CN116867476A - 具有天然衍生的成分的抗菌体系和包含其的组合物 - Google Patents
具有天然衍生的成分的抗菌体系和包含其的组合物 Download PDFInfo
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Abstract
本发明描述具有天然衍生的成分的抗菌体系和包含其的组合物。所述体系具有包含麝香草酚的第一成分和第二天然成分，所述第二天然成分包括对茴香酸、芦荟、葡糖酸内酯、四氢姜黄素、4‑羟基苯乙酮或它们的混合物。
Description
技术领域
本发明涉及包含天然衍生的成分的抗菌体系。更具体地，本发明涉及优异的包含麝香草酚的抗菌体系，所述抗菌体系可以被包含在最终用途配制物中，该最终用途配制物包括化妆品、个人护理和洗涤组合物。除了麝香草酚之外，本发明的抗菌体系还包含第二组分，该第二组分为天然衍生的并且包括对茴香酸、芦荟、葡糖酸内酯、四氢姜黄素、4-羟基苯乙酮或它们的混合物。这样的体系当被加入至最终用途组合物时出人意料地递送优异的抗菌益处。
背景技术
DMDM乙内酰脲、对羟基苯甲酸酯类、甲基异噻唑啉酮以及甲基氯异噻唑啉酮是消费产品中常用的防腐剂。此类防腐剂已经使用多年，并且已知在维持某些最终用途组合物的完整性和稳定性方面起到良好的作用。然而，需要开发包含天然存在的组分的防腐剂体系，所述天然存在的组分适合于在整个消费产品范围内起到良好的作用。天然存在的防腐剂体系应该在保存产品方面有效，不使皮肤过敏，并且不对消费产品的感官特性，特别是局部施加的消费产品的感官特性产生不利的影响。
除了递送优异的抗菌益处之外，该防腐体系不应对环境有害，并且足够温和以用于最脆弱的消费者婴儿上。
因此，本发明涉及具有天然存在的成分的抗菌体系以及包含该抗菌体系的组合物。除了第二天然存在的组分之外，所述第二天然存在的组分包括对茴香酸、芦荟、葡糖酸内酯、四氢姜黄素、4-羟基苯乙酮或它们的混合物，该防腐体系还包含麝香草酚作为第一天然组分。这样的体系出人意料地向它们所用于的最终用途组合物递送优异的抗菌益处。
附加信息
已经公开了为制备防腐剂体系作出的努力。在美国公布的专利申请2012/0190744A1中，描述用于化妆品配制物的防腐体系。
还已经公开了为制备防腐剂体系作出的其他努力。在第7,754,774B2号美国专利中，描述具有1,2-辛二醇的防腐消毒剂。
甚至已经公开了为制备防腐剂体系作出的其他努力。在第7,582,681B2号美国专利中，描述具有1,2-烷二醇的抗微生物活性复合物。
以上附加信息都没有描述如在本申请中描述和要求保护的抗菌体系和具有此类体系的最终用途组合物。
发明内容
在第一方面，本发明涉及抗菌体系，其包含：
(a)第一组分，所述第一组分包含麝香草酚；和
(b)第二组分，所述第二组分包含对茴香酸、芦荟、葡糖酸内酯、四氢姜黄素、4-羟基苯乙酮或它们的混合物。
在第二方面，本发明涉及最终用途组合物，其包含：
(a)第一组分，所述第一组分包含麝香草酚；和
(b)第二组分，所述第二组分包含对茴香酸、芦荟、葡糖酸内酯、四氢姜黄素、4-羟基苯乙酮或它们的混合物。
在第三方面，本发明涉及用具有第一组分和第二组分的组合保存组合物的用途或方法，所述第一组分包含麝香草酚，所述第二组分包含对茴香酸、芦荟、葡糖酸内酯、四氢姜黄素、4-羟基苯乙酮或它们的混合物。
本发明的的所有其它方面从以下描述和实施例中将更易变得明显。
如在本文中使用的“抗菌体系”是指适合于显示出协同抗菌益处的至少二组分且天然的体系，所述协同抗菌益处包括如用防腐剂所观测到的抗菌益处。所述至少二组分体系是指包含麝香草酚和第二组分，所述第二组分包含对茴香酸、芦荟、葡糖酸内酯、四氢姜黄素、4-羟基苯乙酮或它们的混合物，其中所述至少二组分体系是用于最终用途组合物的添加剂(即，可以作为单独的添加剂组合物来出售以用于添加至最终用途组合物，或与这些成分一起单独配制以制备最终用途组合物)。天然衍生是指不需要合成制造并且适合于从例如植物或根(至少以前体形式)回收。在本文中使用的“皮肤”包括在脚部、脸部、颈部、胸部、手臂(包括腋下)、手部、腿部、臀部、背部和头皮(包括毛发)上的皮肤。在本文中描述的最终用途组合物(即，待使用或施加的组合物)包括霜剂(cream)、乳液(lotion)、浆液、凝胶、膏剂(balm)、除臭剂和止汗剂、口腔护理组合物、洗发剂、调节剂、条状物(bar)和液体洗涤产品以及家庭护理组合物，例如硬质表面和窗户清洁剂、抽水马桶清洁剂和衣物洗涤剂。在一个实施方案中，本发明的最终用途组合物是清洁组合物、洗涤产品或免洗型(leave-on)产品，例如施加至面部、身体或手部的霜剂或乳液。在另一实施方案中，该最终用途组合物是适合于在化妆上减少皱纹出现和/或使皮肤湿润的化妆免洗型产品。这样的组合物也可以是引起皮肤具有均匀颜色或色调的组合物。
除非另有明确说明，否则在本文中描述的所有范围意指包括其中纳入的所有范围。术语“包含”意指涵盖术语“基本上由……组成”和“由……组成”。为了避免疑问，包含麝香草酚和对茴香酸的组合物意指包括基本上由这两种物质组成的组合物和由这两种物质组成的组合物。关于在本文中使用的百分比，除非另有说明，否则该百分比意指按重量计。除了在实施例和比较例中，或在另外明确指出的情况下，在本说明书中使用的表示量、材料的比率和/或其用途的所有数值应理解为由“约”修饰。
具体实施方式
除了优选地以最可持续的方式实现对麝香草酚的获得，对于如何寻求用于本发明中的麝香草酚的来源没有限制。通常，对麝香草(thyme)的加压液体萃取或超临界流体萃取可以用于提取麝香草酚。其它技术包括当用苎烯和乙醇萃取时在环境压力下并在30至45℃的温度下从植物回收麝香草酚。可替换地，可以向本发明的抗菌组合物添加包含麝香草酚的麝香草油和/或麝香草提取物，只要所述油和提取物具有麝香草酚。麝香草油和提取物从麝香草植物中获取。此类植物属于百里香属(genus thymus)，并且包括但不限于以下物种：普通百里香(Thymus vulgaris)、洋百里香(Thymus zygis)、Thymus satureoides、乳香色百里香(Thymus mastichina)、Thymus broussaneti、Thymus maroccamus、苍白色百里香(Thymus pallidus)、阿尔及利亚百里香(Thymus algeriensis)、欧百里香(Thymusserpyllum)、宽叶百里香(Thymus pulegoide)和柠檬百里香(Thymus citrodorus)。
通常，具有包含麝香草酚的第一组分的最终用途组合物会具有0.001％至6％的麝香草酚。在本发明的一个实施方案中，基于所述最终用途组合物的总重量，该组合物会具有0.01重量％至4重量％的麝香草酚，并且还在另一实施方案中，该组合物会具有0.1重量％至3重量％的麝香草酚。在最终用途组合物中使用麝香草油和/或提取物的程度上，会以确保在所述最终用途组合物中的麝香草酚水平与本文中描述的水平一致的量来添加该麝香草油和/或提取物。
至于包含对茴香酸、芦荟、葡糖酸内酯、四氢姜黄素、4-羟基苯乙酮或它们的混合物的第二组分，这些组分通常从天然来源中回收。对茴香酸(4-甲氧基苯甲酸)天然地存在于茴香中，而芦荟(aloe)从芦荟植物(aloe vera plant)中回收。葡糖酸内酯从例如玉米中获得。四氢姜黄素是姜黄素(在姜黄中发现的)的代谢物，而4-羟基苯乙酮可以在番茄、肉桂(cassia)和可可粉(cocoa)中发现并从番茄、肉桂和可可粉中回收。
本发明的抗菌体系的第二组分通常会占所述最终用途组合物的0.001重量％至6重量％。在另一实施方案中，基于所述最终用途组合物的总重量，该第二组分占所述最终用途组合物的0.01重量％至4.0重量％，并且在还另一实施方案中，该第二组分占所述最终用途组合物的0.1重量％至3.0重量％。
对于具有包含麝香草酚的第一组分和包含对茴香酸、芦荟、葡糖酸内酯、四氢姜黄素、4-羟基苯乙酮或它们的混合物的第二组分的抗菌体系，在该抗菌体系中的第一组分与第二组分的重量比通常为1:6至6:1。在另一实施方案中，第一组分与第二组分的重量比为4:1至1:4，在还另一实施方案中，第一组分与第二组分的重量比为2:1至1:2，包括其中纳入的所有比率。抗菌体系可以由麝香草酚和第二组分组成，然而抗菌体系包含麝香草酚和第二组分或基本上由麝香草酚和第二组分组成也在本发明的范围内。在本发明的还另一实施方案中，本发明的抗菌体系基本上由，或由麝香草酚和对茴香酸、芦荟、葡糖酸内酯、四氢姜黄素、4-羟基苯乙酮或它们的混合物组成，其中在该抗菌体系中不需要额外的抗菌组分。在还另一实施方案中，抗菌体系另外可以包含香精(fragrance)油和/或香精(占该抗菌体系的0.1重量％至6重量％)和/或水(占该抗菌体系的1重量％至25重量％)。在这样的实施方案中，提供香精和/或香精油以向消费者递送期望的气味或香味。
对于可包含本发明的抗菌体系的最终用途组合物的类型通常没有限制。适合于使用该抗菌体系的最终用途组合物通常会包含在化妆上可接受的载体组分。水是最优选的载体。基于所述最终用途组合物的总重量，水的量可为1重量％至96重量％，优选地为5重量％至90重量％，最优选地为35重量％至80重量％，最佳地为40重量％至75重量％。通常，本发明的最终用途组合物会是水和油的乳状液(emulsion)，最优选地是水包油型种类。然而，油包水型乳状液，特别是通常归类为油包水型且高内相的乳状液的那些是一个选项。适合于包含本发明的抗菌体系的高内相的乳状液的示例性实例被描述于共同拥有的第2008/0311058号美国专利申请公开和第8,425,882号美国专利中，它们的公开内容通过引用并入本文中。
适合用于本发明中的其它在化妆上可接受的载体可包括矿物油、硅油、合成或天然酯、和醇。这些材料的量按所述最终用途组合物的重量计可为0.1重量％至50重量％，优选地是0.1重量％至30重量％，最优选地是1重量％至20重量％，包括其中纳入的所有范围。在还另一实施方案中，此类载体总共占所述最终用途组合物的1重量％至12重量％。
硅油可分为挥发性和非挥发性的种类。如在本文中使用的术语“挥发性”是指在环境温度下具有可测量的蒸气压的那些材料。挥发性硅油优选地选自含有3至9个，优选地含有4至5个硅原子的环状或线性聚二甲基硅氧烷类。
线性挥发性聚硅氧烷(silicone)材料通常在25℃下具有小于5厘沲的粘度，而环状材料通常具有小于10厘沲的粘度(用布鲁克菲尔德粘度计，RV 3号转子在20RPM下测量，被标准化至矿物油)。
可用作载体材料的非挥发性硅油包括聚烷基硅氧烷、聚烷基芳基硅氧烷和聚醚硅氧烷共聚物。在本文中可用的基本上非挥发性的聚烷基硅氧烷包括例如在25℃下具有5至100,000厘沲的粘度的聚二甲基硅氧烷类(polydimethylsiloxanes)(例如聚二甲基硅氧烷(dimethicone))。
通常优选的硅氧烷来源是环戊硅氧烷和聚二甲基硅氧烷醇溶液。
其中，合适的酯为：
(1)具有10至20个碳原子的脂肪酸的烯基酯或烷基酯，例如棕榈酸异丙酯、异硬脂酸异丙酯、异壬酸异壬酯、油醇肉豆蔻酸酯、肉豆蔻酸异丙酯、油醇硬脂酸酯和油醇油酸酯；
(2)醚酯，例如乙氧基化的脂肪醇的脂肪酸酯；
(3)多元醇酯，例如乙二醇单脂肪酸酯和乙二醇二脂肪酸酯、二乙二醇单脂肪酸酯和二乙二醇二脂肪酸酯、聚乙二醇(200-6000)单脂肪酸酯和聚乙二醇(200-6000)二脂肪酸酯、丙二醇单脂肪酸酯和丙二醇二脂肪酸酯、聚丙二醇2000单油酸酯、聚丙二醇2000单硬脂酸酯、乙氧基化的丙二醇单硬脂酸酯、甘油单脂肪酸酯和甘油二脂肪酸酯、聚甘油多脂肪酸酯(polyglycerol poly-fatty easters)、乙氧基化的甘油单硬脂酸酯、1,3-丁二醇单硬脂酸酯、1,3-丁二醇二硬脂酸酯、聚氧乙烯多元醇脂肪酸酯类、脱水山梨糖醇脂肪酸酯类和聚氧乙烯脱水山梨糖醇脂肪酸酯类；
(4)蜡酯，例如蜂蜡、鲸蜡、肉豆蔻醇肉豆蔻酸酯、硬脂醇硬脂酸酯；和
(5)甾醇酯，其中它们的实例为大豆甾醇脂肪酸酯类和胆甾醇脂肪酸酯类。
乳化剂(或表面活性剂)可存在于包含本发明的抗菌体系的最终用途组合物中。按所述最终用途组合物的重量计，乳化剂的总浓度可为0.1重量％至30重量％，优选地为2重量％至20重量％，最优选地为1重量％至8重量％。乳化剂可选自阴离子组分、非离子组分、阳离子组分和两性组分。特别优选的非离子组分是具有以下的那些：每摩尔的疏水物与2至100摩尔的氧化乙烯或氧化丙烯缩合的C10至C20脂肪醇或酸疏水物；与2至20摩尔的氧化烯缩合的C2-C10烷基酚；乙二醇的单-和二-脂肪酸酯；脂肪酸单甘油酯；脱水山梨糖醇单C8-C20脂肪酸酯和脱水山梨糖醇二C8-C20脂肪酸酯；和聚氧乙烯脱水山梨糖醇；以及它们的组合。烷基聚糖苷和糖类脂肪酰胺(例如甲基葡糖酰胺类)也是合适的非离子乳化剂。
优选的阴离子乳化剂包括烷基醚硫酸酯盐(sulfate)和烷基醚磺酸酯盐(sulfonate)、烷基硫酸酯盐和烷基磺酸酯盐、烷基苯磺酸酯盐、烷基磺基琥珀酸酯盐(sulfosuccinate)和二烷基磺基琥珀酸酯盐、C8-C20酰基羟乙磺酸盐(isethionate)、C8-C20烷基醚磷酸酯盐(phosphate)、烷基醚羧酸盐和它们的组合。
可以使用的阳离子乳化剂包括例如棕榈酰氨丙基三甲基氯化铵、二硬脂基二甲基氯化铵和它们的混合物。可用的两性乳化剂包括椰油酰氨丙基甜菜碱、C12-C20三烷基甜菜碱、月桂酰两性基乙酸钠、月桂酰二两性基乙酸钠、或它们的混合物。
其它通常优选的乳化剂包括甘油硬脂酸酯、二醇硬脂酸酯、硬脂酰胺AMP、PEG-100硬脂酸酯、鲸蜡醇以及乳化/增稠添加剂，例如羟基乙基丙烯酸酯/丙烯酰二甲基牛磺酸钠类共聚物/角鲨烯和它们的混合物。
尽管不是必需的，但是可以任选地将传统防腐剂加入至包含本发明的抗菌体系的最终用途组合物中，以帮助抵抗潜在有害微生物的生长。任选用于本发明的组合物中的合适的传统防腐剂包括对羟基苯甲酸的烷基酯。其它防腐剂包括乙内酰脲的衍生物、丙酸类(propionate)盐和各种季铵化合物。通常优选的防腐剂是苯甲酸钠、碘丙炔基丁基氨甲酸酯、苯氧乙醇、羟苯甲酯、羟苯丙酯、咪唑烷基脲、脱氢乙酸钠和苯甲醇。适合与或不与在本发明中任选使用的传统防腐剂一起使用的特别优选的添加剂是1,2-烷二醇类(例如1,2-辛二醇和1,2-己二醇)。
可以任选地添加传统的香精组分(单独添加或与在最终用途组合物中的香精一起添加)，例如丁香酚、香豆素、乙酸芳樟酯、香茅醛、鸢尾浓缩物、乙酸松油酯、蒎烯(α和β蒎烯)和香茅醇。
如果使用的话，传统防腐剂、连位二醇和/或香精组分将占本发明的最终用途组合物的不超过2重量％，优选地不超过1重量％，最优选地不超过0.6重量％。在本发明的一个实施方案中，基于所述最终用途组合物的总重量，使用0.0001重量％至0.85重量％的任选存在的防腐剂、连位二醇和/或香精组分。在本发明的一个优选的实施方案中，在所述最终用途组合物中不使用传统的防腐剂、连位二醇和/或香精组分(除了在所述最终用途组合物中使用的香精中可提供的物质)，因为此类组合物包含本发明的抗菌体系。
增稠剂可以任选地被包括在本发明的最终用途组合物中。特别可用的是多糖类。实例包括柑橘(citrus)纤维、淀粉类、天然/合成树胶和纤维素类。淀粉类的代表是化学改性淀粉类，如羟丙基淀粉磷酸钠和淀粉辛烯基琥珀酸铝。通常优选木薯淀粉。合适的树胶包括黄原胶、菌核胶(sclerotium)、果胶、刺梧桐树胶、阿拉伯树胶、琼脂、瓜耳胶、角叉菜胶、藻酸盐和它们的组合。合适的纤维素类包括羟丙基纤维素、羟丙基甲基纤维素、乙基纤维素和羧基甲基纤维素钠。合成聚合物是另一类的有效的增稠剂。该类别包括交联的聚丙烯酸类(polyacrylates)例如卡波姆类(Carbomers)，聚丙烯酰胺类例如305和牛磺酸盐共聚物例如Simulgel />和/>AVC，该共聚物分别通过INCI命名法被识别为丙烯酸钠/丙烯酰二甲基牛磺酸钠和丙烯酰二甲基牛磺酸盐/乙烯基吡咯烷酮共聚物。适合用于增稠的另一优选的合成聚合物是由Seppic商业制备可获得的且以名称SimulgelIN100出售的基于丙烯酸类的聚合物。
当使用时，按所述最终用途组合物的重量计，所述增稠剂的量可为0.001重量％至5重量％，优选地为0.1重量％至2重量％，最优选地为0.2重量％至0.5重量％。
香精、固定剂和研磨剂可任选地用于包含本发明的抗菌体系的最终用途组合物中。这些物质中的每一种的量可为0.05重量％至5重量％，优选地为0.1重量％至3重量％之间。
在本发明的组合物中可采用常规的湿润剂。这些常规的湿润剂通常是多元醇型材料。典型的多元醇包括丙三醇(glycerol)(即甘油(glycerine)或甘油(glycerin))、丙二醇、二丙二醇、聚丙二醇、聚乙二醇、山梨糖醇、羟丙基山梨糖醇、己二醇、1,3-丁二醇、异戊二醇、1,2,6-己三醇、乙氧基化的甘油，丙氧基化的甘油和它们的混合物。最优选的是甘油、丙二醇或它们的混合物。按所述最终用途组合物的重量计，所采用的湿润剂的量可为0.5重量％至20重量％，优选地为1重量％至15重量％，最优选地为2重量％至10重量％。
本发明的最终用途组合物可包含维生素类。示例性的维生素类是维生素A(视黄醇)以及视黄醇酯例如视黄醇棕榈酸酯和视黄醇丙酸酯、维生素B2、维生素B3(烟酰胺)、维生素B6、维生素C、维生素E、叶酸和生物素。也可以使用维生素的衍生物。例如，维生素C的衍生物包括抗坏血酸四异棕榈酸酯、抗坏血酸磷酸酯镁和抗坏血酸糖苷。维生素E的衍生物包括生育酚乙酸酯、生育酚棕榈酸酯和生育酚亚油酸酯。也可以使用DL-泛醇和衍生物。当存在时，按所述最终用途组合物的重量计，维生素类的总量可为0.001重量％至10重量％，优选地为0.01重量％至5重量％，最佳地为0.1重量％至2重量％。
适合用于本发明的其它任选存在的添加剂包括：间苯二酚类，例如4-乙基间苯二酚、4-己基间苯二酚、4-苯基乙基间苯二酚、二甲氧基甲苯酰基丙基间苯二酚、4-环戊基间苯二酚、4-环己基间苯二酚；α-和/或β-羟基酸类；岩芹酸；共轭的亚油酸；12-羟基硬脂酸；和它们的混合物等。还可包括其它任选存在的添加剂，例如乙醇、季铵化合物(例如西曲氯铵、苯扎氯铵等)和卵磷脂。当使用时，这些添加剂总共占所述最终用途组合物的0.001重量％至12重量％，优选地占0.01重量％至6重量％，最优选地占0.1重量％至4重量％。
去屑促进剂可以存在。示例性的是α-羟基羧酸类、β-羟基羧酸类。术语“酸”是指不仅包括游离酸，还包括游离酸的盐和C1-C30烷基或芳基酯以及由水的去除以形成环状或线性内酯结构而产生的内酯类。代表性的酸是乙醇酸和它的衍生物、乳酸和苹果酸。水杨酸是β-羟基羧酸类的代表。在存在时，按最终用途组合物的重量计，这些材料的量可为0.01重量％至15重量％，优选地为0.1重量％至6重量％。
在本发明的最终用途组合物中可任选地包含多种草本提取物。所述提取物可以或者是水溶性的或者不溶于水的，被承载在分别为亲水性或疏水性的溶剂中。水和乙醇是优选的萃取溶剂。示例性的提取物包括从绿茶、洋蓍草、洋甘菊、甘草、芦荟、葡萄籽、温州蜜柑、柳树皮、鼠尾草和迷迭香中移除的那些。
同样任选适合使用的还包括以下材料：例如螯合剂(例如EDTA)、遮光剂(例如TiO2，粒度为50nm至1200nm，优选地为50nm至350nm)、经C8-22脂肪酸取代的糖类、硫辛酸、视黄氧基三甲基硅烷(从Clariant Corp.以Silcare 1M-75商标可获得)、脱氢表雄甾酮(DHEA)和它们的组合。也可任选地包括神经酰胺类(包括神经酰胺1、神经酰胺3、神经酰胺3B和神经酰胺6)以及假性神经酰胺类(pseudoceramides)。在使用这些材料时，按所述最终用途组合物的重量计，这些材料的量可为0.0001重量％至10重量％，优选地为0.001重量％至6重量％，最优选地为0.001重量％至3重量％。
在本发明的最终用途组合物中也可任选地包含防晒活性剂。特别优选的是如下这样的材料：作为Parsol 可获得的对甲氧基肉桂酸乙基己基酯，市售为Parsol的阿伏苯宗(Avobenzene)，和也已知为羟苯甲酮的二苯酮-3。可以使用无机防晒活性剂，例如微细二氧化钛、氧化锌、聚乙烯和各种其它聚合物。当存在时，该防晒剂的量通常可为0.1重量％至30重量％，优选地为0.5重量％至20重量％，最佳地为0.75重量％至10重量％。
可使用常规的缓冲剂/pH调节剂。这些常规的缓冲剂/pH调节剂包括常用的添加剂，例如氢氧化钠、氢氧化钾、盐酸、柠檬酸、三乙醇胺、柠檬酸盐/柠檬酸缓冲液、或它们的混合物。在一个特别优选的实施方案中，本发明的组合物的pH为4至8，优选地为4.25至7.75，最优选地为5.6至7.5。
在本发明的一个实施方案中，当所述最终用途组合物是常规的清洁或洗涤组合物时，该组合物通常包含10重量％至45重量％的C8至C20，优选地是C10至C20或C12至C18脂肪酸或脂肪酸皂，和小于5重量％的合成表面活性剂，优选地1重量％至3重量％的合成表面活性剂。在本发明的一个实施方案中，该清洁或洗涤组合物包含0至5重量％，优选地包含0.01重量％至4重量％的12-羟基硬脂酸(12-HSA)和0.01重量％至25重量％的甘油。在还另一实施方案中，本发明的最终用途组合物包含0至6重量％的基于硫酸酯盐的表面活性剂(例如月桂醇硫酸酯钠)，但优选地不包含(0.0重量％)基于硫酸酯盐的表面活性剂。
本发明的最终用途组合物的粘度通常为1,000cps至50,000cps。洗去型(washoff)组合物优选地具有低于9,000cps的粘度，而免洗型组合物优选地具有6,000cps至15,000cps的粘度。粘度可以用本领域公认的仪器来测量，该本领域公认的仪器例如布氏粘度计RVT型号D220，使用T型棒转子D，以5RPM在25℃下60秒。
下文描述适合于包含0.001重量％至6重量％的第一组分和0.001重量％至6重量％的第二组分的示例性最终用途组合物。
用于淋浴的身体乳液
| 成分 | 重量％ |
| 水 | 余量 |
| 羟丙基淀粉磷酸酯 | 2.0 |
| 鲸蜡醇磷酸酯 | 1.0 |
| 氢氧化钾 | 0.5 |
| 羟丙基二羟乙基二甲基氯化铵 | 3.0 |
| 硬脂酰氨丙基PG-二甲基氯化铵磷酸酯 | 2.0 |
| 牛油树脂 | 5.0 |
| 椰子油 | 5.5 |
| 椰油基辛酸酯 | 2.0 |
| 鲸蜡硬脂醇 | 1.5 |
| 香精 | 0.1 |
身体乳液
| 水 | 余量 |
| 鲸蜡基羟乙基纤维素 | 0.25 |
| 脱水山梨糖醇油酸酯癸基葡糖苷交联聚合物 | 3.5 |
| 鲸蜡醇磷酸酯钾 | 1.0 |
| 甘油 | 2.0 |
| 棕榈酸乙基己酯 | 3.0 |
| 棕榈酸异丙酯 | 6.0 |
| 鳄梨油 | 3.0 |
| 鲸蜡醇 | 4.0 |
| 琥珀酸二庚酯和辛酰基甘油/癸二酸共聚物 | 2.0 |
| 香精 | 0.1 |
洗发剂组合物
当制备这些组合物时，用中度加热(50℃至60℃)，在大气压下使用搅拌，直至获得均匀的组合物。优选地包括均质化。
可以采用多种的包装以储存和递送包含本发明的抗菌体系的最终用途组合物。包装通常取决于产品的类型和它的用途。例如，免洗型皮肤乳液和霜剂、洗发剂、调节剂和淋浴凝胶通常采用在分配端具有开口的塑料容器，所述开口由封闭件覆盖。由推进剂加压并具有喷嘴的金属罐可以用作摩丝和其它个人护理产品的包装。
提供以下实施例以便于理解本发明。该实施例并不旨在限制权利要求书的范围。
实施例
通过进行类似于下述的研究证实了使用本发明的天然抗菌成分获得的出人意料的协同益处。
如在表II中所示出，通过将麝香草酚与对茴香酸、芦荟、葡糖酸内酯、四氢姜黄素和4-羟基苯乙酮中的一种物质组合，制备了天然衍生的抗菌体系。建立了两种池(pool)，并且每种池包含了两个复制(replication)。所涉及的菌株为：铜绿假单胞菌(Pseudomonasaeruginosa)、恶臭假单胞菌(Pseudomonas putida)、洋葱伯克霍尔德菌(Burkholderiacepacia)、杰高维肠杆菌(Enterobacter gergoviae)和肺炎克雷伯菌(Klebsiellapneumoniae)。对于所有样品，FIC测试范围(％)为2.0-0.008。加入了第一天然组分和第二天然组分(组分A和组分B)以制备天然组分抗菌体系的50/50混合物。
使用分级浓度(Fractional Concentration)和分级抑菌浓度(FractionalInhibitory Concentration)(FIC)的概念，已经广泛探索了抑菌性抗菌剂在分离物和混合物中的不同行为。参见例如JRW Lambert and R Lambert,J.Appl.Microbiol 95,734(2003)；T.Jadavji,CG Prober and R Cheung,Antibacterial Agents and Chemotherapy26,91(1984)；和WO2004/006876。MIC是防止一种或多种细菌的可见生长的组分的最小抑菌浓度。FC和FIC参数可以如下限定：
FC(组分A)＝在混合物中测试的组分A的浓度/MIC(作为单一活性物测试的组分A)。
FIC(组分a)＝MIC(在混合物中测试的组分a)/MIC(作为单一活性物测试的组分a)。
抗菌剂之间的相互作用可以是累积的、协同的或可能是拮抗的，这取决于组合的效力是否等于、大于或小于当单独测试时相同总浓度的单独组分所获得的效力。
这些关系可以通过对在混合物中存在的所有组分的分级MIC值求和以给出“分级抑菌指数”来在数学上表达：
∑FIC＝FIC(组分1)+FIC(组分2)
使得：
∑FIC大于0.5对应于无关的(indifferent)、累积的或拮抗的活性
∑FIC小于或等于0.5对应于协同的活性
可比较的方法是对协同指数(synergy index)(SI)的计算，该方法是由Kull,F.C.、Eisman,P.C.、Sylwestrowicz,H.D.和Mayer,R.L.在Applied Microbiology9:538-541(1961)中描述的在工业上可接受的方法。
测试方法
进行了液体肉汤试验(MIC和棋盘格)，以识别单独和二元组合的防腐化学品的一个或多个最小浓度。利用ISO 20776-1:2006的修订方法以用于如下筛选。对防腐化学品和胰蛋白酶大豆肉汤的储备溶液接种了1×106至5×106个微生物，并在30℃下培养24小时，之后测量了OD600nm处的光密度。将MIC限定为这样的浓度，在该浓度下观察到了与不含防腐化学品的阳性生长对照相比的<25％的生长。在0.008重量％至2重量％的浓度范围内筛选了防腐化学品。
表I：微生物池
表II：协同的组合
*提供为水和明串珠菌/欧洲花楸果实发酵滤液(Water&Leuconostoc/Sorbusaucuparia Fruit Ferment Filtrate)
在表II中提供的数据出人意料地显示出，当组合符合本发明的天然抗菌成分时，观测到抗革兰氏阴性非发酵细菌和革兰氏阴性发酵细菌的协同益处。
Claims (8)
1.抗菌体系，其基本上由以下组成或由以下组成：
(a)第一组分，所述第一组分为麝香草酚；和
(b)第二组分，所述第二组分为对茴香酸、葡糖酸内酯、四氢姜黄素、4-羟基苯乙酮或它们的混合物。
2.根据前述权利要求中的任意一项所述的抗菌体系，其中所述第一组分和所述第二组分的重量比为1:6至6:1。
3.最终用途组合物，其包含根据前述权利要求中的任意一项所述的抗菌体系。
4.根据权利要求3所述的最终用途组合物，其中所述组合物包含0.001重量％至6重量％的所述第一组分和0.001重量％至6重量％的所述第二组分。
5.根据权利要求3至4中的任意一项所述的最终用途组合物，其中所述最终用途组合物是沐浴液、洗发剂或局部皮肤组合物。
6.根据权利要求3至5中的任意一项所述的最终用途组合物，所述最终用途组合物另外包含水杨酸、烟酰胺、12-羟基硬脂酸、视黄醇、间苯二酚或它们的混合物。
7.根据权利要求2至5中的任意一项所述的最终用途组合物，所述最终用途组合物另外包含神经酰胺、防晒剂、甘油或它们的混合物。
8.根据权利要求1所述的抗菌体系的用途，其用于保存最终用途组合物。
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|---|---|---|---|---|
| DE10206759A1 (de) | 2002-02-19 | 2003-08-28 | Dragoco Gerberding Co Ag | Synergistische Mischungen von 1,2-Alkandiolen |
| DE60310406T2 (de) | 2002-07-15 | 2007-04-12 | Unilever N.V. | Zusammensetzung für die behandlung von haar- und/oder kopfhaut |
| ATE551053T1 (de) | 2002-09-26 | 2012-04-15 | Mandom Corp | Antiseptische bakterizide, und kosmetika, arzneimittel und lebensmittel, die die antiseptischen bakterizide enthalten |
| US20080311058A1 (en) | 2007-06-18 | 2008-12-18 | Connopco, Inc., D/B/A Unilever | Stable high internal phase emulsions and compositions comprising the same |
| US8425882B2 (en) | 2008-04-01 | 2013-04-23 | Conopco, Inc. | In-shower and bath compositions |
| US20100120911A1 (en) | 2008-05-02 | 2010-05-13 | Muhammed Majeed | Preservative system for cosmetic formulations |
| PL2774481T3 (pl) * | 2013-03-08 | 2019-03-29 | Symrise Ag | Kompozycje przeciwdrobnoustrojowe |
| US20160000094A1 (en) * | 2013-03-15 | 2016-01-07 | The Trustees Of Columbia University In The City Of New York | Broad spectrum natural preservative composition |
| CN112153958A (zh) * | 2018-06-04 | 2020-12-29 | 荷兰联合利华有限公司 | 防腐组合物 |
| CN108852951B (zh) * | 2018-09-20 | 2021-04-30 | 浙江施维康生物医学材料有限公司 | 一种润肤洁肤组合物及植物沐浴露 |
-
2022
- 2022-02-02 CN CN202280015034.0A patent/CN116867476A/zh active Pending
- 2022-02-02 WO PCT/EP2022/052478 patent/WO2022175090A1/en active Application Filing
- 2022-02-02 US US18/276,932 patent/US20240225982A9/en active Pending
- 2022-02-02 EP EP22703372.7A patent/EP4294358A1/en active Pending
- 2022-02-02 MX MX2023009425A patent/MX2023009425A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MX2023009425A (es) | 2023-08-15 |
| US20240130946A1 (en) | 2024-04-25 |
| WO2022175090A1 (en) | 2022-08-25 |
| US20240225982A9 (en) | 2024-07-11 |
| EP4294358A1 (en) | 2023-12-27 |
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