CN118760973A - A method for predicting intensive care needs of patients with cerebral hemorrhage based on multimodal fusion - Google Patents
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Abstract
本发明公开了一种基于多模态融合的脑出血患者重症监护需求预测方法,涉及脑出血患者重症监护需求预测技术领域,包括采集脑出血患者的多模态数据,对多模态数据进行预处理;对预处理后的多模态数据进行特征提取,采用欠采样和过采样技术处理数据集不平衡问题;构建多模态融合监护需求预测模型,对实时临床数据进行预测,识别脑出血患者重症监护需求。本发明所述方法通过特征提取和数据平衡处理,提高了模型对复杂和不平衡数据的适应能力,提升了预测的精度和可靠性,通过构建多模态融合监护需求预测模型,提高了预测的准确性和实时性,确保了患者能够在病情恶化时及时得到重症监护,降低了患者的死亡率和致残率,提升了整体医疗服务的质量。
The present invention discloses a method for predicting the intensive care needs of patients with cerebral hemorrhage based on multimodal fusion, which relates to the technical field of predicting the intensive care needs of patients with cerebral hemorrhage, including collecting multimodal data of patients with cerebral hemorrhage, preprocessing the multimodal data; extracting features from the preprocessed multimodal data, using undersampling and oversampling techniques to handle the imbalance problem of the data set; constructing a multimodal fusion monitoring demand prediction model, predicting real-time clinical data, and identifying the intensive care needs of patients with cerebral hemorrhage. The method of the present invention improves the adaptability of the model to complex and unbalanced data through feature extraction and data balancing processing, improves the accuracy and reliability of the prediction, and improves the accuracy and real-time nature of the prediction by constructing a multimodal fusion monitoring demand prediction model, ensuring that patients can receive intensive care in a timely manner when their condition worsens, reducing the mortality and disability rates of patients, and improving the overall quality of medical services.
Description
技术领域Technical Field
本发明涉及脑出血患者重症监护需求预测技术领域,具体为一种基于多模态融合的脑出血患者重症监护需求预测方法。The present invention relates to the technical field of intensive care demand prediction for patients with cerebral hemorrhage, and in particular to a method for predicting intensive care demand for patients with cerebral hemorrhage based on multimodal fusion.
背景技术Background Art
随着医学影像技术、数据挖掘技术和人工智能技术的快速发展,医学诊断和治疗逐渐进入数据驱动的时代,脑出血是一种严重的神经系统疾病,具有高死亡率和高致残率,对其进行及时有效的监护和治疗至关重要,传统的脑出血监护主要依靠临床医生的经验和单一的医学影像手段,如CT(计算机断层扫描)和MRI(磁共振成像),然而,单一的影像手段难以全面反映患者的病情,特别是对于病情复杂的脑出血患者,综合多模态数据进行分析显得尤为重要。With the rapid development of medical imaging technology, data mining technology and artificial intelligence technology, medical diagnosis and treatment have gradually entered the data-driven era. Cerebral hemorrhage is a serious neurological disease with high mortality and disability rates. Timely and effective monitoring and treatment are crucial. Traditional cerebral hemorrhage monitoring mainly relies on the experience of clinicians and a single medical imaging method, such as CT (computed tomography) and MRI (magnetic resonance imaging). However, a single imaging method is difficult to fully reflect the patient's condition, especially for patients with complex cerebral hemorrhage. Comprehensive multimodal data analysis is particularly important.
尽管多模态数据融合和人工智能技术在医学领域取得了进展,但现有技术在脑出血患者重症监护需求预测方面仍存在诸多不足,现有的多模态数据融合方法大多局限于静态数据的融合,缺乏对时间序列数据的动态分析能力,脑出血患者的病情变化迅速,需要实时监测和预测,而传统的多模态融合模型难以捕捉这种动态变化,现有的多模态融合模型在处理数据不平衡问题时,往往采用简单的欠采样或过采样方法,这些方法虽然能够在一定程度上缓解数据不平衡的问题,但容易导致模型过拟合或欠拟合,影响预测的准确性和鲁棒性,尤其在重症监护需求预测中,少数类(需要重症监护的患者)样本往往更为重要,简单的采样方法难以有效提升模型对少数类的识别能力,此外,现有的多模态融合技术在特征提取方面存在不足,传统的特征提取方法大多依赖于人工经验,难以充分挖掘数据中的深层次特征,而基于深度学习的自动特征提取方法,虽然能够提取高维特征,但往往缺乏可解释性,难以被临床医生接受和信赖。Although multimodal data fusion and artificial intelligence technology have made progress in the medical field, the existing technology still has many shortcomings in predicting the intensive care needs of patients with cerebral hemorrhage. Most of the existing multimodal data fusion methods are limited to the fusion of static data and lack the ability to dynamically analyze time series data. The condition of patients with cerebral hemorrhage changes rapidly and requires real-time monitoring and prediction, while traditional multimodal fusion models are difficult to capture such dynamic changes. When dealing with data imbalance problems, existing multimodal fusion models often use simple undersampling or oversampling methods. Although these methods can alleviate the problem of data imbalance to a certain extent, they are prone to overfitting or underfitting of the model, affecting the accuracy and robustness of the prediction. Especially in the prediction of intensive care needs, minority class (patients requiring intensive care) samples are often more important, and simple sampling methods are difficult to effectively improve the model's recognition ability for minority classes. In addition, the existing multimodal fusion technology has shortcomings in feature extraction. Traditional feature extraction methods mostly rely on manual experience and are difficult to fully mine the deep-level features in the data. Although the automatic feature extraction method based on deep learning can extract high-dimensional features, it often lacks interpretability and is difficult to be accepted and trusted by clinicians.
发明内容Summary of the invention
鉴于上述存在的问题,提出了本发明。In view of the above-mentioned problems, the present invention is proposed.
因此,本发明解决的技术问题是:现有的脑出血患者重症监护需求预测方法存在准确性低,效率低,可靠性低,以及如何对于病情复杂的脑出血患者,如何综合多模态数据进行监护需求分析的问题。Therefore, the technical problem solved by the present invention is: the existing methods for predicting the intensive care needs of patients with cerebral hemorrhage have low accuracy, low efficiency, and low reliability, and how to integrate multimodal data to perform monitoring needs analysis for patients with complex cerebral hemorrhage conditions.
为解决上述技术问题,本发明提供如下技术方案:一种基于多模态融合的脑出血患者重症监护需求预测方法,包括采集脑出血患者的多模态数据,对多模态数据进行预处理;对预处理后的多模态数据进行特征提取,采用欠采样和过采样技术处理数据集不平衡问题;构建多模态融合监护需求预测模型,对实时临床数据进行预测,识别脑出血患者重症监护需求。To solve the above technical problems, the present invention provides the following technical solutions: a method for predicting the intensive care needs of patients with cerebral hemorrhage based on multimodal fusion, comprising collecting multimodal data of patients with cerebral hemorrhage and preprocessing the multimodal data; extracting features from the preprocessed multimodal data, and using undersampling and oversampling techniques to deal with the imbalance problem of the data set; constructing a multimodal fusion monitoring demand prediction model, predicting real-time clinical data, and identifying the intensive care needs of patients with cerebral hemorrhage.
作为本发明所述的基于多模态融合的脑出血患者重症监护需求预测方法的一种优选方案,其中:所述脑出血患者的多模态数据包括临床数据和影像数据;临床数据包括患者人口学信息、生命体征、实验室检测结果、病史信息;影像数据包括CT图像、MRI图像、超声图像。As a preferred solution of the method for predicting the intensive care demand of patients with cerebral hemorrhage based on multimodal fusion described in the present invention, the multimodal data of the patients with cerebral hemorrhage include clinical data and imaging data; the clinical data include patient demographic information, vital signs, laboratory test results, and medical history information; the imaging data include CT images, MRI images, and ultrasound images.
作为本发明所述的基于多模态融合的脑出血患者重症监护需求预测方法的一种优选方案,其中:所述预处理包括对脑出血患者的多模态数据进行数据清洗、数据集成、数据转换;数据清洗包括对数据进行重新审查和校验,检查数据一致性,删除无效值填补缺失值;数据集成包括将不同来源和格式的数据整合在一起,通过患者的唯一标识符将数据统一到同一个数据集中;数据转换包括对数据进行归一化处理。As a preferred solution of the method for predicting the intensive care demand of patients with cerebral hemorrhage based on multimodal fusion described in the present invention, the preprocessing includes data cleaning, data integration, and data conversion of the multimodal data of patients with cerebral hemorrhage; data cleaning includes re-examining and verifying the data, checking data consistency, deleting invalid values and filling missing values; data integration includes integrating data from different sources and formats, and unifying the data into the same data set through the patient's unique identifier; data conversion includes normalizing the data.
作为本发明所述的基于多模态融合的脑出血患者重症监护需求预测方法的一种优选方案,其中:所述特征提取包括基于预处理后的多模态数据,适应脑出血患者病情的随时间的动态变化,进行非线性特征提取,表示为:As a preferred solution of the method for predicting the intensive care needs of patients with cerebral hemorrhage based on multimodal fusion described in the present invention, the feature extraction includes performing nonlinear feature extraction based on the preprocessed multimodal data to adapt to the dynamic changes of the condition of patients with cerebral hemorrhage over time, which is expressed as:
其中,gj(X(t))表示第j个非线性特征提取函数,用于从时间t上的多模态数据X(t)中提取非线性特征,X'(t)为时间t上的多模态数据集,包含脑出血患者在不同时间点的临床数据和影像数据,q为数据点的总数,bjl为第j个特征提取函数和第l个数据点之间的非线性权重系数,Xl(t)为时间t上多模态数据集中第l个数据点。Wherein, gj (X(t)) represents the j-th nonlinear feature extraction function, which is used to extract nonlinear features from the multimodal data X(t) at time t, X'(t) is the multimodal dataset at time t, which contains the clinical data and imaging data of patients with cerebral hemorrhage at different time points, q is the total number of data points, bjl is the nonlinear weight coefficient between the j-th feature extraction function and the l-th data point, and Xl (t) is the l-th data point in the multimodal dataset at time t.
作为本发明所述的基于多模态融合的脑出血患者重症监护需求预测方法的一种优选方案,其中:所述处理数据集不平衡问题包括基于过采样调节模型对少数类的识别能力,欠采样平衡数据集的分布,获取平衡后的数据集,表示为:As a preferred solution of the method for predicting the intensive care needs of patients with cerebral hemorrhage based on multimodal fusion described in the present invention, the problem of processing the imbalanced data set includes adjusting the recognition ability of the minority class based on the oversampling adjustment model, undersampling the distribution of the balanced data set, and obtaining the balanced data set, which is expressed as:
其中,Dbalanced为平衡后的数据集,表示通过欠采样与过采样技术处理后的脑出血患者多模态数据集,n为数据集中样本的总数,Xi表示数据集中第i个样本,X表示多模态数据集,包括临床数据和影像数据,d(Xi,X)表示距离函数,计算第i个样本与整个数据集X的距离,λ表示调节参数,用于控制数据合成的幅度,NN(X(t))表示在时间t上的最近邻样本函数,表示为:Where D balanced is the balanced data set, which represents the multimodal data set of patients with cerebral hemorrhage after undersampling and oversampling techniques. n is the total number of samples in the data set. Xi represents the i-th sample in the data set. X represents the multimodal data set, including clinical data and imaging data. d( Xi , X) represents the distance function, which calculates the distance between the i-th sample and the entire data set X. λ represents the adjustment parameter used to control the amplitude of data synthesis. NN(X(t)) represents the nearest neighbor sample function at time t, which is expressed as:
其中,X'表示最近邻样本,计算第i个样本与整个数据集X的距离表示为:Among them, X' represents the nearest neighbor sample, and the distance between the i-th sample and the entire data set X is expressed as:
其中,Xij'表示数据集中第i个样本的第j'个特征值,Xj'表示数据集中第j'个特征,m表示每个样本向量中包含的特征数量。Among them, Xij ' represents the j'th eigenvalue of the i-th sample in the data set, Xj ' represents the j'th feature in the data set, and m represents the number of features contained in each sample vector.
作为本发明所述的基于多模态融合的脑出血患者重症监护需求预测方法的一种优选方案,其中:所述构建多模态融合监护需求预测模型包括基于提取出的临床数据和影像数据的特征,进行多模态特征融合,表示为:As a preferred solution of the method for predicting the intensive care needs of patients with cerebral hemorrhage based on multimodal fusion described in the present invention, the construction of a multimodal fusion monitoring needs prediction model includes performing multimodal feature fusion based on the features of the extracted clinical data and imaging data, which is expressed as:
其中,Φfusion为融合特征集,nc表示临床特征的数量,αc表示第c个临床特征的权重系数,T表示时间周期,Φclinical,c表示第c个临床特征随时间t变化的值,nk表示影像特征的数量,βk表示第k个影像特征的权重系数,Φimaging,k表示第k个影像特征随时间t变化的值;将多模态特征融合后的特征作为输入,通过时间变化的权重矩阵对特征数据进行加权处理,构建多模态融合监护需求预测模型,表示为:Among them, Φ fusion is the fusion feature set, n c represents the number of clinical features, α c represents the weight coefficient of the cth clinical feature, T represents the time period, Φ clinical,c represents the value of the cth clinical feature changing with time t, n k represents the number of imaging features, β k represents the weight coefficient of the kth imaging feature, and Φ imaging,k represents the value of the kth imaging feature changing with time t. The features after multimodal feature fusion are taken as input, and the feature data are weighted by the time-varying weight matrix to construct a multimodal fusion monitoring demand prediction model, which is expressed as:
其中,为预测结果,W(t)为时间t上的权重矩阵,基于时间变换进行调整,Xtarget(t)表示目标领域在时间t上的多模态数据,包括临床特征和影像特征的向量或矩阵,Wt(t)与Xtarget(t)的维度一致,ftarget表示目标领域的预测函数,包括逻辑回归函数。in, is the prediction result, W(t) is the weight matrix at time t, which is adjusted based on the time transformation, Xtarget (t) represents the multimodal data of the target field at time t, including the vector or matrix of clinical features and imaging features, Wt (t) has the same dimension as Xtarget (t), and ftarget represents the prediction function of the target field, including the logistic regression function.
作为本发明所述的基于多模态融合的脑出血患者重症监护需求预测方法的一种优选方案,其中:所述识别脑出血患者重症监护需求包括基于多模态融合监护需求预测模型的预测结果,对实时临床数据进行预测,识别脑出血患者重症监护需求;当预测结果大于等于0且小于等于0.3时,脑出血患者不进行重症监护,将患者安排在普通病房进行监护,同时进行常规的医疗检查和护理;当预测结果大于0.3且小于等于0.7时,脑出血患者存在重症监护需求,将患者进行进一步的评估和密切监控,进行额外的诊断测试,确定是否需要转入重症监护病房,患者有优先访问重症监护资源的预案;当预测结果大于0.7且小于等于1时,脑出血患者必须进行重症监护,将患者立即转入重症监护病房进行密切监护和治疗,预防和处理潜在的严重并发症。As a preferred solution of the method for predicting the intensive care needs of patients with cerebral hemorrhage based on multimodal fusion described in the present invention, wherein: the identification of the intensive care needs of patients with cerebral hemorrhage includes predicting the real-time clinical data based on the prediction results of the multimodal fusion monitoring needs prediction model to identify the intensive care needs of patients with cerebral hemorrhage; when the prediction results When the predicted result is greater than or equal to 0 and less than or equal to 0.3, the patient with cerebral hemorrhage will not be placed in intensive care, but will be placed in a general ward for monitoring and undergo routine medical examinations and care. When the value is greater than 0.3 and less than or equal to 0.7, the patient with cerebral hemorrhage needs intensive care. The patient will be further evaluated and closely monitored, and additional diagnostic tests will be performed to determine whether he needs to be transferred to the intensive care unit. The patient has a plan for priority access to intensive care resources. When the predicted result is When it is greater than 0.7 and less than or equal to 1, patients with cerebral hemorrhage must receive intensive care and be immediately transferred to the intensive care unit for close monitoring and treatment to prevent and deal with potential serious complications.
本发明的另外一个目的是提供一种基于多模态融合的脑出血患者重症监护需求预测系统,其能通过构建多模态融合监护需求预测模型,对实时临床数据进行预测,识别脑出血患者重症监护需求,解决了目前的脑出血患者重症监护需求预测含有可靠性低的问题。Another object of the present invention is to provide a system for predicting the intensive care needs of patients with cerebral hemorrhage based on multimodal fusion, which can predict real-time clinical data and identify the intensive care needs of patients with cerebral hemorrhage by constructing a multimodal fusion monitoring needs prediction model, thereby solving the problem of low reliability in the current prediction of the intensive care needs of patients with cerebral hemorrhage.
作为本发明所述的基于多模态融合的脑出血患者重症监护需求预测系统的一种优选方案,其中:包括数据处理模块,特征提取模块,需求预测模块;所述数据处理模块用于采集脑出血患者的多模态数据,对多模态数据进行预处理;所述特征提取模块用于对预处理后的多模态数据进行特征提取,采用欠采样和过采样技术处理数据集不平衡问题;所述需求预测模块用于构建多模态融合监护需求预测模型,对实时临床数据进行预测,识别脑出血患者重症监护需求。As a preferred solution of the intensive care demand prediction system for cerebral hemorrhage patients based on multimodal fusion described in the present invention, it includes: a data processing module, a feature extraction module, and a demand prediction module; the data processing module is used to collect multimodal data of cerebral hemorrhage patients and preprocess the multimodal data; the feature extraction module is used to extract features from the preprocessed multimodal data, and use undersampling and oversampling techniques to deal with the imbalance problem of data sets; the demand prediction module is used to construct a multimodal fusion monitoring demand prediction model, predict real-time clinical data, and identify the intensive care needs of cerebral hemorrhage patients.
一种计算机设备,包括存储器和处理器,所述存储器存储有计算机程序,所述处理器执行所述计算机程序是实现基于多模态融合的脑出血患者重症监护需求预测方法的步骤。A computer device includes a memory and a processor, wherein the memory stores a computer program, and the processor executes the computer program to implement a method for predicting intensive care requirements of patients with cerebral hemorrhage based on multimodal fusion.
一种计算机可读存储介质,其上存储有计算机程序,所述计算机程序被处理器执行时实现基于多模态融合的脑出血患者重症监护需求预测方法的步骤。A computer-readable storage medium stores a computer program, which, when executed by a processor, implements the steps of a method for predicting intensive care requirements of patients with cerebral hemorrhage based on multimodal fusion.
本发明的有益效果:本发明提供的基于多模态融合的脑出血患者重症监护需求预测方法通过数据预处理,降低了由于数据问题带来的预测误差,提高了模型的鲁棒性和准确性,为后续的特征提取和预测模型构建奠定了坚实基础,通过对预处理后的多模态数据进行特征提取,采用欠采样和过采样技术处理数据集不平衡问题,实现了对数据中潜在有用信息的深度挖掘和数据分布的均衡化,通过特征提取和数据平衡处理,提高了模型对复杂和不平衡数据的适应能力,使得预测模型能够更准确地识别需要重症监护的患者,从而提升了预测的精度和可靠性,通过构建多模态融合监护需求预测模型,实现了对脑出血患者重症监护需求的实时预测,提高了预测的准确性和实时性,确保了患者能够在病情恶化时及时得到重症监护,降低了患者的死亡率和致残率,提升了整体医疗服务的质量,本发明在精准度、可靠性以及实时性方面都取得更加良好的效果。Beneficial effects of the present invention: The method for predicting the intensive care needs of patients with cerebral hemorrhage based on multimodal fusion provided by the present invention reduces the prediction error caused by data problems through data preprocessing, improves the robustness and accuracy of the model, and lays a solid foundation for subsequent feature extraction and prediction model construction. By extracting features from the preprocessed multimodal data and using undersampling and oversampling techniques to deal with the imbalance problem of the data set, deep mining of potentially useful information in the data and balanced data distribution are achieved. Through feature extraction and data balancing processing, the adaptability of the model to complex and unbalanced data is improved, so that the prediction model can more accurately identify patients who need intensive care, thereby improving the accuracy and reliability of the prediction. By constructing a multimodal fusion monitoring demand prediction model, real-time prediction of the intensive care needs of patients with cerebral hemorrhage is achieved, the accuracy and real-time of the prediction are improved, and it is ensured that patients can receive intensive care in time when their condition worsens, reducing the mortality and disability rates of patients and improving the overall quality of medical services. The present invention achieves better results in terms of accuracy, reliability and real-time performance.
附图说明BRIEF DESCRIPTION OF THE DRAWINGS
为了更清楚地说明本发明实施例的技术方案,下面将对实施例描述中所需要使用的附图作简单地介绍,显而易见地,下面描述中的附图仅仅是本发明的一些实施例,对于本领域普通技术人员来讲,在不付出创造性劳动的前提下,还可以根据这些附图获得其它的附图。In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the accompanying drawings required for use in the description of the embodiments will be briefly introduced below. Obviously, the accompanying drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other accompanying drawings can be obtained based on these accompanying drawings without paying creative work.
图1为本发明第一个实施例提供的一种基于多模态融合的脑出血患者重症监护需求预测方法的整体流程图。FIG1 is an overall flow chart of a method for predicting intensive care needs of patients with cerebral hemorrhage based on multimodal fusion provided in a first embodiment of the present invention.
图2为本发明第三个实施例提供的一种基于多模态融合的脑出血患者重症监护需求预测系统的整体流程图。FIG2 is an overall flow chart of a system for predicting the intensive care needs of patients with cerebral hemorrhage based on multimodal fusion according to a third embodiment of the present invention.
具体实施方式DETAILED DESCRIPTION
为使本发明的上述目的、特征和优点能够更加明显易懂,下面结合说明书附图对本发明的具体实施方式做详细的说明,显然所描述的实施例是本发明的一部分实施例,而不是全部实施例。基于本发明中的实施例,本领域普通人员在没有做出创造性劳动前提下所获得的所有其他实施例,都应当属于本发明的保护的范围。In order to make the above-mentioned purposes, features and advantages of the present invention more obvious and easy to understand, the specific implementation methods of the present invention are described in detail below in conjunction with the drawings of the specification. Obviously, the described embodiments are part of the embodiments of the present invention, but not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary persons in the art without creative work should fall within the scope of protection of the present invention.
实施例1Example 1
参照图1,为本发明的一个实施例,提供了一种基于多模态融合的脑出血患者重症监护需求预测方法,包括:Referring to FIG. 1 , an embodiment of the present invention provides a method for predicting the intensive care needs of patients with cerebral hemorrhage based on multimodal fusion, including:
S1:采集脑出血患者的多模态数据,对多模态数据进行预处理。S1: Collect multimodal data of patients with cerebral hemorrhage and preprocess the multimodal data.
更进一步的,脑出血患者的多模态数据包括临床数据和影像数据;临床数据包括患者人口学信息(如年龄、性别、体重、身高)、生命体征(如血压、心率、呼吸频率)、实验室检测结果(如血糖、血脂、肝肾功能指标)、病史信息(如高血压史、糖尿病史、心脏病史);影像数据包括CT图像、MRI图像、超声图像。Furthermore, the multimodal data of patients with cerebral hemorrhage include clinical data and imaging data; clinical data include patient demographic information (such as age, gender, weight, height), vital signs (such as blood pressure, heart rate, respiratory rate), laboratory test results (such as blood sugar, blood lipids, liver and kidney function indicators), and medical history information (such as history of hypertension, diabetes, and heart disease); imaging data include CT images, MRI images, and ultrasound images.
应说明的是,预处理包括对脑出血患者的多模态数据进行数据清洗、数据集成、数据转换;数据清洗包括对数据进行重新审查和校验,检查数据一致性,删除无效值填补缺失值;数据集成包括将不同来源和格式的数据整合在一起,通过患者的唯一标识符将数据统一到同一个数据集中;数据转换包括对数据进行归一化处理。It should be noted that preprocessing includes data cleaning, data integration, and data conversion of multimodal data of patients with cerebral hemorrhage; data cleaning includes re-examination and verification of data, checking data consistency, deleting invalid values and filling missing values; data integration includes integrating data from different sources and formats, and unifying the data into the same data set through the patient's unique identifier; data conversion includes normalizing the data.
还应说明的是,数据清洗通过重新审查和校验数据,检查数据一致性,删除无效值和填补缺失值,从而提高了数据的质量和可靠性,无效数据和缺失值可能导致模型训练过程中的误差和偏差,通过数据清洗,保证了模型训练数据的准确性和完整性,从而提升了预测模型的准确度,数据集成通过将不同来源和格式的数据整合在一起,利用患者的唯一标识符将数据统一到同一个数据集中,这样可以消除不同数据源之间的差异,形成一个全面且一致的患者数据视图,提高了数据的完整性和可用性,数据转换通过对数据进行归一化处理,使得不同量纲的数据能够在同一尺度上进行比较和分析,减少了由于量纲差异引起的误差,提高了数据的可比性和模型训练的稳定性。It should also be noted that data cleaning improves the quality and reliability of data by re-examining and verifying data, checking data consistency, deleting invalid values and filling missing values. Invalid data and missing values may cause errors and deviations in the model training process. Through data cleaning, the accuracy and completeness of model training data are guaranteed, thereby improving the accuracy of the predictive model. Data integration integrates data from different sources and formats and uses the patient's unique identifier to unify the data into the same data set. This can eliminate differences between different data sources, form a comprehensive and consistent patient data view, and improve data integrity and availability. Data conversion normalizes the data so that data of different dimensions can be compared and analyzed on the same scale, reducing errors caused by dimensional differences and improving data comparability and the stability of model training.
S2:对预处理后的多模态数据进行特征提取,采用欠采样和过采样技术处理数据集不平衡问题。S2: Perform feature extraction on the preprocessed multimodal data and use undersampling and oversampling techniques to deal with the imbalanced data set problem.
更进一步的,特征提取包括基于预处理后的多模态数据,适应脑出血患者病情的随时间的动态变化,进行非线性特征提取,表示为:Furthermore, feature extraction includes nonlinear feature extraction based on preprocessed multimodal data to adapt to the dynamic changes of the condition of patients with cerebral hemorrhage over time, which can be expressed as:
其中,gj(X(t))表示第j个非线性特征提取函数,用于从时间t上的多模态数据X(t)中提取非线性特征,X'(t)为时间t上的多模态数据集,包含脑出血患者在不同时间点的临床数据和影像数据,q为数据点的总数,bjl为第j个特征提取函数和第l个数据点之间的非线性权重系数,Xl(t)为时间t上多模态数据集中第l个数据点。Wherein, gj (X(t)) represents the j-th nonlinear feature extraction function, which is used to extract nonlinear features from the multimodal data X(t) at time t, X'(t) is the multimodal dataset at time t, which contains the clinical data and imaging data of patients with cerebral hemorrhage at different time points, q is the total number of data points, bjl is the nonlinear weight coefficient between the j-th feature extraction function and the l-th data point, and Xl (t) is the l-th data point in the multimodal dataset at time t.
应说明的是,处理数据集不平衡问题包括基于过采样调节模型对少数类的识别能力,欠采样平衡数据集的分布,获取平衡后的数据集,表示为:It should be noted that dealing with the imbalanced data set problem includes adjusting the recognition ability of the model for the minority class based on oversampling, balancing the distribution of the data set by undersampling, and obtaining the balanced data set, which is expressed as:
其中,Dbalanced为平衡后的数据集,表示通过欠采样与过采样技术处理后的脑出血患者多模态数据集,n为数据集中样本的总数,Xi表示数据集中第i个样本,X表示多模态数据集,包括临床数据和影像数据,d(Xi,X)表示距离函数,计算第i个样本与整个数据集X的距离,λ表示调节参数,用于控制数据合成的幅度,NN(X(t))表示在时间t上的最近邻样本函数,表示为:Where D balanced is the balanced data set, which represents the multimodal data set of patients with cerebral hemorrhage after undersampling and oversampling techniques. n is the total number of samples in the data set. Xi represents the i-th sample in the data set. X represents the multimodal data set, including clinical data and imaging data. d( Xi , X) represents the distance function, which calculates the distance between the i-th sample and the entire data set X. λ represents the adjustment parameter used to control the amplitude of data synthesis. NN(X(t)) represents the nearest neighbor sample function at time t, which is expressed as:
其中,X'表示最近邻样本,计算第i个样本与整个数据集X的距离表示为:Among them, X' represents the nearest neighbor sample, and the distance between the i-th sample and the entire data set X is expressed as:
其中,Xij'表示数据集中第i个样本的第j'个特征值,Xj'表示数据集中第j'个特征,m表示每个样本向量中包含的特征数量。Among them, Xij ' represents the j'th eigenvalue of the i-th sample in the data set, Xj ' represents the j'th feature in the data set, and m represents the number of features contained in each sample vector.
还应说明的是,特征提取通过适应脑出血患者病情的随时间的动态变化,进行非线性特征提取,提升了模型对复杂病情的捕捉能力,从时间序列数据中提取出具有高度信息量的非线性特征,增强了模型的预测准确性,数据不平衡处理采用欠采样和过采样技术,提高了模型对少数类样本的识别能力。It should also be noted that feature extraction improves the model's ability to capture complex conditions by adapting to the dynamic changes in the condition of patients with cerebral hemorrhage over time and performing nonlinear feature extraction, thereby extracting highly informative nonlinear features from time series data and enhancing the model's prediction accuracy. Data imbalance processing uses undersampling and oversampling techniques to improve the model's ability to recognize minority samples.
S3:构建多模态融合监护需求预测模型,对实时临床数据进行预测,识别脑出血患者重症监护需求。S3: Build a multimodal fusion monitoring demand prediction model to predict real-time clinical data and identify the intensive care needs of patients with cerebral hemorrhage.
更进一步的,构建多模态融合监护需求预测模型包括基于提取出的临床数据和影像数据的特征,进行多模态特征融合,表示为:Furthermore, constructing a multimodal fusion monitoring demand prediction model includes performing multimodal feature fusion based on the features of the extracted clinical data and imaging data, which is expressed as:
其中,Φfusion为融合特征集,nc表示临床特征的数量,αc表示第c个临床特征的权重系数,T表示时间周期,Φclinical,c表示第c个临床特征随时间t变化的值,nk表示影像特征的数量,βk表示第k个影像特征的权重系数,Φimaging,k表示第k个影像特征随时间t变化的值;将多模态特征融合后的特征作为输入,通过时间变化的权重矩阵对特征数据进行加权处理,构建多模态融合监护需求预测模型,表示为:Among them, Φ fusion is the fusion feature set, n c represents the number of clinical features, α c represents the weight coefficient of the cth clinical feature, T represents the time period, Φ clinical,c represents the value of the cth clinical feature changing with time t, n k represents the number of imaging features, β k represents the weight coefficient of the kth imaging feature, and Φ imaging,k represents the value of the kth imaging feature changing with time t. The features after multimodal feature fusion are taken as input, and the feature data are weighted by the time-varying weight matrix to construct a multimodal fusion monitoring demand prediction model, which is expressed as:
其中,为预测结果,W(t)为时间t上的权重矩阵,基于时间变换进行调整,Xtarget(t)表示目标领域在时间t上的多模态数据,包括临床特征和影像特征的向量或矩阵,Wt(t)与Xtarget(t)的维度一致,ftarget表示目标领域的预测函数,包括逻辑回归函数。in, is the prediction result, W(t) is the weight matrix at time t, which is adjusted based on the time transformation, Xtarget (t) represents the multimodal data of the target field at time t, including the vector or matrix of clinical features and imaging features, Wt (t) has the same dimension as Xtarget (t), and ftarget represents the prediction function of the target field, including the logistic regression function.
应说明的是,识别脑出血患者重症监护需求包括基于多模态融合监护需求预测模型的预测结果,对实时临床数据进行预测,识别脑出血患者重症监护需求;当预测结果大于等于0且小于等于0.3时,脑出血患者不进行重症监护,将患者安排在普通病房进行监护,同时进行常规的医疗检查和护理;当预测结果大于0.3且小于等于0.7时,脑出血患者存在重症监护需求,将患者进行进一步的评估和密切监控,进行额外的诊断测试,确定是否需要转入重症监护病房,患者有优先访问重症监护资源的预案;当预测结果大于0.7且小于等于1时,脑出血患者必须进行重症监护,将患者立即转入重症监护病房进行密切监护和治疗,预防和处理潜在的严重并发症。It should be noted that identifying the intensive care needs of patients with cerebral hemorrhage includes predicting the real-time clinical data based on the prediction results of the multimodal fusion monitoring needs prediction model to identify the intensive care needs of patients with cerebral hemorrhage; when the prediction results When the predicted result is greater than or equal to 0 and less than or equal to 0.3, the patient with cerebral hemorrhage will not be placed in intensive care, but will be placed in a general ward for monitoring and undergo routine medical examinations and care. When the value is greater than 0.3 and less than or equal to 0.7, the patient with cerebral hemorrhage needs intensive care. The patient will be further evaluated and closely monitored, and additional diagnostic tests will be performed to determine whether he needs to be transferred to the intensive care unit. The patient has a plan for priority access to intensive care resources. When the predicted result is When it is greater than 0.7 and less than or equal to 1, patients with cerebral hemorrhage must receive intensive care and be immediately transferred to the intensive care unit for close monitoring and treatment to prevent and deal with potential serious complications.
还应说明的是,动态加权处理确保了模型在面对不断变化的病情数据时,能够及时调整预测结果,为医护人员提供准确的实时决策支持,提取多模态数据中的非线性特征,能够捕捉复杂的病情变化模式,在脑出血患者的病情预测中尤为有效,因为脑出血病情往往具有复杂的动态变化特征,非线性特征提取能够提供更高的预测精度,通过综合采用欠采样与过采样技术,平衡数据集的分布,提高模型对少数类样本(如需要重症监护的患者)的识别能力,通过调节参数和最近邻样本函数的结合,增强了数据合成的灵活性和适应性,避免了传统方法中过拟合或欠拟合的问题。It should also be noted that dynamic weighted processing ensures that the model can adjust the prediction results in time when facing constantly changing disease data, provide accurate real-time decision support for medical staff, extract nonlinear features in multimodal data, and capture complex disease change patterns. It is particularly effective in predicting the condition of patients with cerebral hemorrhage, because cerebral hemorrhage often has complex dynamic change characteristics. Nonlinear feature extraction can provide higher prediction accuracy. By combining undersampling and oversampling techniques, the distribution of the data set is balanced, and the model's recognition ability for minority samples (such as patients requiring intensive care) is improved. By adjusting the combination of parameters and nearest neighbor sample functions, the flexibility and adaptability of data synthesis are enhanced, avoiding the problems of overfitting or underfitting in traditional methods.
实施例2Example 2
本发明的一个实施例,提供了一种基于多模态融合的脑出血患者重症监护需求预测方法,为了验证本发明的有益效果,通过经济效益计算和仿真实验进行科学论证。One embodiment of the present invention provides a method for predicting the intensive care needs of patients with cerebral hemorrhage based on multimodal fusion. In order to verify the beneficial effects of the present invention, scientific demonstration is carried out through economic benefit calculation and simulation experiments.
首先,选择了10名脑出血患者,采集其多模态数据,包括临床数据和影像数据,采集每位脑出血患者的多模态数据,包括临床数据(人口学信息、生命体征、实验室检测结果、病史信息)和影像数据(CT图像、MRI图像、超声图像),对采集到的数据进行清洗,检查数据的一致性,删除无效值并填补缺失值,对于生命体征中的血压数据,检查其范围是否合理,对于缺失的检测结果数据,采用均值填补,将不同来源和格式的数据整合在一起,通过患者的唯一标识符将数据统一到同一个数据集中,整合CT、MRI和临床数据,形成一个完整的数据记录,对整合后的数据进行归一化处理,使不同量纲的数据在同一尺度上进行分析,将血糖、血压等数据归一化到[0,1]的范围内,基于预处理后的多模态数据,适应脑出血患者病情随时间的动态变化,进行非线性特征提取,采用欠采样和过采样技术处理数据集的不平衡问题,过采样调节模型对少数类(需要重症监护的患者)的识别能力,欠采样平衡数据集的分布,获取平衡后的数据集,基于提取出的临床数据和影像数据的特征,进行多模态特征融合,将多模态特征融合后的特征作为输入,通过时间变化的权重矩阵对特征数据进行加权处理,构建多模态融合监护需求预测模型,根据预测结果,识别脑出血患者的重症监护需求,并根据不同的预测值采取相应的医疗措施,参考表1,对实验数据进行记录分析。First, 10 patients with cerebral hemorrhage were selected, and their multimodal data, including clinical data and imaging data, were collected. Multimodal data of each patient with cerebral hemorrhage, including clinical data (demographic information, vital signs, laboratory test results, medical history information) and imaging data (CT images, MRI images, ultrasound images), were collected, the collected data were cleaned, the consistency of the data was checked, invalid values were deleted, and missing values were filled. For the blood pressure data in the vital signs, its range was checked to see if it was reasonable. For the missing test result data, the mean was filled. Data from different sources and formats were integrated together and unified into the same data set through the patient's unique identifier. CT, MRI and clinical data were integrated to form a complete data record, and the integrated data were normalized so that data of different dimensions could be analyzed on the same scale. , normalize blood sugar, blood pressure and other data to the range of [0,1], based on the preprocessed multimodal data, adapt to the dynamic changes of the condition of patients with cerebral hemorrhage over time, perform nonlinear feature extraction, use undersampling and oversampling techniques to deal with the imbalance of the data set, oversampling adjusts the model's recognition ability for the minority class (patients who need intensive care), undersampling balances the distribution of the data set, obtains the balanced data set, and based on the extracted features of the clinical data and imaging data, performs multimodal feature fusion, takes the features after multimodal feature fusion as input, and weights the feature data through the time-varying weight matrix to construct a multimodal fusion monitoring demand prediction model. According to the prediction results, identify the intensive care needs of patients with cerebral hemorrhage, and take corresponding medical measures according to different prediction values. Refer to Table 1 to record and analyze the experimental data.
表1实验数据记录表Table 1 Experimental data record table
表格中展示了不同患者的临床数据和影像数据,包括年龄、性别、血压、血糖、CT异常评分和MRI异常评分,通过多模态融合模型,能够综合这些多源数据,实现更高准确度的重症监护需求预测,例如,患者1的预测结果为0.72,患者2的预测结果为0.85,这些结果反映了模型对不同患者病情的精确评估,我方发明模型能够处理随时间变化的多模态数据,捕捉患者病情的动和影像数据变化,模型能够及时调整预测结果,提供实时的重症监护需求建议,采用欠采样和过采样技术处理数据不平衡问题,使得模型在面对少数类样本(需要重症监护的患者)时仍能保持高识别率,例如,表格中展示了多位需要重症监护的患者,预测结果均在0.7以上,表明模型对重症患者的高识别能力,通过非线性特征提取方法,从复杂的多模态数据中提取出关键特征,提升了模型的预测性能,如患者4的预测结果为0.90,结合其高CT和MRI异常评分,表明模型能够准确提取和利用这些非线性特征进行预测,与现有技术相比,本发明的多模态融合监护需求预测方法具有创新性和优势,传统方法多依赖单一数据源,无法充分利用多模态数据的优势,而本发明通过融合多源数据,提高了预测的准确性和稳定性,此外,处理数据不平衡问题的技术应用,使得模型在实际应用中更具鲁棒性和实用性。The table shows the clinical data and imaging data of different patients, including age, gender, blood pressure, blood sugar, CT abnormality score and MRI abnormality score. Through the multimodal fusion model, these multi-source data can be integrated to achieve a more accurate prediction of intensive care needs. For example, the prediction result for patient 1 is 0.72, and the prediction result for patient 2 is 0.85. These results reflect the model's accurate assessment of the conditions of different patients. Our invented model can process multimodal data that changes over time, capture the dynamic and imaging data changes of the patient's condition, and adjust the prediction results in time to provide real-time intensive care needs recommendations. Undersampling and oversampling techniques are used to deal with data imbalance problems, so that the model can still maintain a high recognition rate when facing minority samples (patients requiring intensive care). For example, in the table Several patients who required intensive care were displayed, and the prediction results were all above 0.7, indicating that the model had a high recognition ability for critically ill patients. Through the nonlinear feature extraction method, key features were extracted from complex multimodal data, which improved the prediction performance of the model. For example, the prediction result of patient 4 was 0.90, combined with his high CT and MRI abnormality scores, indicating that the model was able to accurately extract and utilize these nonlinear features for prediction. Compared with the prior art, the multimodal fusion monitoring demand prediction method of the present invention is innovative and advantageous. Traditional methods mostly rely on a single data source and cannot fully utilize the advantages of multimodal data. The present invention improves the accuracy and stability of prediction by fusing multi-source data. In addition, the application of technology to deal with data imbalance problems makes the model more robust and practical in practical applications.
实施例3Example 3
参照图2,为本发明的一个实施例,提供了一种基于多模态融合的脑出血患者重症监护需求预测系统,包括数据处理模块,特征提取模块,需求预测模块。2 , which is an embodiment of the present invention, provides a system for predicting the intensive care needs of patients with cerebral hemorrhage based on multimodal fusion, including a data processing module, a feature extraction module, and a demand prediction module.
其中数据处理模块用于采集脑出血患者的多模态数据,对多模态数据进行预处理;特征提取模块用于对预处理后的多模态数据进行特征提取,采用欠采样和过采样技术处理数据集不平衡问题;需求预测模块用于构建多模态融合监护需求预测模型,对实时临床数据进行预测,识别脑出血患者重症监护需求。The data processing module is used to collect multimodal data of patients with cerebral hemorrhage and preprocess the multimodal data; the feature extraction module is used to extract features from the preprocessed multimodal data and use undersampling and oversampling techniques to deal with the imbalance problem of data sets; the demand prediction module is used to build a multimodal fusion monitoring demand prediction model, predict real-time clinical data, and identify the intensive care needs of patients with cerebral hemorrhage.
功能如果以软件功能单元的形式实现并作为独立的产品销售或使用时,可以存储在一个计算机可读取存储介质中。基于这样的理解,本发明的技术方案本质上或者说对现有技术做出贡献的部分或者该技术方案的部分可以以软件产品的形式体现出来,该计算机软件产品存储在一个存储介质中,包括若干指令用以使得一台计算机设备(可以是个人计算机,服务器,或者网络设备等)执行本发明各个实施例方法的全部或部分步骤。而前述的存储介质包括:U盘、移动硬盘、只读存储器(ROM,Read-Only Memory)、随机存取存储器(RAM,Random Access Memory)、磁碟或者光盘等各种可以存储程序代码的介质。If the function is implemented in the form of a software functional unit and sold or used as an independent product, it can be stored in a computer-readable storage medium. Based on this understanding, the technical solution of the present invention, or the part that contributes to the prior art, or the part of the technical solution, can be embodied in the form of a software product. The computer software product is stored in a storage medium, including several instructions for a computer device (which can be a personal computer, server, or network device, etc.) to perform all or part of the steps of the methods of each embodiment of the present invention. The aforementioned storage medium includes: U disk, mobile hard disk, read-only memory (ROM, Read-Only Memory), random access memory (RAM, Random Access Memory), disk or optical disk, etc. Various media that can store program codes.
在流程图中表示或在此以其他方式描述的逻辑和/或步骤,例如,可以被认为是用于实现逻辑功能的可执行指令的定序列表,可以具体实现在任何计算机可读介质中,以供指令执行系统、装置或设备(如基于计算机的系统、包括处理器的系统或其他可以从指令执行系统、装置或设备取指令并执行指令的系统)使用,或结合这些指令执行系统、装置或设备而使用。就本说明书而言,“计算机可读介质”可以是任何可以包含、存储、通信、传播或传输程序以供指令执行系统、装置或设备或结合这些指令执行系统、装置或设备而使用的装置。The logic and/or steps represented in the flowchart or otherwise described herein, for example, can be considered as an ordered list of executable instructions for implementing logical functions, and can be embodied in any computer-readable medium for use by an instruction execution system, device or apparatus (such as a computer-based system, a system including a processor, or other system that can fetch instructions from an instruction execution system, device or apparatus and execute instructions), or in conjunction with such instruction execution systems, devices or apparatuses. For the purposes of this specification, "computer-readable medium" can be any device that can contain, store, communicate, propagate or transmit a program for use by an instruction execution system, device or apparatus, or in conjunction with such instruction execution systems, devices or apparatuses.
计算机可读介质的更具体的示例(非穷尽性列表)包括以下:具有一个或多个布线的电连接部(电子装置)、便携式计算机盘盒(磁装置)、随机存取存储器(RAM)、只读存储器(ROM)、可擦除可编辑只读存储器(EPROM或闪速存储器)、光纤装置以及便携式光盘只读存储器(CDROM)。另外,计算机可读介质甚至可以是可在其上打印程序的纸或其他合适的介质,因为可以例如通过对纸或其他介质进行光学扫描,接着进行编辑、解译或必要时以其他合适方式进行处理来以电子方式获得程序,然后将其存储在计算机存储器中。More specific examples of computer-readable media (a non-exhaustive list) include the following: an electrical connection with one or more wires (electronic device), a portable computer disk case (magnetic device), a random access memory (RAM), a read-only memory (ROM), an erasable and programmable read-only memory (EPROM or flash memory), an optical fiber device, and a portable compact disk read-only memory (CDROM). In addition, the computer-readable medium may even be a paper or other suitable medium on which the program is printed, since the program may be obtained electronically, for example, by optically scanning the paper or other medium, followed by editing, deciphering or, if necessary, processing in another suitable manner, and then stored in a computer memory.
应当理解,本发明的各部分可以用硬件、软件、固件或它们的组合来实现。在上述实施方式中,多个步骤或方法可以用存储在存储器中且由合适的指令执行系统执行的软件或固件来实现。例如,如果用硬件来实现,和在另一实施方式中一样,可用本领域公知的下列技术中的任一项或他们的组合来实现:具有用于对数据信号实现逻辑功能的逻辑门电路的离散逻辑电路,具有合适的组合逻辑门电路的专用集成电路,可编程门阵列(PGA),现场可编程门阵列(FPGA)等。应说明的是,以上实施例仅用以说明本发明的技术方案而非限制,尽管参照较佳实施例对本发明进行了详细说明,本领域的普通技术人员应当理解,可以对本发明的技术方案进行修改或者等同替换,而不脱离本发明技术方案的精神和范围,其均应涵盖在本发明的权利要求范围当中。It should be understood that the various parts of the present invention can be implemented by hardware, software, firmware or a combination thereof. In the above-mentioned embodiments, multiple steps or methods can be implemented by software or firmware stored in a memory and executed by a suitable instruction execution system. For example, if implemented by hardware, as in another embodiment, it can be implemented by any one of the following technologies known in the art or their combination: a discrete logic circuit having a logic gate circuit for implementing a logic function for a data signal, a dedicated integrated circuit having a suitable combination of logic gate circuits, a programmable gate array (PGA), a field programmable gate array (FPGA), etc. It should be noted that the above embodiments are only used to illustrate the technical solution of the present invention and are not limited. Although the present invention is described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that the technical solution of the present invention can be modified or replaced by equivalents without departing from the spirit and scope of the technical solution of the present invention, which should be included in the scope of the claims of the present invention.
应说明的是,以上实施例仅用以说明本发明的技术方案而非限制,尽管参照较佳实施例对本发明进行了详细说明,本领域的普通技术人员应当理解,可以对本发明的技术方案进行修改或者等同替换,而不脱离本发明技术方案的精神和范围,其均应涵盖在本发明的权利要求范围当中。It should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention rather than to limit it. Although the present invention has been described in detail with reference to the preferred embodiments, those skilled in the art should understand that the technical solutions of the present invention may be modified or replaced by equivalents without departing from the spirit and scope of the technical solutions of the present invention, which should all be included in the scope of the claims of the present invention.
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