsäuren.
EP0374620A3 (de) Verfahren und Mittel zur Bestimmung von Maleimidgruppen
ES2037659T3 (es) Metodos y reactivos para realizar analisis de subpoblaciones de particulas.
DE3765147D1 (de) Verfahren und reagenz zur bestimmung von gesamt-bilirubin.
KR880701885A (ko) 2개의 표식물을 이용한 분석물질의 농도 검정 방법 및 기기
DE68927101D1 (de) Vorrichtung zur durchführung mehrerer gleichzeitiger messungen electrochemilumineszenter phänomene
DE69026006D1 (de) Enzymatisches Verfahren zur Bestimmung der Analyt-Konzentration
DK173884D0 (da) Fremgangsmaade til kvantitativ bestemmelse af haemoglobinkoncentrationen i en biologisk proeve
ATE80665T1 (de) Verfahren und reagens zur bestimmung von ld-1isoenzym.
DK0790494T3 (da) Flerlaget testmiddel
ES2001988A6 (es) Un metodo para la determinacion de bilirrubina total en una muestra biologica
EP0355655A3 (de) Chlorid-Bestimmung
ATE57022T1 (de) Verfahren zur bestimmung von parathormon.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition