CN114474482A - A kind of preparation technology of bioceramic-degradable polymer composite granulation - Google Patents

Abstract

The invention discloses a preparation process of bioceramic-degradable polymer composite granulation, comprising: mixing bioceramic powder and degradable polymer material powder in proportion, putting them into a ball mill, and using large, medium and small grinding balls Perform mechanical ball milling to obtain composite powder, put the composite powder into the vacuum system for vacuum drying; put the composite powder into the extruder, start the water-cooled strand pelletizing system, water circulation system, blow dryer and pelletizer. Extruder basis, cooling molding, cutting into granules to obtain bioceramic-degradable polymer composite materials. The invention combines the advantages of mechanical ball milling and extrusion granulation technology, and utilizes the strong impact force, shear force and rolling force of the mechanical ball milling process to achieve uniform mixing of ceramics and polymers; It can realize the plasticization, packaging and granulation of ceramics and polymers, and prepare a composite material that meets the requirements of regenerating tissues and organs.

Description

A kind of preparation technology of bioceramic-degradable polymer composite granulation

technical field

The invention belongs to the technical field of biological material preparation, and more particularly, the invention relates to a preparation process of bioceramic-degradable polymer composite granulation.

Background technique

Bioceramics have good biocompatibility, bioactivity and tissue conductivity due to their similarity in composition and structure to the inorganic components of human hard tissues, but they have problems such as poor toughness, high brittleness, and slow degradation rate; high biodegradability Molecular materials have good biocompatibility, biodegradability, non-toxicity, and good mechanical compatibility and formability. They are the most used scaffold materials in tissue regeneration and repair, but the disadvantage is that their mechanical strength is poor. , does not have biological activity and tissue conductivity. Therefore, a single bioceramic or biodegradable polymer material is not an ideal tissue repair and regeneration material. By compounding two or more materials together, complementary properties can be achieved and the properties of the materials are better.

The uniform dispersion of bioceramic particles in degradable polymer materials is the key to determine the properties of their composites. At present, the commonly used dispersion methods mainly include ultrasonic dispersion, mechanical stirring, and mechanical ball milling. Among them, mechanical ball milling can repeatedly impact, grind, and shear the powder by applying a discontinuous high strain rate, changing the size, characteristic length, shape, etc. of the powder, so as to cause the powder to plastically deform, fracture, and refine the agglomerated powder. So as to promote the uniform dispersion of ceramic particles in the polymer material. In addition, the ball milling process will generate mechanical driving force and thermodynamic driving force, and the combination of the two forces can induce the forced mixing of chemical substances in the solid, thereby enhancing the uniformity of ceramic and polymer blends at the atomic scale.

It should be pointed out that the composite powder after mechanical ball milling is only combined by simple mechanical embedding, surface adsorption, physical contact, etc., and the binding force is weak. Differences reappear stratified. As a thermoplastic composite process, extrusion granulation process can generate plastic heat dissipation, viscous heat dissipation and mutual friction heat between powders in the extrusion process, and promote the melting, mixing and dispersion of composite powders; at the same time, this process The rotation of the screw can generate strong extrusion force, tensile force and shear force, which can cause the composite powder to plastically deform, realize the plasticization, wrapping and granulation of the composite powder, so as to maintain the uniformity of the ceramic in the polymer material matrix. dispersion.

SUMMARY OF THE INVENTION

SUMMARY OF THE INVENTION An object of the present invention is to address at least the above-mentioned problems and/or disadvantages and to provide at least the advantages that will be described hereinafter.

In order to achieve these objects and other advantages according to the present invention, a preparation process of bioceramic-Hakka coagulation polymer composite granulation is provided, comprising:

Preferably, the process includes mechanical ball milling and extrusion granulation, wherein the mechanical ball milling process includes: after mixing the bioceramic powder and the degradable polymer material powder in proportion, put it into a ball mill, and use large, medium and small The grinding ball is subjected to mechanical ball milling to obtain composite powder, and the composite powder is put into a vacuum system for vacuum drying;

The extrusion granulation process is carried out after the mechanical ball milling. The extrusion granulation process includes: setting the temperature of each zone of the extruder, setting the residual heat time and temperature, setting the screw speed, material residence time, melt pressure, starting the feeding motor, Put the composite powder into the extruder, start the water-cooled strand pelletizing system, the water circulation system, the dryer and the pelletizer. Molecular composites.

Preferably, wherein, in the mechanical ball milling process, the mass ratio of large, medium and small grinding balls is 1:1:1 to 1:5:7;

The large, medium and small grinding balls are all zirconia balls, wherein the diameter ranges of the large, medium and small zirconia balls are 3-4 cm, 1-3 cm and 0-1 cm respectively; The weight ratio of the total mass of the bioceramic powder and the degradable polymer material powder is 1:1-1:20.

Preferably, the particle size of the bioceramic powder is 1-300 μm, and the particle size of the biodegradable polymer material powder is 1-300 μm.

Preferably, the mass ratio of the bioceramic powder to the biodegradable polymer powder is 1:1 to 1:30; the bioceramic powder is one of bioceramic HA powder or bioceramic BaTiO ₃ powder The degradable polymer material powder is one of degradable polymer PLA powder or degradable polymer PGA powder.

Preferably, when the mechanical ball milling process is performed, the frequency conversion parameters of the ball mill are set, firstly rotate clockwise, the rotational speed is 100-300 rad/min, the ball milling time is 10-30 minutes, and the stop is 1-5 minutes; then rotate counterclockwise, and the rotational speed is 100～300rad/min, ball milling time is 10～30min, stop for 1～5min; cycle back and forth, total ball milling time is 3～7h, obtain uniformly dispersed bioceramic-degradable polymer mixed powder.

Preferably, the vacuum degree of the vacuum system is 99.99%, the temperature of vacuum drying is 60-70° C., and the drying time is 3-7 hours.

Preferably, the extruder is a twin-screw extruder, and the barrel of the twin-screw extruder includes six temperature zones, which are the first zone and the second zone from the feeding port to the extrusion port. , the third zone, the fourth zone, the fifth zone and the sixth zone, wherein the temperature of the first zone is 100～400℃, the temperature of the second zone is 100～400℃, the temperature of the third zone is 100～400℃, and the temperature of the fourth zone is 100～400℃. The temperature of the zone is 100～400℃, the temperature of the fifth zone is 100～400℃, and the temperature of the sixth zone is 100～400℃; the preheating time is set to 1～3h, and the preheat temperature is 100～400℃.

Preferably, the screw speed of melt blending is set to be 10-300rad/min; the material residence time is 1-5min, the melt pressure is 3-15MPa; the feeding speed is 1-100kg/h; The temperature is 0-10℃; the cutting speed is 1-3m/min.

Preferably, after the bioceramic powder and the degradable polymer material powder are mixed in proportion, the mixed powder of the bioceramic powder and the degradable polymer material powder is dispersed with a dispersant before being put into the ball mill, and the The preparation method of dispersant comprises the following steps:

S1, by weight, weigh 8-12 parts of paraffin, 2-4 parts of graphite powder, 0.5-1 part of medical polycarbonate, 1-1.5 parts of polyacrylamide, 50-80 parts of ethanol, 4-7 parts of amino acid, Add paraffin and medical polycarbonate to the ethanol solution, stir and mix evenly to obtain mixed solution A, and let stand for 1-2 hours;

S2, add polyacrylamine to mixed solution A, and heat up solution A to 60～80 ℃, after heating up, stir at a rotating speed of 200 rpm to obtain mixed solution B; after mixed solution B is cooled to 25 ℃, add graphite to it Powder, ultrasonically disperse for 60-140min, and the ultrasonic frequency is 20-50kHz to obtain mixed slurry A;

S3. Heat the mixed slurry A to 35-50°C, add amino acids to the mixed slurry, conduct ammoniation on the mixed slurry, stir at a speed of 160-300 rpm, stir for 20 minutes, and let stand for 4 hours after stirring to obtain ammoniation The mixed slurry B is separated from solid and liquid, and the solid is dried and pulverized, and the pulverized particle size is 500-1000 mesh to obtain a dispersant;

The specific method of using a dispersant to disperse the mixed powder of the bioceramic powder and the degradable polymer material powder includes: using an ethanol solution as a dispersion medium, adding the mixed powder to the ethanol solution, and the mass fraction of the ethanol solution is 10-30% , the mass ratio of the ethanol solution to the mixed powder is 7-10:1, add a dispersant to the ethanol solution, and carry out ultrasonic dispersion, the ultrasonic dispersion frequency is 60-100kHz; the dispersion time is 1-2h, and the dispersed slurry is obtained; The dispersion slurry is subjected to solid-liquid separation, and the solids are dried and pulverized to obtain dispersed mixed powder;

Wherein, the mass ratio of dispersant to mixed powder is 1:500-1200; the amino acids are tryptophan, methionine, threonine, valine, lysine, histidine, leucine, isoleucine One of acid, alanine, phenylalanine, cystine, cysteine, and arginine.

The present invention includes at least the following beneficial effects:

(1) The present invention is difficult to meet the performance requirements of tissue repair and regeneration for a single bioceramic or biodegradable polymer material. By compounding two or more materials together, the advantages of the materials are complemented and the performance of the materials is better.

(2), the present invention combines the advantages of mechanical ball milling and extrusion granulation technology. On the one hand, the powerful impact force, shear force and rolling force of the mechanical ball milling process are used to achieve uniform mixing of ceramics and polymers; The excellent melting, extrusion and mixing capabilities of the granulation process can be achieved, and the plasticization, packaging and granulation of ceramics and polymers can be realized, thereby preparing a composite material that meets the requirements of regeneration of tissues and organs.

(3) The present invention uses a dispersant to disperse the bioceramic powder and the degradable polymer material powder, which improves the mixing uniformity of the two, so that the prepared composite material has more excellent mechanical properties; Paraffin and graphite powder are the main raw materials, and the harmless medical carbonate and polyacrylamide are additives, and the mixed slurry is ammoniated with amino acid, so that a small amount of paraffin, medical polycarbonate and polyacrylamide can adhere or adsorb in the form of a small amount. Absorbed by graphite powder, the particle size of the graphite powder is fuller and the surface structure is smooth. During the dispersion process of the composite powder, the agglomeration of the bioceramic powder and the degradable polymer powder is reduced. And polymer material powder has a good dispersion effect.

(4), in order to obtain the best ball milling effect in the present invention, the mass ratio of large, medium and small grinding balls is set to 1:1:1～1:5:7, and the diameter ranges of large, medium and small zirconia balls are respectively taken as 3 to 4 cm, 1 to 3 cm and 0 to 1 cm, the inventors found that the ratio of the diameter of the grinding balls has a great influence on the performance of the final material. If the proportion of large balls is too large, the grinding and dispersing composite powder will be uneven, which in turn affects the granulation of the extruder; If the proportion of large powder balls is too small, there may be shaking during the movement of the ball mill, or there may be large particles of powder that have not been ball-milled. The particle size of the bioceramic powder used in the present invention is 1-300 μm, and the particle size of the biodegradable polymer material powder is 1-300 μm. The inventors found that the particle size of the biodegradable polymer material powder has a great influence on the final material properties. If the particle size is too large, the doping will be uneven on the formed composite material, thereby affecting the effect of the extruder, and finally reducing the mechanical properties of the composite matrix.

The mass ratio of the bioceramic powder and the biodegradable polymer material powder used in the present invention is set to be 1:1 to 1:30. The inventor found that the mass ratio will affect the pH and degradation of the composite granulated product in the human body simulated solution soaking experiment. time.

The invention sets the frequency conversion parameters of the ball mill, firstly rotates clockwise, the rotation speed is 100-300rad/min, the ball milling time is 10-30min, and the stop is 1-5min; -30min, stop for 1-5min; cycle back and forth, the total time of ball milling is 3-7h, and a uniformly dispersed bioceramic-degradable polymer mixed powder is obtained. The inventors found that each time set by the ball milling will affect the effect of uniform dispersion, and if the time is too short, obvious single material agglomeration will occur.

The barrel of the twin-screw extruder used in the present invention is divided into first-sixth zones, the temperature of the first zone is 100-400°C, the temperature of the second zone is 100-400°C, and the temperature of the third zone is 100-400°C , the temperature of the fourth zone is 100-400°C, the temperature of the fifth zone is 100-400°C, and the temperature of the sixth zone is 100-4000°C; the preheating time is set to 1-3h, and the preheating temperature is 100-400°C. The inventor found that the temperature will affect whether the material is completely melted, which in turn affects whether it can be smoothly extruded.

When the present invention performs extrusion granulation, the feeding speed is set to 1-100kg/h. The inventors found that if the feeding speed is too fast, the screw blockage will occur.

Other advantages, objects, and features of the present invention will appear in part from the description that follows, and in part will be appreciated by those skilled in the art from the study and practice of the invention.

Description of drawings

Fig. 1 is the general structure diagram of the present invention;

Fig. 2 is the structure diagram of double inlet and outlet cooling pipes of the present invention;

Fig. 3 is the detailed structure diagram of the feeding unit of the present invention;

Fig. 4 is the top plan view of the screed table of the present invention;

Fig. 5 is the top view structure diagram of the batching box of the present invention;

FIG. 6 is a top plan view of the push-pull plate of the present invention;

Fig. 7 is a side structural view of one of the twin screws of the present invention;

Fig. 8 shows the external spline teeth of one of the twin screws of the present invention.

Detailed ways

The present invention will be further described in detail below, so that those skilled in the art can implement it with reference to the description.

It should be understood that terms such as "having", "comprising" and "including" as used herein do not exclude the presence or addition of one or more other elements or combinations thereof.

It should be noted that, in the description of the present invention, the azimuth or positional relationship indicated by the terms is based on the azimuth or positional relationship shown in the accompanying drawings, which is only for the convenience of describing the present invention and simplifying the description, and does not indicate or imply that A device or element must have a particular orientation, be constructed and operate in a particular orientation, and therefore should not be construed as limiting the invention. Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be construed to indicate or imply relative importance.

In the description of the present invention, unless otherwise expressly specified and limited, the terms "installed", "provided with", "sleeved/connected", "connected", etc., should be understood in a broad sense, for example, "connected" may be A fixed connection can also be a detachable connection, or an integral connection, a mechanical connection, an electrical connection, a direct connection, an indirect connection through an intermediate medium, or an internal connection between two components. Those of ordinary skill in the art can understand the specific meanings of the above terms in the present invention in specific situations.

In addition, in the present invention, unless otherwise expressly specified and limited, a first feature "on" or "under" a second feature may be in direct contact with the first and second features, or the first and second features through the middle indirect contact with the media. Also, the first feature being "above", "over" and "above" the second feature may mean that the first feature is directly above or obliquely above the second feature, or simply means that the first feature is level higher than the second feature. The first feature being "below", "below" and "below" the second feature may mean that the first feature is directly below or obliquely below the second feature, or simply means that the first feature has a lower level than the second feature.

Example 1:

Weigh 0.1kg of bioceramic HA powder with a particle size of 10um and 0.9kg of biodegradable polymer material PLA powder with a particle size of 20um according to the mass ratio of 1:9, add the two into the ball mill and add the large, medium and The mass ratio of small grinding balls is 1:1:1 (the ratio of balls to material is 1:1). First, the clockwise rotation speed is 100rad/min, the ball milling time is 10min, and the stop is 1min; then the counterclockwise rotation speed is 100rad/min, the ball milling time is 10min, and the stoppage time is 1min; Degradable polymer mixed powder. Using the above-mentioned composite powder as the raw material, set the temperature of the first-sixth zone of the barrel of the twin-screw extruder, the temperature of the first zone is 170 ℃, the temperature of the second zone is 175 ℃, the temperature of the third zone is 170 ℃, The temperature of the fourth zone is 160°C, the temperature of the fifth zone is 180°C, and the temperature of the sixth zone is 160°C; the preheating time is 1h; the preheating temperature is 160°C; the screw speed of melt blending is 50rad/min; the material residence time is 1min; the melt pressure is 3MPa; the feeding speed is 10kg/h; the temperature of the cooling and forming system is 3℃; the cutting speed is 1m/min.

In the microstructure test, it was found that the HA powder and the PLA powder could be mostly uniformly dispersed, and a small amount of HA self-agglomeration and PLA self-agglomeration appeared.

The ball-milled composite powder can be extruded on a twin-screw extruder, and the extruded strands are basically smooth, with a diameter of 3mm, but there will be intermittent filaments.

The prepared composite granulation product was subjected to a human body simulated solution soaking experiment. The volume ratio of the material to be soaked to the human body simulated solution was 1:5 of the degradation product, and the soaking temperature was 37 °C. pH; degradation time is 6 months.

The mechanical properties of the composite granulated product were tested, and the compressive strength was 8 MPa and the tensile strength was 6 MPa.

Example 2:

Weigh 0.2kg of bioceramic HA powder with a particle size of 10um and 0.8kg of biodegradable polymer material PLA powder with a particle size of 20um according to the mass ratio of 1:4, add the two into the ball mill and add the large, medium and The mass ratio of small grinding balls is 1:3:5 (the ratio of balls to material is 1:1). First, the clockwise rotation speed is 100rad/min, the ball milling time is 10min, and the stop is 1min; then the counterclockwise rotation speed is 100rad/min, the ball milling time is 10min, and the stoppage time is 1min; Degradable polymer mixed powder. Using the above-mentioned composite powder as the raw material, set the temperature of the first-sixth zone of the barrel of the twin-screw extruder, the temperature of the first zone is 170 ℃, the temperature of the second zone is 175 ℃, the temperature of the third zone is 170 ℃, The temperature of the fourth zone is 160°C, the temperature of the fifth zone is 180°C, and the temperature of the sixth zone is 160°C; the preheating time is 1h; the preheating temperature is 160°C; the screw speed of melt blending is 50rad/min; the material residence time is 1min; the melt pressure is 3MPa; the feeding speed is 10kg/h; the temperature of the cooling and forming system is 3℃; the cutting speed is 1m/min.

In the microstructure test, it was found that the HA powder and the PLA powder were basically uniformly dispersed, and a small amount of HA self-agglomeration and PLA self-agglomeration occurred.

The ball-milled composite powder can be extruded on a twin-screw extruder, and the extruded strands are smooth, with a diameter of 3mm, but intermittent filaments often appear.

The prepared composite granulation product was subjected to a human body simulated solution soaking experiment. The volume ratio of the material to be soaked to the human body simulated solution was 1:5 for degradation products, and the soaking temperature was 37 °C. After soaking for 28 days, the test pH value was 6.2, which was slightly smaller than that of human body fluids. pH; degradation time is 7 months.

The mechanical properties of the composite granulated product were tested, and the compressive strength was 10.0 MPa and the tensile strength was 8.7 MPa.

Example 3:

Weigh 0.2kg of bioceramic HA powder with a particle size of 10um and 0.8kg of biodegradable polymer material PLA powder with a particle size of 20um according to the mass ratio of 1:4, add the two into the ball mill and add the large, medium and The mass ratio of small grinding balls is 1:3:5 (the ratio of balls to material is 1:1). First, the clockwise speed is 200rad/min, the ball milling time is 20min, and the stop is 2min; then the counterclockwise rotation is 200rad/min, the ball milling time is 20min, and the stop is 2min; Degradable polymer mixed powder. Using the above-mentioned composite powder as the raw material, set the temperature of the first-sixth zone of the barrel of the twin-screw extruder, the temperature of the first zone is 170 ℃, the temperature of the second zone is 175 ℃, the temperature of the third zone is 170 ℃, The temperature of the fourth zone is 160°C, the temperature of the fifth zone is 180°C, and the temperature of the sixth zone is 160°C; the preheating time is 1h; the preheating temperature is 160°C; the screw speed of melt blending is 50rad/min; the material residence time is 1min; the melt pressure is 3MPa; the feeding speed is 10kg/h; the temperature of the cooling and forming system is 3℃; the cutting speed is 1m/min.

In the microstructure test, it was found that the HA powder and the PLA powder were basically uniformly dispersed, and there was no self-agglomeration of HA and PLA.

The ball-milled composite powder can be extruded on a twin-screw extruder, and the extruded strands are smooth, with a diameter of 3mm, but intermittent filaments often appear.

The prepared composite granulation product was subjected to a human body simulated solution soaking experiment. The volume ratio of the material to be soaked to the human body simulated solution was 1:5 for degradation products, and the soaking temperature was 37 °C. After soaking for 28 days, the test pH value was 6.15, which was slightly smaller than that of human body fluids. pH; degradation time is 7 months.

The mechanical properties of the composite granulated product were tested, and the compressive strength was 11.2 MPa and the tensile strength was 9.6 MPa.

Example 4:

Weigh 0.2kg of bioceramic HA powder with a particle size of 10um and 0.8kg of biodegradable polymer material PLA powder with a particle size of 20um according to the mass ratio of 1:4, add the two into the ball mill and add the large, medium and The mass ratio of small grinding balls is 1:3:5 (the ratio of balls to material is 1:1). First, the clockwise speed is 200rad/min, the ball milling time is 20min, and the stop is 2min; then the counterclockwise rotation is 200rad/min, the ball milling time is 20min, and the stop is 2min; Degradable polymer mixed powder. Using the above-mentioned composite powder as the raw material, set the temperature of the first to sixth zones of the barrel of the twin-screw extruder, the temperature of the first zone is 180 ° C, the temperature of the second zone is 185 ° C, the temperature of the third zone is 185 ° C, The temperature of the fourth zone is 185°C, the temperature of the fifth zone is 190°C, and the temperature of the sixth zone is 190°C; the preheating time is 1.5h; the preheating temperature is 190°C; the screw speed of melt blending is 50rad/min; the material residence time The melt pressure is 3MPa; the feeding speed is 10kg/h; the cooling and forming system temperature is 3℃; the pelletizing speed is 1m/min.

In the microstructure test, it was found that the HA powder and the PLA powder were basically uniformly dispersed, and there was no self-agglomeration of HA and PLA.

The ball-milled composite powder can be extruded on a twin-screw extruder, and the extruded strands are smooth, with a diameter of 3mm, but occasionally there will be intermittent filaments.

The prepared composite granulation product was subjected to a human body simulated solution soaking experiment. The volume ratio of the material to be soaked to the human body simulated solution was 1:5 for degradation products, and the soaking temperature was 37 °C. After soaking for 28 days, the test pH value was 6.15, which was slightly smaller than that of human body fluids. pH; degradation time is 7 months.

The mechanical properties of the composite granulated product were tested, and the compressive strength was 11.5 MPa and the tensile strength was 9.7 MPa.

Example 5:

Weigh 0.2kg of bioceramic HA powder with a particle size of 10um and 0.8kg of biodegradable polymer material PLA powder with a particle size of 20um according to the mass ratio of 1:4, add the two into the ball mill and add the large, medium and The mass ratio of small grinding balls is 1:3:5 (the ratio of balls to material is 1:1). First, the clockwise speed is 200rad/min, the ball milling time is 20min, and the stop is 2min; then the counterclockwise rotation is 200rad/min, the ball milling time is 20min, and the stop is 2min; Degradable polymer mixed powder. Using the above-mentioned composite powder as the raw material, set the temperature of the first to sixth zones of the barrel of the twin-screw extruder, the temperature of the first zone is 180 ° C, the temperature of the second zone is 185 ° C, the temperature of the third zone is 185 ° C, The temperature of the fourth zone is 185°C, the temperature of the fifth zone is 190°C, and the temperature of the sixth zone is 190°C; the preheating time is 1.5h; the preheating temperature is 190°C; the screw speed of melt blending is 50rad/min; the material residence time The melt pressure is 4MPa; the feeding speed is 10kg/h; the cooling and forming system temperature is 3℃; the pelletizing speed is 1m/min.

In the microstructure test, it was found that the HA powder and the PLA powder were basically uniformly dispersed, and there was no self-agglomeration of HA and PLA.

The ball-milled composite powder can be extruded on a twin-screw extruder, and the extruded strands are smooth, with a diameter of 3mm, and the strands are smooth.

The prepared composite granulation product was subjected to a human body simulated solution soaking experiment. The volume ratio of the material to be soaked to the human body simulated solution was 1:5 for degradation products, and the soaking temperature was 37 °C. After soaking for 28 days, the test pH value was 6.15, which was slightly smaller than that of human body fluids. pH; degradation time is 7 months.

The mechanical properties of the composite granulated product were tested, and the compressive strength was 11.7 MPa and the tensile strength was 9.9 MPa.

Example 6:

According to the mass ratio of 3:7, weigh 0.3kg bioceramic HA powder with a particle size of 10um and 0.7kg biodegradable polymer material PLA powder with a particle size of 20um, add the two into the ball mill and add the large, medium, and The mass ratio of small grinding balls is 1:3:5 (the ratio of balls to material is 1:1). First, the clockwise speed is 200rad/min, the ball milling time is 20min, and the stop is 2min; then the counterclockwise rotation is 200rad/min, the ball milling time is 20min, and the stop is 2min; Degradable polymer mixed powder. Using the above-mentioned composite powder as the raw material, set the temperature of the first to sixth zones of the barrel of the twin-screw extruder, the temperature of the first zone is 180 ° C, the temperature of the second zone is 185 ° C, the temperature of the third zone is 185 ° C, The temperature of the fourth zone is 185°C, the temperature of the fifth zone is 190°C, and the temperature of the sixth zone is 190°C; the preheating time is 1.5h; the preheating temperature is 190°C; the screw speed of melt blending is 50rad/min; the material residence time The melt pressure is 4MPa; the feeding speed is 10kg/h; the cooling and forming system temperature is 3℃; the pelletizing speed is 1m/min.

In the microstructure test, it was found that the HA powder and the PLA powder were basically uniformly dispersed, and there was no self-agglomeration of HA and PLA.

The ball-milled composite powder can be extruded on a twin-screw extruder, and the extruded strands are smooth, with a diameter of 3mm, and the strands are smooth.

The prepared composite granulation product was subjected to a human body simulated solution soaking experiment. The volume ratio of the material to be soaked to the human body simulated solution was 1:5 of the degradation product, the soaking temperature was 37 °C, and after soaking for 28 days, the test pH value was 7.3, which belongs to human body fluid pH; degradation time is 10 months.

The mechanical properties of the composite granulated product were tested, and the compressive strength was 15 MPa and the tensile strength was 10.9 MPa.

Example 7

Weigh 0.3kg of bioceramic HA powder with a particle size of 10um and 0.7kg of biodegradable polymer material PLA powder with a particle size of 20um according to the mass ratio of 3:7. The mixed powder of the material PLA powder is dispersed, and the preparation method of the dispersant comprises the following steps:

S1. Weigh 8g of paraffin, 2g of graphite powder, 0.5g of medical polycarbonate, 1g of polyacrylamide, 150g of ethanol, and 4g of alanine by weight, add paraffin and medical polycarbonate to the ethanol solution, and stir Mix evenly to obtain mixed solution A, which is left to stand for 1 hour;

S2. Add polyacrylamine to the mixed solution A, and heat the solution A to 60° C., and stir at a rotational speed of 200 rpm after heating to obtain a mixed solution B; after the mixed solution B is cooled to 25° C., add graphite powder to it, Ultrasonic dispersion was carried out for 60 min, and the ultrasonic frequency was 20 kHz to obtain mixed slurry A;

S3. Heat the mixed slurry A to 35°C, add alanine to the mixed slurry, aminate the mixed slurry, stir at a speed of 160 rpm, stir for 20 min, and let stand for 4 h after stirring to obtain an ammoniated mixture Slurry B, solid-liquid separation, drying and pulverizing the solid, and the pulverized particle size is 500 meshes to obtain a dispersant;

The specific method of using a dispersant to disperse the mixed powder of the bioceramic powder and the degradable polymer material powder includes: using an ethanol solution as a dispersion medium, adding the mixed powder to the ethanol solution, the mass fraction of the ethanol solution is 20%, and the ethanol solution is 20%. The dosage of the solution is 7kg, 2g of dispersant is added to the ethanol solution, and ultrasonic dispersion is carried out, and the ultrasonic dispersion frequency is 60kHz; the dispersion time is 1h, and a dispersed slurry is obtained; Pulverized to obtain dispersed mixed powder;

Add the dispersed mixed powder into the ball mill tank and add the large, medium and small grinding balls in a mass ratio of 1:3:5 (the ball-to-material ratio is 1:1). First, the clockwise speed is 200rad/min, the ball milling time is 20min, and the stop is 2min; then the counterclockwise rotation is 200rad/min, the ball milling time is 20min, and the stop is 2min; Degradable polymer mixed powder. Using the above-mentioned composite powder as the raw material, set the temperature of the first zone to the sixth zone of the twin-screw extruder, the temperature of the first zone is 180 ° C, the temperature of the second zone is 185 ° C, the temperature of the third zone is 185 ° C, and the temperature of the first zone is 185 ° C. The temperature of the fourth zone is 185°C, the temperature of the fifth zone is 190°C, and the temperature of the sixth zone is 190°C; the preheating time is 1.5h; the preheating temperature is 190°C; the screw speed of melt blending is 50rad/min; the material residence time The melt pressure is 4MPa; the feeding speed is 10kg/h; the cooling and forming system temperature is 3℃; the pelletizing speed is 1m/min.

In the microstructure test, it was found that the HA powder and PLA powder had good dispersion uniformity, and there was no self-agglomeration of HA and PLA.

The ball-milled composite powder can be extruded on a twin-screw extruder, and the extruded strands are smooth, with a diameter of 3m and smooth strands.

The prepared composite granulation product was subjected to a human body simulated solution soaking experiment. The volume ratio of the material to be soaked to the human body simulated solution was 1:5 of the degradation product, the soaking temperature was 37 °C, and after soaking for 28 days, the test pH value was 7.3, which belongs to human body fluid pH; degradation time is 7 months.

The mechanical properties of the composite granulated product were tested, and the compressive strength was 22 MPa and the tensile strength was 11.8 MPa.

Example 8

Weigh 0.3kg of bioceramic HA powder with a particle size of 10um and 0.7kg of biodegradable polymer material PLA powder with a particle size of 20um according to the mass ratio of 3:7. The mixed powder of the material PLA powder is dispersed, and the preparation method of the dispersant comprises the following steps:

S1. Weigh 12g of paraffin, 4g of graphite powder, 1g of medical polycarbonate, 1.5g of polyacrylamide, 80g of ethanol, 7g of lysine by weight, add paraffin and medical polycarbonate to the ethanol solution, stir and mix Evenly, get mixed solution A, let stand for 2h;

S2. Add polyacrylamine to the mixed solution A, and heat the solution A to 80° C. After heating up, stir at a rotational speed of 200 rpm to obtain a mixed solution B; after the mixed solution B is cooled to 25° C., add graphite powder to it, Ultrasonic dispersion was carried out for 140 min, and the ultrasonic frequency was 50 kHz to obtain mixed slurry A;

S3. Heat the mixed slurry A to 50°C, add lysine to the mixed slurry, aminate the mixed slurry, stir at a speed of 300 rpm, stir for 20 minutes, and let stand for 4 hours after stirring to obtain an ammoniated mixture Slurry B, solid-liquid separation, drying and pulverizing the solid, and the pulverized particle size is 1000 mesh to obtain a dispersant;

The specific method of using a dispersant to disperse the mixed powder of the bioceramic powder and the degradable polymer material powder includes: using an ethanol solution as a dispersion medium, adding the mixed powder to the ethanol solution, the mass fraction of the ethanol solution is 30%, and the ethanol solution is 30%. The dosage of the solution is 10kg, 1g of dispersant is added to the ethanol solution, and ultrasonic dispersion is performed, and the frequency of ultrasonic dispersion is 100kHz; the dispersion time is 2h, and a dispersed slurry is obtained; Pulverized to obtain dispersed mixed powder;

Add the dispersed mixed powder into the ball mill tank and add the large, medium and small grinding balls in a mass ratio of 1:3:5 (the ball-to-material ratio is 1:1). First, the clockwise speed is 200rad/min, the ball milling time is 20min, and the stop is 2min; then the counterclockwise rotation is 200rad/min, the ball milling time is 20min, and the stop is 2min; Degradable polymer mixed powder. Using the above-mentioned composite powder as the raw material, set the temperature of the first to sixth zones of the barrel of the twin-screw extruder, the temperature of the first zone is 180 ° C, the temperature of the second zone is 185 ° C, the temperature of the third zone is 185 ° C, The temperature of the fourth zone is 185°C, the temperature of the fifth zone is 190°C, and the temperature of the sixth zone is 190°C; the preheating time is 1.5h; the preheating temperature is 190°C; the screw speed of melt blending is 50rad/min; the material residence time The melt pressure is 4MPa; the feeding speed is 10kg/h; the cooling and forming system temperature is 3℃; the pelletizing speed is 1m/min.

In the microstructure test, it was found that the HA powder and PLA powder had good dispersion uniformity, and there was no self-agglomeration of HA and PLA.

The ball-milled composite powder can be extruded on a twin-screw extruder, and the extruded strands are smooth, with a diameter of 3mm, and the strands are smooth.

The prepared composite granulation product was subjected to a human body simulated solution soaking experiment. The volume ratio of the material to be soaked to the human body simulated solution was 1:5 of the degradation product, the soaking temperature was 37 °C, and after soaking for 28 days, the test pH value was 7.3, which belongs to human body fluid pH; degradation time is 8 months.

The mechanical properties of the composite granulated product were tested, and the compressive strength was 23 MPa and the tensile strength was 12.1 MPa.

Figures 1-8 show the schematic structural diagrams of the twin-screw extruders used in Examples 1-8, including:

The segmented barrel 1 includes a plurality of heating barrels 11 arranged at intervals; a cooling unit 2 is arranged between the plurality of the heating barrels 11; The feeding unit 3; the segmented barrel 1 is provided with an extrusion unit 4 for exporting materials.

Working principle: When using the present invention, the materials to be processed are introduced into the feeding unit 3, and the 3 feeding units successively feed the materials into the segmented cylinder 1, and install the pre-set heating cylinders 11 at all levels. Heating temperature, the heating device inside the heating barrel 11 uniformly heats and melts the material, and extrudes the material while evenly stirring the material through the extrusion unit 4. The barrel 11 is cooled and cooled accordingly, so that the material is circulated in the segmented barrel 1 according to the process of heating→cooling→heating→cooling in the whole process of melting, stirring and extrusion, and finally until the molten material is exported, and finally Just send the material. The twin-screw extruder shown in FIG. 1 is provided with 6 heating barrels 11, which correspond to the first temperature zone, the second temperature zone, the Three temperature zones, fourth temperature zone, fifth temperature zone and sixth temperature zone.

The advantage of this technical solution is that the present invention adopts the plurality of heating barrels 11 in the segmented barrel 1 to cooperate with the cooling units 2 arranged at intervals, so as to realize precise and independent temperature control of different processing sections (heating barrels 11 ). , which solves the common problem of local high temperature degradation caused by the inability of rapid temperature response in the traditional molten material extrusion process, so that the bioceramic-degradable polymer mixed powder with uniform physical properties can be produced with high stability and high productivity.

In the above technical solution, the cooling unit 2 includes: a cooling barrel 21 is arranged between a plurality of the heating barrels 11; Water tank 22; a water pump is provided inside the cooling water tank 22, and a cooling water inlet main pipe 23 and a cooling water outlet main pipe 24 are respectively connected to the input end and the output end; a built-in cooling water inlet pipe 23 and the cooling water outlet main pipe 24 are arranged between the cooling water main pipe 23 and the cooling water outlet main pipe 24 cooling manifolds 25 of multiple water circuits; dual inlet and outlet cooling pipes 26 are respectively provided between the plurality of cooling barrels 21 and the cooling manifolds 25; the dual inlet and outlet cooling pipes 26 respectively include an inner cooling pipe 261 and an outer cooling pipe Pipe 262; both ends of the inner cooling pipe 261 (ie, the water inlet end and the water outlet end) are butted to the cooling manifold 25; the middle of the inner cooling pipe 261 is wound into multiple circles, and is fitted and fixed to the outer wall of the cooling barrel 21 ; The two ends of the outer cooling pipe 262 (ie the water inlet end and the water outlet end) are butted to the cooling manifold 25; A double-in and double-out cooling water channel is formed; both ends of the inner cooling pipe 261 and the outer cooling pipe 262 are arranged in front and back along the axis of the cooling barrel 21 , and the cooling barrel 21 is on the same side.

The advantages of this technical solution are:

(1) The various components in the cooling unit 2 together form a "double-in and double-out" water channel system, which further improves the cooling efficiency of each cooling barrel 21, and cooperates with the segmented barrel 1 to solve the problem of biological problems under the traditional process. The melt extrusion of ceramic-degradable polymer mixed powder has a common problem of local high temperature degradation due to the inability to respond quickly to temperature, so that the materials in the segmented barrel 1 can be carried out differently in the cooling barrels 21 arranged at intervals. Through such a process, the preparation efficiency and finished product quality of melt extrusion of bioceramic-degradable polymer mixed powder can be significantly improved;

(2) Compared with the single-channel cooling, this kind of double-inlet and double-outlet cooling pipes has better heat transfer effect; at the same time, the use of the double-inlet-outlet cooling pipe 26 with the outer ring wrapping the inner ring means that the water outlet end of the outer ring is used for cooling. It can take away the heat of the inner ring, and the cooling water inlet end can take away the heat of the cooling water outlet end, which is a circulating cooling mode, so that the heat transfer effect is better, the cylinder body is cooled evenly, and it is not easy to deform;

(3) At the same time, the dual water channels of the dual inlet and outlet cooling pipes 26 are arranged in the front and rear of the axis of the cooling barrel 21. Compared with the left and right arrangement of the traditional dual water channels, the length of the cooling area does not increase, but it saves installation space and saves material cost.

In the above technical solution, the feeding unit 3 includes a batching bucket 31; the batching bucket 31 has four built-in guide bins 32 with upper ends open; the middle of the four guide bins 32 is integrally connected with a support column 321; The bottoms of the four guide bins 32 are slanted toward the middle, converge together to form leaks, and extend downward to form discharge pipes 322; the leaks are arranged at intervals below the support column 321; the bottoms of the four guide bins 32 The upper part is slidably provided with a step-by-step discharge plate 33 that can be pulled out to the outside; four sides of the bottom of the four guide bins 32 are provided with chute I; The slide bars I of the two chutes I are respectively embedded to form a sliding connection; the lower ends of the support columns 321 are provided with a plurality of limit slots 320; the front ends of the four step-by-step discharge plates 33 are provided with handles; The rear end of the step-by-step discharge plate is provided with a wedge 330 which is inserted into the limiting groove 320; the four step-by-step discharge plates 33 are provided with four positioning pin holes 331 at intervals; the four guide bins 32 The sides are provided with sliding pins 323 which are vertically downward and match with the four positioning pin holes 331 .

The advantages of this technical solution are: firstly, the batching bucket 31 has four guide bins 32, which can realize pre-distribution and storage of bioceramic-degradable polymer mixed powder, which is convenient for preliminary mixing of different materials; the support column 321 is used for Connect the side walls of the four guide bins 32 to ensure more stable fixation; during the introduction of ingredients, the four positioning pin holes can be regarded as the size of the discharge volume of each guide bin, that is, more guides need to be invested. In the silo, the stepped discharge plate can be pulled out to the maximum extent, and the sliding pin 323 can be inserted into the positioning pin hole at the far right end of the stepped discharge plate to open a maximum space for the material to be exported. The positioning pin hole is fixed to control the amount of material flowing out of the guide bin; by performing different above configurations in four different guide bins, different mixing ratios of the exported materials can be formed in the four guide bins to achieve A function of adjusting the mixing ratio of materials, the mixed materials can be discharged downwards in a unified discharge pipe 322, and the unified discharge function of the mixed materials is completed.

In the above technical solution, a vibrating frame 34 is arranged in the batching bucket 31; the support column is a hollow structure; Linear bearings 342 are arranged at both ends of the support column 321; the upper end of the sliding rod 341 is fixedly arranged on the inner ring of one of the linear bearings 342, and a turning frame 35 is fixed after passing through; the upper end of the turning frame 35 is fixed The output end of the linear reciprocating motor 350 is connected; the turning frame 35 includes four turning rods 351 extending into the four material guide bins 32 respectively; the four turning rods 351 are provided with a plurality of Oblique rods 352; a plurality of turning material pieces 353 are arranged laterally on a plurality of the inclined rods 352; A material table 36; the screed table 36 is suspended in the discharge pipe 322; the screed table 36 is provided with a cross-structure turning claw 361; the upper ends of the four turning claw 361 are respectively provided with two A curved surface 362 abutting in the middle;

The advantages of this technical solution are:

(1) By using a vibrating frame 34 with a composite structure, the materials inside the four guide bins 32 are turned uniformly together; the sliding rod 341 is used as a sliding member to slide in the middle of the hollow fixed column 321, through two straight lines The bearing 342 performs stable up and down reciprocating motion, and the linear reciprocating motor 350 provides the motion power; after the four turning rods 351 extend into the guide bin 32 respectively, the turning rods 351 and the turning pieces on the plurality of inclined rods 352 cooperate with the turning rods 351 353, carry out a stable up and down cyclic turning of materials to ensure that the materials can be stably and uniformly exported from the bottom;

(2) The screeding table 36 under the vibrating frame also shakes up and down with the sliding bar 341, so that different materials gathered from four directions can be scattered, mixed into a more uniform state, and then discharged downward; at the same time The four turning claws 361 on the screed table move up and down continuously, which can prevent the accumulation of materials gathered in the discharge pipe 322 and improve the discharge efficiency; The material can slide and fall, and improve the overall discharge effect.

In the above technical solution, a screw feeder 30 is also included; the output end of the screw feeder 30 is connected to the first section of the segmented barrel 1; the lower end of the batching barrel 31 is integrally provided with a conical row The feeding funnel 311; the input end of the screw feeder 30 is connected to the lower port of the discharging funnel 311; the middle part of the discharging funnel 311 is slidably provided with a push-pull plate 37; the side surface of the discharging funnel 311 is provided through There is a strip-shaped sliding frame; sliding grooves II are arranged on both sides of the sliding frame; sliding bars II that can be respectively embedded in two sliding grooves II are provided on both sides of the push-pull plate 37, thereby realizing a slidable connection; The push-pull plate 37 is provided with large, medium and small restrictors that can be matched with the discharge pipe 322; elastic baffles 374 are provided on both sides of the middle restrictor 372; the small restrictor 371 and the large restrictor Fixed baffles 375 are respectively provided on one side of the lower flow restricting port 373 .

The advantage of this technical solution is that the operator can adjust the push-pull plate by sliding continuously, so that the different restrictor ports are connected to the lower port of the discharge pipe 322, so as to adjust the final discharge volume after the material is mixed; two elastic The baffle 374 can achieve the position limit to ensure that the middle flow restricting port 372 can be accurately connected to the lower port of the discharge pipe 322. At the same time, when the push-pull plate is dragged as a whole, the elastic baffle can be compressed, ensuring that the large flow restricting port 373 and the small restricting port 373 can be compressed. The flow port 371 can be slidably connected to the lower port of the discharge pipe 322, and the two fixed baffles can limit the sliding push-pull plate as a whole at the initial end and the extreme end, making it more stable.

In the above technical solution, the extrusion unit 4 includes: large-lead twin screws 41 arranged in opposite directions, which are axially rotatably penetrated in the segmented barrel 1; the twin screws 41 are externally splined. The teeth 410 are inclined by 1°.

The advantage of this technical solution is that the extrusion unit 4 adopts a twin screw 41 with an anisotropic large lead thread structure, which realizes the circumferential flow and material exchange of the polymer melt, and overcomes the long-term residence degradation of the heat-sensitive polymer. At the same time, the double-screw external spline teeth are inclined by 1°, and the involute small-angle spline connection technology is proposed, which ensures the stability of the shear stress on the runner wall and breaks through the runner. The key technical bottleneck of inner wall scaling and static layer formation.

In the above technical solution, a power unit is also included; the power unit includes: a feeding motor 51 and a main shaft motor 52; the feeding motor 51 is arranged in front of the feeding unit 3, and the main shaft motor 52 is arranged in a segmented The front of the barrel 1 is connected with the twin screw 41 through a gearbox 53 .

The advantages of this technical solution are: the feeding motor 51 and the spindle motor 52 configured in the power unit 5 provide stable and controllable power energy for the relevant operating equipment of the extrusion unit and the feeding unit, and the configuration is convenient and the material is squeezed out. out more stable.

In the above technical solution, a heating unit is also included; the heating unit includes: a solenoid valve, a heater, and a temperature control meter; there are multiple heaters 61 and are respectively arranged in the multiple heating cylinders 11 .

The advantages of this technical solution are: the heating capacity is provided for the heating barrel through the equipment in the heating unit, the configuration is convenient, and the heating temperature is easy to control.

In the above technical solution, a protection unit is also included; the protection unit includes: an inlet pipe 71, a booster pump 72, an outlet pipe 73, and a nitrogen tank 74; the input end of the booster pump 72 is connected to the nitrogen tank 74 through the gas outlet pipe 73. ; The output end of the booster pump 72 is connected to the first section of the segmented barrel 1 through the air outlet pipe 73 .

The advantage of this technical solution is that each equipment of the protection unit forms a pressurized nitrogen injection protection system. During the melt extrusion process of the bioceramic-degradable polymer mixed powder, nitrogen is continuously introduced for cooperation, which can effectively The thermo-oxidative degradation of the bioceramic-degradable polymer mixed powder in a high temperature environment is prevented, and the preparation quality of the material hot-melt mixture is improved.

In the above technical solution, an operation unit is also included; the operation unit includes a control frame 81 fixedly arranged on one side of the segmented barrel 1 ; the control frame 81 is provided with a display control screen 82 .

The advantages of this technical solution are: it is convenient for the operator to control the relevant operation equipment by manipulating the display control screen 82 in time, the control is convenient, and the parameter adjustment is timely.

The number of apparatuses and processing scales described here are intended to simplify the description of the present invention. Applications, modifications and variations to the present invention will be apparent to those skilled in the art.

Although the embodiment of the present invention has been disclosed as above, it is not limited to the application listed in the description and the embodiment, and it can be applied to various fields suitable for the present invention. For those skilled in the art, it can be easily Therefore, the invention is not limited to the specific details and illustrations shown and described herein without departing from the general concept defined by the appended claims and the scope of equivalents.

Claims (9)

1. a preparation technology of bioceramics-degradable polymer composite granulation, is characterized in that, comprises mechanical ball milling and extrusion granulation process, wherein said mechanical ball milling process comprises: bioceramic powder and degradable polymer material After the powder is mixed in proportion, it is put into a ball mill and mechanically ball-milled with large, medium and small grinding balls to obtain composite powder, which is put into a vacuum system for vacuum drying; The extrusion granulation process is carried out after the mechanical ball milling. The extrusion granulation process includes: setting the temperature of each zone of the extruder, setting the residual heat time and temperature, setting the screw speed, material residence time, melt pressure, starting the feeding motor, Put the composite powder into the extruder, start the water-cooled strand pelletizing system, the water circulation system, the dryer and the pelletizer. Molecular composites. 2. The preparation process of bioceramic-degradable polymer composite granulation according to claim 1, wherein in the mechanical ball milling process, the mass ratio of large, medium and small grinding balls is 1:1:1 ~1:5:7; The large, medium and small grinding balls are all zirconia balls, wherein the diameter ranges of the large, medium and small zirconia balls are 3-4 cm, 1-3 cm and 0-1 cm respectively; The weight ratio of the total mass of the bioceramic powder and the degradable polymer material powder is 1:1-1:20. 3 . The preparation process of bioceramics-degradable polymer composite granulation according to claim 1 , wherein the particle size of the bioceramic powder is 1-300 μm, and the particle size of the biodegradable polymer material powder is 1 μm. 4 . ~300μm. 4. The preparation process of bioceramic-degradable polymer composite granulation according to claim 1, wherein the mass ratio of the bioceramic powder to the biodegradable polymer material powder is 1:1～1: 30. The bioceramic powder is one of bioceramic HA powder or bioceramic BaTiO ₃ powder, and the degradable polymer material powder is one of degradable polymer PLA powder or degradable polymer PGA powder. 5. The preparation process of bioceramic-degradable polymer composite granulation as claimed in claim 1, characterized in that, when performing the mechanical ball milling process, the frequency conversion parameters of the ball mill are set, firstly rotate clockwise, and the rotating speed is 100～300rad/ min, ball milling time is 10-30min, stop for 1-5min; turn counterclockwise again, the speed is 100-300rad/min, ball-milling time is 10-30min, stop for 1-5min; cycle back and forth, the total ball milling time is 3-7h, A uniformly dispersed bioceramic-degradable polymer mixed powder is obtained. 6 . The preparation process of bioceramics-degradable polymer composite granulation according to claim 1 , wherein the vacuum degree of the vacuum system is 99.99%, the vacuum drying temperature is 60-70° C., and the drying time is 99.99%. 7 . For 3 ~ 7h. 7. The preparation process of bioceramic-degradable polymer composite granulation as claimed in claim 1, wherein the extruder is a twin-screw extruder, and the barrel of the twin-screw extruder comprises: Six temperature zones, from the feeding port to the extrusion port, are the first zone, the second zone, the third zone, the fourth zone, the fifth zone and the sixth zone, wherein the temperature of the first zone is 100～400℃, and the temperature of the first zone is 100～400℃. The temperature of the second zone is 100～400℃, the temperature of the third zone is 100～400℃, the temperature of the fourth zone is 100～400℃, the temperature of the fifth zone is 100～400℃, and the temperature of the sixth zone is 100～400℃; set The preheating time is 1～3h, and the preheating temperature is 100～400℃. 8. The preparation process of bioceramics-degradable polymer composite granulation according to claim 1, wherein the screw speed of melt blending is set to be 10-300 rad/min; The body pressure is 3-15MPa; the feeding speed is 1-100kg/h; the temperature of the cooling and forming system is 0-10℃; the pelletizing speed is 1-3m/min. 9. The preparation process of bioceramics-degradable polymer composite granulation as claimed in claim 1, characterized in that, after mixing bioceramic powder and degradable polymer material powder in proportion, before putting into a ball mill, use The dispersant disperses the mixed powder of the bioceramic powder and the degradable polymer material powder, and the preparation method of the dispersant comprises the following steps: S1, by weight, weigh 8-12 parts of paraffin, 2-4 parts of graphite powder, 0.5-1 part of medical polycarbonate, 1-1.5 parts of polyacrylamide, 50-80 parts of ethanol, 4-7 parts of amino acid, Add paraffin and medical polycarbonate to the ethanol solution, stir and mix evenly to obtain mixed solution A, and let stand for 1-2 hours; S2, add polyacrylamine to mixed solution A, and heat up solution A to 60～80 ℃, after heating up, stir at a rotating speed of 200 rpm to obtain mixed solution B; after mixed solution B is cooled to 25 ℃, add graphite to it Powder, ultrasonically disperse for 60-140min, and the ultrasonic frequency is 20-50kHz to obtain mixed slurry A; S3. Heat the mixed slurry A to 35-50 °C, add amino acids to the mixed slurry, conduct ammoniation on the mixed slurry, stir at a speed of 160-300 rpm, stir for 20 minutes, and let stand for 4 hours after stirring to obtain ammoniation The mixed slurry B is separated from solid and liquid, and the solid is dried and pulverized, and the pulverized particle size is 500-1000 mesh to obtain a dispersant; The specific method of using a dispersant to disperse the mixed powder of the bioceramic powder and the degradable polymer material powder includes: using an ethanol solution as a dispersion medium, adding the mixed powder to the ethanol solution, and the mass fraction of the ethanol solution is 10-30% , the mass ratio of the ethanol solution to the mixed powder is 7-10:1, add a dispersant to the ethanol solution, and carry out ultrasonic dispersion, the ultrasonic dispersion frequency is 60-100kHz; the dispersion time is 1-2h, and the dispersed slurry is obtained; The dispersion slurry is subjected to solid-liquid separation, and the solids are dried and pulverized to obtain dispersed mixed powder; Wherein, the mass ratio of dispersant to mixed powder is 1:500-1200; the amino acids are tryptophan, methionine, threonine, valine, lysine, histidine, leucine, isoleucine One of acid, alanine, phenylalanine, cystine, cysteine, and arginine.

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