CN114794131A - Acaricidal composition containing Spidoxamat and spirodiclofen - Google Patents

Abstract

The invention relates to an acaricidal composition containing Spidoxamat and spirodiclofen, wherein the effective active components are Spidoxamat and spirodiclofen, and the weight ratio of Spidoxamat and spirodiclofen is 1:10-10:1. The composition can also be made into various formulations with other pesticide adjuvants, and a certain mass ratio can be used to produce synergistic effect, which can reduce the dosage of the pesticide and slow down the generation of drug resistance of mites.

Description

A kind of acaricidal composition containing Spidoxamat and spirodiclofen

technical field

The invention relates to a compound acaricide and its application, in particular to a composition containing Spidoxamat and spirodiclofen as main active components, belonging to the technical field of compound pesticides.

technical background

Mites belong to Arachnida, and most common pest mites belong to the order Acarina and Acarina. As one of the important pests of crops, they often harm various economic crops. Due to the strong fecundity, serious overlapping of generations, small individuals, concealed active parts, and rapid resistance increase, the pest mites have become one of the pests that are difficult to control. At present, most of the acaricides are aimed at a certain period or stage of injuring mites, such as hexythifen, tetramethicone, and spirodiclofen, which mainly kill the eggs of mites, but are ineffective against adult mites; propargite and abamectin mainly kill nymphs. As for adult mites, there are not many effective agents on the market for the prevention and control of harmful mites throughout the growth period, including pyridaben and spirodiclofen, so the compounding of pharmaceuticals and the development of new acaricides have attracted much attention.

Spidoxamat is a spirocyclic quaternary ketone ester acaricide. Its IUPAC name is: 11-(4-Chloro-2,6-dimethylphenyl)-12-hydroxy-1,4-dioxa-9-azabispiro[4.2.48.25]tetradec-11 -En-10-one; CAS accession number: 907187-07-9; Molecular formula: C19H22CINO4. The structure is as follows:

The mechanism of action of spirodiclofen is to inhibit the fat synthesis in the body of the mites, destroy the energy metabolism of the mites, and finally kill the mites. The control features are broad-spectrum killing of mites, larvae killing, long lasting effect, low toxicity, good safety, and no cross-resistance with other acaricides. According to the classification standard of pesticide toxicity in my country, spirodiclofen is a low-toxic acaricide. It is widely used in the control of various mites, such as spider mites apple, citrus panclaw mites, cotton spider mites, cinnabar spider mites, tarsus mites rust mites), Trichophyllidae (grape short mites). However, the single preparation has the defects of easy to produce resistance and slow action speed in the process of use.

So far, there is no relevant report on the combination of Spidoxamat and spirodiclofen to control pest mites.

SUMMARY OF THE INVENTION

The present invention is used in combination with Spidoxamat and spirodiclofen, and can be used for preventing and controlling various agricultural pest mites such as red spider mites, two-spotted spider mite, cinnabar leaf mites and the like on fruits, vegetables and crops.

The present invention is realized through the following technical solutions.

One aspect of the present invention relates to an acaricidal composition, the effective active ingredients of which are Spidoxamat and spirodiclofen, and the weight ratio of Spidoxamat and spirodiclofen is 1:10-10:1, preferably 1:10-1:1 , the better one is 1:5.

Further, the acaricidal composition also contains adjuvants or fillers that are allowed to be used and accepted in pesticides.

Further, the pesticide formulation known in the art can be prepared from the acaricidal composition, and the specific pesticide formulation is one of conventional formulations such as suspending agent, water dispersible granule, emulsifiable concentrate, wettable powder and the like. Optional auxiliary agents include, but are not limited to: solvents, emulsifiers, wetting and dispersing agents, thickeners, stabilizers, antifreeze agents, pH adjusters, carriers or fillers, and the like.

Further, the acaricidal composition in the present invention is preferably prepared as a suspension, wherein the active ingredients Spidoxamat and spirodiclofen are used in an amount of 1-75%.

In the preparation of the above formulations, any commonly used auxiliaries in the processing of pesticide formulations can be selected, such as:

Wetting and dispersing agents can be selected: polyoxyethylene alkyl phenol ether, dodecylbenzene sulfonate, lignin sulfonate, naphthalene sulfonate formaldehyde condensate, naphthalene sulfonate formaldehyde condensate sodium salt, fatty alcohol polymer Oxyethylene ether, fatty alcohol polyoxyethylene ether phosphate, nonylphenol polyoxyethylene ether, sodium lauryl sulfate, sodium polyoxyethylene lauryl ether carboxylate, calcium dodecylbenzenesulfonate, isooctyl alcohol One or more of sodium succinate sulfonate, sodium oleoyl methyl taurate, sodium lauroyl sarcosinate, dioctyl sulfosuccinate, polycarboxylate, etc.

The thickener can be selected from: one or more of xanthan gum, magnesium aluminum silicate, sodium alginate, sodium carboxymethyl cellulose, and gum arabic.

Antifreeze can be selected from one or more of glycerol, ethylene glycol and propylene glycol.

The defoamer can be selected from one or more of silicone defoamer, isobutyl phosphate and n-octanol.

The optional pH adjuster can be selected from one or more of citric acid and phosphoric acid.

The acaricidal composition of the present invention is used for crops, fruits and vegetables to prevent and control harmful mites. The harmful mites include citrus spider mites, two-spotted spider mites, cinnabar leaf mites, and the like.

Compared with the prior art, the present invention has the following advantages:

The present invention is a novel compound composition, when the mass ratio of Spidoxamat and spirodiclofen is 1:10-1:1, the composition has a significant synergistic effect on Tetranychus two-spotted mites; the dosage of pesticides can be reduced, and the Delay drug resistance. Therefore, the composition has wide application prospects in the field of acaricides.

Detailed ways

The following examples are helpful to understand the present invention, but do not limit the content of the present invention.

1. Determination of indoor acaricidal activity

1. Determination of drug toxicity

Test insect source: two-spotted spider mite, collected in the field, raised indoors;

Test reagents: Spidoxamat TC, Spirofenac TC;

Test method: refer to (Li Jianjian, Indoor virulence and field efficacy test of 9 kinds of acaricides against Tetranychus chinensis on strawberries, Northwest Agricultural Journal) using the leaf dipping method, select female adult mites with the same physiological state, and access the growth conditions On the leaves of good strawberries, cut them off after the activity of the tested mites is stable, and each leaf has 40 adult mites. According to the pre-test results, 5 dilution concentrations and 1 blank control were set for each drug, respectively, the leaves were immersed in the pre-prepared drug, shaken gently, taken out after 10s, and the excess drug solution was absorbed with filter paper and placed in the culture. On the dish, in order to prevent the leaves from dehydration and the escape of the two-spotted spider mites, the leaf margins were wrapped with moist absorbent cotton, and each treatment was repeated 4 times. The body of the mites was touched, the feet and limbs of the mites did not move, and those who did not respond were recorded as dead individuals. The total number of mites, the number of dead and the number of survival in each treatment were counted.

Mortality = (number of dead mites/number of tested mites) × 100%;

Adjusted death rate = (death rate of treatment group - death rate of control group) / (1 - death rate of control group) × 100%

The obtained data were processed by DPS, the virulence regression equation was established, the LC ₅₀ value and the co-toxicity coefficient (CTC) of the compounded drug were calculated respectively.

The combined effect of the mixture was evaluated. Based on LC ₅₀ , the type of the combined effect of the mixture was evaluated by calculating the co-toxicity coefficient of the mixture.

The standard of co-toxicity coefficient is that CTC≥120 is synergistic effect, 80≤CTC<120 is additive effect, and CTC<80 is antagonistic effect.

2. Test results

Table 1 shows the indoor toxicity test results of Spidoxamat and Spirofenafen. The results show that both agents have acaricidal effect. The LC ₅₀ of Spidoxamat is 0.3943mg/L, and the LC ₅₀ of Spidoxamat is 26.9157mg/L. The combination of the two agents showed a certain synergistic effect in a specific ratio. When the mass ratio of Spidoxamat and spirodiclofen is 1:10-1:1, the composition has a significant synergistic effect on Tetranychus two-spotted; when the mass ratio of Spidoxamat and spirodiclofen is 5:1-10: At 1, the composition had an additive effect on Tetranychus two-spotted mites. When the composition exhibits a synergistic effect, the dosage of the medicament can be reduced and the generation of mites resistance can be slowed down.

Table 1 Determination of indoor virulence of different ratios of Spidoxamat and spirodiclofen against Tetranychus two-spotted

Second, the preparation example

Example 1: 24% Spidoxamat·Spirodifen Suspension

Spidoxamat 4wt%, Spirofenac 20wt%, Polycarboxylate D-425 4wt%, Calcium Lignosulfonate 4wt%, Xanthan Gum 0.2wt%, Magnesium Aluminum Silicate 0.1%, Glycerol 3wt%, Silicone 0.2wt% of antifoaming agent, 1wt% of bentonite, and 100% of deionized water.

Example 2: 10% Spidoxamat·Spirodifen Suspension

Spidoxamat 5wt%, Spirofena 5wt%, Polycarboxylate D-425 3wt%, Calcium Lignosulfonate 3wt%, Xanthan Gum 0.3wt%, Magnesium Aluminum Silicate 0.1%, Glycerol 2wt%, Silicone 0.2wt% of antifoaming agent, 1wt% of bentonite, and 100% of deionized water.

Example 3: 22% Spidoxamat·Spirodifen Suspension

Spidoxamat 2wt%, Spirofenac 20wt%, Polycarboxylate D-425 5wt%, Calcium Lignosulfonate 2wt%, Xanthan Gum 0.4wt%, Magnesium Aluminum Silicate 0.2%, Glycerol 4wt%, Silicone 0.3wt% of antifoaming agent, 1wt% of bentonite, and 100% of deionized water.

Example 4 24% Spidoxamat · Spirofenac wettable powder

Spidoxamat 4wt%, spirodiclofen 20wt%, sodium lauryl sulfate 8%, calcium lignosulfonate 4wt%, silica 5wt%, kaolin supplement 100%.

Example 5 20% Spidoxamat·Spirobifen wettable powder

Spidoxamat 10wt%, spirodiclofen 10wt%, sodium lauryl sulfate 6%, calcium lignosulfonate 8wt%, silica 3%, kaolin supplement 100%.

Example 6 33% Spidoxamat·Spirobifen wettable powder

Spidoxamat 3wt%, spirodiclofen 30wt%, sodium lauryl sulfate 7%, calcium lignosulfonate 4wt%, silica 4%, kaolin supplement 100%.

3. Field efficacy test

1. Test crops and pests: two-spotted spider mite in pepper; the test period is the pepper fruiting period, and the growth is good;

2. Test agents: Examples 1-6 agents

3. Test method: Set up plots according to Table 2, each treatment is repeated 4 times, the plot area is 35m2, and it is arranged in random blocks. The pesticides were sprayed twice at an interval of 7 days; the base number of insect populations was investigated before the application, and the number of residual insects was investigated 7 and 14 days after the second application. Investigation method: Sampling at 5 points in each plot, 5 pepper plants in each point, a total of 25 plants in each plot, 5 leaves were fixed in the middle and upper part of each pepper plant, and the number of two-spotted spider mites was investigated on fixed plants.

4. Test results

Table 2 shows the results of the field efficacy test of Spidoxamat and spirodiclofen for the control of Tetranychus two-spotted mites. From Table 2, it can be seen that different examples have better control effects on Tetranychus two-spotted mites. Compared with the wettable powder, in the Under the condition of the same dilution ratio, the suspension agent prepared by the present invention can significantly improve the control effect.

Table 2 Test results of preventing and controlling Tetranychus two-spotted mites in different embodiments

All similar substitutes and modifications apparent to those skilled in the art are deemed to be included within the scope of the present invention.

Claims (8)

1. The acaricidal composition is characterized in that the effective active ingredients are Spidoxamat and spirodiclofen, and the weight ratio of Spidoxamat to spirodiclofen is 1: 10-10: 1.

2. an acaricidal composition according to claim 1, characterized in that the weight ratio of Spidoxamat to spirodiclofen is preferably 1:10 to 1: 1.

3. a miticidal composition according to claim 2, characterized in that the weight ratio of Spidoxamat to spirodiclofen is further preferably 1: 5.

4. An acaricidal composition according to any one of claims 1 to 3, characterized in that it further comprises adjuvants or fillers permitted and accepted in pesticides.

5. A miticidal composition according to claim 4, in the form of suspension, water dispersible granules, emulsifiable concentrate or wettable powder.

6. An acaricidal composition according to claim 5, characterized in that the formulation of the acaricidal composition is preferably a suspension concentrate.

7. Use of the acaricidal composition according to any one of claims 1 to 6 for crops, fruits and vegetables for the control of acarids.

8. The use of claim 7, wherein the pest mites comprise tetranychus cinnabarinus or tetranychus urticae.