CN117761124A - Pressure product correction method and device with temperature compensation - Google Patents
Pressure product correction method and device with temperature compensation Download PDFInfo
- Publication number
- CN117761124A CN117761124A CN202311789657.6A CN202311789657A CN117761124A CN 117761124 A CN117761124 A CN 117761124A CN 202311789657 A CN202311789657 A CN 202311789657A CN 117761124 A CN117761124 A CN 117761124A
- Authority
- CN
- China
- Prior art keywords
- hematocrit value
- temperature compensation
- temperature
- hematocrit
- value
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Investigating Or Analysing Biological Materials (AREA)
Abstract
The application discloses a packed volume correction method and device with temperature compensation, which are applied to the field of measurement of packed volume values of erythrocytes. The method provided by the application comprises the following steps: acquiring an original electric signal and a current test temperature of a sample to be tested; substituting the original electric signal into a correction function to calculate an initial hematocrit value; substituting the current test temperature into a temperature compensation function to calculate a Wen Bu coefficient; and determining a target hematocrit value according to the initial hematocrit value and the temperature compensation coefficient. According to the method and the device, through the corresponding relation between the original electrical signal in the correction function and the hematocrit value, the obtained initial hematocrit value is accurate, meanwhile, the temperature compensation coefficient in the temperature compensation function and the target hematocrit value determined by the initial hematocrit value compensate the problem that the hematocrit value is affected by temperature, and the accurate target hematocrit value is provided for the final measurement result of the sample to be measured.
Description
Technical Field
The present application relates to the field of measurement of hematocrit values, and in particular, to a hematocrit correction method and apparatus with temperature compensation.
Background
The electrochemical biosensor reacts with the molecules to be detected in a specific mode and converts the reaction signals into measurable electric signals, so that the aim of quantitatively testing the molecules to be detected is fulfilled. The sensor has the advantages of convenience, rapidness, high sensitivity, strong specificity and the like. The device is widely applied to bedside detection and household chronic disease monitoring, such as portable blood sugar and uric acid testers. However, such portable testers are susceptible to the influence of hematocrit when testing blood samples, thereby causing interference to test results and inaccurate test values.
The impedance method in the current testing method of the hematocrit value is widely applied because of high testing accuracy. However, the impedance method is susceptible to temperature, so that compensation correction of temperature is necessary to obtain more accurate hematocrit value.
In view of the above, it is a problem to be solved by those skilled in the art to find a method for correcting the pressure product with temperature compensation.
Disclosure of Invention
The purpose of the application is to provide a pressure product correction method and device with temperature compensation. The influence of the hematocrit value measured by the impedance method under the temperature change can be solved.
In order to solve the above technical problems, the present application provides a pressure product correction method with temperature compensation, including:
acquiring an original electric signal and a current test temperature of a sample to be tested;
substituting the original electric signal into a correction function to calculate an initial hematocrit value;
substituting the current test temperature into a temperature compensation function to calculate a Wen Bu coefficient;
and determining a target hematocrit value according to the initial hematocrit value and the temperature compensation coefficient.
Preferably, the correction function is determined by the following method:
respectively configuring a plurality of packed samples with different packed values of red blood cells;
respectively acquiring first target electric signals of each packed sample at a preset temperature;
fitting the first target electric signal and the first reference hematocrit value of each convolution sample by adopting a regression analysis method to obtain a correction function.
Preferably, the correction function is determined by the following method:
respectively configuring a plurality of packed samples with different packed values of red blood cells;
respectively acquiring first target electric signals of each packed sample at a preset temperature;
fitting each first target electric signal belonging to the same pressure-accumulation zone and a corresponding first reference red blood cell pressure-accumulation value by adopting a regression analysis method to obtain each initial correction function of each pressure-accumulation zone; wherein, each initial correction function is used as the correction function of the corresponding pressure product interval.
Preferably, the temperature compensation function is determined by the following method:
respectively configuring a plurality of packed samples with different packed values of red blood cells;
respectively acquiring second target electric signals of each packed sample at different test temperatures
Carrying the second target electric signals into a correction function to calculate first red blood cell packed value of each packed sample at different test temperatures;
and performing data fitting on the second reference hematocrit value, the first hematocrit value and the corresponding test temperature of each hematocrit sample to obtain a temperature compensation function.
Preferably, the fitting of data to the second reference hematocrit value, the first hematocrit value, and the corresponding test temperatures of each hematocrit sample to obtain a temperature compensation function includes:
fitting the second reference hematocrit value of each hematocrit sample and the ratio of the corresponding first hematocrit value to the test temperature corresponding to the first hematocrit value to obtain a temperature compensation function.
Preferably, the fitting of data to the second reference hematocrit value, the first hematocrit value, and the corresponding test temperatures of each hematocrit sample to obtain a temperature compensation function includes:
acquiring an average value of the ratio of the second reference hematocrit value to the corresponding first hematocrit value of each hematocrit sample at each test temperature;
performing data fitting on the test temperature and the corresponding average value which belong to one temperature interval to obtain an initial temperature compensation function corresponding to each temperature interval; wherein, each initial temperature compensation function is used as the temperature compensation function of the corresponding temperature interval.
Preferably, determining the target hematocrit value from the initial hematocrit value and the temperature compensation coefficient includes:
taking the product of the initial hematocrit value and the temperature compensation coefficient as a target hematocrit value.
Preferably, the primary electric start signal includes: at least one of an impedance signal, a resistance signal, an inductive reactance signal and a phase signal.
Preferably, the raw electrical signal comprises an impedance signal and a resistance signal.
For solving the technical problem, the application further provides a pressure product correction device with temperature compensation, which comprises:
the acquisition module is used for acquiring an original electric signal and a current test temperature of a sample to be tested;
the first calculation module is used for substituting the original electric signal into the correction function to calculate an initial hematocrit value;
the second calculation module is used for substituting the current test temperature into the temperature compensation function to calculate a Wen Bu coefficient;
and the determining module is used for determining a target hematocrit value according to the initial hematocrit value and the temperature compensation coefficient.
The application provides a pressure product correction method with temperature compensation, which comprises the following steps: acquiring an original electric signal and a current test temperature of a sample to be tested; substituting the original electric signal into a correction function to calculate an initial hematocrit value; substituting the current test temperature into a temperature compensation function to calculate a Wen Bu coefficient; and determining a target hematocrit value according to the initial hematocrit value and the temperature compensation coefficient. According to the method and the device, through the corresponding relation between the original electrical signal in the correction function and the hematocrit value, the obtained initial hematocrit value is accurate, meanwhile, the temperature compensation coefficient in the temperature compensation function and the target hematocrit value determined by the initial hematocrit value compensate the problem that the hematocrit value is affected by temperature, and the accurate target hematocrit value is provided for the final measurement result of the sample to be measured.
Drawings
For a clearer description of the embodiments of the present application, the drawings that are needed in the embodiments will be briefly described, it being apparent that the drawings in the following description are only some embodiments of the present application, and that other drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.
FIG. 1 is a flow chart of a pressure product correction method with temperature compensation according to an embodiment of the present application;
fig. 2 is a block diagram of a pressure-accumulation correcting device with temperature compensation according to another embodiment of the present application.
Detailed Description
The following description of the technical solutions in the embodiments of the present application will be made clearly and completely with reference to the drawings in the embodiments of the present application, and it is apparent that the described embodiments are only some embodiments of the present application, but not all embodiments. All other embodiments obtained by those skilled in the art based on the embodiments herein without making any inventive effort are intended to fall within the scope of the present application.
The core of the application is to provide a method and a device for correcting the pressure product with temperature compensation.
In order to provide a better understanding of the present application, those skilled in the art will now make further details of the present application with reference to the drawings and detailed description.
The electrochemical biosensor reacts with the molecules to be detected in a specific mode and converts the reaction signal into a measurable electric signal, so that the aim of quantitatively testing the molecules to be detected is fulfilled. However, such portable testers are susceptible to the hematocrit during testing of a blood sample, and thus interfere with the test result, resulting in inaccurate test values, and when the hematocrit is low, the test current may be high, and when the hematocrit is high, the test current may be low, so that in order to obtain a more accurate test value, correction of the hematocrit is necessary.
The current methods for testing the hematocrit value include a flow velocity method, a pulse method and an impedance method, wherein the impedance method is widely applied because of high testing accuracy. However, the hematocrit value of the impedance method is easily affected by temperature, when the temperature is too high, the impedance value may be too low, when the temperature is too low, the impedance value may be too high, whether the impedance value is too high or too low, and the hematocrit value obtained by the final test is inaccurate. Therefore, in order to obtain a more accurate hematocrit value, a compensation correction must be made for the temperature.
To this end, the present application provides a flowchart of a method for correcting a pressure product with temperature compensation, as shown in fig. 1, including:
s10: and acquiring an original electric signal and a current test temperature of the sample to be tested.
In a specific embodiment, the liquid to be tested passes the electrochemical impedance test, and the original electrical signal corresponding to the liquid to be tested and related to the liquid to be tested can be obtained. Wherein, in the process of actual acquisition, the original electrical signal comprises various signals, such as: impedance signals, resistance signals, inductive reactance signals, phase signals, etc. Meanwhile, the hematocrit value is related to the temperature, so that the current test temperature corresponding to the current liquid to be tested needs to be obtained, so that the hematocrit value of the sample to be tested is subjected to temperature compensation according to the subsequent steps.
The hematocrit value of the sample to be measured has a certain corresponding relation with the original electric signal of the sample to be measured. In the process of calculating the hematocrit value, the more the variety included in the original electrical signal, the more accurate the calculation of the hematocrit value, but the corresponding calculation amount is also larger. In order to ensure that the obtained hematocrit value is accurate and reduce the calculated amount, the method and the device can preferably obtain an impedance signal and a resistance signal which are high in correlation with the hematocrit value in the original electric signal. That is, in the calculation of the hematocrit value, the corresponding hematocrit value may be determined by the impedance signal and the resistance signal.
S11: and substituting the original electric signal into a correction function to calculate an initial hematocrit value.
In a specific embodiment, the original electrical signal is an important parameter for determining the initial hematocrit value, and in order to avoid the influence of the environmental parameter on the initial hematocrit value obtained in step S11, it is necessary to ensure that the environment in which the step is located is uniform in the process of substituting the original electrical signal into the correction function to calculate the initial hematocrit value. The correction function in the present application is a correspondence between the original electrical signal and the initial hematocrit value, because the original electrical signal is an important parameter for determining the initial hematocrit value. It should be noted that, the correction function may be one or more, and for the case that the correction function is one, the original electrical signal is substituted into the correction function to calculate, so as to obtain the initial hematocrit value corresponding to the original electrical signal; for the case that the correction functions are multiple, the correction functions can be different initial correction functions corresponding to different pressure-accumulation regions, the correction functions are composed of the multiple initial correction functions, after the sample to be detected in the step S10 is obtained, the pressure-accumulation region to which the sample to be detected belongs is estimated, then the initial correction function corresponding to the current pressure-accumulation region is determined, then the original electric signal of the sample to be detected is obtained, the original electric signal is brought into the determined initial correction function, and the initial red blood cell pressure-accumulation value corresponding to the current original electric signal can be obtained through calculation.
As a preference, when the original electrical signal comprises an impedance signal and a resistance signal, the correction function may be a binary linear function expressed as:
H ct ＝A*Z+B*R+C；
wherein H is ct For the initial hematocrit value, Z is the impedance signal, R is the resistance signal, A, B and C are the fitting coefficients corresponding to the correction function.
In practical applications, the fitting coefficients of the correction function are determined, and the specific values of the fitting coefficients are not specifically limited in this application. The initial hematocrit value is calculated from the original electrical signal, and is a calculated value.
It should be noted that, the correction function expression provided in the present application is only one implementation manner, but is not limited to only this manner, and may be set according to the needs of the user.
S12: and substituting the current test temperature into a temperature compensation function to calculate a Wen Bu coefficient.
In a specific embodiment, since the temperature has a large influence on the final determined target hematocrit value, temperature compensation is required in the calculation process, and in order to ensure the effect of temperature compensation, and at the same time, to avoid the influence of the change of the surrounding environment on the effect of compensation, it is required to ensure that the environment in which the process is located is uniform. The test temperature is an important factor affecting accuracy of the hematocrit value, so the temperature compensation function in the application is a corresponding relation between the reaction test temperature and the temperature compensation coefficient. It should be noted that, the temperature compensation function may be one or more, for the case that the temperature compensation function is one, after the current test temperature is obtained, the current test temperature is brought into the temperature compensation function to calculate, so as to obtain a Wen Bu coefficient corresponding to the current test temperature; for the case that the temperature compensation functions are multiple, different temperature intervals correspond to different initial temperature compensation functions, namely the temperature compensation functions are formed by the initial temperature compensation functions, after the current test temperature is obtained, the temperature interval to which the current test temperature belongs is firstly determined, then the initial temperature compensation function corresponding to the interval is determined, and then the current test temperature is carried into the determined initial temperature compensation function to be calculated, so that the Wen Bu coefficient corresponding to the current test temperature can be obtained.
Preferably, the temperature compensation function is a unitary quadratic function, and the expression is:
H t ＝a*T 2 +b*T+c；
wherein H is t And T is the temperature, and a, b and c are fitting coefficients corresponding to temperature compensation functions.
In practical applications, the fitting coefficient of the temperature compensation function is determined, and the specific numerical value of the fitting coefficient is not specifically limited in the application. In the calculation of the temperature compensation coefficient, the corresponding Wen Bu coefficient can be determined only according to the current test temperature and the temperature compensation function.
It should be noted that, the temperature compensation function expression provided in the application is only one mode that can be implemented, but is not limited to only this mode, and can be set according to the needs of users.
S13: and determining a target hematocrit value according to the initial hematocrit value and the temperature compensation coefficient.
In a specific embodiment, according to step S11, an initial hematocrit value of the sample to be tested calculated at the current test temperature may be obtained, and according to step S12, a Wen Bu coefficient corresponding to the current test temperature may be obtained. According to the initial hematocrit value and the corresponding temperature compensation coefficient, the accurate target hematocrit value of the sample to be tested at the current test temperature can be determined.
The product of the initial hematocrit value and the temperature compensation coefficient may be used as a target hematocrit value, or a ratio of the initial hematocrit value to the temperature compensation coefficient may be used as a target hematocrit value, or the target hematocrit value corresponding to the initial hematocrit value and the Wen Bu coefficient may be determined according to a preset calculation formula, which is not limited in this application and may be set automatically according to a user's requirement.
The application provides a pressure product correction method with temperature compensation, which comprises the following steps: acquiring an original electric signal and a current test temperature of a sample to be tested; calculating an initial hematocrit value according to the original electrical signal substituted into the correction function; calculating Wen Bu coefficients according to the temperature compensation function substituted by the current test temperature; and determining a target hematocrit value according to the initial hematocrit value and the temperature compensation coefficient. According to the method and the device, through the corresponding relation between the original electrical signal in the correction function and the hematocrit value, the obtained initial hematocrit value is accurate, meanwhile, the temperature compensation coefficient in the temperature compensation function and the target hematocrit value determined by the initial hematocrit value compensate the problem that the hematocrit value is affected by temperature, and the accurate target hematocrit value is provided for the final measurement result of the sample to be measured.
From the above, when the correction function is 1, the correction function is determined by the following method:
respectively configuring a plurality of packed samples with different packed values of red blood cells;
respectively acquiring first target electric signals of each packed sample at a preset temperature;
fitting the first target electric signal and the first reference hematocrit value of each convolution sample by adopting a regression analysis method to obtain a correction function.
In a specific embodiment, obtaining the correction function includes: firstly configuring each packed sample corresponding to different packed values, then acquiring each first target electric signal of each packed sample in the normal temperature environment under the normal temperature environment, simultaneously acquiring a preset measurement method to determine each first reference packed value of each packed sample in the normal temperature environment, and fitting by adopting a regression analysis method according to each first target electric signal and each corresponding first reference packed value at the moment to obtain a correction function.
According to the above, examples are: at a preset temperature (e.g., 25 ℃), samples of the hematocrit at 7 different hematocrit values were prepared, with the assigned hematocrit values: 10%, 20%, 30%, 40%, 50%, 60%, 70%. Meanwhile, the measured hematocrit value of each hematocrit sample measured by a conventional capillary tube measuring method with higher measuring accuracy is used as a first reference hematocrit value of each sample, and the first reference hematocrit value is respectively as follows: 10% H ct ，20％H ct ，30％H ct ，40％H ct ，50％H ct ，60％H ct And 70% H ct . At a preset temperature, first, each first target electric signal corresponding to each convolution sample is obtained, wherein the first target electric signals are impedance signals and resistance signals. Each set of data is a different erythrocyte pressureThe data under the product value are the impedance signal, the resistance signal and the first reference hematocrit value, respectively. At this time, the 7 packed samples correspond to seven groups of data, and the data regression analysis is performed by taking the impedance signal and the resistance signal in each group of data as an X value and taking the first reference packed red blood cell value as a Y value, so that a correction function can be obtained. In order to improve the accuracy of regression analysis, each of the packed samples may be tested multiple times, and the impedance signal, the resistance signal, and the first reference hematocrit value obtained by the testing may be involved in the regression analysis.
As a preferred option, the correction function may be a binary linear function expressed as:
H ct ＝A*Z+B*R+C；
wherein H is ct For the initial hematocrit value, Z is the impedance signal, R is the resistance signal, A, B and C are the fitting coefficients corresponding to the correction function.
It should be noted that, the 7 different convolution samples in the embodiment of the present application are only one implementation manner, but are not limited to only this implementation manner, and may be set according to the needs of the user. Meanwhile, the capillary method adopted to measure the first reference hematocrit value in the embodiment of the application is only one implementation mode, but is not limited to only the implementation mode, and the method can be set according to the needs of users.
It should be further noted that, the method for acquiring the first target electrical signals corresponding to the pressure product samples is not limited, and the first target electrical signals can be acquired according to corresponding instruments or by adopting an electrochemical impedance test method, and can be set according to the needs of users.
From the above, when the correction function is plural, the step of acquiring the correction function may be further: respectively configuring a plurality of packed samples with different packed values of red blood cells; respectively acquiring first target electric signals of each packed sample at a preset temperature; fitting each first target electric signal belonging to the same pressure-accumulation zone and a corresponding first reference red blood cell pressure-accumulation value by adopting a regression analysis method to obtain each initial correction function of each pressure-accumulation zone; as the correction function of the corresponding pressure interval, referring to table 1, the pressure interval in the present application is divided into a first pressure interval, a second pressure interval, and a third pressure interval according to the data in table 1. Taking the first convolution interval as an example: the first pressure product interval comprises three different pressure product values, namely corresponding to three pressure product samples, and simultaneously, corresponding to three groups of data, and carrying out data regression analysis on the three groups of data to obtain an initial correction function corresponding to the first pressure product interval. The second and third press-accumulation regions are the same. The steps provided in the present application are considered in practical application, and we cannot ensure that the correction function obtained according to regression analysis is a good function, and the possible correction function is a piecewise function. Therefore, before calculation, the classification of the pressure-product intervals is performed during configuration, and the calculation of the pressure-product intervals is performed separately, so that the initial correction function under a plurality of pressure-product intervals can be obtained and used as the correction function under the corresponding pressure-product interval.
TABLE 1
Based on the above, as a preferable mode, in the process of respectively acquiring each first target electric signal of each packed sample at the preset temperature, each first target electric signal of the same packed sample may be acquired multiple times, and an average value of the multiple times may be adopted as the final first target electric signal.
The specific steps for obtaining the correction function provided by the application can realize the function of determining the initial hematocrit value by calling the correction function. The capillary vessel method is adopted to respectively measure the hematocrit value of 7 hematocrit samples, and it can be understood that the configured samples are enough, and the final fitting coefficient is more accurate, namely the final calculated initial hematocrit value is more accurate.
From the above, when the temperature compensation function is 1, the temperature compensation function is determined by the following method:
respectively configuring a plurality of packed samples with different packed values of red blood cells;
respectively acquiring second target electric signals of each packed sample at different test temperatures;
according to the second target electric signals brought into the correction function, calculating first red blood cell packed value of each packed sample at different test temperatures;
and performing data fitting on the second reference hematocrit value, the first hematocrit value and the corresponding test temperature of each hematocrit sample to obtain a temperature compensation function.
The method for obtaining the temperature compensation function includes the steps of:
fitting the second reference hematocrit value of each hematocrit sample and the ratio of the corresponding first hematocrit value to the test temperature corresponding to the first hematocrit value to obtain a temperature compensation function.
In a specific embodiment, the specific steps for obtaining the temperature compensation function are: firstly, respectively acquiring second target electric signals of all packed samples under different red blood cell packed values at different test temperatures; bringing each second target electric signal into a correction function to calculate each first hematocrit value at different temperatures; fitting the second reference hematocrit value of each hematocrit sample and the ratio of the corresponding first hematocrit value to the test temperature corresponding to the first hematocrit value to obtain a temperature compensation function.
In summary, the above is exemplified by: similarly, each packed sample of 7 different packed values (10%, 20%, 30%, 40%, 50%, 60%, 70%) is prepared, and similarly, since the whole specified packed value cannot be ensured at the time of preparation, the measured packed value of each sample measured by a conventional capillary measurement method with high measurement accuracy is used as the second reference packed value of each sample; then, the test is carried out at 7 different test temperatures (10-40 ℃) to obtain second target electric signals at different temperatures (49 data at the moment when the pressure product samples are 7 and the temperature is 7), and the second target electric signals are substituted into the correction function to respectively calculate the first red blood cell pressure product values (calculated values) at different temperatures. At this time, obtaining the ratio of the second reference hematocrit value to the corresponding first hematocrit value at different temperatures; likewise, the test may be repeated a plurality of times under the same conditions and the average value may be obtained. That is, the average value of the ratio of the second reference hematocrit value to the corresponding first hematocrit value is obtained separately, the data is applied to the coordinate system to represent different discrete points, and then the average value at the different temperatures is fitted to the corresponding temperature to obtain a temperature compensation function, that is, the discrete points are fitted to obtain the temperature compensation function.
Preferably, the temperature compensation function is a unitary quadratic function, and the expression is:
H t ＝a*T 2 +b*T+c；
wherein H is t And T is the temperature, and a, b and c are fitting coefficients corresponding to temperature compensation functions.
It should be noted that, in the embodiment of the present application, 7 different pressure product samples and 7 different test temperatures are only one realizable mode, but not limited to only this realization mode, and may be set according to the needs of the user. Meanwhile, the capillary method adopted to measure the second reference hematocrit value in the embodiment of the application is only one implementation mode, but is not limited to only the implementation mode, and can be set according to the needs of users.
From the above, when the temperature compensation function is plural, the temperature compensation function is determined by the following method: acquiring an average value of the ratio of the second reference hematocrit value to the corresponding first hematocrit value of each hematocrit sample at each test temperature; performing data fitting on the test temperature and the corresponding average value which belong to one temperature interval to obtain an initial temperature compensation function corresponding to each temperature interval; wherein, each initial temperature compensation function is used as the temperature compensation function of the corresponding temperature interval, see table 2. As can be seen from the data in table 2, the present application divides the test temperature into three intervals, respectively: a first temperature interval, a second temperature interval, and a third temperature interval. Examples of the first temperature interval are: the first temperature interval comprises three different test temperatures, which is equivalent to the first temperature interval comprising three groups of data, and the initial temperature compensation function corresponding to the first temperature interval can be obtained by fitting the three groups of data. The second temperature interval and the third temperature interval are the same. The method comprises the steps that in practical application, fitting of discrete points cannot be guaranteed, a complete temperature compensation function with good fitting effect can be obtained, and the temperature compensation function is a piecewise function possibly. Therefore, before calculation, the temperature intervals are classified and calculated in different temperature intervals, and at this time, the initial temperature compensation functions corresponding to the temperature intervals can be obtained and used as the temperature compensation functions corresponding to the temperature intervals.
TABLE 2
The specific steps for acquiring the temperature compensation function can be used for determining the temperature compensation coefficient by calling the temperature compensation function and finally determining the accurate target hematocrit value. The initial hematocrit value is temperature compensated.
It can be seen from the foregoing that the purpose of the present application is to compensate for the hematocrit value, and thus the compensation effect of the present application can be expressed by the deviation, as can be seen from the data in table 3, the absolute deviation corresponding to each hematocrit sample at each test temperature is mostly lower than 2, and only a small part is slightly higher than 2. That is to say, at low temperature, normal temperature and high temperature, the method provided by the application is adopted, the deviation between the temperature compensated hematocrit value and the standard reference value is smaller, even a plurality of test results are the same as the standard reference value, so that the hematocrit correction method with temperature compensation provided by the application can well reduce the influence of temperature on the hematocrit test, and improve the accuracy of hematocrit correction.
TABLE 3 Table 3
The application provides a pressure product correction method with temperature compensation, which comprises the following steps: acquiring an original electric signal and a current test temperature of a sample to be tested; substituting the original electric signal into a correction function to calculate an initial hematocrit value; substituting the current test temperature into a temperature compensation function to calculate a Wen Bu coefficient; and determining a target hematocrit value according to the initial hematocrit value and the temperature compensation coefficient. According to the method and the device, through the corresponding relation between the original electrical signal in the correction function and the hematocrit value, the obtained initial hematocrit value is accurate, meanwhile, the temperature compensation coefficient in the temperature compensation function and the target hematocrit value determined by the initial hematocrit value compensate the problem that the hematocrit value is affected by temperature, and the accurate target hematocrit value is provided for the final measurement result of the sample to be measured.
In the above embodiments, the detailed description is given of the method for correcting the pressure product with temperature compensation, and the application also provides the corresponding embodiments of the pressure product correction device with temperature compensation.
FIG. 2 is a block diagram of a pressure-accumulation correcting device with temperature compensation according to another embodiment of the present application, including:
the acquisition module 11 is used for acquiring an original electric signal and a current test temperature of a sample to be tested;
a first calculation module 12 for substituting the original electrical signal into a correction function to calculate an initial hematocrit value;
the second calculation module 13 is used for substituting the current test temperature into the temperature compensation function to calculate Wen Bu coefficients;
the determining module 14 is configured to determine a target hematocrit value according to the initial hematocrit value and the temperature compensation coefficient.
Since the embodiments of the apparatus portion and the embodiments of the method portion correspond to each other, the embodiments of the apparatus portion are referred to the description of the embodiments of the method portion, and are not repeated herein.
The above describes in detail a method and apparatus for pressure correction with temperature compensation. In the description, each embodiment is described in a progressive manner, and each embodiment is mainly described by the differences from other embodiments, so that the same similar parts among the embodiments are mutually referred. For the device disclosed in the embodiment, since it corresponds to the method disclosed in the embodiment, the description is relatively simple, and the relevant points refer to the description of the method section. It should be noted that it would be obvious to those skilled in the art that various improvements and modifications can be made to the present application without departing from the principles of the present application, and such improvements and modifications fall within the scope of the claims of the present application.
It should also be noted that in this specification, relational terms such as first and second, and the like are used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Moreover, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus. Without further limitation, an element defined by the phrase "comprising one … …" does not exclude the presence of other like elements in a process, method, article, or apparatus that comprises the element.
Claims (10)
1. A method of pressure correction with temperature compensation, comprising:
acquiring an original electric signal and a current test temperature of a sample to be tested;
substituting the original electric signal into a correction function to calculate an initial hematocrit value;
substituting the current test temperature into a temperature compensation function to calculate a Wen Bu coefficient;
and determining a target hematocrit value according to the initial hematocrit value and the temperature compensation coefficient.
2. The method of pressure correction with temperature compensation of claim 1, wherein the correction function is determined by:
respectively configuring a plurality of packed samples with different packed values of red blood cells;
respectively acquiring first target electrical signals of each packed sample at a preset temperature;
fitting the first target electric signals of the pressure product samples and the first reference red blood cell pressure product value thereof by adopting a regression analysis method to obtain the correction function.
3. The method of pressure correction with temperature compensation of claim 1, wherein the correction function is determined by:
respectively configuring a plurality of packed samples with different packed values of red blood cells;
respectively acquiring first target electrical signals of each packed sample at a preset temperature;
fitting each first target electric signal and a corresponding first reference red blood cell pressure product value belonging to the same pressure product interval by adopting a regression analysis method to obtain each initial correction function of each pressure product interval; wherein each initial correction function serves as the correction function for a corresponding pressure product interval.
4. The pressure product correction method with temperature compensation according to claim 1, characterized in that the temperature compensation function is determined by the following method:
respectively configuring a plurality of packed samples with different packed values of red blood cells;
respectively acquiring second target electrical signals of each packed sample at different test temperatures;
bringing each second target electric signal into the correction function to calculate a first red blood cell packed value of each packed sample at different test temperatures;
and performing data fitting on the second reference hematocrit value, the first hematocrit value and the corresponding test temperature of each hematocrit sample to obtain the temperature compensation function.
5. The method of claim 4, wherein fitting data to the second reference hematocrit value, the first hematocrit value, and the corresponding test temperature of each of the hematocrit samples to obtain the temperature compensation function comprises:
fitting the second reference hematocrit value of each hematocrit sample, the ratio of the second reference hematocrit value to the first hematocrit value, and the test temperature corresponding to the first hematocrit value to obtain the temperature compensation function.
6. The method of claim 4, wherein fitting data to the second reference hematocrit value, the first hematocrit value, and the corresponding test temperature of each of the hematocrit samples to obtain the temperature compensation function comprises:
acquiring an average value of the ratio of the second reference hematocrit value to the corresponding first hematocrit value of each of the hematocrit samples at each test temperature;
performing data fitting on the test temperature and the corresponding average value which belong to one temperature interval to obtain an initial temperature compensation function corresponding to each temperature interval; wherein each initial temperature compensation function is used as the temperature compensation function of the corresponding temperature interval.
7. The method of claim 1, wherein determining a target hematocrit value based on the initial hematocrit value and the temperature compensation coefficient comprises:
taking the product of the initial hematocrit value and the temperature compensation coefficient as the target hematocrit value.
8. The method of pressure correction with temperature compensation according to any one of claims 1-7, wherein the raw electrical start signal comprises: at least one of an impedance signal, a resistance signal, an inductive reactance signal and a phase signal.
9. The method of pressure correction with temperature compensation of claim 8, wherein the raw electrical signal comprises the impedance signal and the resistance signal.
10. A pressure-build-up correction device with temperature compensation, comprising:
the acquisition module is used for acquiring an original electric signal and a current test temperature of a sample to be tested;
the first calculation module is used for substituting the original electric signal into a correction function to calculate an initial hematocrit value;
the second calculation module is used for substituting the current test temperature into a temperature compensation function to calculate a Wen Bu coefficient;
and the determining module is used for determining a target hematocrit value according to the initial hematocrit value and the temperature compensation coefficient.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311789657.6A CN117761124A (en) | 2023-12-25 | 2023-12-25 | Pressure product correction method and device with temperature compensation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311789657.6A CN117761124A (en) | 2023-12-25 | 2023-12-25 | Pressure product correction method and device with temperature compensation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN117761124A true CN117761124A (en) | 2024-03-26 |
Family
ID=90323450
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202311789657.6A Pending CN117761124A (en) | 2023-12-25 | 2023-12-25 | Pressure product correction method and device with temperature compensation |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN117761124A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN118643262A (en) * | 2024-08-15 | 2024-09-13 | 南京瑞波医学科技有限公司 | Power calibration method, device and electronic equipment for radiofrequency ablation system |
-
2023
- 2023-12-25 CN CN202311789657.6A patent/CN117761124A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN118643262A (en) * | 2024-08-15 | 2024-09-13 | 南京瑞波医学科技有限公司 | Power calibration method, device and electronic equipment for radiofrequency ablation system |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2413976C (en) | Biosensor apparatus and method with sample type and volume detection | |
| US7018843B2 (en) | Instrument | |
| US5827963A (en) | System and method for determining a density of a fluid | |
| CN109682968B (en) | Temperature correction method for quantitative detection test signal of fluorescence immunoassay strip | |
| CN108680622A (en) | Packed cell volume measures and the method for correction in a kind of electrochemica biological sensor | |
| JP2005518527A (en) | Methods and apparatus for assays for electrochemical properties | |
| CN111812175B (en) | Blood detection method for reducing interference of hematocrit and biosensor | |
| US11644434B2 (en) | Biosensor system analyte measurement | |
| CN117761124A (en) | Pressure product correction method and device with temperature compensation | |
| CN112198207B (en) | Formaldehyde detection method and formaldehyde detection device | |
| CN113063833B (en) | Measurement method of hematocrit | |
| CN116208152B (en) | High-precision analog quantity acquisition device and method | |
| CN114371195B (en) | Correction method for hematocrit | |
| CN115876864B (en) | Test correction method and system for electrochemical biosensor | |
| CN107389743B (en) | Measurement precision detection method of blood test instrument and blood test instrument | |
| CN112986365B (en) | Electrochemical measurement correction method and system | |
| CN118758924B (en) | Calibration method and calibration device of physiological index detector | |
| US20230023581A1 (en) | Method for medical detection, medical detection device, and storage medium | |
| JP3850237B2 (en) | Device for measuring minute changes in solution | |
| CN115910383A (en) | Method for determining concentration of immunoassay sample | |
| CN115856279A (en) | Calibration method of immunodetection main curve | |
| CN114118702A (en) | A method and system for evaluating vacuum drying effect of capacitors | |
| KR101079790B1 (en) | The method for estimating the features of target material using kinetic changing information and the apparatus thereof | |
| CN110726796A (en) | Calibration method and system for transformer oil chromatography online monitoring gas model, monitor and monitoring method | |
| TW201525456A (en) | Detection method for a biosensor |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |