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CZ78095A3 - Novel 17 beta-substituted derivatives of 4-azaandrostane, pharmaceutical preparations based thereon and process of their preparation - Google Patents

Novel 17 beta-substituted derivatives of 4-azaandrostane, pharmaceutical preparations based thereon and process of their preparation

Info

Publication number
CZ78095A3
CZ78095A3 CZ95780A CZ78095A CZ78095A3 CZ 78095 A3 CZ78095 A3 CZ 78095A3 CZ 95780 A CZ95780 A CZ 95780A CZ 78095 A CZ78095 A CZ 78095A CZ 78095 A3 CZ78095 A3 CZ 78095A3
Authority
CZ
Czechia
Prior art keywords
azaandrostane
beta
novel
preparation
pharmaceutical preparations
Prior art date
Application number
CZ95780A
Other languages
English (en)
Other versions
CZ282170B6 (cs
Inventor
Zoltan Tuba
Judit Horvath
Laszlo Kollar
Marsai Maria Lovasne
Gabor Balogh
Attila Scehi
Andras Javor
Gyorgy Hajos
Laszlo Szporny
Original Assignee
Richter Gedeon Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszet filed Critical Richter Gedeon Vegyeszet
Publication of CZ78095A3 publication Critical patent/CZ78095A3/cs
Publication of CZ282170B6 publication Critical patent/CZ282170B6/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
    • C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CZ95780A 1992-10-02 1993-10-01 Nově 17 ß - substituované deriváty 4-azaandrostanu, farmaceutické přípravky na jejich bázi a způsob jejich přípravy CZ282170B6 (cs)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU9203135A HU212459B (en) 1992-10-02 1992-10-02 Process for producing new 17-beta-substituted 4-aza-androstane-derivatives and pharmaceutical compositions containing them

Publications (2)

Publication Number Publication Date
CZ78095A3 true CZ78095A3 (en) 1995-11-15
CZ282170B6 CZ282170B6 (cs) 1997-05-14

Family

ID=10982391

Family Applications (1)

Application Number Title Priority Date Filing Date
CZ95780A CZ282170B6 (cs) 1992-10-02 1993-10-01 Nově 17 ß - substituované deriváty 4-azaandrostanu, farmaceutické přípravky na jejich bázi a způsob jejich přípravy

Country Status (13)

Country Link
US (1) US5583138A (cs)
EP (1) EP0662977A1 (cs)
JP (1) JPH08502059A (cs)
KR (1) KR950703577A (cs)
AU (1) AU672046B2 (cs)
CA (1) CA2146164A1 (cs)
CZ (1) CZ282170B6 (cs)
FI (1) FI951561A (cs)
HU (1) HU212459B (cs)
RU (1) RU95110751A (cs)
SK (1) SK40895A3 (cs)
WO (1) WO1994007909A1 (cs)
ZA (1) ZA936774B (cs)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU212459B (en) * 1992-10-02 1996-06-28 Richter Gedeon Vegyeszet Process for producing new 17-beta-substituted 4-aza-androstane-derivatives and pharmaceutical compositions containing them
TW369521B (en) * 1993-09-17 1999-09-11 Smithkline Beecham Corp Androstenone derivative
US5541322A (en) * 1994-10-14 1996-07-30 Glaxo Wellcome Inc. Synthesis of 6-azaandrostenones
US5543417A (en) * 1994-10-21 1996-08-06 Merck & Co., Inc. Combination method of treating acne using 4-AZA-5α-cholestan-ones and 4-AZA-5α-androstan-ones as selective 5α-reductase inhibitors with anti-bacterial, keratolytic, or anti-inflammatory agents
US5656613A (en) * 1995-01-04 1997-08-12 Merck & Co., Inc. Treatment of hyperandrogenic conditions
WO2004100874A2 (en) * 2003-05-07 2004-11-25 Merck & Co., Inc. Androgen receptor modulators and methods of use thereof
EP2362872A4 (en) * 2008-10-28 2012-05-30 Biomarin Pharm Inc DECAHYDRO-1H-INDENOCHINOLINONE AND DECAHYDRO-3H-CYCLOPENTAPHENANTHRIDINONE CYP17 HEMMER
CN103554213A (zh) * 2012-01-05 2014-02-05 中国药科大学 4-氧杂-雄甾-3-酮-17β-酰胺类衍生物、其制备方法及其医药用途

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4377584A (en) * 1978-04-13 1983-03-22 Merck & Co., Inc. 4-Aza-17β-substituted-5α-androstan-3-one-reductase inhibitors
US4220775A (en) * 1979-03-15 1980-09-02 Merck & Co., Inc. Preparation of 4-aza-17-substituted-5α-androstan-3-ones useful as 5α-reductase inhibitors
US4885289A (en) * 1983-12-12 1989-12-05 Breuer Miklos M Alteration of character of male beard growth
IL74365A (en) * 1984-02-27 1990-07-26 Merck & Co Inc 17beta-(n-t.-butylcarbamoyl)-4-aza-5alpha-androst-1-en-3-one and pharmaceutical compositions containing it
US5312984A (en) * 1984-12-19 1994-05-17 The B. F. Goodrich Company Amidation of vinyl chloride with dimethylamine using a supported palladium catalyst
GB8505862D0 (en) * 1985-03-07 1985-04-11 Erba Farmitalia Steroidic 5alpha-reductase inhibitors
HU195972B (en) * 1985-07-01 1988-08-29 Richter Gedeon Vegyeszet Process for producing new diamino-androstane derivatives and pharmaceutical compositions containing them
DE3607651A1 (de) * 1986-03-06 1987-09-10 Schering Ag Kombination von aromatasehemmer und testosteron-5(alpha)-reduktase-hemmer
US4845104A (en) * 1986-11-20 1989-07-04 Merck & Co., Inc. Oxidized analogs of 17β-N-monosubstituted-carbamoyl-4-aza-5-α-androstan-3-ones
US4888336A (en) * 1987-01-28 1989-12-19 Smithkline Beckman Corporation Steroid 5-alpha-reductase inhibitors
EP0285383B1 (en) * 1987-04-03 1994-03-16 Merck & Co. Inc. Treatment of prostatic carcinoma with 17beta-n-monosubstituted-carbamoyl-4-aza-5alpha-androst-1-en-3-ones
EP0285382B1 (en) * 1987-04-03 1994-04-13 Merck & Co. Inc. Treatment of androgenic alopecia with 17beta-n-monosubstituted-carbamoyl-4-aza-5alpha-androst-1-en-3-ones
US5237061A (en) * 1988-10-31 1993-08-17 Merck & Co., Inc. Methods of synthesizing benign prostatic hypertropic agents and their intermediates
GB9002922D0 (en) * 1990-02-09 1990-04-04 Erba Carlo Spa 17 beta-substituted-4-aza-5 alpha-androstan-3-one derivatives and process for their preparation
EP0462662A3 (en) * 1990-06-20 1992-08-19 Merck & Co. Inc. 17beta-n-monosubstituted adamantyl/norbornanyl carbamoyl-4-aza-5alpha-androst-1-en-3-ones and androstan-3-ones
IE76452B1 (en) * 1990-10-29 1997-10-22 Sankyo Co Azasteroid compounds for the treatment of prostatic hypertrophy their preparation and use
US5304562A (en) * 1991-10-09 1994-04-19 Ciba-Geigy Corporation 17β-substituted Aza-androstane derivatives
GB9216329D0 (en) * 1992-07-31 1992-09-16 Erba Carlo Spa 17beta-substituted 4-aza-5alpha-androstan-3-one derivatives
HU212459B (en) * 1992-10-02 1996-06-28 Richter Gedeon Vegyeszet Process for producing new 17-beta-substituted 4-aza-androstane-derivatives and pharmaceutical compositions containing them
ATE215092T1 (de) * 1993-06-24 2002-04-15 Richter Gedeon Vegyeszet Neues verfahren zum herstellen von 17 beta- substituierten 4-azaandrostan-derivaten
UA41934C2 (uk) * 1993-06-24 2001-10-15 Ріхтер Гедеон Ведьесеті Дьяр Рт Похідні 17-галоген-4-азаандростену

Also Published As

Publication number Publication date
HU212459B (en) 1996-06-28
RU95110751A (ru) 1996-11-20
ZA936774B (en) 1994-04-14
HUT65768A (en) 1994-07-28
AU672046B2 (en) 1996-09-19
US5583138A (en) 1996-12-10
JPH08502059A (ja) 1996-03-05
WO1994007909A1 (en) 1994-04-14
FI951561A0 (fi) 1995-03-31
CA2146164A1 (en) 1994-04-14
EP0662977A1 (en) 1995-07-19
FI951561A (fi) 1995-03-31
HU9203135D0 (en) 1992-12-28
AU5118393A (en) 1994-04-26
CZ282170B6 (cs) 1997-05-14
KR950703577A (ko) 1995-09-20
SK40895A3 (en) 1995-07-11

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