CN115887316A - Mild liquid glycine surfactant crystalline facial cleanser and preparation method thereof - Google Patents
Mild liquid glycine surfactant crystalline facial cleanser and preparation method thereof Download PDFInfo
- Publication number
- CN115887316A CN115887316A CN202211298661.8A CN202211298661A CN115887316A CN 115887316 A CN115887316 A CN 115887316A CN 202211298661 A CN202211298661 A CN 202211298661A CN 115887316 A CN115887316 A CN 115887316A
- Authority
- CN
- China
- Prior art keywords
- surfactant
- crystalline
- parts
- facial cleanser
- glycerol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 title claims abstract description 62
- 239000004094 surface-active agent Substances 0.000 title claims abstract description 52
- 239000007788 liquid Substances 0.000 title claims abstract description 33
- 239000004471 Glycine Substances 0.000 title claims abstract description 31
- 238000002360 preparation method Methods 0.000 title claims abstract description 6
- 230000001815 facial effect Effects 0.000 title claims description 33
- 239000008367 deionised water Substances 0.000 claims abstract description 13
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 13
- 230000002378 acidificating effect Effects 0.000 claims abstract description 11
- 239000002994 raw material Substances 0.000 claims abstract description 9
- 239000003995 emulsifying agent Substances 0.000 claims abstract description 8
- 239000003381 stabilizer Substances 0.000 claims abstract description 8
- 230000008719 thickening Effects 0.000 claims abstract description 8
- 239000002085 irritant Substances 0.000 claims abstract description 7
- 150000005846 sugar alcohols Polymers 0.000 claims abstract description 7
- 230000003020 moisturizing effect Effects 0.000 claims abstract description 5
- 239000004599 antimicrobial Substances 0.000 claims abstract description 4
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 3
- 239000002973 irritant agent Substances 0.000 claims abstract description 3
- 239000002131 composite material Substances 0.000 claims abstract 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 48
- TXFPEBPIARQUIG-UHFFFAOYSA-N 4'-hydroxyacetophenone Chemical compound CC(=O)C1=CC=C(O)C=C1 TXFPEBPIARQUIG-UHFFFAOYSA-N 0.000 claims description 22
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid group Chemical group C(CC(O)(C(=O)O)CC(=O)O)(=O)O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 21
- 238000003756 stirring Methods 0.000 claims description 21
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims description 19
- -1 alkyl glycoside Chemical class 0.000 claims description 19
- 238000004519 manufacturing process Methods 0.000 claims description 19
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 12
- 150000001413 amino acids Chemical class 0.000 claims description 12
- 238000001816 cooling Methods 0.000 claims description 11
- MQFYRUGXOJAUQK-UHFFFAOYSA-N 2-[2-[2-(2-octadecanoyloxyethoxy)ethoxy]ethoxy]ethyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCOCCOCCOCCOC(=O)CCCCCCCCCCCCCCCCC MQFYRUGXOJAUQK-UHFFFAOYSA-N 0.000 claims description 10
- 238000010438 heat treatment Methods 0.000 claims description 10
- 229940105132 myristate Drugs 0.000 claims description 10
- 229920002261 Corn starch Polymers 0.000 claims description 9
- 239000008120 corn starch Substances 0.000 claims description 9
- 229930182478 glucoside Natural products 0.000 claims description 9
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 8
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 8
- 239000000600 sorbitol Substances 0.000 claims description 8
- ANZUDYZHSVGBRF-UHFFFAOYSA-N 3-ethylnonane-1,2,3-triol Chemical compound CCCCCCC(O)(CC)C(O)CO ANZUDYZHSVGBRF-UHFFFAOYSA-N 0.000 claims description 7
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 7
- 239000007864 aqueous solution Substances 0.000 claims description 7
- 239000011734 sodium Substances 0.000 claims description 7
- 229910052708 sodium Inorganic materials 0.000 claims description 7
- 229940083542 sodium Drugs 0.000 claims description 7
- IXOCGRPBILEGOX-UHFFFAOYSA-N 3-[3-(dodecanoylamino)propyl-dimethylazaniumyl]-2-hydroxypropane-1-sulfonate Chemical compound CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC(O)CS([O-])(=O)=O IXOCGRPBILEGOX-UHFFFAOYSA-N 0.000 claims description 6
- 238000007599 discharging Methods 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 6
- 229920000223 polyglycerol Polymers 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 5
- 229940065859 sodium cocoyl glycinate Drugs 0.000 claims description 5
- IKGKWKGYFJBGQJ-UHFFFAOYSA-M sodium;2-(dodecanoylamino)acetate Chemical group [Na+].CCCCCCCCCCCC(=O)NCC([O-])=O IKGKWKGYFJBGQJ-UHFFFAOYSA-M 0.000 claims description 5
- GYDYJUYZBRGMCC-INIZCTEOSA-N (2s)-2-amino-6-(dodecanoylamino)hexanoic acid Chemical group CCCCCCCCCCCC(=O)NCCCC[C@H](N)C(O)=O GYDYJUYZBRGMCC-INIZCTEOSA-N 0.000 claims description 4
- 239000002253 acid Substances 0.000 claims description 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 4
- 229940079988 potassium cocoyl glycinate Drugs 0.000 claims description 4
- DCXXMTOCNZCJGO-UHFFFAOYSA-N tristearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCCCC DCXXMTOCNZCJGO-UHFFFAOYSA-N 0.000 claims description 4
- 229940064064 purslane extract Drugs 0.000 claims description 3
- ARIWANIATODDMH-AWEZNQCLSA-N 1-lauroyl-sn-glycerol Chemical compound CCCCCCCCCCCC(=O)OC[C@@H](O)CO ARIWANIATODDMH-AWEZNQCLSA-N 0.000 claims description 2
- RZRNAYUHWVFMIP-KTKRTIGZSA-N 1-oleoylglycerol Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(O)CO RZRNAYUHWVFMIP-KTKRTIGZSA-N 0.000 claims description 2
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 claims description 2
- IDUUXROOZBOOPH-QHHAFSJGSA-N 2-{[(2E)-3-(3,4-dihydroxyphenyl)-1-hydroxyprop-2-en-1-ylidene]amino}-5-hydroxybenzoic acid Chemical compound OC(=O)C1=CC(O)=CC=C1NC(=O)\C=C\C1=CC=C(O)C(O)=C1 IDUUXROOZBOOPH-QHHAFSJGSA-N 0.000 claims description 2
- DDGPBVIAYDDWDH-UHFFFAOYSA-N 3-[dodecyl(dimethyl)azaniumyl]-2-hydroxypropane-1-sulfonate Chemical compound CCCCCCCCCCCC[N+](C)(C)CC(O)CS([O-])(=O)=O DDGPBVIAYDDWDH-UHFFFAOYSA-N 0.000 claims description 2
- 229930190481 Avenanthramide Natural products 0.000 claims description 2
- 244000060011 Cocos nucifera Species 0.000 claims description 2
- 235000013162 Cocos nucifera Nutrition 0.000 claims description 2
- 241001076416 Dendrobium tosaense Species 0.000 claims description 2
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 claims description 2
- 244000119298 Emblica officinalis Species 0.000 claims description 2
- 235000015489 Emblica officinalis Nutrition 0.000 claims description 2
- 239000004386 Erythritol Substances 0.000 claims description 2
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 claims description 2
- FPVVYTCTZKCSOJ-UHFFFAOYSA-N Ethylene glycol distearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCOC(=O)CCCCCCCCCCCCCCCCC FPVVYTCTZKCSOJ-UHFFFAOYSA-N 0.000 claims description 2
- ARIWANIATODDMH-UHFFFAOYSA-N Lauric acid monoglyceride Natural products CCCCCCCCCCCC(=O)OCC(O)CO ARIWANIATODDMH-UHFFFAOYSA-N 0.000 claims description 2
- 229910019142 PO4 Inorganic materials 0.000 claims description 2
- 244000179560 Prunella vulgaris Species 0.000 claims description 2
- ULUAUXLGCMPNKK-UHFFFAOYSA-N Sulfobutanedioic acid Chemical compound OC(=O)CC(C(O)=O)S(O)(=O)=O ULUAUXLGCMPNKK-UHFFFAOYSA-N 0.000 claims description 2
- LUEWUZLMQUOBSB-UHFFFAOYSA-N UNPD55895 Natural products OC1C(O)C(O)C(CO)OC1OC1C(CO)OC(OC2C(OC(OC3C(OC(O)C(O)C3O)CO)C(O)C2O)CO)C(O)C1O LUEWUZLMQUOBSB-UHFFFAOYSA-N 0.000 claims description 2
- 235000009754 Vitis X bourquina Nutrition 0.000 claims description 2
- 235000012333 Vitis X labruscana Nutrition 0.000 claims description 2
- 240000006365 Vitis vinifera Species 0.000 claims description 2
- 235000014787 Vitis vinifera Nutrition 0.000 claims description 2
- OCKWAZCWKSMKNC-UHFFFAOYSA-N [3-octadecanoyloxy-2,2-bis(octadecanoyloxymethyl)propyl] octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(COC(=O)CCCCCCCCCCCCCCCCC)(COC(=O)CCCCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCCCC OCKWAZCWKSMKNC-UHFFFAOYSA-N 0.000 claims description 2
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 claims description 2
- MRUAUOIMASANKQ-UHFFFAOYSA-N cocamidopropyl betaine Chemical compound CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC([O-])=O MRUAUOIMASANKQ-UHFFFAOYSA-N 0.000 claims description 2
- 229940073507 cocamidopropyl betaine Drugs 0.000 claims description 2
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 2
- GLSRFBDXBWZNLH-UHFFFAOYSA-L disodium;2-chloroacetate;2-(4,5-dihydroimidazol-1-yl)ethanol;hydroxide Chemical compound [OH-].[Na+].[Na+].[O-]C(=O)CCl.OCCN1CCN=C1 GLSRFBDXBWZNLH-UHFFFAOYSA-L 0.000 claims description 2
- 235000013399 edible fruits Nutrition 0.000 claims description 2
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 claims description 2
- 229940009714 erythritol Drugs 0.000 claims description 2
- 235000019414 erythritol Nutrition 0.000 claims description 2
- 229930195729 fatty acid Natural products 0.000 claims description 2
- 239000000194 fatty acid Substances 0.000 claims description 2
- 150000004665 fatty acids Chemical class 0.000 claims description 2
- 150000002191 fatty alcohols Chemical class 0.000 claims description 2
- YQEMORVAKMFKLG-UHFFFAOYSA-N glycerine monostearate Natural products CCCCCCCCCCCCCCCCCC(=O)OC(CO)CO YQEMORVAKMFKLG-UHFFFAOYSA-N 0.000 claims description 2
- UHUSDOQQWJGJQS-UHFFFAOYSA-N glycerol 1,2-dioctadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(CO)OC(=O)CCCCCCCCCCCCCCCCC UHUSDOQQWJGJQS-UHFFFAOYSA-N 0.000 claims description 2
- RZRNAYUHWVFMIP-HXUWFJFHSA-N glycerol monolinoleate Natural products CCCCCCCCC=CCCCCCCCC(=O)OC[C@H](O)CO RZRNAYUHWVFMIP-HXUWFJFHSA-N 0.000 claims description 2
- SVUQHVRAGMNPLW-UHFFFAOYSA-N glycerol monostearate Natural products CCCCCCCCCCCCCCCCC(=O)OCC(O)CO SVUQHVRAGMNPLW-UHFFFAOYSA-N 0.000 claims description 2
- 229930182470 glycoside Natural products 0.000 claims description 2
- ACCCMOQWYVYDOT-UHFFFAOYSA-N hexane-1,1-diol Chemical compound CCCCCC(O)O ACCCMOQWYVYDOT-UHFFFAOYSA-N 0.000 claims description 2
- 239000001341 hydroxy propyl starch Substances 0.000 claims description 2
- 235000013828 hydroxypropyl starch Nutrition 0.000 claims description 2
- 239000004310 lactic acid Substances 0.000 claims description 2
- 235000014655 lactic acid Nutrition 0.000 claims description 2
- 229940070765 laurate Drugs 0.000 claims description 2
- UYQJCPNSAVWAFU-UHFFFAOYSA-N malto-tetraose Natural products OC1C(O)C(OC(C(O)CO)C(O)C(O)C=O)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(O)C(CO)O2)O)C(CO)O1 UYQJCPNSAVWAFU-UHFFFAOYSA-N 0.000 claims description 2
- LUEWUZLMQUOBSB-OUBHKODOSA-N maltotetraose Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@H](CO)O[C@@H](O[C@@H]2[C@@H](O[C@@H](O[C@@H]3[C@@H](O[C@@H](O)[C@H](O)[C@H]3O)CO)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O LUEWUZLMQUOBSB-OUBHKODOSA-N 0.000 claims description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 2
- OEIJHBUUFURJLI-UHFFFAOYSA-N octane-1,8-diol Chemical compound OCCCCCCCCO OEIJHBUUFURJLI-UHFFFAOYSA-N 0.000 claims description 2
- 125000002801 octanoyl group Chemical group C(CCCCCCC)(=O)* 0.000 claims description 2
- 229960005323 phenoxyethanol Drugs 0.000 claims description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 2
- 239000010452 phosphate Substances 0.000 claims description 2
- 239000003755 preservative agent Substances 0.000 claims description 2
- 230000002335 preservative effect Effects 0.000 claims description 2
- 108700004121 sarkosyl Proteins 0.000 claims description 2
- 235000008113 selfheal Nutrition 0.000 claims description 2
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims description 2
- 235000010234 sodium benzoate Nutrition 0.000 claims description 2
- 239000004299 sodium benzoate Substances 0.000 claims description 2
- 229940096501 sodium cocoamphoacetate Drugs 0.000 claims description 2
- 229940045885 sodium lauroyl sarcosinate Drugs 0.000 claims description 2
- KSAVQLQVUXSOCR-UHFFFAOYSA-M sodium lauroyl sarcosinate Chemical compound [Na+].CCCCCCCCCCCC(=O)N(C)CC([O-])=O KSAVQLQVUXSOCR-UHFFFAOYSA-M 0.000 claims description 2
- GOJYXPWOUJYXJC-UHFFFAOYSA-M sodium;2-[1-(2-hydroxyethyl)-2-undecyl-4,5-dihydroimidazol-1-ium-1-yl]acetate;hydroxide Chemical compound [OH-].[Na+].CCCCCCCCCCCC1=NCC[N+]1(CCO)CC([O-])=O GOJYXPWOUJYXJC-UHFFFAOYSA-M 0.000 claims description 2
- LPUQAYUQRXPFSQ-DFWYDOINSA-M monosodium L-glutamate Chemical compound [Na+].[O-]C(=O)[C@@H](N)CCC(O)=O LPUQAYUQRXPFSQ-DFWYDOINSA-M 0.000 claims 1
- 229940079781 sodium cocoyl glutamate Drugs 0.000 claims 1
- BCISDMIQYBCHAT-UHFFFAOYSA-M sodium;2-(dodecanoylamino)ethanesulfonate Chemical compound [Na+].CCCCCCCCCCCC(=O)NCCS([O-])(=O)=O BCISDMIQYBCHAT-UHFFFAOYSA-M 0.000 claims 1
- 239000006071 cream Substances 0.000 abstract description 13
- 238000004140 cleaning Methods 0.000 abstract description 10
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- 231100000021 irritant Toxicity 0.000 abstract description 2
- 238000005260 corrosion Methods 0.000 abstract 1
- 235000001014 amino acid Nutrition 0.000 description 11
- 229940015975 1,2-hexanediol Drugs 0.000 description 9
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 description 9
- 210000003491 skin Anatomy 0.000 description 9
- 229940045944 sodium lauroyl glutamate Drugs 0.000 description 9
- IWIUXJGIDSGWDN-UQKRIMTDSA-M sodium;(2s)-2-(dodecanoylamino)pentanedioate;hydron Chemical compound [Na+].CCCCCCCCCCCC(=O)N[C@H](C([O-])=O)CCC(O)=O IWIUXJGIDSGWDN-UQKRIMTDSA-M 0.000 description 9
- 210000004027 cell Anatomy 0.000 description 8
- TUNFSRHWOTWDNC-UHFFFAOYSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCCC(O)=O TUNFSRHWOTWDNC-UHFFFAOYSA-N 0.000 description 8
- 239000000243 solution Substances 0.000 description 6
- 238000005187 foaming Methods 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
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- 206010050637 Skin tightness Diseases 0.000 description 4
- 239000003599 detergent Substances 0.000 description 4
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- 239000000843 powder Substances 0.000 description 4
- 239000000344 soap Substances 0.000 description 4
- 230000000638 stimulation Effects 0.000 description 4
- 229940104261 taurate Drugs 0.000 description 4
- YASYEJJMZJALEJ-UHFFFAOYSA-N Citric acid monohydrate Chemical compound O.OC(=O)CC(O)(C(O)=O)CC(O)=O YASYEJJMZJALEJ-UHFFFAOYSA-N 0.000 description 3
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 3
- 230000007794 irritation Effects 0.000 description 3
- KVTFEOAKFFQCCX-UHFFFAOYSA-N N-hexadecanoylglycine Chemical compound CCCCCCCCCCCCCCCC(=O)NCC(O)=O KVTFEOAKFFQCCX-UHFFFAOYSA-N 0.000 description 2
- 235000019864 coconut oil Nutrition 0.000 description 2
- 239000003240 coconut oil Substances 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 231100000263 cytotoxicity test Toxicity 0.000 description 2
- 229940079886 disodium lauryl sulfosuccinate Drugs 0.000 description 2
- KHIQYZGEUSTKSB-UHFFFAOYSA-L disodium;4-dodecoxy-4-oxo-3-sulfobutanoate Chemical compound [Na+].[Na+].CCCCCCCCCCCCOC(=O)C(S(O)(=O)=O)CC([O-])=O.CCCCCCCCCCCCOC(=O)C(S(O)(=O)=O)CC([O-])=O KHIQYZGEUSTKSB-UHFFFAOYSA-L 0.000 description 2
- 239000004247 glycine and its sodium salt Substances 0.000 description 2
- 235000013905 glycine and its sodium salt Nutrition 0.000 description 2
- 229940075639 palmitoyl glycine Drugs 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 229940029258 sodium glycinate Drugs 0.000 description 2
- WUWHFEHKUQVYLF-UHFFFAOYSA-M sodium;2-aminoacetate Chemical compound [Na+].NCC([O-])=O WUWHFEHKUQVYLF-UHFFFAOYSA-M 0.000 description 2
- AVBJHQDHVYGQLS-AWEZNQCLSA-N (2s)-2-(dodecanoylamino)pentanedioic acid Chemical compound CCCCCCCCCCCC(=O)N[C@H](C(O)=O)CCC(O)=O AVBJHQDHVYGQLS-AWEZNQCLSA-N 0.000 description 1
- 239000004721 Polyphenylene oxide Substances 0.000 description 1
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- 238000005238 degreasing Methods 0.000 description 1
- 238000013461 design Methods 0.000 description 1
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- LQZZUXJYWNFBMV-UHFFFAOYSA-N dodecan-1-ol Chemical compound CCCCCCCCCCCCO LQZZUXJYWNFBMV-UHFFFAOYSA-N 0.000 description 1
- 125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
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- GZWNUORNEQHOAW-UHFFFAOYSA-M potassium;2-aminoacetate Chemical compound [K+].NCC([O-])=O GZWNUORNEQHOAW-UHFFFAOYSA-M 0.000 description 1
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- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Detergent Compositions (AREA)
- Cosmetics (AREA)
Abstract
A mild liquid glycine surfactant crystalline cleansing cream and a preparation method thereof relate to the technical field of cosmetics, in particular to a mild and low-irritation liquid glycine surfactant crystalline cleansing formula. The composite material consists of the following raw materials in parts by weight: liquid glycine surfactant with active matter content of 20-30%, auxiliary surfactant, polyalcohol, emulsifier, thickening stabilizer, appearance regulator, acidic pH regulator, antiseptic agent, moisturizing anti-irritant agent, and deionized water. After the technical scheme is adopted, the invention has the beneficial effects that: the glycine surfactant is added with an auxiliary surfactant, polyhydric alcohol, an emulsifier, an acidity regulator, a thickening stabilizer, a moisturizing anti-irritant, an appearance regulator, an anti-corrosion effect agent and the like, so that the pH value of the cleansing cream is weakly acidic, the cleansing cream is more skin-friendly, mild and non-irritant, good in cleaning effect, rich in foam, easy to wash, not dry and not tight after washing, stable in body, beautiful in pearly luster, fine and smooth in cream body, easy to push away and quick to foam.
Description
Technical Field
The invention relates to the technical field of cosmetics, in particular to a warm and low-irritation liquid glycine surfactant crystalline facial cleanser.
Background
With the development of society and the improvement of living standard, more and more consumers pay attention to skin care, make-up and the like, and in order to realize effective facial cleaning, the facial cleanser is gradually accepted as a necessity for cleaning faces. The mechanism of face cleaning is to reduce the surface tension of dirt by using a surfactant and remove dust, microorganisms, cosmetic residues, skin metabolites and the like attached to the face through the actions of dispersion, foaming and emulsification, and the face cleaning is the first step of skin care which is popular at present.
The traditional facial cleanser can be divided into a soap-based type and a non-soap-based type according to the formula types, and has certain disadvantages when used: 1. the soap-based facial cleanser has alkaline pH, is relatively irritant to facial skin, is easy to excessively clean, makes the washed skin feel tight, causes the skin stratum corneum to be thin and dry, and is easy to damage the skin barrier after long-term use. 2. Most of the non-soap-based facial cleansers in the market use lauryl alcohol sulfate or lauryl polyether sulfate as a main cleaning agent, and the sulfate surfactants have strong degreasing capability and certain irritation. 3. The existing amino acid surfactant facial cleansing product is more and more favored by consumers due to mild and low stimulation, but the manufacturing cost is higher, particularly, the amino acid surfactant with the powder specification is used, the production cost is greatly improved, the liquid amino acid surfactant is difficult to form paste, even the paste is formed, the viscosity is too low, the stability is poor, and the like.
Disclosure of Invention
The invention aims to provide mild liquid glycine surfactant crystal type facial cleanser and a preparation method thereof aiming at the defects and deficiencies of the prior art, the mild liquid glycine surfactant crystal type facial cleanser adopts a mild, green and natural glycine surfactant with relatively low cost in a liquid form, does not use an expensive amino acid surfactant with a powder specification, can reduce the formula cost of the facial cleanser, has mild and low stimulation in formula, is easy to form paste, is fine and smooth in cream body, good in stability, beautiful in pearly luster and good in use feeling; the pH is faintly acid, the cleaning effect is good, the foam is rich, the cleaning is easy, the detergent is not dry and tight after being washed, and the viscosity of the detergent is stable.
In order to achieve the purpose, the invention adopts the following technical scheme: a warm and low-irritation liquid glycine surfactant crystalline facial cleanser comprises the following raw materials in parts by weight: 30-70 parts of liquid glycine surfactant with 25-30% of active matter content, 2-15 parts of auxiliary surfactant, 10-40 parts of polyol, 0.2-10 parts of emulsifier, 0.2-1 part of thickening stabilizer, 0.2-5 parts of appearance regulator, 2-10 parts of acidic pH regulator, 0.2-5 parts of preservative efficacy agent, 0.5-10 parts of anti-irritant and the balance of deionized water.
The amino acid surfactant is sodium cocoyl glycinate or potassium cocoyl glycinate.
The auxiliary surfactant is one or two or more of lauramidopropyl hydroxysultaine, cocamidopropyl betaine, sodium lauroamphoacetate, sodium cocoamphoacetate, lauryl hydroxysultaine, sodium cocoyl taurate, sodium lauroyl glutamate, sodium cocoyl amidopropionate, sodium lauroyl sarcosinate, coconut fatty acid monoethanolamide, alkyl glycoside, cocamidoMEA, cocamidomethyl MEA, and disodium fatty alcohol sulfosuccinate.
The polyalcohol is one or the combination of two or more of glycerol, propylene glycol, butanediol, sorbitol and erythritol.
The emulsifier is one or a combination of two or more of polyglycerol 10-laurate, polyglycerol 10-myristate, polyglycerol 10-stearate, glycerol monostearate, glycerol monolaurate, glycerol monooleate, glycerol distearate and glycerol tristearate.
The thickening stabilizer is one or the combination of two or more of PEG-150 distearate, PEG-120 methyl grape dioleate, PEG-150 pentaerythritol tetrastearate, PEG-150 distearate and hydroxypropyl starch phosphate.
The appearance regulator is lauroyl lysine or ethylene glycol distearate.
The acidic pH regulator is citric acid or lactic acid aqueous solution.
The antiseptic agent is one or a combination of two or more of sodium benzoate, phenoxyethanol, hexanediol, ethylhexyl glycerol, p-hydroxyacetophenone, octanediol and caprylyl hydroximic acid.
The moisturizing anti-irritant is one or a combination of two or more of hydrolyzed corn starch, maltotetraose, glycerol glucoside, avenanthramide, dendrobium officinale extract, purslane extract, fructus cnidii extract, selfheal extract and emblic leafflower fruit extract.
The preparation method of the warm and low-irritation liquid glycine surfactant crystalline facial cleanser comprises the following steps:
the method comprises the following steps: mixing deionized water, liquid amino acid surfactant, auxiliary surfactant, polyalcohol, emulsifier, thickening stabilizer and appearance regulator, heating at high temperature for dissolving, maintaining temperature, adding acidic pH regulator, and dissolving.
Step two: cooling the mixture, stirring with a stirrer for a certain time, adding the antiseptic and anti-irritant agents at 45 deg.C, stirring, cooling to room temperature, and discharging.
The high-temperature heating temperature in the first step is 75-85 ℃.
In the second step, the stirring speed of the stirrer for the first time is 50-150 revolutions per minute, and the stirring time is 60-90 minutes.
After the technical scheme is adopted, the invention has the beneficial effects that: the glycine surfactant which is mild, green, natural in source and relatively low in cost and in a liquid form is adopted, the amino acid surfactant with high price and powder specification is not used, the formula cost of the facial cleanser can be reduced, and meanwhile, the formula is mild and low in stimulation, the cream is easy to form, fine and smooth, good in stability, beautiful in pearly luster and good in use feeling; the pH is faintly acid, the cleaning effect is good, the foam is rich, the cleaning is easy, the detergent is not dry and tight after being washed, and the viscosity of the detergent is stable.
Detailed Description
The sodium cocoyl glycinate used in the embodiment is Eversoft TM YCS-30SF, 25-30% of active matter.
The model of the coconut oil acyl potassium glycinate is Eversoft TM YCK-30KR with 25-30% active substance.
Sodium cocoyl methyl taurate is Eversoft TM TCS-40S, the active content is 35-40%.
The model of sodium lauroyl glutamate is Eversoft TM ULS-30SN, active content 25-30%.
The lauramidopropyl hydroxysultaine is the Evermil TM SB450, active matter content is 40-45%.
The type of the p-hydroxyacetophenone is Everguard TM HP。
Model number of ethylhexyl glycerol Evermild TM EHG。
The model of 1, 2-hexanediol is Evermiled TM HG。
Hydrolyzed corn starch type BioEase TM MY-75, active content 75%.
Glycerol glucoside type is Evermoist TM AGG-50, active content 50%.
The herba Portulacae extract is Everextract TM PO。
The raw materials are all from New materials of Nanjing Hua Shi Limited company.
Other raw materials are all commercially available.
Example 1
The technical scheme adopted by the specific implementation mode is as follows: a warm and low-irritation liquid glycine surfactant crystalline facial cleanser comprises the following raw materials in parts by weight: 47 parts of cocoyl sodium glycinate (active content 25%), 3 parts of sodium lauroyl glutamate (active content 25%), 25 parts of glycerol, 8 parts of lauramidopropyl hydroxysultaine (active content 42%), 2 parts of sorbitol, 0.5 part of polyglycerol-10 myristate, 0.5 part of PEG-150 distearate, 1 part of lauroyl lysine, 0.2 part of glycerol stearate, 2.5 parts of 50% citric acid aqueous solution, 0.5 part of p-hydroxyacetophenone, 0.2 part of ethylhexylglycerol, 0.3 part of 1, 2-hexanediol, 3 parts of hydrolyzed corn starch (active content 75%), 2 parts of glycerol glucoside (active content 50%), and the balance of deionized water;
the manufacturing method comprises the following steps:
step one, mixing deionized water, sodium cocoyl glycinate, sodium lauroyl glutamate, glycerol, lauramidopropyl hydroxysulfobetaine, sorbitol, polyglycerol-10 myristate, PEG-150 distearate, lauroyl lysine and glycerol stearate, heating at 85 ℃ to dissolve uniformly, keeping the temperature at 85 ℃, adding 50% citric acid aqueous solution and dissolving p-hydroxyacetophenone uniformly;
(2) Cooling the mixture, stirring by a stirrer, stirring for 70 minutes at a stirring speed of 100 revolutions per minute, adding ethylhexyl glycerol, 1, 2-hexanediol, hydrolyzed corn starch and glycerol glucoside at 45 ℃, continuously stirring until the temperature is room temperature, and discharging.
The specific embodiment is easy to crystallize, and the prepared material body is uniform and fine in appearance, bright in pearly luster, weakly acidic in pH, stable in paste, free of layering at 48 ℃ for one week, easy to push away in use, high in foaming speed, rich in foam, fresh and cool in skin after use, and free of skin tightness.
Example 2
The technical scheme adopted by the specific implementation mode is as follows: a warm and low-irritation liquid glycine surfactant crystalline facial cleanser comprises the following raw materials in parts by weight: 47 parts of cocoyl potassium glycinate (active content is 28%), 3 parts of lauroyl glutamic acid (active content is 25%), 25 parts of glycerol, 8 parts of sodium cocoyl methyl taurate (active content is 35%), 2 parts of sorbitol, 0.5 part of polyglycerol-10 myristate, 0.5 part of PEG-150 distearate, 0.2 part of glycerol stearate, 2.5 parts of 50% citric acid aqueous solution, 0.8 part of p-hydroxyacetophenone, 1 part of 1, 2-hexanediol, 3 parts of hydrolyzed corn starch (active content is 75%), 3 parts of glycerol glucoside (active content is 50%), 0.5 part of purslane extract and the balance of deionized water;
the manufacturing method comprises the following steps:
the method comprises the following steps: mixing deionized water, potassium cocoyl glycinate, sodium lauroyl glutamate, glycerol, sodium cocoyl methyl taurate, sorbitol, polyglycerol-10 myristate, PEG-150 distearate, and glycerol stearate, heating at 85 deg.C to dissolve, maintaining the temperature at 85 deg.C, adding 50% citric acid water solution, and dissolving p-hydroxyacetophenone uniformly;
step two: and cooling the mixture body, stirring at the speed of 120 revolutions per minute by a stirrer, and stirring for 60 minutes. Adding 1, 2-hexanediol, hydrolyzed corn starch, glycerol glucoside, and herba Portulacae extract at 45 deg.C, stirring, cooling to room temperature, and discharging.
The specific embodiment is easy to crystallize, and the prepared material body is uniform and fine in appearance, bright in pearly luster, weakly acidic in pH, stable in paste, free of layering at 48 ℃ for one week, easy to push away in use, high in foaming speed, rich in foam, fresh and cool in skin after use, and free of skin tightness.
Example 3
The technical scheme adopted by the specific implementation mode is as follows: a warm and low-stimulation liquid glycine surfactant crystalline facial cleanser is composed of the following raw materials in parts by weight: 47 parts of cocoyl sodium glycinate (active content 25%), 3 parts of sodium lauroyl glutamate (active content 25%), 30 parts of glycerol, 5 parts of disodium lauryl sulfosuccinate, 3 parts of lauramidopropyl hydroxysultaine (active content 42%), 2 parts of sorbitol, 0.5 part of polyglycerol-10 myristate, 0.2 part of glycerol stearate, 3 parts of 50% citric acid aqueous solution, 0.5 part of p-hydroxyacetophenone, 0.2 part of ethylhexyl glycerol, 0.3 part of 1, 2-hexanediol, 2 parts of glycerol glucoside (active content 50%), and the balance of deionized water;
the manufacturing method comprises the following steps:
the method comprises the following steps: mixing deionized water, sodium cocoyl glycinate, sodium lauroyl glutamate, glycerol, disodium lauryl sulfosuccinate, lauramidopropyl hydroxysultaine, sorbitol, polyglycerol-10 myristate, and glyceryl stearate, heating at 85 deg.C to dissolve, adding 50% citric acid water solution, and heating p-hydroxyacetophenone at 85 deg.C to dissolve;
step two: and cooling the mixture, stirring at the speed of 80 revolutions per minute by a stirrer, and stirring for 80 minutes. Adding ethylhexyl glycerol, 1, 2-hexanediol and glycerol glucoside at 45 deg.C, stirring, cooling to room temperature, and discharging.
The specific embodiment is easy to crystallize, and the prepared material body is uniform and fine in appearance, bright in pearly luster, weakly acidic in pH, stable in paste, free of layering at 48 ℃ for one week, easy to push away in use, high in foaming speed, rich in foam, fresh and cool in skin after use, and free of skin tightness.
Example 4
The technical scheme adopted by the specific implementation mode is as follows: a warm and low-irritation liquid glycine surfactant crystalline facial cleanser comprises the following raw materials in parts by weight: 57 parts of coconut oil acyl potassium glycinate, 3 parts of sodium lauroyl glutamate, 25 parts of glycerol, 5 parts of lauramidopropyl hydroxysulfobetaine, 2 parts of propylene glycol, 0.5 part of polyglycerol-10 myristate, 0.5 part of PEG-150 distearate, 0.25 part of glycerol stearate, 2 parts of palmitoyl glycine, 2.5 parts of 50% citric acid aqueous solution, 0.8 part of p-hydroxyacetophenone, 1 part of 1, 2-hexanediol, 3 parts of hydrolyzed corn starch and the balance of deionized water;
the manufacturing method comprises the following steps:
the method comprises the following steps: mixing deionized water, potassium cocoyl glycinate, sodium lauroyl glutamate, glycerol, lauramidopropyl hydroxysulfobetaine, propylene glycol, polyglycerol-10 myristate, PEG-150 distearate, glycerol stearate and palmitoyl glycine, heating and dissolving at 85 deg.C, adding 50% citric acid water solution and p-hydroxyacetophenone, heating and dissolving at 85 deg.C;
(2) And cooling the mixture body, stirring at the speed of 60 revolutions per minute by a stirrer, and stirring for 65 minutes. Adding 1, 2-hexanediol and hydrolyzed corn starch at 45 ℃, continuously stirring, cooling to room temperature, and discharging.
The body manufactured by the embodiment has uniform and fine appearance, pearly luster, weak pH value, stable paste body, no layering at 48 ℃ for one week, easy pushing away during use, high foaming speed, rich foam, fresh skin after use and no skin tightness.
The invention has reasonable design, simple and feasible manufacturing method, uses the amino acid surfactant with mild, green and natural liquid form, does not use the amino acid surfactant with powder specification, can reduce the manufacturing cost of the formula of the facial cleanser, and has the characteristics of mild and low stimulation, easy paste forming, fine paste body, beautiful pearly luster, good cleaning effect, rich foam, easy washing, no dryness, no puckery and no tightness after washing and good stability of the material body.
MTT50 cytotoxicity assay
And (3) performing cytotoxicity test on the cleansing cream samples of the four embodiments and three commercially available amino acid surfactant cleansing cream samples, wherein the test cells are human epidermal cells, and the test method is an MTT microplate reader staining method. The test results are shown in the attached Table 1. The test value is the facial cleanser concentration value (PPM) shown by half the cell death, the higher the concentration, the better the mildness. The results show that the cleansing cream samples of the examples all have higher IC50 values than the commercial product, are less irritating and are milder.
Corneal cell assay in Rabbit eyes
The four examples of the cleansing cream samples and three commercially available amino acid cleansing cream samples were subjected to a rabbit eye cell irritation test, and the test cells were rabbit eye corneal cells. The cleansing cream was diluted to a concentration of 0.5% using PBS buffer solution, and the percentage of survival of the corneal cells of the rabbit eyes was observed as the relative activity of the cells, the higher the relative activity of the cells, the lower the irritation. The results show that the cleansing cream samples of the examples are less irritating and milder than the commercial products.
The above description is only for the purpose of illustrating the technical solutions of the present invention and not for the purpose of limiting the same, and other modifications or equivalent substitutions made by those skilled in the art to the technical solutions of the present invention should be covered within the scope of the claims of the present invention without departing from the spirit and scope of the technical solutions of the present invention.
Claims (11)
1. The mild liquid glycine surfactant crystalline facial cleanser and the preparation method thereof are characterized in that: the composite material consists of the following raw materials in parts by weight: 30-70 parts of liquid glycine surfactant with 20-30% of active matter content, 2-15 parts of auxiliary surfactant, 10-40 parts of polyhydric alcohol, 0.2-10 parts of emulsifier, 0.2-1 part of thickening stabilizer, 0.2-5 parts of appearance regulator, 2-10 parts of acidic pH regulator, 0.2-5 parts of preservative efficacy agent, 0.5-10 parts of anti-irritant and the balance of deionized water.
2. The mild liquid glycine surfactant crystalline facial cleanser of claim 1 and method of making same, wherein: the glycine surfactant is sodium cocoyl glycinate or potassium cocoyl glycinate.
3. The mild liquid glycine surfactant crystalline facial cleanser of claim 1 and method of making same, wherein: the auxiliary surfactant is one or a combination of two or more of lauramidopropyl hydroxysultaine, cocamidopropyl betaine, sodium lauroamphoacetate, sodium cocoamphoacetate, lauryl hydroxysultaine, sodium cocoylmethyltaurate, sodium lauroyltaurate, sodium cocoylglutamate, sodium cocoamidopropionate, sodium lauroyl sarcosinate, coconut fatty acid monoethanolamide, alkyl glycoside, cocamidoMEA, cocamidomethyl MEA, and disodium fatty alcohol sulfosuccinate.
4. The mild liquid glycine surfactant crystalline facial cleanser of claim 1 and method of making same, wherein: the polyalcohol is one or the combination of two or more of glycerol, propylene glycol, butanediol, sorbitol and erythritol.
5. The mild liquid glycine surfactant crystalline facial cleanser of claim 1 and method of making same, wherein: the emulsifier is one or a combination of two or more of polyglycerol 10-laurate, polyglycerol 10-myristate, polyglycerol 10-stearate, glycerol monostearate, glycerol monolaurate, glycerol monooleate, glycerol distearate and glycerol tristearate.
6. The mild liquid glycine surfactant crystalline facial cleanser of claim 1 and method of making same, wherein: the thickening stabilizer is one or the combination of two or more of PEG-150 distearate, PEG-120 methyl grape dioleate, PEG-150 pentaerythritol tetrastearate, PEG-150 distearate and hydroxypropyl starch phosphate.
7. The mild liquid glycine surfactant crystalline facial cleanser of claim 1 and method of making same, wherein: the appearance regulator is lauroyl lysine or ethylene glycol distearate.
8. The mild liquid glycine surfactant crystalline facial cleanser of claim 1 and method of making same, wherein: the acidic pH regulator is citric acid or lactic acid aqueous solution.
9. The mild liquid glycine surfactant crystalline facial cleanser of claim 1 and method of making same, wherein: the antiseptic agent is one or a combination of two or more of sodium benzoate, phenoxyethanol, hexanediol, ethylhexyl glycerol, p-hydroxyacetophenone, octanediol and caprylyl hydroximic acid.
10. The mild liquid glycine surfactant crystalline facial cleanser of claim 1 and method of making same, wherein: the moisturizing anti-irritant is one or a combination of two or more of hydrolyzed corn starch, maltotetraose, glycerol glucoside, avenanthramide, dendrobium officinale extract, purslane extract, fructus cnidii extract, selfheal extract and emblic leafflower fruit extract.
11. The mild liquid glycine surfactant crystalline facial cleanser of claim 1 and method of making same, wherein: the manufacturing method comprises the following steps:
the method comprises the following steps: mixing deionized water, liquid amino acid surfactant, auxiliary surfactant, polyalcohol, emulsifier, thickening stabilizer and appearance regulator, heating at high temperature for dissolving, maintaining temperature, adding acidic pH regulator, and dissolving; the high-temperature heating temperature is 75-85 ℃.
Step two: cooling the mixture, stirring with a stirrer for a certain time, adding the antiseptic agent and the moisturizing anti-irritant agent at 45 ℃, continuously stirring, cooling to room temperature, and discharging; the stirring speed of the stirrer for the first time is 50-150 revolutions per minute, and the stirring time is 60-90 minutes.
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